PB0032

DATABASE

Click here to access PB0032 phyletic profile

PBID	Uniprot	Name	Gene	Alternative	Organism	Uniprot Description
PB0032	Q53GQ0	Very-long-chain 3-oxoacyl-CoA reductase	HSD17B12	hydroxysteroid 17-beta dehydrogenase 12, KAR, SDR12C1	Homo_sapiens	Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation.

Domains

Gene Ontology

PF00106 (adh_short)

GO:0001968 (enables) fibronectin binding GO:0004303 (enables) estradiol 17-beta-dehydrogenase activity GO:0005515 (enables) protein binding GO:0005518 (enables) collagen binding GO:0008201 (enables) heparin binding GO:0016491 (enables) oxidoreductase activity GO:0016509 (enables) long-chain-3-hydroxyacyl-CoA dehydrogenase activity GO:0044594 (enables) 17-beta-hydroxysteroid dehydrogenase (NAD+) activity GO:0050062 (enables) long-chain-fatty-acyl-CoA reductase activity GO:0072582 (enables) 17-beta-hydroxysteroid dehydrogenase (NADP+) activity GO:0102339 (enables) 3-oxo-arachidoyl-CoA reductase activity GO:0102340 (enables) 3-oxo-behenoyl-CoA reductase activity GO:0102341 (enables) 3-oxo-lignoceroyl-CoA reductase activity GO:0102342 (enables) 3-oxo-cerotoyl-CoA reductase activity GO:0006629 (involved in) lipid metabolic process GO:0006633 (involved in) fatty acid biosynthetic process GO:0006694 (involved in) steroid biosynthetic process GO:0006703 (involved in) estrogen biosynthetic process GO:0010811 (involved in) positive regulation of cell-substrate adhesion GO:0030198 (involved in) extracellular matrix organization GO:0035338 (involved in) long-chain fatty-acyl-CoA biosynthetic process GO:0005783 (located in) endoplasmic reticulum GO:0005789 (located in) endoplasmic reticulum membrane GO:0016020 (located in) membrane GO:0016021 (located in) integral component of membrane GO:0031012 (located in) extracellular matrix GO:0009923 (part of) fatty acid elongase complex

External Links	Description
Intact	Open source database system and analysis tools for molecular interaction data.
Protein Atlas	An open access resource for human proteins
InterPro (new pfam)	InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish) >sp|Q53GQ0|DHB12_HUMAN Very-long-chain 3-oxoacyl-CoA reductase OS=Homo sapiens OX=9606 GN=HSD17B12 PE=1 SV=2 MESALPAAGFLYWVGAGTVAYLALRISYSLFTALRVWGVGNEAGVGPGLGEWAVVTGSTD GIGKSYAEELAKHGMKVVLISRSKDKLDQVSSEIKEKFKVETRTIAVDFASEDIYDKIKT GLAGLEIGILVNNVGMSYEYPEYFLDVPDLDNVIKKMININILSVCKMTQLVLPGMVERS KGAILNISSGSGMLPVPLLTIYSATKTFVDFFSQCLHEEYRSKGVFVQSVLPYFVATKLA KIRKPTLDKPSPETFVKSAIKTVGLQSRTNGYLIHALMGSIISNLPSWIYLKIVMNMNKS TRAHYLKKTKKN >tr|A7MCK2|A7MCK2_DANRE Hsd17b12b protein OS=Danio rerio OX=7955 GN=hsd17b12b PE=2 SV=1 MEPFADALFWVGAVTVLWLSVSSLWSLINGIRVWILGNGNLMRASSLGKWAVVTGATDGI GKAYAEELARRGFAIVLISRTQEKLDEVSKAIESKYKVETKTISADFGSVDIYPKIESGL AGLEIGVLVNNVGVSYSYPEFFLNIPDVDSFINNMININIMSVCQMTRLVLPRMVDRSKG VILNVASASGMYPVPLLTLYSSTKAFVDFFSRGLDAEYKSKGIIIQSVLPFYVTTKLSKI RKPTLDIPTPERYVKAQLSTIGLQTQSNGYLPHAIMGWVTASLLPAKLLNKYVMGMGLSQ RARYLKKQKQG
Selected proteins from model organisms >NP_057226.1 very-long-chain 3-oxoacyl-CoA reductase [Homo sapiens] MESALPAAGFLYWVGAGTVAYLALRISYSLFTALRVWGVGNEAGVGPGLGEWAVVTGSTDGIGKSYAEEL AKHGMKVVLISRSKDKLDQVSSEIKEKFKVETRTIAVDFASEDIYDKIKTGLAGLEIGILVNNVGMSYEY PEYFLDVPDLDNVIKKMININILSVCKMTQLVLPGMVERSKGAILNISSGSGMLPVPLLTIYSATKTFVD FFSQCLHEEYRSKGVFVQSVLPYFVATKLAKIRKPTLDKPSPETFVKSAIKTVGLQSRTNGYLIHALMGS IISNLPSWIYLKIVMNMNKSTRAHYLKKTKKN >tr|A7MCK2|A7MCK2_DANRE Hsd17b12b protein OS=Danio rerio OX=7955 GN=hsd17b12b PE=2 SV=1 MEPFADALFWVGAVTVLWLSVSSLWSLINGIRVWILGNGNLMRASSLGKWAVVTGATDGI GKAYAEELARRGFAIVLISRTQEKLDEVSKAIESKYKVETKTISADFGSVDIYPKIESGL AGLEIGVLVNNVGVSYSYPEFFLNIPDVDSFINNMININIMSVCQMTRLVLPRMVDRSKG VILNVASASGMYPVPLLTLYSSTKAFVDFFSRGLDAEYKSKGIIIQSVLPFYVTTKLSKI RKPTLDIPTPERYVKAQLSTIGLQTQSNGYLPHAIMGWVTASLLPAKLLNKYVMGMGLSQ RARYLKKQKQG >XP_043338175.1 very-long-chain 3-oxoacyl-CoA reductase [Cervus canadensis] MESVLPATGFLYWVGAGTVAYLALRISCLLFTAVRVWGLGNESGVGPRLGEWAVVTGSTDGIGKSYAEELAKRGMKIVLI SRSQDKLNQVSSEIREKFKVETKTIAVDFTLEDIYDKIKTSLAGLEIGVLVNNVGMSYEYPEYFLDVPDLDNTIQKLINV NVLSVCKMTRLVLPRMVERSKGVILNISSATGMYPVPLLTIYSATKAFVDFFSQCLHEEYKSKGIFVQSVLPYYVATKLA KIRKPTLDKPSSETFVKSAIKTIGMQPRTNGYFIHSLMASVVSILPSWLYFKVTMNVNKSIRAHYLKKMKKN >XP_020763161.1 very-long-chain 3-oxoacyl-CoA reductase [Odocoileus virginianus texanus] MKIVLISRSQDKLNQVSSEIREKFKVETKTIAVDFTLEDIYDKIKTSLAGLEIGVLVNNVGMAYEYPEYFLDVPDLDSTI KKLINVNVLSVCKMTRLILPGMVERSKGVILNISSASGLYPVPLLTIYSATKAFVDFFSQCLHEEYKSKGIFVQSVLPYY VATKLAKIRKPTLDKPSSETFVKSAIKTIGMQSRTNGYFIHSLMASVVSILPSWLYFKVIMNVNKSVRAHYFKKMKKN >OCT82029.1 hypothetical protein XELAEV_18024537mg [Xenopus laevis] MAPESLAEVPGCNCFWYLGVVAATWWGLRAAWCLLNGARVWVLGSGAQVGPRIGKWAVVTGATDGIGKAYAEELARRGMN IVLISRSPEKLEEAAIHIKQKFKVETKIIAADFGKPTEIYERIEAGLRDLEIGVLVNNVGISYEYPEYFLEIPDLENTLD KMININIMSVCQMTRLVLPGMLGRGKGVVLNISSASGMYPVPLLTVYSATKAFVDFFSRGLHAEYRSKGVTVQSVLPFFV ATKLAKIRKPTWDKPSPETYVRSALNTVGLQTQTNGYLPHAIMGWISTSLVPVSAAISMGMKMNKGLRARFLKKAKQN >KAF4009401.1 hypothetical protein G4228_000209, partial [Cervus hanglu yarkandensis] VTGSTDGIGKSYAEELAKRGMKIVLISRSQDKLNQVSSEIREKFKVETKTIAVDFTLEDIYDKIKTSLAGLEIGVLVNNV GMSYEYPEYFLDVPDLDNTIQKLINVNVLSVCKVRKLIINISKGVILNISSATGMYPVPLLTIYSATKSVLPYYVATKLA KIRKPTLDKPSSETFVKSAIKTIGMQPRTNGYFIHSLMASVVSILPSWLYFKVTMNVNKSIRAHYLKKMKKN >XP_038053153.1 very-long-chain 3-oxoacyl-CoA reductase-B-like isoform X1 [Patiria miniata] MPEFTPFGALNPALATLGAVVAFYAVFRLVTSLLNGLKAFFLAGPLGLSANVKNYGDWAAVTGATDGIGKAYAEQLAAKG LNIILLSRSEDKLNNVAAEIESKYSVKTKTIAVDFTGGEEIYTKIAKEVAGLSIGVLVNNVGISYRFPEYFHEIPDRQKM LMNMLNLNCMSVTQMTSIVLPGMLDRKKGIVVNVSSASGMQPSPLLTVYSATKAYVDYLTRALQTEYASKGIIFQSVLPF FVSTKMSKIRRSSITIPTPTAFVRSALATLGIEDRTNGCLSHSIQGWVVDVAPAWLVNKVTVSMHLGIRKSALRRLEQKK VN >XP_030848589.1 very-long-chain 3-oxoacyl-CoA reductase-B [Strongylocentrotus purpuratus] MSSYVPPTVVINIFAVIGVIAALNKILRVLWSILKNVKTFILARPLGLATDPKRHGKWAVVTGATDGIGKAYAEQLAAKG LNIYLLSRSPDKLKDVATQIEQRYKVETKTFAVDFTGGGDIYPSIGDQLTGLDIGVLVNNVGMSYSFPQYFCELADAEKF LPNIININCLSVVMMTNLVLPGMVERKRGIIINVSSASGMNPSPMLTVYSATKVFVDFFSRGLDVEYRSKGIQVQSVMPF YVTTKLSKLRRETMTIPSPTSYVKTALATLGSGNRTNGCLMHNLQGWVVGSVPDWLLDSVQMSIHSAIRKVSLKKLAEKK TK >XP_039248329.1 very-long-chain 3-oxoacyl-CoA reductase-like [Styela clava] MECNCVAYIGLASLTYLSLRLLWDIYSGVKLYFLSNYPDFRQYGEWSVVTGATDGIGKATARVLAQRGQKIVLISRNLAK LQSTAKEIENDFNVETKIVRVDFTHDESIYEEISSEIKDLDIGVLVNNMGISYEHPEYFLQLPDLSATIMRMIRGNIMSV VKMTEIVLPGMADRKRGIILNITSAAALKPTPMLALYSASKDFVNHFSKSIAYEYEDQGIKIQSVMPFYVTTKLSKIRAS SLLVPTPEVYAKSMLRGAGVTKFTHGYWAHGLEGWIVRLLPNWVYAYIMLQKGEAIRQKAYKKKEWQKKNNSGEVKKEQ >XP_031563323.1 very-long-chain 3-oxoacyl-CoA reductase-B-like [Actinia tenebrosa] MVYSTALEVIGGCFIAYYLINLLRRAVTGLRAFVLPSLGIKKNLKSFGSWAVVTGCTDGIGKSFVYELAKEGINIVLMSR TLEKLQNLEAEIKSVYKVKTKVIAMDFSGGAEIYDGLDEKLDGLDIGILINNVGVSHYPEFFTNMKREDCWKMINVNDMS VIMMTHIILPGMVSRGKGVVMNISSRAGVEPLPLLSTYSSSKAFVDFFSEAIATEYAGKGIIVQSVMPLYVATKMSKIKR PSLFVPGPDDYARQALGTIGVEQRTNGCWSHSLQEFVVGLIPRWVREKLAWNILMASRRAVLKKLNQQGKQD >NP_572420.1 spidey [Drosophila melanogaster] MEENNSQVLSLLGGLAIGIVGFQVFRKVLPWIYANVVGPKVFGSSVDLSKMGEWAVVTGSTDGIGKAYAKELARRGLKLV LISRSLEKLNVVAKEIGDKYGVEVRVIDVDFTGGDEIYDKIREKTTGLNVGVLVNNVGISYGHPEYFLDCYKADPPFLRN IVAANIHSVTHMTALFLPGMISQRRGVIINVSSTAGVIPNPLLSVYSSTKAFVNKFSDDLQTEYKEHGILIQSVQPGFVA TNMSKIRKASVFAPSPETYVRSALSTLGIATQTAGYLPHALLQLVIHFTEAVFGEQFARNIVMKNILGTRKRALRRLAKE Q >CAE1306451.1 HSD17B12 [Sepia pharaonis] MHEEFINFIRYYLGPTTEYFSCLGFIIYALAMCRIMTSVLTLATQSLFSRNLGWMSRLTYLGEWAVITGSTDGIGKAYAE ELAALGLKIILISRSPEKLAAVAKEIEEAHKVEVRTIAVDFSDNESIYNKIKNELKGLDISILVNNVGMSYPHPEYFVEI PNRTETLSSLIKLNVVAMTMMTSIVLPDMVKKNCGVIVNVSSASAAGPCPLLTAYSACKAYVKYFSEGLSAEYSDKGVVI QCLMPFYVTTKMSKLRKSSAMVPTPTAYVKSSLSSLGISSCSFGYWSHNFLGWFTKTLPRFFLTCKKRKYNSVFPNLMKE TGFSYWFKYFTCRLWGGMVLNWISFMMLVTLTISVLASS >OWK16467.1 HSDL1 [Cervus elaphus hippelaphus] MAAMAAVDSFYLLYREIARSCNCYMEALALVGAWYTARKSITVVCDFYSLIRLHFIPRLVSRADLIKQYGRWAVVSGATD GIGRAYAEELASRGLNIVLISRNQEKLQMVAKDIADTYKVETDVIVADFSSGREIYDMIREALQDRDIGILVNNVGVFYP YPQYFTQVSEDTLWDIVNVNIAAASLMVHIVLPGMVERKKGAIVTISSGSCCKPTPQLAAFSASKAYLDHFSRALQYEYA SKGIFVQSLIPFYVATNVAAPGSFLHKCPWLVPSPKVYAHHAVSTLGISKRTTGYWSHSIQFLFAQYMPEWLWVWGANIL NRSLRKEALSCKA >KAB0350251.1 hypothetical protein FD754_015108 [Muntiacus muntjak] MAAVDSFYLLYREIARSCNCYMEALALVGAWYTARKSITVVCDFYSLIRLHFIPRLVSRADLIKQYGRWAVVSGATDGIG RAYAEELASRGLNIVLISRNQEKLQMVAKDIADTYKVETDIIVADFSSGREIYGVIREALQDRDIGILVNNVGVFYPYPQ YFTQVSEDTLWDIVNVNIAAASLMVHIVLPGMVERKKGAIVTISSGSCCKPTPQLAAFSASKAYLDHFSRALQYEYASKG IFVQSLIPFYVATNVASPGSFLHKCPWLVPSPKVYAHHAVSTLGISKRTTGYWSHSIQFLFAQYMPEWLWVWGANILNRS LRKEALSCKA >KAB0383238.1 hypothetical protein FD755_005155 [Muntiacus reevesi] MAAVDSFYLLYREIARSCNCYMEALALVGAWYTARKSITVVCDFYSLIRLHFIPRLVSRADLIKQYGRWAVVSGATDGIG RAYAEELASRGLNIVLISRNQEKLQMVAKDIADTYKVETDIIVADFSSGREIYGVIREALQDRDIGILVNNVGVFYPYPQ YFTQVSEDTLWDIVNVNIAAASLMVHIVLPGMVERKKGAIVTISSGSCCKPTPQLAAFSASKAYLDHFSRALQYEYASKG IFVQSLIPFYVATNVAAPGSFLHKCPWLVPSPKVYAHHAVSTLGISKRTTGYWSHSIQFLFAQYMPEWLWVWGANILNRS LRKEALSCKA >XP_001121130.1 very-long-chain 3-oxoacyl-CoA reductase [Apis mellifera] MSLTCWEKISFVLLGLFGLRILWRISVLVWKKLIGPNFGFGIDPKTQGKWAVITGATSGIGKAYAEQLAKKGLDIVLVSR SLSKLEEVAKEIKERYGVQVRIVDADLTEGQAVYAKIAKATEELEIGIVVNNAGASYNHPELFTNVSEESIAQILQLNVA SMTGVARALLPQMFERKKGILINISSATAVMPSPYLTVYAASKCYVIKLSEDLAAEAAPYGVTVQCIIPGPVATKMSKIT KPTWMAPTPEKYVKHTLKTIGLELCTTGYLPHGLLVASVNALRYICEKGTLWLVCKTMCNIRKRALKKKEKVVEKITNEE TSVTTK >NP_001254936.1 Very-long-chain 3-oxooacyl-coA reductase let-767 [Caenorhabditis elegans] MACQCFLVGAGYVALAAVAYRLLTIFSNILGPYVLLSPIDLKKRAGASWAVVTGATDGIGKAYAFELARRGFNVLLVSRT QSKLDETKKEILEKYSSIEVRTAAFDFTNAAPSAYKDLLATLNQVEIGVLINNVGMSYEYPDVLHKVDGGIERLANITTI NTLPPTLLSAGILPQMVARKAGVIVNVGSSAGANQMALWAVYSATKKYVSWLTAILRKEYEHQGITVQTIAPMMVATKMS KVKRTSFFTPDGAVFAKSALNTVGNTSDTTGYITHQLQLELMDLIPTFIRDKILTNMSVGTRAAALRKKEREAKSQ >NP_062631.1 very-long-chain 3-oxoacyl-CoA reductase [Mus musculus] MECAPPAAGFLYWVGASTIAYLALRASYSLFRAFQVWCVGNEALVGPRLGEWAVVTGGTDGIGKAYAEEL AKRGMKIVLISRSQDKLNQVSNNIKEKFNVETRTIAVDFSLDDIYDKIKTGLSGLEIGVLVNNVGMSYEY PEYFLEIPDLDNTIKKLININVLSVCKVTRLVLPGMVERSKGVILNISSASGMLPVPLLTIYSATKAFVD FFSQCLHEEYKSKGIFVQSVMPYLVATKLAKIQKPTLDKPSAETFVKSAIKTVGLQTRTTGYVIHSLMGS INSIMPRWMYFKIIMGFSKSLRNRYLKKRKKN >NP_114455.2 very-long-chain 3-oxoacyl-CoA reductase [Rattus norvegicus] MERALPAAGFLYWVGASTIAYLTLRASYSLFRAFQVWCVGNQAFVGPRLGEWAVVTGGTDGIGKSYAEEL AKRGMKIVLISRSQDKLKEVSNNIKEKFNVETRTIAVDFSLDDIYDKIKTGLSGLEIGVLVNNVGMSYEY PEYFLEIPDLDNTIKKLININVLSICKVTRLVLPGMVERSKGVILNISSASGMLPVPLLTVYSATKAFVD FFSQCLHEEYKSKGIFVQSVLPFFVATKLAKIRKPTLDKPSAETFVKSAIKTVGLQTRTTGYVIHAIMGS INSILPRWIYFKTIMGFNKSLRNRYLKKTKKN >XP_848504.1 very-long-chain 3-oxoacyl-CoA reductase isoform X1 [Canis lupus familiaris] MESALPAAGLLYWVGAGTVAYVALRLSCSLFTALRLWGLSHEAGVGPQLGEWAVVTGSTDGIGKSYAEEL AKHGMKVVLISRSQDKLNQVSSEIREKFKVETRTVAVDFASEDIYDKIKTSLAGLKIGVLVNNVGMSYEY PEYFLDVPDLDNTIKKLININVLSVCKMTRLVLPGMVERSKGAILNISSASGMAPVPLLAIYSATKAFVD FFSRCLHEEYRSKGIFVQSVLPYYVATKLSKIRKPTLDKPSAETYVKSAIQTVGLQSRTTGYLIHSLMDS IISAMPTWLYFKITMNLGKSTRARYMKKAKKN >XP_001158375.1 very-long-chain 3-oxoacyl-CoA reductase [Pan troglodytes] MESALPAAGFLYWVGAGTVAYLALRISYSLFTALRVWGVGNEAGVGPGLGEWAVVTGSTDGIGKSYAEEL AKHGMKVVLISRSKDKLDQVSSEIKEKFKVETRTIAVDFASEDIYDKIKTALAGLEIGILVNNVGMSYEY PEYFLDVPDLDNVIKKMININILSVCKMTQLVLPGMVERSKGAILNISSGSGMLPVPLLTIYSATKTFVD FFSQCLHEEYRSKGVFVQSVLPYFVATKLAKIRKPTLDKPSPETFVKSAIKTVGLQSRTNGYLIHALMGS IISNLPSWIYLKIVMNMNKSTRAHYLKKTKKN >XP_015142684.1 very-long-chain 3-oxoacyl-CoA reductase [Gallus gallus] MAVRERCRPRGAQAASSTGACGRALPSPSLPAARAQGGRGRPRRQVTARLSAPSANGSAAGAGAAAAAGR RWPGGFSPVAAASAGSMLAPAALPAAGLFYWVGALGVLYTAVLCAFRLLSGLRVWVLGGGRAVGPQLGAW AVVTGATDGIGKAYAEELARHGMKVALISRSKEKLDQVAGEIKEKYKVETKVIVADFGEREGIYDRIKAG LEGLEIGVLVNNVGISYSYPEYFIDVPDLDKMIDQMININIMSVCKMTRLVLPGMLERSKGVILNISSAA GMYPTPLLTLYSATKAFVDYFSRGLHAEYKSKGIIVQSVLPFYVATKLSKIRKPTFSKPSPETYVRAAIG TVGLQSQTNGCLPHAVMAWIFSILPTPAVKSLLMKTNKQVRARFLRKLKEK >NP_001094777.1 very-long-chain 3-oxoacyl-CoA reductase [Bos taurus] MESFLPATGFLYWVGVGTVAYLALRISCFLFTAVRVWGLGNESGVGPRLGEWAVVTGSTDGIGKSYAEKL AERGMKIVLISRSQDKLNQVSSEIREKFKVETKTIAVDFTLEDIYDKIKTSLAGLEIGVLVNNVGMSYEY PEYFLDIPDLDNTIKKLISVNVLSVCKMTQLVLPGMVERSKGVILNISSATGRYPVPLLTIYSATKAFVD FFSQCLHEEYKSKGIFVQSVLPFFVATKLAKIRKPTLDKPSSENFVKCAIKTIGVQSRTSGYFIHYLMAS VTSLLPSWLYFKIVMNVNKSFRARYFKKMKKN >XP_020938823.1 very-long-chain 3-oxoacyl-CoA reductase isoform X1 [Sus scrofa] METALPAAGFLYWVGASTVAYLALRISCWFFTALRVWGLGHEAGVGPWLGEWAVVTGGTDGIGKSYAEEL AKRGMKIVLISRSQDKLDQVSSEISEKFKVETKTIAVDFTSEDIYDKIKASLAGLNIGVLVNNVGMSYEY PEYFLDVPDLDNTIKKLITVNALSVCKMTRLVLPGMVERSKGAILNISSASGMYPVPLLTIYSATKAFVD FFSQCLHEEYKSKGVIVQSVLPYYVATKLAKIKRPTWDKPSPETFVKSAMKTIGVQSRTNGYPIHSLVAS VSASLPSWLYFKIAMYSGNSIRVRYLKKMKMN >XP_002709111.1 PREDICTED: very-long-chain 3-oxoacyl-CoA reductase [Oryctolagus cuniculus] METALPAAGFLYWVGAGTVAYLALRISYSLFWALRVWGVGNEAWVGPGLGEWAVVTGSTDGIGKSYAEQL AKRGMNVVLISRSQDKLNQVSNEIKEKFKVETRTIAVDFASEDIYNKIETGLAGLEIGVLVNNVGMSYEY PEYFLDIPDLDNTIKKLININVLSVCKMTRLVLPRMVERSKGAILNISSASGTFPVPLLTIYSATKAFVD FFSQCLHEEYRSKGIFVQSVLPYYVATKLAKIRKPTFDKPSSETFVKSAIKTVGLQSRTNGYLVHSLMGT IHSMLPSWVFVKISMDVNKSVRARYLKKYKKN >XP_024110605.1 very-long-chain 3-oxoacyl-CoA reductase [Pongo abelii] MESALPAAGFLYWVGAGTVAYLALRISYSLFTALRVWGMGNEAGVGPGLGEWAVVTGSTDGIGKSYAEEL AKHGMKVVLISRSQDKLDQVSSEIKEKFKVETRTIAVDFASEDIYDKIKTGLSGLEIGILVNNVGMSYEY PEYFLDVPDLDNVIKKMININILSVCKMTQLVLPGMVERSKGAILNISSGSGMLPVPLLTIYSATKTFVD FFSRCLHEEYRSKGVFVQSVLPYFVATKLAKIRKPTLDKPSPETFVKSAIKTVGLQSRTNGYLIHALMGS IISNLPSWIYFKIVMNMNKSTRAHHLKKTKKN >XP_003808259.1 very-long-chain 3-oxoacyl-CoA reductase [Pan paniscus] MESALPAAGFLYWVGAGTVAYLALRISYSLFTALRVWGVGNEAGVGPGLGEWAVVTGSTDGIGKSYAEEL AKHGMKVVLISRSKDKLDQVSSEIKEKFKVETRTIAVDFASEDIYDKIKTALAGLEIGILVNNVGMSYEY PEYFLDVPDLDNVIKKMININILSVCKMTQLVLPGMVERSKGAILNISSGSGMLPVPLLTIYSATKTFVD FFSQCLHEEYRSKGVFVQSVLPYFVATKLAKIRKPTLDKPSPETFVKSAIKTVGLQSRTNGYLIHALMGS IISNLPSWIYLKIVMNMNKSTRAHYLKKTKKN >XP_003993234.1 very-long-chain 3-oxoacyl-CoA reductase [Felis catus] MESALPAAGFLYWVGAGTVAYLALRISCSLFTALRVWGLSHEVGVGPGLGEWAVVTGSTDGIGKSYAEEL AKHGMKIVLISRSQDKLNQVSSEIREKFKVETMTIAVDFASEDIYDKIKTSLAGLKIGVLVNNVGVSYEY PEYFLDVPDLDNTIKKLINVNVLSVCKMTRLVLPGMVERSKGAILNISSASGLVPVPLLAMYSATKAFVD FFSQCLHEEYRSKGIFVQSVLPFFIATKLSKIRKPTLDTPSAETFVKSAIKTVGLQSRTTGYLIHSLMGS IISVMPTWLYFKITTNMGKSTRARYLKKAKKN >XP_004016470.1 very-long-chain 3-oxoacyl-CoA reductase [Ovis aries] MESVLPATGFLYWVGAGTVAYLALRILCWLFTAVRVWGLGNESGVGPRLGEWAVVTGSTDGIGKSYAEEL AKRGMKIVLISRSQDKLNQVSSEIREKFKVETKTVAVDFTLEDIYDKIKTSLAGLEIGVLVNNVGMSYEY PEYFLDVPDLDSTIKKLINVNVLSVCKMTRLVLPGMVERSKGVILNISSASGMYPVPLLTIYSATKAFVD FFSQCLHEEYKSKGIFVQSVLPYFVATKLAKIRRATLDKPSSETFVKSAIKTIGVQSRTNGYFIHSLLFS VASILPSWLYLKVSMNMNKSIRAHYFKKMKKN >XP_004051019.1 