PB0028

DATABASE

Click here to access PB0028 phyletic profile

PBID	Uniprot	Name	Gene	Alternative	Organism	Uniprot Description
PB0028	Q8N474	Secreted frizzled-related protein 1	SFRP1	FRP, FRP-1, FRP1, FrzA, SARP2	Homo_sapiens	Inhibits WNT1/WNT4-mediated TCF-dependent transcription.

Domains

Gene Ontology

PF01392 (Fz) PF01759 (NTR)

GO:0004197 (enables) cysteine-type endopeptidase activity GO:0005109 (enables) frizzled binding GO:0005515 (enables) protein binding GO:0008201 (enables) heparin binding GO:0017147 (enables) Wnt-protein binding GO:0042802 (enables) identical protein binding GO:0001649 (involved in) osteoblast differentiation GO:0001657 (involved in) ureteric bud development GO:0001756 (involved in) somitogenesis GO:0001843 (involved in) neural tube closure GO:0001954 (involved in) positive regulation of cell-matrix adhesion GO:0002244 (involved in) hematopoietic progenitor cell differentiation GO:0006508 (involved in) proteolysis GO:0008284 (involved in) positive regulation of cell population proliferation GO:0008285 (involved in) negative regulation of cell population proliferation GO:0008584 (involved in) male gonad development GO:0008585 (involved in) female gonad development GO:0009267 (involved in) cellular response to starvation GO:0009410 (involved in) response to xenobiotic stimulus GO:0009950 (involved in) dorsal/ventral axis specification GO:0009952 (involved in) anterior/posterior pattern specification GO:0010564 (involved in) regulation of cell cycle process GO:0010629 (involved in) negative regulation of gene expression GO:0010719 (involved in) negative regulation of epithelial to mesenchymal transition GO:0010975 (involved in) regulation of neuron projection development GO:0014034 (involved in) neural crest cell fate commitment GO:0014070 (involved in) response to organic cyclic compound GO:0016055 (involved in) Wnt signaling pathway GO:0021915 (involved in) neural tube development GO:0030097 (involved in) hemopoiesis GO:0030154 (involved in) cell differentiation GO:0030177 (involved in) positive regulation of Wnt signaling pathway GO:0030178 (involved in) negative regulation of Wnt signaling pathway GO:0030279 (involved in) negative regulation of ossification GO:0030307 (involved in) positive regulation of cell growth GO:0030308 (involved in) negative regulation of cell growth GO:0030336 (involved in) negative regulation of cell migration GO:0030514 (involved in) negative regulation of BMP signaling pathway GO:0033689 (involved in) negative regulation of osteoblast proliferation GO:0035019 (involved in) somatic stem cell population maintenance GO:0043065 (involved in) positive regulation of apoptotic process GO:0043066 (involved in) negative regulation of apoptotic process GO:0043508 (involved in) negative regulation of JUN kinase activity GO:0043547 (involved in) positive regulation of GTPase activity GO:0044344 (involved in) cellular response to fibroblast growth factor stimulus GO:0044345 (involved in) stromal-epithelial cell signaling involved in prostate gland development GO:0045578 (involved in) negative regulation of B cell differentiation GO:0045600 (involved in) positive regulation of fat cell differentiation GO:0045668 (involved in) negative regulation of osteoblast differentiation GO:0045671 (involved in) negative regulation of osteoclast differentiation GO:0045765 (involved in) regulation of angiogenesis GO:0045880 (involved in) positive regulation of smoothened signaling pathway GO:0045892 (involved in) negative regulation of transcription, DNA-templated GO:0045893 (involved in) positive regulation of transcription, DNA-templated GO:0046546 (involved in) development of primary male sexual characteristics GO:0046676 (involved in) negative regulation of insulin secretion GO:0046851 (involved in) negative regulation of bone remodeling GO:0048147 (involved in) negative regulation of fibroblast proliferation GO:0048546 (involved in) digestive tract morphogenesis GO:0050679 (involved in) positive regulation of epithelial cell proliferation GO:0050680 (involved in) negative regulation of epithelial cell proliferation GO:0050732 (involved in) negative regulation of peptidyl-tyrosine phosphorylation GO:0051496 (involved in) positive regulation of stress fiber assembly GO:0051894 (involved in) positive regulation of focal adhesion assembly GO:0060070 (involved in) canonical Wnt signaling pathway GO:0060071 (involved in) Wnt signaling pathway, planar cell polarity pathway GO:0060218 (involved in) hematopoietic stem cell differentiation GO:0060346 (involved in) bone trabecula formation GO:0060527 (involved in) prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis GO:0060687 (involved in) regulation of branching involved in prostate gland morphogenesis GO:0060766 (involved in) negative regulation of androgen receptor signaling pathway GO:0071305 (involved in) cellular response to vitamin D GO:0071347 (involved in) cellular response to interleukin-1 GO:0071356 (involved in) cellular response to tumor necrosis factor GO:0071363 (involved in) cellular response to growth factor stimulus GO:0071380 (involved in) cellular response to prostaglandin E stimulus GO:0071391 (involved in) cellular response to estrogen stimulus GO:0071392 (involved in) cellular response to estradiol stimulus GO:0071456 (involved in) cellular response to hypoxia GO:0071481 (involved in) cellular response to X-ray GO:0071504 (involved in) cellular response to heparin GO:0071542 (involved in) dopaminergic neuron differentiation GO:0071560 (involved in) cellular response to transforming growth factor beta stimulus GO:0071773 (involved in) cellular response to BMP stimulus GO:0090090 (involved in) negative regulation of canonical Wnt signaling pathway GO:0090175 (involved in) regulation of establishment of planar polarity GO:0090179 (involved in) planar cell polarity pathway involved in neural tube closure GO:0090244 (involved in) Wnt signaling pathway involved in somitogenesis GO:0090246 (involved in) convergent extension involved in somitogenesis GO:0090263 (involved in) positive regulation of canonical Wnt signaling pathway GO:1902043 (involved in) positive regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1904956 (involved in) regulation of midbrain dopaminergic neuron differentiation GO