very-long-chain 3-oxoacyl-CoA reductase [Gorilla gorilla gorilla] MESALPAAGFLYWVGAGTVAYLALRISYSLFTALRVWGVGNEAGVGPGLGEWAVVTGSTDGIGKSYAEEL AKHGMKVVLISRSKDKLDQVSSEIKEKFKVETRTIAVDFASEDIYDKIKTGLAGLEIGILVNNVGMSYEY PEYFLDVPDLDNVIKKMININILSVCKMTQLVLPGMVERSKGAILNISSGSGMLPVPLLTIYSATKTFVD FFSRCLHEEYRSKGVFVQSVLPYFVATKLAKIRKPTLDKPSPEMFVKSAIKTVGLQSRTNGYLIHALMGS IISNLPSWIYLKIVMNMNKSTRAHYLKKTKKN >XP_004069451.1 very-long-chain 3-oxoacyl-CoA reductase-A [Oryzias latipes] MNRMNAEEMIRRAEPLFFWVGAFTLAFFALWLLYRLVTGFRIWVLGNGTLLSPKLGKWAVVTGATDGIGK SYAEELARRGFAMMLISRSQEKLDDVAKSLEEQFGVETKTIAVDFGKTDIYPKIEAGLVGLEIGVLVNNV GVSYHYPEYYLNIPDLDNFLTNMINVNMTSVCQMTRLVLPGMVSRAKGVILNISSASGMYPLPLLTVYSA TKAFMDFFSRGLQEEYRRQGIIIQSVLPFFVATKMTRIRKPTLDKPTPERYVAAELTTVGLQNQTNGYFP HAVMGWVTTKLVPTSIVIFLGASMNRVQRSGYLHRRKLREMKNGASLKSE >XP_013227387.2 very-long-chain 3-oxoacyl-CoA reductase [Columba livia] MEKVLVAQASPAGSQALWKCQLCLECGSTASIVCIFSVSTDHIVYYDMDTLRWGRFTEPAGRRWGPLESG EGAIAFPVPGSRYSRVVTGATDGIGKAYAEELARRGMKVALISRSKEKLDQVASEIKEKYKVETRVIVAD FGEREDIYSGIKSGLEGLEIGVLVNNVGISYVYPEYFLDVPDLDKTVDKMININIMAVCKMTRLVLPGML ERSKGVILNISSAAGMYPTPLLTLYSATKAFVDYFSRGLHAEYKSKGIIVQSVLPYYVATKMSKIRKPTF DKPSPETYVRAALGTVGLQSQTNGCLPHALMGWIFSLLPTPTIINFLMKTNKGIRARYLKKMKEK >XP_005690184.1 PREDICTED: very-long-chain 3-oxoacyl-CoA reductase [Capra hircus] MESVLPATGFLYWVGAGTVAYLALRILCWLFTAVRVWGLGNESGVGPRLGEWAVVTGSTDGIGKSYAEEL AKRGMKIVLISRSQDKLNQVSSEIREKFKVETKTVAVDFTLEDIYDKIKTSLAGLEIGVLVNNVGMSYEY PEYFLDVPDLDNTIKKLINVNVLSVCKMTRLVLPGMVERSKGVILNISSASGMYPVPLLTIYSATKAFVD FFSQCLHEEYKSKGIFVQSVLPYFVATKLAKIRKATLDKPSSETFVKSAIKTIGVQSRTNGYFIHSLLFS VASILPSWLYLKVSMNMNKSIRAHYFKKMKKN >XP_014377653.1 very-long-chain 3-oxoacyl-CoA reductase, partial [Alligator sinensis] EKFNVETKIIVADFGEREDIYTKIKAALEGLEIGVLVNNVGISYAYPEYFLDVPDLDNTIDKMININIMS VCKMTRLVLPGMLERSKGAILNISSASGMFPTPLLTLYSGTKAFVDFFSQGLHAEYKSKGIIVQSVLPYY VATKMARIRKPTFDKPSPETYVKAALGTVGLQSRTNGCLPHAIMGWFMSLFPTSTVVNFTMSRNKQVRAR FLKKAKAN >XP_014457595.1 PREDICTED: very-long-chain 3-oxoacyl-CoA reductase isoform X1 [Alligator mississippiensis] MATIASLPAAGFLYWVGALSAAYVTLRAGYCLVAGLRVWVLGRRVLPGPGLGAWAVVTGATDGIGKAYAE ELARCGMKIALISRSQEKLDQVASQIKEKFNVETKIIVADFGEREDIYTKIKAALEGLEIGVLVNNVGIS YAYPEYFLDVPDLDNTIDKIININIMSVCKMTRLVLPGMLERSKGVILNISSASGMFPVPLLTLYSGTKA FVDFFSQGLHAEYKSKGIIVQSVLPYFVATKMARIRKPTFDKPSPETYVKAALGTVGLQSRTNGCLPHAI MGWFTSLFPTSTVVNFTMSHNKKVRARFLKKVKAN >XP_031409404.1 very-long-chain 3-oxoacyl-CoA reductase [Meleagris gallopavo] MTRLVLPGMLERSKGVILNISSAAGMYPTPLLTLYSATKAFVDYFSRGLHAEYKSKGIIVQSVLPYYVAT KLSKIRKPTFSKPSPETFVRAAIGTVGLQSQTNGCLPHAIMAWIFSILPTPAAKSLVMKTNKQIRARFLK KLKEK >XP_015819348.1 PREDICTED: very-long-chain 3-oxoacyl-CoA reductase-A-like [Nothobranchius furzeri] MCVMLQPPYKGTLSHIVAWKLEPKIEVYTHRHTHIHTHLHIHTRQVTESRRMSMEEMICRAETPLFWVGA LTVAFLTLWLLYRLLTGFRIWVLGNGQLLSPKLGKWAVVTGATDGIGKSYAEELARRGFAMMLISRSQDK LDDVAKSIEEQFKVETRTIAVDFGKTDIYRKIEAGLTGLEIGVLVNNVGVSYPYPEYYLHIPDLEHFITN TINVNMTSVCQMTRLVLPRMVDRSKGVILNISSASGMYPVPLLTVYSATKAFVDFFSRGLQEEYRRQGII IQSVLPFFVVTKMTRIRKPTLDKPTPERYVAAELNTVGLQSQTNGYFPHAIMGWVTTRLVPSSIVIFLGA RMNRLQRTGYLQRRKLREQKNGASLKNE >XP_030282561.1 very-long-chain 3-oxoacyl-CoA reductase-A-like [Sparus aurata] MNWMNVEETLRRAETPLFWVGAFTVASLVLWLLYRLLSGFRIWVLGNGQLLTPKLGKWAVVTGATDGIGK SYAEELARRGFAMMLISRSQDKLDDVARSLEDQFKVETRTIAVDYGRSDIYPKIEAGLAGLEIGVLVNNV GVSYPYPEYFLHIPDLDNFITNMINVNITSVCQMTRLVLPRMSERSKGVILNISSASGMYPVPLLTVYSS SKAFVDFFSRGLQEEYKRRGIIIQSVLPFFVATKMTRIRKPTLDKPTPERYVAAELKTVGLQTQTNGYFP HAVMGWLTTKLVPSYLVNFFGARMNRLQRTGYLRRRKLREQRNGKSLKTE >XP_040183956.1 very-long-chain 3-oxoacyl-CoA reductase [Rana temporaria] MASEVLAGLPVPCAHFFCYVGVLAASWWGVRAAWRLLSAVRVWVLGRGTEVGPGLGKWAVVTGATDGIGK AYAEELARHGVSIVLISRSQDKLDEVAKNIREKFKVETKVIAADFGKPAEIYERIEVGLKSLEIGVLVNN VGVSYEYPEYFLDIPDLDNTLDMLININITSVCKMTRLVMPGMLERSKGVILNISSASGMYPVPLLTVYS ATKAFVDFFSRGLHAEYRNKGITVQSVLPFFVATKLSKIRKPTWDKPSPENYVRSALNTVGLQTRTNGYL AHALMGWVTASVLPSCLAIKLAMNMNKGLRARFLKRAKKN
Mafft alignment of selected proteins >NP_057226.1 very-long-chain 3-oxoacyl-CoA reductase [Homo sapiens] ---ME------------------------------------------------------- ------------------------------------SALPAA---GFLYWVGAGTV---A YLALRISYSLFT-------------------ALRVW-----GVGNEAGV---GPGLGEWA VVTGSTDGIGKSYAEELAKHGMKVVLISRSKDKLDQVSSEIKEKF-KVETRTIAVDF-AS E-DIYDKIKTGLAGLEIGILVNNVGMSYEYPEYFLDVPDLDN-VIKKMININILSVCKMT QLVLPGMVERSKGAILNISSGSGMLPVPLLTIYSATKTFVDFFSQCLHEEYRSKGVFVQS VLPYFVATKL----AKIRKPTLDKPSPETFVKSAIKTVGLQSRTNGYLIHALMGSII-SN L----PSWIYL-----------KIVMNMNKSTRAHYLKKTK-----------KN------ ------ >tr|A7MCK2|A7MCK2_DANRE Hsd17b12b protein OS=Danio rerio OX=7955 GN=hsd17b12b PE=2 SV=1 ---ME------------------------------------------------------- ---------------------------------------PFA---DALFWVGAVTV---L WLSVSSLWSLIN-------------------GIRVW-----ILGNGNLM--RASSLGKWA VVTGATDGIGKAYAEELARRGFAIVLISRTQEKLDEVSKAIESKY-KVETKTISADF-GS V-DIYPKIESGLAGLEIGVLVNNVGVSYSYPEFFLNIPDVDS-FINNMININIMSVCQMT RLVLPRMVDRSKGVILNVASASGMYPVPLLTLYSSTKAFVDFFSRGLDAEYKSKGIIIQS VLPFYVTTKL----SKIRKPTLDIPTPERYVKAQLSTIGLQTQSNGYLPHAIMGWVTASL L----PAKLLN-----------KYVMGMGLSQRARYLKKQK-----------QG------ ------ >XP_043338175.1 very-long-chain 3-oxoacyl-CoA reductase [Cervus canadensis] ---ME------------------------------------------------------- ------------------------------------SVLPAT---GFLYWVGAGTV---A YLALRISCLLFT-------------------AVRVW-----GLGNESGV---GPRLGEWA VVTGSTDGIGKSYAEELAKRGMKIVLISRSQDKLNQVSSEIREKF-KVETKTIAVDF-TL E-DIYDKIKTSLAGLEIGVLVNNVGMSYEYPEYFLDVPDLDN-TIQKLINVNVLSVCKMT RLVLPRMVERSKGVILNISSATGMYPVPLLTIYSATKAFVDFFSQCLHEEYKSKGIFVQS VLPYYVATKL----AKIRKPTLDKPSSETFVKSAIKTIGMQPRTNGYFIHSLMASVV-SI L----PSWLYF-----------KVTMNVNKSIRAHYLKKMK-----------KN------ ------ >XP_020763161.1 very-long-chain 3-oxoacyl-CoA reductase [Odocoileus virginianus texanus] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------MKIVLISRSQDKLNQVSSEIREKF-KVETKTIAVDF-TL E-DIYDKIKTSLAGLEIGVLVNNVGMAYEYPEYFLDVPDLDS-TIKKLINVNVLSVCKMT RLILPGMVERSKGVILNISSASGLYPVPLLTIYSATKAFVDFFSQCLHEEYKSKGIFVQS VLPYYVATKL----AKIRKPTLDKPSSETFVKSAIKTIGMQSRTNGYFIHSLMASVV-SI L----PSWLYF-----------KVIMNVNKSVRAHYFKKMK-----------KN------ ------ >OCT82029.1 hypothetical protein XELAEV_18024537mg [Xenopus laevis] ---MA------------------------------------------------------- ------------------------------PESL--AEVPGC---NCFWYLGVVAA---T WWGLRAAWCLLN-------------------GARVW-----VLGSGAQV---GPRIGKWA VVTGATDGIGKAYAEELARRGMNIVLISRSPEKLEEAAIHIKQKF-KVETKIIAADFGKP T-EIYERIEAGLRDLEIGVLVNNVGISYEYPEYFLEIPDLEN-TLDKMININIMSVCQMT RLVLPGMLGRGKGVVLNISSASGMYPVPLLTVYSATKAFVDFFSRGLHAEYRSKGVTVQS VLPFFVATKL----AKIRKPTWDKPSPETYVRSALNTVGLQTQTNGYLPHAIMGWISTSL V----PVSAAI-----------SMGMKMNKGLRARFLKKAK-----------QN------ ------ >KAF4009401.1 hypothetical protein G4228_000209, partial [Cervus hanglu yarkandensis] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -VTGSTDGIGKSYAEELAKRGMKIVLISRSQDKLNQVSSEIREKF-KVETKTIAVDF-TL E-DIYDKIKTSLAGLEIGVLVNNVGMSYEYPEYFLDVPDLDN-TIQKLINVNVLSVCKVR KLI----INISKGVILNISSATGMYPVPLLTIYSATK----------------------S VLPYYVATKL----AKIRKPTLDKPSSETFVKSAIKTIGMQPRTNGYFIHSLMASVV-SI L----PSWLYF-----------KVTMNVNKSIRAHYLKKMK-----------KN------ ------ >XP_038053153.1 very-long-chain 3-oxoacyl-CoA reductase-B-like isoform X1 [Patiria miniata] ---MP------------------------------------------------------- ------------------------------------EFTPFGALNPALATLGAVVA---F YAVFRLVTSLLN-------------------GLKAF-----FLAGPLGLSANVKNYGDWA AVTGATDGIGKAYAEQLAAKGLNIILLSRSEDKLNNVAAEIESKY-SVKTKTIAVDFTGG E-EIYTKIAKEVAGLSIGVLVNNVGISYRFPEYFHEIPDRQK-MLMNMLNLNCMSVTQMT SIVLPGMLDRKKGIVVNVSSASGMQPSPLLTVYSATKAYVDYLTRALQTEYASKGIIFQS VLPFFVSTKM----SKIRRSSITIPTPTAFVRSALATLGIEDRTNGCLSHSIQGWVV-DV A----PAWLVN-----------KVTVSMHLGIRKSALRRLE-----------QKKVN--- ------ >XP_030848589.1 very-long-chain 3-oxoacyl-CoA reductase-B [Strongylocentrotus purpuratus] ---MS------------------------------------------------------- ------------------------------------SYVPPTVVINIFAVIGVIAA---L NKILRVLWSILK-------------------NVKTF-----ILARPLGLATDPKRHGKWA VVTGATDGIGKAYAEQLAAKGLNIYLLSRSPDKLKDVATQIEQRY-KVETKTFAVDFTGG G-DIYPSIGDQLTGLDIGVLVNNVGMSYSFPQYFCELADAEK-FLPNIININCLSVVMMT NLVLPGMVERKRGIIINVSSASGMNPSPMLTVYSATKVFVDFFSRGLDVEYRSKGIQVQS VMPFYVTTKL----SKLRRETMTIPSPTSYVKTALATLGSGNRTNGCLMHNLQGWVV-GS V----PDWLLD-----------SVQMSIHSAIRKVSLKKLA-----------EKKTK--- ------ >XP_039248329.1 very-long-chain 3-oxoacyl-CoA reductase-like [Styela clava] ---MEC------------------------------------------------------ ---------------------------------------------NCVAYIGLASL---T YLSLRLLWDIYS-------------------GVKLY-----FLSNYPDF----RQYGEWS VVTGATDGIGKATARVLAQRGQKIVLISRNLAKLQSTAKEIENDF-NVETKIVRVDFTHD E-SIYEEISSEIKDLDIGVLVNNMGISYEHPEYFLQLPDLSA-TIMRMIRGNIMSVVKMT EIVLPGMADRKRGIILNITSAAALKPTPMLALYSASKDFVNHFSKSIAYEYEDQGIKIQS VMPFYVTTKL----SKIRASSLLVPTPEVYAKSMLRGAGVTKFTHGYWAHGLEGWIV-RL L----PNWVYA-----------YIMLQKGEAIRQKAYKKKE-----------WQKKNNSG EVKKEQ >XP_031563323.1 very-long-chain 3-oxoacyl-CoA reductase-B-like [Actinia tenebrosa] ---MV------------------------------------------------------- -------------------------------------------YSTALEVIGGCFI---A YYLINLLRRAVT-------------------GLRAF-----VLPS-LGIKKNLKSFGSWA VVTGCTDGIGKSFVYELAKEGINIVLMSRTLEKLQNLEAEIKSVY-KVKTKVIAMDFSGG A-EIYDGLDEKLDGLDIGILINNVGVSH-YPEFFTNMK--RE-DCWKMINVNDMSVIMMT HIILPGMVSRGKGVVMNISSRAGVEPLPLLSTYSSSKAFVDFFSEAIATEYAGKGIIVQS VMPLYVATKM----SKIKRPSLFVPGPDDYARQALGTIGVEQRTNGCWSHSLQEFVV-GL I----PRWVRE-----------KLAWNILMASRRAVLKKLN-----------QQGKQD-- ------ >NP_572420.1 spidey [Drosophila melanogaster] ---ME------------------------------------------------------- ---------------------------EN--------------NSQVLSLLGGLAI---G IVGFQVFRKVLP-------------------WIYAN----VVGPKVFGSSVDLSKMGEWA VVTGSTDGIGKAYAKELARRGLKLVLISRSLEKLNVVAKEIGDKY-GVEVRVIDVDFTGG D-EIYDKIREKTTGLNVGVLVNNVGISYGHPEYFLDCYKADPPFLRNIVAANIHSVTHMT ALFLPGMISQRRGVIINVSSTAGVIPNPLLSVYSSTKAFVNKFSDDLQTEYKEHGILIQS VQPGFVATNM----SKIRKASVFAPSPETYVRSALSTLGIATQTAGYLPHALLQLVI-HF TEAVFGEQFAR-----------NIVMKNILGTRKRALRRLA-----------KEQ----- ------ >CAE1306451.1 HSD17B12 [Sepia pharaonis] ---MH------------------------------------------------------- ---------------------------EEFINFIRYYLGPTT---EYFSCLGFIIY---A LAMCRIMTSVLT-------------------LATQS-----LFSRNLGWMSRLTYLGEWA VITGSTDGIGKAYAEELAALGLKIILISRSPEKLAAVAKEIEEAH-KVEVRTIAVDFSDN E-SIYNKIKNELKGLDISILVNNVGMSYPHPEYFVEIPNRTE-TLSSLIKLNVVAMTMMT SIVLPDMVKKNCGVIVNVSSASAAGPCPLLTAYSACKAYVKYFSEGLSAEYSDKGVVIQC LMPFYVTTKM----SKLRKSSAMVPTPTAYVKSSLSSLGISSCSFGYWSHNFLGWFT-KT L----PRFFLTCKKRKYNSVFPNLMKETGFSYWFKYFTCRLWGGMVLNWISFMMLVTLTI SVLASS >OWK16467.1 HSDL1 [Cervus elaphus hippelaphus] MAAMAAV----------------------------------------------------- ---------------------------DSFYLLYREIARSCNCYMEALALVGAWYT---A RKSITVVCDFYS-------------------LIRLH-----FIPRLVSRADLIKQYGRWA VVSGATDGIGRAYAEELASRGLNIVLISRNQEKLQMVAKDIADTY-KVETDVIVADFSSG R-EIYDMIREALQDRDIGILVNNVGVFYPYPQYFTQVS--ED-TLWDIVNVNIAAASLMV HIVLPGMVERKKGAIVTISSGSCCKPTPQLAAFSASKAYLDHFSRALQYEYASKGIFVQS LIPFYVATNVAAPGSFLHKCPWLVPSPKVYAHHAVSTLGISKRTTGYWSHSIQFLFA-QY M----PEWLWV-----------WGANILNRSLRKEALSCKA------------------- ------ >KAB0350251.1 hypothetical protein FD754_015108 [Muntiacus muntjak] ---MAAV----------------------------------------------------- ---------------------------DSFYLLYREIARSCNCYMEALALVGAWYT---A RKSITVVCDFYS-------------------LIRLH-----FIPRLVSRADLIKQYGRWA VVSGATDGIGRAYAEELASRGLNIVLISRNQEKLQMVAKDIADTY-KVETDIIVADFSSG R-EIYGVIREALQDRDIGILVNNVGVFYPYPQYFTQVS--ED-TLWDIVNVNIAAASLMV HIVLPGMVERKKGAIVTISSGSCCKPTPQLAAFSASKAYLDHFSRALQYEYASKGIFVQS LIPFYVATNVASPGSFLHKCPWLVPSPKVYAHHAVSTLGISKRTTGYWSHSIQFLFA-QY M----PEWLWV-----------WGANILNRSLRKEALSCKA------------------- ------ >KAB0383238.1 hypothetical protein FD755_005155 [Muntiacus reevesi] ---MAAV----------------------------------------------------- ---------------------------DSFYLLYREIARSCNCYMEALALVGAWYT---A RKSITVVCDFYS-------------------LIRLH-----FIPRLVSRADLIKQYGRWA VVSGATDGIGRAYAEELASRGLNIVLISRNQEKLQMVAKDIADTY-KVETDIIVADFSSG R-EIYGVIREALQDRDIGILVNNVGVFYPYPQYFTQVS--ED-TLWDIVNVNIAAASLMV HIVLPGMVERKKGAIVTISSGSCCKPTPQLAAFSASKAYLDHFSRALQYEYASKGIFVQS LIPFYVATNVAAPGSFLHKCPWLVPSPKVYAHHAVSTLGISKRTTGYWSHSIQFLFA-QY M----PEWLWV-----------WGANILNRSLRKEALSCKA------------------- ------ >XP_001121130.1 very-long-chain 3-oxoacyl-CoA reductase [Apis mellifera] ---MSL------------------------------------------------------ ---------------------------------------------TCWEKISFVLL---G LFGLRILWRISV-------------------LVWKK-----LIGPNFGFGIDPKTQGKWA VITGATSGIGKAYAEQLAKKGLDIVLVSRSLSKLEEVAKEIKERY-GVQVRIVDADLTEG Q-AVYAKIAKATEELEIGIVVNNAGASYNHPELFTNVS--EE-SIAQILQLNVASMTGVA RALLPQMFERKKGILINISSATAVMPSPYLTVYAASKCYVIKLSEDLAAEAAPYGVTVQC IIPGPVATKM----SKITKPTWMAPTPEKYVKHTLKTIGLELCTTGYLPHGLLVASV-NA L-----RYICEKGT-------LWLVCKTMCNIRKRALKKKEK--------VVEKITNEET SVTTK- >NP_001254936.1 Very-long-chain 3-oxooacyl-coA reductase let-767 [Caenorhabditis elegans] ---MACQ----------------------------------------------------- ---------------------------------------------CFLVGAGYVAL---A AVAYRLLTIFSN-------------------ILGPY-----VLLSPIDL--KKRAGASWA VVTGATDGIGKAYAFELARRGFNVLLVSRTQSKLDETKKEILEKYSSIEVRTAAFDFTNA APSAYKDLLATLNQVEIGVLINNVGMSYEYPDVLHKVDGGIE-RLANITTINTLPPTLLS AGILPQMVARKAGVIVNVGSSAGANQMALWAVYSATKKYVSWLTAILRKEYEHQGITVQT IAPMMVATKM----SKVKRTSFFTPDGAVFAKSALNTVGNTSDTTGYITHQLQLELM-DL I----PTFIRD-----------KILTNMSVGTRAAALRKKE-----------REAKSQ-- ------ >NP_062631.1 very-long-chain 3-oxoacyl-CoA reductase [Mus musculus] ---ME------------------------------------------------------- ------------------------------------CAPPAA---GFLYWVGASTI---A YLALRASYSLFR-------------------AFQVW-----CVGNEALV---GPRLGEWA VVTGGTDGIGKAYAEELAKRGMKIVLISRSQDKLNQVSNNIKEKF-NVETRTIAVDF-SL D-DIYDKIKTGLSGLEIGVLVNNVGMSYEYPEYFLEIPDLDN-TIKKLININVLSVCKVT RLVLPGMVERSKGVILNISSASGMLPVPLLTIYSATKAFVDFFSQCLHEEYKSKGIFVQS VMPYLVATKL----AKIQKPTLDKPSAETFVKSAIKTVGLQTRTTGYVIHSLMGSIN-SI M----PRWMYF-----------KIIMGFSKSLRNRYLKKRK-----------KN------ ------ >NP_114455.2 very-long-chain 3-oxoacyl-CoA reductase [Rattus norvegicus] ---ME------------------------------------------------------- ------------------------------------RALPAA---GFLYWVGASTI---A YLTLRASYSLFR-------------------AFQVW-----CVGNQAFV---GPRLGEWA VVTGGTDGIGKSYAEELAKRGMKIVLISRSQDKLKEVSNNIKEKF-NVETRTIAVDF-SL D-DIYDKIKTGLSGLEIGVLVNNVGMSYEYPEYFLEIPDLDN-TIKKLININVLSICKVT RLVLPGMVERSKGVILNISSASGMLPVPLLTVYSATKAFVDFFSQCLHEEYKSKGIFVQS VLPFFVATKL----AKIRKPTLDKPSAETFVKSAIKTVGLQTRTTGYVIHAIMGSIN-SI L----PRWIYF-----------KTIMGFNKSLRNRYLKKTK-----------KN------ ------ >XP_848504.1 very-long-chain 3-oxoacyl-CoA reductase isoform X1 [Canis lupus familiaris] ---ME------------------------------------------------------- ------------------------------------SALPAA---GLLYWVGAGTV---A YVALRLSCSLFT-------------------ALRLW-----GLSHEAGV---GPQLGEWA VVTGSTDGIGKSYAEELAKHGMKVVLISRSQDKLNQVSSEIREKF-KVETRTVAVDF-AS E-DIYDKIKTSLAGLKIGVLVNNVGMSYEYPEYFLDVPDLDN-TIKKLININVLSVCKMT RLVLPGMVERSKGAILNISSASGMAPVPLLAIYSATKAFVDFFSRCLHEEYRSKGIFVQS VLPYYVATKL----SKIRKPTLDKPSAETYVKSAIQTVGLQSRTTGYLIHSLMDSII-SA M----PTWLYF-----------KITMNLGKSTRARYMKKAK-----------KN------ ------ >XP_001158375.1 very-long-chain 3-oxoacyl-CoA reductase [Pan troglodytes] ---ME------------------------------------------------------- ------------------------------------SALPAA---GFLYWVGAGTV---A YLALRISYSLFT-------------------ALRVW-----GVGNEAGV---GPGLGEWA VVTGSTDGIGKSYAEELAKHGMKVVLISRSKDKLDQVSSEIKEKF-KVETRTIAVDF-AS E-DIYDKIKTALAGLEIGILVNNVGMSYEYPEYFLDVPDLDN-VIKKMININILSVCKMT QLVLPGMVERSKGAILNISSGSGMLPVPLLTIYSATKTFVDFFSQCLHEEYRSKGVFVQS VLPYFVATKL----AKIRKPTLDKPSPETFVKSAIKTVGLQSRTNGYLIHALMGSII-SN L----PSWIYL-----------KIVMNMNKSTRAHYLKKTK-----------KN------ ------ >XP_015142684.1 very-long-chain 3-oxoacyl-CoA reductase [Gallus gallus] ---MAVRERCRPRGAQAASSTGACGRALPSPSLPAARAQGGRGRPR---RQVTARLSAPS ANGSAAGAGAAAAAGRRWPGGFSPVAAASAGSMLAPAALPAA---GLFYWVGALGV---L YTAVLCAFRLLS-------------------GLRVW-----VLGGGRAV---GPQLGAWA VVTGATDGIGKAYAEELARHGMKVALISRSKEKLDQVAGEIKEKY-KVETKVIVADFGER E-GIYDRIKAGLEGLEIGVLVNNVGISYSYPEYFIDVPDLDK-MIDQMININIMSVCKMT RLVLPGMLERSKGVILNISSAAGMYPTPLLTLYSATKAFVDYFSRGLHAEYKSKGIIVQS VLPFYVATKL----SKIRKPTFSKPSPETYVRAAIGTVGLQSQTNGCLPHAVMAWIF-SI L----PTPAVK-----------SLLMKTNKQVRARFLRKLK-----------EK------ ------ >NP_001094777.1 very-long-chain 3-oxoacyl-CoA reductase [Bos taurus] ---ME------------------------------------------------------- ------------------------------------SFLPAT---GFLYWVGVGTV---A YLALRISCFLFT-------------------AVRVW-----GLGNESGV---GPRLGEWA VVTGSTDGIGKSYAEKLAERGMKIVLISRSQDKLNQVSSEIREKF-KVETKTIAVDF-TL E-DIYDKIKTSLAGLEIGVLVNNVGMSYEYPEYFLDIPDLDN-TIKKLISVNVLSVCKMT QLVLPGMVERSKGVILNISSATGRYPVPLLTIYSATKAFVDFFSQCLHEEYKSKGIFVQS VLPFFVATKL----AKIRKPTLDKPSSENFVKCAIKTIGVQSRTSGYFIHYLMASVT-SL L----PSWLYF-----------KIVMNVNKSFRARYFKKMK-----------KN------ ------ >XP_020938823.1 very-long-chain 3-oxoacyl-CoA reductase isoform X1 [Sus scrofa] ---ME------------------------------------------------------- ------------------------------------TALPAA---GFLYWVGASTV---A YLALRISCWFFT-------------------ALRVW-----GLGHEAGV---GPWLGEWA VVTGGTDGIGKSYAEELAKRGMKIVLISRSQDKLDQVSSEISEKF-KVETKTIAVDF-TS E-DIYDKIKASLAGLNIGVLVNNVGMSYEYPEYFLDVPDLDN-TIKKLITVNALSVCKMT RLVLPGMVERSKGAILNISSASGMYPVPLLTIYSATKAFVDFFSQCLHEEYKSKGVIVQS VLPYYVATKL----AKIKRPTWDKPSPETFVKSAMKTIGVQSRTNGYPIHSLVASVS-AS L----PSWLYF-----------KIAMYSGNSIRVRYLKKMK-----------MN------ ------ >XP_002709111.1 PREDICTED: very-long-chain 3-oxoacyl-CoA reductase [Oryctolagus cuniculus] ---ME------------------------------------------------------- ------------------------------------TALPAA---GFLYWVGAGTV---A YLALRISYSLFW-------------------ALRVW-----GVGNEAWV---GPGLGEWA VVTGSTDGIGKSYAEQLAKRGMNVVLISRSQDKLNQVSNEIKEKF-KVETRTIAVDF-AS E-DIYNKIETGLAGLEIGVLVNNVGMSYEYPEYFLDIPDLDN-TIKKLININVLSVCKMT RLVLPRMVERSKGAILNISSASGTFPVPLLTIYSATKAFVDFFSQCLHEEYRSKGIFVQS VLPYYVATKL----AKIRKPTFDKPSSETFVKSAIKTVGLQSRTNGYLVHSLMGTIH-SM L----PSWVFV-----------KISMDVNKSVRARYLKKYK-----------KN------ ------ >XP_024110605.1 very-long-chain 3-oxoacyl-CoA reductase [Pongo abelii] ---ME------------------------------------------------------- ------------------------------------SALPAA---GFLYWVGAGTV---A YLALRISYSLFT-------------------ALRVW-----GMGNEAGV---GPGLGEWA VVTGSTDGIGKSYAEELAKHGMKVVLISRSQDKLDQVSSEIKEKF-KVETRTIAVDF-AS E-DIYDKIKTGLSGLEIGILVNNVGMSYEYPEYFLDVPDLDN-VIKKMININILSVCKMT QLVLPGMVERSKGAILNISSGSGMLPVPLLTIYSATKTFVDFFSRCLHEEYRSKGVFVQS VLPYFVATKL----AKIRKPTLDKPSPETFVKSAIKTVGLQSRTNGYLIHALMGSII-SN L----PSWIYF-----------KIVMNMNKSTRAHHLKKTK-----------KN------ ------ >XP_003808259.1 very-long-chain 3-oxoacyl-CoA reductase [Pan paniscus] ---ME------------------------------------------------------- ------------------------------------SALPAA---GFLYWVGAGTV---A YLALRISYSLFT-------------------ALRVW-----GVGNEAGV---GPGLGEWA VVTGSTDGIGKSYAEELAKHGMKVVLISRSKDKLDQVSSEIKEKF-KVETRTIAVDF-AS E-DIYDKIKTALAGLEIGILVNNVGMSYEYPEYFLDVPDLDN-VIKKMININILSVCKMT QLVLPGMVERSKGAILNISSGSGMLPVPLLTIYSATKTFVDFFSQCLHEEYRSKGVFVQS VLPYFVATKL----AKIRKPTLDKPSPETFVKSAIKTVGLQSRTNGYLIHALMGSII-SN L----PSWIYL-----------KIVMNMNKSTRAHYLKKTK-----------KN------ ------ >XP_003993234.1 very-long-chain 3-oxoacyl-CoA reductase [Felis catus] ---ME------------------------------------------------------- ------------------------------------SALPAA---GFLYWVGAGTV---A YLALRISCSLFT-------------------ALRVW-----GLSHEVGV---GPGLGEWA VVTGSTDGIGKSYAEELAKHGMKIVLISRSQDKLNQVSSEIREKF-KVETMTIAVDF-AS E-DIYDKIKTSLAGLKIGVLVNNVGVSYEYPEYFLDVPDLDN-TIKKLINVNVLSVCKMT RLVLPGMVERSKGAILNISSASGLVPVPLLAMYSATKAFVDFFSQCLHEEYRSKGIFVQS VLPFFIATKL----SKIRKPTLDTPSAETFVKSAIKTVGLQSRTTGYLIHSLMGSII-SV M----PTWLYF-----------KITTNMGKSTRARYLKKAK-----------KN------ ------ >XP_004016470.1 very-long-chain 3-oxoacyl-CoA reductase [Ovis aries] ---ME------------------------------------------------------- ------------------------------------SVLPAT---GFLYWVGAGTV---A YLALRILCWLFT-------------------AVRVW-----GLGNESGV---GPRLGEWA VVTGSTDGIGKSYAEELAKRGMKIVLISRSQDKLNQVSSEIREKF-KVETKTVAVDF-TL E-DIYDKIKTSLAGLEIGVLVNNVGMSYEYPEYFLDVPDLDS-TIKKLINVNVLSVCKMT RLVLPGMVERSKGVILNISSASGMYPVPLLTIYSATKAFVDFFSQCLHEEYKSKGIFVQS VLPYFVATKL----AKIRRATLDKPSSETFVKSAIKTIGVQSRTNGYFIHSLLFSVA-SI L----PSWLYL-----------KVSMNMNKSIRAHYFKKMK-----------KN------ ------ >XP_004051019.1 very-long-chain 3-oxoacyl-CoA reductase [Gorilla gorilla gorilla] ---ME------------------------------------------------------- ------------------------------------SALPAA---GFLYWVGAGTV---A YLALRISYSLFT-------------------ALRVW-----GVGNEAGV---GPGLGEWA VVTGSTDGIGKSYAEELAKHGMKVVLISRSKDKLDQVSSEIKEKF-KVETRTIAVDF-AS E-DIYDKIKTGLAGLEIGILVNNVGMSYEYPEYFLDVPDLDN-VIKKMININILSVCKMT QLVLPGMVERSKGAILNISSGSGMLPVPLLTIYSATKTFVDFFSRCLHEEYRSKGVFVQS VLPYFVATKL----AKIRKPTLDKPSPEMFVKSAIKTVGLQSRTNGYLIHALMGSII-SN L----PSWIYL-----------KIVMNMNKSTRAHYLKKTK-----------KN------ ------ >XP_004069451.1 very-long-chain 3-oxoacyl-CoA reductase-A [Oryzias latipes] ---MN------------------------------------------------------- ------------------------------RMNAEEMIRRAE---PLFFWVGAFTL---A FFALWLLYRLVT-------------------GFRIW-----VLGNGTLL---SPKLGKWA VVTGATDGIGKSYAEELARRGFAMMLISRSQEKLDDVAKSLEEQF-GVETKTIAVDF-GK T-DIYPKIEAGLVGLEIGVLVNNVGVSYHYPEYYLNIPDLDN-FLTNMINVNMTSVCQMT RLVLPGMVSRAKGVILNISSASGMYPLPLLTVYSATKAFMDFFSRGLQEEYRRQGIIIQS VLPFFVATKM----TRIRKPTLDKPTPERYVAAELTTVGLQNQTNGYFPHAVMGWVTTKL V----PTSIVI-----------FLGASMNRVQRSGYLHRRK-----------LREMKNGA SLKSE- >XP_013227387.2 very-long-chain 3-oxoacyl-CoA reductase [Columba livia] ---ME------------------------------------------------------- -------------------------------KVLVAQASPAG---SQALWKCQLCLECGS TASIVCIFSVSTDHIVYYDMDTLRWGRFTEPAGRRWGPLESGEGAIAFP---VPGSRYSR VVTGATDGIGKAYAEELARRGMKVALISRSKEKLDQVASEIKEKY-KVETRVIVADFGER E-DIYSGIKSGLEGLEIGVLVNNVGISYVYPEYFLDVPDLDK-TVDKMININIMAVCKMT RLVLPGMLERSKGVILNISSAAGMYPTPLLTLYSATKAFVDYFSRGLHAEYKSKGIIVQS VLPYYVATKM----SKIRKPTFDKPSPETYVRAALGTVGLQSQTNGCLPHALMGWIF-SL L----PTPTII-----------NFLMKTNKGIRARYLKKMK-----------EK------ ------ >XP_005690184.1 PREDICTED: very-long-chain 3-oxoacyl-CoA reductase [Capra hircus] ---ME------------------------------------------------------- ------------------------------------SVLPAT---GFLYWVGAGTV---A YLALRILCWLFT-------------------AVRVW-----GLGNESGV---GPRLGEWA VVTGSTDGIGKSYAEELAKRGMKIVLISRSQDKLNQVSSEIREKF-KVETKTVAVDF-TL E-DIYDKIKTSLAGLEIGVLVNNVGMSYEYPEYFLDVPDLDN-TIKKLINVNVLSVCKMT RLVLPGMVERSKGVILNISSASGMYPVPLLTIYSATKAFVDFFSQCLHEEYKSKGIFVQS VLPYFVATKL----AKIRKATLDKPSSETFVKSAIKTIGVQSRTNGYFIHSLLFSVA-SI L----PSWLYL-----------KVSMNMNKSIRAHYFKKMK-----------KN------ ------ >XP_014377653.1 very-long-chain 3-oxoacyl-CoA reductase, partial [Alligator sinensis] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------EKF-NVETKIIVADFGER E-DIYTKIKAALEGLEIGVLVNNVGISYAYPEYFLDVPDLDN-TIDKMININIMSVCKMT RLVLPGMLERSKGAILNISSASGMFPTPLLTLYSGTKAFVDFFSQGLHAEYKSKGIIVQS VLPYYVATKM----ARIRKPTFDKPSPETYVKAALGTVGLQSRTNGCLPHAIMGWFM-SL F----PTSTVV-----------NFTMSRNKQVRARFLKKAK-----------AN------ ------ >XP_014457595.1 PREDICTED: very-long-chain 3-oxoacyl-CoA reductase isoform X1 [Alligator mississippiensis] ---MA------------------------------------------------------- ----------------------------------TIASLPAA---GFLYWVGALSA---A YVTLRAGYCLVA-------------------GLRVW-----VLGRRVLP---GPGLGAWA VVTGATDGIGKAYAEELARCGMKIALISRSQEKLDQVASQIKEKF-NVETKIIVADFGER E-DIYTKIKAALEGLEIGVLVNNVGISYAYPEYFLDVPDLDN-TIDKIININIMSVCKMT RLVLPGMLERSKGVILNISSASGMFPVPLLTLYSGTKAFVDFFSQGLHAEYKSKGIIVQS VLPYFVATKM----ARIRKPTFDKPSPETYVKAALGTVGLQSRTNGCLPHAIMGWFT-SL F----PTSTVV-----------NFTMSHNKKVRARFLKKVK-----------AN------ ------ >XP_031409404.1 very-long-chain 3-oxoacyl-CoA reductase [Meleagris gallopavo] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------MT RLVLPGMLERSKGVILNISSAAGMYPTPLLTLYSATKAFVDYFSRGLHAEYKSKGIIVQS VLPYYVATKL----SKIRKPTFSKPSPETFVRAAIGTVGLQSQTNGCLPHAIMAWIF-SI L----PTPAAK-----------SLVMKTNKQIRARFLKKLK-----------EK------ ------ >XP_015819348.1 PREDICTED: very-long-chain 3-oxoacyl-CoA reductase-A-like [Nothobranchius furzeri] ---MCVMLQPPYKGTL---SHIVAWKLEPKIEVYTHRHTHIHTHLHIHTRQVT------- ---------------------------ESRRMSMEEMICRAE---TPLFWVGALTV---A FLTLWLLYRLLT-------------------GFRIW-----VLGNGQLL---SPKLGKWA VVTGATDGIGKSYAEELARRGFAMMLISRSQDKLDDVAKSIEEQF-KVETRTIAVDF-GK T-DIYRKIEAGLTGLEIGVLVNNVGVSYPYPEYYLHIPDLEH-FITNTINVNMTSVCQMT RLVLPRMVDRSKGVILNISSASGMYPVPLLTVYSATKAFVDFFSRGLQEEYRRQGIIIQS VLPFFVVTKM----TRIRKPTLDKPTPERYVAAELNTVGLQSQTNGYFPHAIMGWVTTRL V----PSSIVI-----------FLGARMNRLQRTGYLQRRK-----------LREQKNGA SLKNE- >XP_030282561.1 very-long-chain 3-oxoacyl-CoA reductase-A-like [Sparus aurata] ---MN------------------------------------------------------- ------------------------------WMNVEETLRRAE---TPLFWVGAFTV---A SLVLWLLYRLLS-------------------GFRIW-----VLGNGQLL---TPKLGKWA VVTGATDGIGKSYAEELARRGFAMMLISRSQDKLDDVARSLEDQF-KVETRTIAVDY-GR S-DIYPKIEAGLAGLEIGVLVNNVGVSYPYPEYFLHIPDLDN-FITNMINVNITSVCQMT RLVLPRMSERSKGVILNISSASGMYPVPLLTVYSSSKAFVDFFSRGLQEEYKRRGIIIQS VLPFFVATKM----TRIRKPTLDKPTPERYVAAELKTVGLQTQTNGYFPHAVMGWLTTKL V----PSYLVN-----------FFGARMNRLQRTGYLRRRK-----------LREQRNGK SLKTE- >XP_040183956.1 very-long-chain 3-oxoacyl-CoA reductase [Rana temporaria] ---MA------------------------------------------------------- ------------------------------SEVLAGLPVPCA---HFFCYVGVLAA---S WWGVRAAWRLLS-------------------AVRVW-----VLGRGTEV---GPGLGKWA VVTGATDGIGKAYAEELARHGVSIVLISRSQDKLDEVAKNIREKF-KVETKVIAADFGKP A-EIYERIEVGLKSLEIGVLVNNVGVSYEYPEYFLDIPDLDN-TLDMLININITSVCKMT RLVMPGMLERSKGVILNISSASGMYPVPLLTVYSATKAFVDFFSRGLHAEYRNKGITVQS VLPFFVATKL----SKIRKPTWDKPSPENYVRSALNTVGLQTRTNGYLAHALMGWVTASV L----PSCLAI-----------KLAMNMNKGLRARFLKRAK-----------KN------ ------
BMGE Cleaned alignment of selected proteins >NP_057226.1 very-long-chain 3-oxoacyl-CoA reductase [Homo sapiens] ALPAAGFLYWVGAGTVAYLALRISALRVWGPGLGEWAVVTGSTDGIGKSYAEELAKHGMKVVLISRSKDKLDQVSSEIKEKFKVETRTIAVDFDIYDKIKTGLAGLEIGILVNNVGMSYEYPEYFLDVPDLDNVIKKMININILSVCKMTQLVLPGMVERSKGAILNISSGSGMLPVPLLTIYSATKTFVDFFSQCLHEEYRSKGVFVQSVLPYFVATKLAKIRKPTLDKPSPETFVKSAIKTVGLQSRTNGYLIHALMGSIINKSTRAHYLKKTK >tr|A7MCK2|A7MCK2_DANRE Hsd17b12b protein OS=Danio rerio OX=7955 GN=hsd17b12b PE=2 SV=1 --PFADALFWVGAVTVLWLSVSSLGIRVWASSLGKWAVVTGATDGIGKAYAEELARRGFAIVLISRTQEKLDEVSKAIESKYKVETKTISADFDIYPKIESGLAGLEIGVLVNNVGVSYSYPEFFLNIPDVDSFINNMININIMSVCQMTRLVLPRMVDRSKGVILNVASASGMYPVPLLTLYSSTKAFVDFFSRGLDAEYKSKGIIIQSVLPFYVTTKLSKIRKPTLDIPTPERYVKAQLSTIGLQTQSNGYLPHAIMGWVTGLSQRARYLKKQK >XP_043338175.1 very-long-chain 3-oxoacyl-CoA reductase [Cervus canadensis] VLPATGFLYWVGAGTVAYLALRISAVRVWGPRLGEWAVVTGSTDGIGKSYAEELAKRGMKIVLISRSQDKLNQVSSEIREKFKVETKTIAVDFDIYDKIKTSLAGLEIGVLVNNVGMSYEYPEYFLDVPDLDNTIQKLINVNVLSVCKMTRLVLPRMVERSKGVILNISSATGMYPVPLLTIYSATKAFVDFFSQCLHEEYKSKGIFVQSVLPYYVATKLAKIRKPTLDKPSSETFVKSAIKTIGMQPRTNGYFIHSLMASVVNKSIRAHYLKKMK >XP_020763161.1 very-long-chain 3-oxoacyl-CoA reductase [Odocoileus virginianus texanus] ----------------------------------------------------------MKIVLISRSQDKLNQVSSEIREKFKVETKTIAVDFDIYDKIKTSLAGLEIGVLVNNVGMAYEYPEYFLDVPDLDSTIKKLINVNVLSVCKMTRLILPGMVERSKGVILNISSASGLYPVPLLTIYSATKAFVDFFSQCLHEEYKSKGIFVQSVLPYYVATKLAKIRKPTLDKPSSETFVKSAIKTIGMQSRTNGYFIHSLMASVVNKSVRAHYFKKMK >OCT82029.1 hypothetical protein XELAEV_18024537mg [Xenopus laevis] EVPGCNCFWYLGVVAATWWGLRAAGARVWGPRIGKWAVVTGATDGIGKAYAEELARRGMNIVLISRSPEKLEEAAIHIKQKFKVETKIIAADFEIYERIEAGLRDLEIGVLVNNVGISYEYPEYFLEIPDLENTLDKMININIMSVCQMTRLVLPGMLGRGKGVVLNISSASGMYPVPLLTVYSATKAFVDFFSRGLHAEYRSKGVTVQSVLPFFVATKLAKIRKPTWDKPSPETYVRSALNTVGLQTQTNGYLPHAIMGWISNKGLRARFLKKAK >KAF4009401.1 hypothetical protein G4228_000209, partial [Cervus hanglu yarkandensis] --------------------------------------VTGSTDGIGKSYAEELAKRGMKIVLISRSQDKLNQVSSEIREKFKVETKTIAVDFDIYDKIKTSLAGLEIGVLVNNVGMSYEYPEYFLDVPDLDNTIQKLINVNVLSVCKVRKLI----INISKGVILNISSATGMYPVPLLTIYSATK----------------------SVLPYYVATKLAKIRKPTLDKPSSETFVKSAIKTIGMQPRTNGYFIHSLMASVVNKSIRAHYLKKMK >XP_038053153.1 very-long-chain 3-oxoacyl-CoA reductase-B-like isoform X1 [Patiria miniata] FTPFGPALATLGAVVAFYAVFRLVGLKAFVKNYGDWAAVTGATDGIGKAYAEQLAAKGLNIILLSRSEDKLNNVAAEIESKYSVKTKTIAVDFEIYTKIAKEVAGLSIGVLVNNVGISYRFPEYFHEIPDRQKMLMNMLNLNCMSVTQMTSIVLPGMLDRKKGIVVNVSSASGMQPSPLLTVYSATKAYVDYLTRALQTEYASKGIIFQSVLPFFVSTKMSKIRRSSITIPTPTAFVRSALATLGIEDRTNGCLSHSIQGWVVHLGIRKSALRRLE >XP_030848589.1 very-long-chain 3-oxoacyl-CoA reductase-B [Strongylocentrotus purpuratus] YVPPTNIFAVIGVIAALNKILRVLNVKTFPKRHGKWAVVTGATDGIGKAYAEQLAAKGLNIYLLSRSPDKLKDVATQIEQRYKVETKTFAVDFDIYPSIGDQLTGLDIGVLVNNVGMSYSFPQYFCELADAEKFLPNIININCLSVVMMTNLVLPGMVERKRGIIINVSSASGMNPSPMLTVYSATKVFVDFFSRGLDVEYRSKGIQVQSVMPFYVTTKLSKLRRETMTIPSPTSYVKTALATLGSGNRTNGCLMHNLQGWVVHSAIRKVSLKKLA >XP_039248329.1 very-long-chain 3-oxoacyl-CoA reductase-like [Styela clava] -----NCVAYIGLASLTYLSLRLLGVKLY-RQYGEWSVVTGATDGIGKATARVLAQRGQKIVLISRNLAKLQSTAKEIENDFNVETKIVRVDFSIYEEISSEIKDLDIGVLVNNMGISYEHPEYFLQLPDLSATIMRMIRGNIMSVVKMTEIVLPGMADRKRGIILNITSAAALKPTPMLALYSASKDFVNHFSKSIAYEYEDQGIKIQSVMPFYVTTKLSKIRASSLLVPTPEVYAKSMLRGAGVTKFTHGYWAHGLEGWIVGEAIRQKAYKKKE >XP_031563323.1 very-long-chain 3-oxoacyl-CoA reductase-B-like [Actinia tenebrosa] -----TALEVIGGCFIAYYLINLLGLRAFLKSFGSWAVVTGCTDGIGKSFVYELAKEGINIVLMSRTLEKLQNLEAEIKSVYKVKTKVIAMDFEIYDGLDEKLDGLDIGILINNVGVSH-YPEFFTNMK--REDCWKMINVNDMSVIMMTHIILPGMVSRGKGVVMNISSRAGVEPLPLLSTYSSSKAFVDFFSEAIATEYAGKGIIVQSVMPLYVATKMSKIKRPSLFVPGPDDYARQALGTIGVEQRTNGCWSHSLQEFVVLMASRRAVLKKLN >NP_572420.1 spidey [Drosophila melanogaster] -----QVLSLLGGLAIGIVGFQVFWIYANLSKMGEWAVVTGSTDGIGKAYAKELARRGLKLVLISRSLEKLNVVAKEIGDKYGVEVRVIDVDFEIYDKIREKTTGLNVGVLVNNVGISYGHPEYFLDCYKADPFLRNIVAANIHSVTHMTALFLPGMISQRRGVIINVSSTAGVIPNPLLSVYSSTKAFVNKFSDDLQTEYKEHGILIQSVQPGFVATNMSKIRKASVFAPSPETYVRSALSTLGIATQTAGYLPHALLQLVIILGTRKRALRRLA >CAE1306451.1 HSD17B12 [Sepia pharaonis] LGPTTEYFSCLGFIIYALAMCRIMLATQSLTYLGEWAVITGSTDGIGKAYAEELAALGLKIILISRSPEKLAAVAKEIEEAHKVEVRTIAVDFSIYNKIKNELKGLDISILVNNVGMSYPHPEYFVEIPNRTETLSSLIKLNVVAMTMMTSIVLPDMVKKNCGVIVNVSSASAAGPCPLLTAYSACKAYVKYFSEGLSAEYSDKGVVIQCLMPFYVTTKMSKLRKSSAMVPTPTAYVKSSLSSLGISSCSFGYWSHNFLGWFTGFSYWFKYFTCRL >OWK16467.1 HSDL1 [Cervus elaphus hippelaphus] ARSCNEALALVGAWYTARKSITVVLIRLHIKQYGRWAVVSGATDGIGRAYAEELASRGLNIVLISRNQEKLQMVAKDIADTYKVETDVIVADFEIYDMIREALQDRDIGILVNNVGVFYPYPQYFTQVS--EDTLWDIVNVNIAAASLMVHIVLPGMVERKKGAIVTISSGSCCKPTPQLAAFSASKAYLDHFSRALQYEYASKGIFVQSLIPFYVATNVSFLHKCPWLVPSPKVYAHHAVSTLGISKRTTGYWSHSIQFLFANRSLRKEALSCKA >KAB0350251.1 hypothetical protein FD754_015108 [Muntiacus muntjak] ARSCNEALALVGAWYTARKSITVVLIRLHIKQYGRWAVVSGATDGIGRAYAEELASRGLNIVLISRNQEKLQMVAKDIADTYKVETDIIVADFEIYGVIREALQDRDIGILVNNVGVFYPYPQYFTQVS--EDTLWDIVNVNIAAASLMVHIVLPGMVERKKGAIVTISSGSCCKPTPQLAAFSASKAYLDHFSRALQYEYASKGIFVQSLIPFYVATNVSFLHKCPWLVPSPKVYAHHAVSTLGISKRTTGYWSHSIQFLFANRSLRKEALSCKA >KAB0383238.1 hypothetical protein FD755_005155 [Muntiacus reevesi] ARSCNEALALVGAWYTARKSITVVLIRLHIKQYGRWAVVSGATDGIGRAYAEELASRGLNIVLISRNQEKLQMVAKDIADTYKVETDIIVADFEIYGVIREALQDRDIGILVNNVGVFYPYPQYFTQVS--EDTLWDIVNVNIAAASLMVHIVLPGMVERKKGAIVTISSGSCCKPTPQLAAFSASKAYLDHFSRALQYEYASKGIFVQSLIPFYVATNVSFLHKCPWLVPSPKVYAHHAVSTLGISKRTTGYWSHSIQFLFANRSLRKEALSCKA >XP_001121130.1 very-long-chain 3-oxoacyl-CoA reductase [Apis mellifera] -----TCWEKISFVLLGLFGLRILLVWKKPKTQGKWAVITGATSGIGKAYAEQLAKKGLDIVLVSRSLSKLEEVAKEIKERYGVQVRIVDADLAVYAKIAKATEELEIGIVVNNAGASYNHPELFTNVS--EESIAQILQLNVASMTGVARALLPQMFERKKGILINISSATAVMPSPYLTVYAASKCYVIKLSEDLAAEAAPYGVTVQCIIPGPVATKMSKITKPTWMAPTPEKYVKHTLKTIGLELCTTGYLPHGLLVASVMCNIRKRALKKKE >NP_001254936.1 Very-long-chain 3-oxooacyl-coA reductase let-767 [Caenorhabditis elegans] -----CFLVGAGYVALAAVAYRLLILGPYKRAGASWAVVTGATDGIGKAYAFELARRGFNVLLVSRTQSKLDETKKEILEKYSIEVRTAAFDFSAYKDLLATLNQVEIGVLINNVGMSYEYPDVLHKVDGGIERLANITTINTLPPTLLSAGILPQMVARKAGVIVNVGSSAGANQMALWAVYSATKKYVSWLTAILRKEYEHQGITVQTIAPMMVATKMSKVKRTSFFTPDGAVFAKSALNTVGNTSDTTGYITHQLQLELMSVGTRAAALRKKE >NP_062631.1 very-long-chain 3-oxoacyl-CoA reductase [Mus musculus] APPAAGFLYWVGASTIAYLALRASAFQVWGPRLGEWAVVTGGTDGIGKAYAEELAKRGMKIVLISRSQDKLNQVSNNIKEKFNVETRTIAVDFDIYDKIKTGLSGLEIGVLVNNVGMSYEYPEYFLEIPDLDNTIKKLININVLSVCKVTRLVLPGMVERSKGVILNISSASGMLPVPLLTIYSATKAFVDFFSQCLHEEYKSKGIFVQSVMPYLVATKLAKIQKPTLDKPSAETFVKSAIKTVGLQTRTTGYVIHSLMGSINSKSLRNRYLKKRK >NP_114455.2 very-long-chain 3-oxoacyl-CoA reductase [Rattus norvegicus] ALPAAGFLYWVGASTIAYLTLRASAFQVWGPRLGEWAVVTGGTDGIGKSYAEELAKRGMKIVLISRSQDKLKEVSNNIKEKFNVETRTIAVDFDIYDKIKTGLSGLEIGVLVNNVGMSYEYPEYFLEIPDLDNTIKKLININVLSICKVTRLVLPGMVERSKGVILNISSASGMLPVPLLTVYSATKAFVDFFSQCLHEEYKSKGIFVQSVLPFFVATKLAKIRKPTLDKPSAETFVKSAIKTVGLQTRTTGYVIHAIMGSINNKSLRNRYLKKTK >XP_848504.1 very-long-chain 3-oxoacyl-CoA reductase isoform X1 [Canis lupus familiaris] ALPAAGLLYWVGAGTVAYVALRLSALRLWGPQLGEWAVVTGSTDGIGKSYAEELAKHGMKVVLISRSQDKLNQVSSEIREKFKVETRTVAVDFDIYDKIKTSLAGLKIGVLVNNVGMSYEYPEYFLDVPDLDNTIKKLININVLSVCKMTRLVLPGMVERSKGAILNISSASGMAPVPLLAIYSATKAFVDFFSRCLHEEYRSKGIFVQSVLPYYVATKLSKIRKPTLDKPSAETYVKSAIQTVGLQSRTTGYLIHSLMDSIIGKSTRARYMKKAK >XP_001158375.1 very-long-chain 3-oxoacyl-CoA reductase [Pan troglodytes] ALPAAGFLYWVGAGTVAYLALRISALRVWGPGLGEWAVVTGSTDGIGKSYAEELAKHGMKVVLISRSKDKLDQVSSEIKEKFKVETRTIAVDFDIYDKIKTALAGLEIGILVNNVGMSYEYPEYFLDVPDLDNVIKKMININILSVCKMTQLVLPGMVERSKGAILNISSGSGMLPVPLLTIYSATKTFVDFFSQCLHEEYRSKGVFVQSVLPYFVATKLAKIRKPTLDKPSPETFVKSAIKTVGLQSRTNGYLIHALMGSIINKSTRAHYLKKTK >XP_015142684.1 very-long-chain 3-oxoacyl-CoA reductase [Gallus gallus] ALPAAGLFYWVGALGVLYTAVLCAGLRVWGPQLGAWAVVTGATDGIGKAYAEELARHGMKVALISRSKEKLDQVAGEIKEKYKVETKVIVADFGIYDRIKAGLEGLEIGVLVNNVGISYSYPEYFIDVPDLDKMIDQMININIMSVCKMTRLVLPGMLERSKGVILNISSAAGMYPTPLLTLYSATKAFVDYFSRGLHAEYKSKGIIVQSVLPFYVATKLSKIRKPTFSKPSPETYVRAAIGTVGLQSQTNGCLPHAVMAWIFNKQVRARFLRKLK >NP_001094777.1 very-long-chain 3-oxoacyl-CoA reductase [Bos taurus] FLPATGFLYWVGVGTVAYLALRISAVRVWGPRLGEWAVVTGSTDGIGKSYAEKLAERGMKIVLISRSQDKLNQVSSEIREKFKVETKTIAVDFDIYDKIKTSLAGLEIGVLVNNVGMSYEYPEYFLDIPDLDNTIKKLISVNVLSVCKMTQLVLPGMVERSKGVILNISSATGRYPVPLLTIYSATKAFVDFFSQCLHEEYKSKGIFVQSVLPFFVATKLAKIRKPTLDKPSSENFVKCAIKTIGVQSRTSGYFIHYLMASVTNKSFRARYFKKMK >XP_020938823.1 very-long-chain 3-oxoacyl-CoA reductase isoform X1 [Sus scrofa] ALPAAGFLYWVGASTVAYLALRISALRVWGPWLGEWAVVTGGTDGIGKSYAEELAKRGMKIVLISRSQDKLDQVSSEISEKFKVETKTIAVDFDIYDKIKASLAGLNIGVLVNNVGMSYEYPEYFLDVPDLDNTIKKLITVNALSVCKMTRLVLPGMVERSKGAILNISSASGMYPVPLLTIYSATKAFVDFFSQCLHEEYKSKGVIVQSVLPYYVATKLAKIKRPTWDKPSPETFVKSAMKTIGVQSRTNGYPIHSLVASVSGNSIRVRYLKKMK >XP_002709111.1 PREDICTED: very-long-chain 3-oxoacyl-CoA reductase [Oryctolagus cuniculus] ALPAAGFLYWVGAGTVAYLALRISALRVWGPGLGEWAVVTGSTDGIGKSYAEQLAKRGMNVVLISRSQDKLNQVSNEIKEKFKVETRTIAVDFDIYNKIETGLAGLEIGVLVNNVGMSYEYPEYFLDIPDLDNTIKKLININVLSVCKMTRLVLPRMVERSKGAILNISSASGTFPVPLLTIYSATKAFVDFFSQCLHEEYRSKGIFVQSVLPYYVATKLAKIRKPTFDKPSSETFVKSAIKTVGLQSRTNGYLVHSLMGTIHNKSVRARYLKKYK >XP_024110605.1 very-long-chain 3-oxoacyl-CoA reductase [Pongo abelii] ALPAAGFLYWVGAGTVAYLALRISALRVWGPGLGEWAVVTGSTDGIGKSYAEELAKHGMKVVLISRSQDKLDQVSSEIKEKFKVETRTIAVDFDIYDKIKTGLSGLEIGILVNNVGMSYEYPEYFLDVPDLDNVIKKMININILSVCKMTQLVLPGMVERSKGAILNISSGSGMLPVPLLTIYSATKTFVDFFSRCLHEEYRSKGVFVQSVLPYFVATKLAKIRKPTLDKPSPETFVKSAIKTVGLQSRTNGYLIHALMGSIINKSTRAHHLKKTK >XP_003808259.1 very-long-chain 3-oxoacyl-CoA reductase [Pan paniscus] ALPAAGFLYWVGAGTVAYLALRISALRVWGPGLGEWAVVTGSTDGIGKSYAEELAKHGMKVVLISRSKDKLDQVSSEIKEKFKVETRTIAVDFDIYDKIKTALAGLEIGILVNNVGMSYEYPEYFLDVPDLDNVIKKMININILSVCKMTQLVLPGMVERSKGAILNISSGSGMLPVPLLTIYSATKTFVDFFSQCLHEEYRSKGVFVQSVLPYFVATKLAKIRKPTLDKPSPETFVKSAIKTVGLQSRTNGYLIHALMGSIINKSTRAHYLKKTK >XP_003993234.1 very-long-chain 3-oxoacyl-CoA reductase [Felis catus] ALPAAGFLYWVGAGTVAYLALRISALRVWGPGLGEWAVVTGSTDGIGKSYAEELAKHGMKIVLISRSQDKLNQVSSEIREKFKVETMTIAVDFDIYDKIKTSLAGLKIGVLVNNVGVSYEYPEYFLDVPDLDNTIKKLINVNVLSVCKMTRLVLPGMVERSKGAILNISSASGLVPVPLLAMYSATKAFVDFFSQCLHEEYRSKGIFVQSVLPFFIATKLSKIRKPTLDTPSAETFVKSAIKTVGLQSRTTGYLIHSLMGSIIGKSTRARYLKKAK >XP_004016470.1 very-long-chain 3-oxoacyl-CoA reductase [Ovis aries] VLPATGFLYWVGAGTVAYLALRILAVRVWGPRLGEWAVVTGSTDGIGKSYAEELAKRGMKIVLISRSQDKLNQVSSEIREKFKVETKTVAVDFDIYDKIKTSLAGLEIGVLVNNVGMSYEYPEYFLDVPDLDSTIKKLINVNVLSVCKMTRLVLPGMVERSKGVILNISSASGMYPVPLLTIYSATKAFVDFFSQCLHEEYKSKGIFVQSVLPYFVATKLAKIRRATLDKPSSETFVKSAIKTIGVQSRTNGYFIHSLLFSVANKSIRAHYFKKMK >XP_004051019.1 very-long-chain 3-oxoacyl-CoA reductase [Gorilla gorilla gorilla] ALPAAGFLYWVGAGTVAYLALRISALRVWGPGLGEWAVVTGSTDGIGKSYAEELAKHGMKVVLISRSKDKLDQVSSEIKEKFKVETRTIAVDFDIYDKIKTGLAGLEIGILVNNVGMSYEYPEYFLDVPDLDNVIKKMININILSVCKMTQLVLPGMVERSKGAILNISSGSGMLPVPLLTIYSATKTFVDFFSRCLHEEYRSKGVFVQSVLPYFVATKLAKIRKPTLDKPSPEMFVKSAIKTVGLQSRTNGYLIHALMGSIINKSTRAHYLKKTK >XP_004069451.1 very-long-chain 3-oxoacyl-CoA reductase-A [Oryzias latipes] IRRAEPLFFWVGAFTLAFFALWLLGFRIWSPKLGKWAVVTGATDGIGKSYAEELARRGFAMMLISRSQEKLDDVAKSLEEQFGVETKTIAVDFDIYPKIEAGLVGLEIGVLVNNVGVSYHYPEYYLNIPDLDNFLTNMINVNMTSVCQMTRLVLPGMVSRAKGVILNISSASGMYPLPLLTVYSATKAFMDFFSRGLQEEYRRQGIIIQSVLPFFVATKMTRIRKPTLDKPTPERYVAAELTTVGLQNQTNGYFPHAVMGWVTNRVQRSGYLHRRK >XP_013227387.2 very-long-chain 3-oxoacyl-CoA reductase [Columba livia] ASPAGSQALWKCQLCLSTASIVCIAGRRWVPGSRYSRVVTGATDGIGKAYAEELARRGMKVALISRSKEKLDQVASEIKEKYKVETRVIVADFDIYSGIKSGLEGLEIGVLVNNVGISYVYPEYFLDVPDLDKTVDKMININIMAVCKMTRLVLPGMLERSKGVILNISSAAGMYPTPLLTLYSATKAFVDYFSRGLHAEYKSKGIIVQSVLPYYVATKMSKIRKPTFDKPSPETYVRAALGTVGLQSQTNGCLPHALMGWIFNKGIRARYLKKMK >XP_005690184.1 PREDICTED: very-long-chain 3-oxoacyl-CoA reductase [Capra hircus] VLPATGFLYWVGAGTVAYLALRILAVRVWGPRLGEWAVVTGSTDGIGKSYAEELAKRGMKIVLISRSQDKLNQVSSEIREKFKVETKTVAVDFDIYDKIKTSLAGLEIGVLVNNVGMSYEYPEYFLDVPDLDNTIKKLINVNVLSVCKMTRLVLPGMVERSKGVILNISSASGMYPVPLLTIYSATKAFVDFFSQCLHEEYKSKGIFVQSVLPYFVATKLAKIRKATLDKPSSETFVKSAIKTIGVQSRTNGYFIHSLLFSVANKSIRAHYFKKMK >XP_014377653.1 very-long-chain 3-oxoacyl-CoA reductase, partial [Alligator sinensis] -------------------------------------------------------------------------------EKFNVETKIIVADFDIYTKIKAALEGLEIGVLVNNVGISYAYPEYFLDVPDLDNTIDKMININIMSVCKMTRLVLPGMLERSKGAILNISSASGMFPTPLLTLYSGTKAFVDFFSQGLHAEYKSKGIIVQSVLPYYVATKMARIRKPTFDKPSPETYVKAALGTVGLQSRTNGCLPHAIMGWFMNKQVRARFLKKAK >XP_014457595.1 PREDICTED: very-long-chain 3-oxoacyl-CoA reductase isoform X1 [Alligator mississippiensis] SLPAAGFLYWVGALSAAYVTLRAGGLRVWGPGLGAWAVVTGATDGIGKAYAEELARCGMKIALISRSQEKLDQVASQIKEKFNVETKIIVADFDIYTKIKAALEGLEIGVLVNNVGISYAYPEYFLDVPDLDNTIDKIININIMSVCKMTRLVLPGMLERSKGVILNISSASGMFPVPLLTLYSGTKAFVDFFSQGLHAEYKSKGIIVQSVLPYFVATKMARIRKPTFDKPSPETYVKAALGTVGLQSRTNGCLPHAIMGWFTNKKVRARFLKKVK >XP_031409404.1 very-long-chain 3-oxoacyl-CoA reductase [Meleagris gallopavo] ----------------------------------------------------------------------------------------------------------------------------------------------------MTRLVLPGMLERSKGVILNISSAAGMYPTPLLTLYSATKAFVDYFSRGLHAEYKSKGIIVQSVLPYYVATKLSKIRKPTFSKPSPETFVRAAIGTVGLQSQTNGCLPHAIMAWIFNKQIRARFLKKLK >XP_015819348.1 PREDICTED: very-long-chain 3-oxoacyl-CoA reductase-A-like [Nothobranchius furzeri] ICRAETPLFWVGALTVAFLTLWLLGFRIWSPKLGKWAVVTGATDGIGKSYAEELARRGFAMMLISRSQDKLDDVAKSIEEQFKVETRTIAVDFDIYRKIEAGLTGLEIGVLVNNVGVSYPYPEYYLHIPDLEHFITNTINVNMTSVCQMTRLVLPRMVDRSKGVILNISSASGMYPVPLLTVYSATKAFVDFFSRGLQEEYRRQGIIIQSVLPFFVVTKMTRIRKPTLDKPTPERYVAAELNTVGLQSQTNGYFPHAIMGWVTNRLQRTGYLQRRK >XP_030282561.1 very-long-chain 3-oxoacyl-CoA reductase-A-like [Sparus aurata] LRRAETPLFWVGAFTVASLVLWLLGFRIWTPKLGKWAVVTGATDGIGKSYAEELARRGFAMMLISRSQDKLDDVARSLEDQFKVETRTIAVDYDIYPKIEAGLAGLEIGVLVNNVGVSYPYPEYFLHIPDLDNFITNMINVNITSVCQMTRLVLPRMSERSKGVILNISSASGMYPVPLLTVYSSSKAFVDFFSRGLQEEYKRRGIIIQSVLPFFVATKMTRIRKPTLDKPTPERYVAAELKTVGLQTQTNGYFPHAVMGWLTNRLQRTGYLRRRK >XP_040183956.1 very-long-chain 3-oxoacyl-CoA reductase [Rana temporaria] PVPCAHFFCYVGVLAASWWGVRAAAVRVWGPGLGKWAVVTGATDGIGKAYAEELARHGVSIVLISRSQDKLDEVAKNIREKFKVETKVIAADFEIYERIEVGLKSLEIGVLVNNVGVSYEYPEYFLDIPDLDNTLDMLININITSVCKMTRLVMPGMLERSKGVILNISSASGMYPVPLLTVYSATKAFVDFFSRGLHAEYRNKGITVQSVLPFFVATKLSKIRKPTWDKPSPENYVRSALNTVGLQTRTNGYLAHALMGWVTNKGLRARFLKRAK
PhyML tree of selected proteins (XP_040183956_1_very_long_chain_3_oxoacyl_CoA_reductase__Rana_temporaria_:0.10876701,OCT82029_1_hypothetical_protein_XELAEV_18024537mg__Xenopus_laevis_:0.11962879,(((tr_A7MCK2_A7MCK2_DANRE_Hsd17b12b_protein_OS_Danio_rerio_OX_7955_GN_hsd17b12b_PE_2_SV_1:0.15896706,(XP_030282561_1_very_long_chain_3_oxoacyl_CoA_reductase_A_like__Sparus_aurata_:0.06154488,(XP_015819348_1_PREDICTED__very_long_chain_3_oxoacyl_CoA_reductase_A_like__Nothobranchius_furzeri_:0.04099989,XP_004069451_1_very_long_chain_3_oxoacyl_CoA_reductase_A__Oryzias_latipes_:0.0956954):0.02007866):0.19332132):0.10647422,((XP_001121130_1_very_long_chain_3_oxoacyl_CoA_reductase__Apis_mellifera_:0.95012891,NP_572420_1_spidey__Drosophila_melanogaster_:0.45447789):0.27439109,(XP_039248329_1_very_long_chain_3_oxoacyl_CoA_reductase_like__Styela_clava_:0.71091324,((XP_031563323_1_very_long_chain_3_oxoacyl_CoA_reductase_B_like__Actinia_tenebrosa_:0.67947959,(XP_038053153_1_very_long_chain_3_oxoacyl_CoA_reductase_B_like_isoform_X1__Patiria_miniata_:0.24339872,XP_030848589_1_very_long_chain_3_oxoacyl_CoA_reductase_B__Strongylocentrotus_purpuratus_:0.40845784):0.13042857):0.09326634,((CAE1306451_1_HSD17B12__Sepia_pharaonis_:0.67493048,(OWK16467_1_HSDL1__Cervus_elaphus_hippelaphus_:0.00000001,(KAB0350251_1_hypothetical_protein_FD754_015108__Muntiacus_muntjak_:0.00000001,KAB0383238_1_hypothetical_protein_FD755_005155__Muntiacus_reevesi_:0.00000001):0.01071014):0.61860495):0.12212218,NP_001254936_1_Very_long_chain_3_oxooacyl_coA_reductase_let_767__Caenorhabditis_elegans_:1.39806845):0.00615259):0.05352097):0.06757855):0.25895344):0.06402954,((((XP_002709111_1_PREDICTED__very_long_chain_3_oxoacyl_CoA_reductase__Oryctolagus_cuniculus_:0.05800243,(((NP_057226_1_very_long_chain_3_oxoacyl_CoA_reductase__Homo_sapiens_:0.00000001,(XP_001158375_1_very_long_chain_3_oxoacyl_CoA_reductase__Pan_troglodytes_:0.00000001,XP_003808259_1_very_long_chain_3_oxoacyl_CoA_reductase__Pan_paniscus_:0.00000001):0.00363944):0.00000001,(XP_004051019_1_very_long_chain_3_oxoacyl_CoA_reductase__Gorilla_gorilla_gorilla_:0.00366983,XP_024110605_1_very_long_chain_3_oxoacyl_CoA_reductase__Pongo_abelii_:0.01100869):0.00365928):0.05189148,(XP_003993234_1_very_long_chain_3_oxoacyl_CoA_reductase__Felis_catus_:0.03595231,XP_848504_1_very_long_chain_3_oxoacyl_CoA_reductase_isoform_X1__Canis_lupus_familiaris_:0.0484143):0.03589807):0.01290137):0.0169915,(NP_114455_2_very_long_chain_3_oxoacyl_CoA_reductase__Rattus_norvegicus_:0.02968169,NP_062631_1_very_long_chain_3_oxoacyl_CoA_reductase__Mus_musculus_:0.0264754):0.08652403):0.00985373,(XP_020938823_1_very_long_chain_3_oxoacyl_CoA_reductase_isoform_X1__Sus_scrofa_:0.08938331,(NP_001094777_1_very_long_chain_3_oxoacyl_CoA_reductase__Bos_taurus_:0.05891378,((XP_020763161_1_very_long_chain_3_oxoacyl_CoA_reductase__Odocoileus_virginianus_texanus_:0.02375687,(KAF4009401_1_hypothetical_protein_G4228_000209__partial__Cervus_hanglu_yarkandensis_:0.03640417,XP_043338175_1_very_long_chain_3_oxoacyl_CoA_reductase__Cervus_canadensis_:0.00000001):0.01806027):0.00735241,(XP_005690184_1_PREDICTED__very_long_chain_3_oxoacyl_CoA_reductase__Capra_hircus_:0.00000001,XP_004016470_1_very_long_chain_3_oxoacyl_CoA_reductase__Ovis_aries_:0.00710257):0.02319867):0.00571724):0.02243661):0.03121023):0.16756644,((XP_013227387_2_very_long_chain_3_oxoacyl_CoA_reductase__Columba_livia_:0.17792185,(XP_031409404_1_very_long_chain_3_oxoacyl_CoA_reductase__Meleagris_gallopavo_:0.01017964,XP_015142684_1_very_long_chain_3_oxoacyl_CoA_reductase__Gallus_gallus_:0.03862203):0.04970335):0.06788903,(XP_014457595_1_PREDICTED__very_long_chain_3_oxoacyl_CoA_reductase_isoform_X1__Alligator_mississippiensis_:0.02492982,XP_014377653_1_very_long_chain_3_oxoacyl_CoA_reductase__partial__Alligator_sinensis_:0.01391874):0.06419902):0.06369181):0.05839839):0.11731627);
BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)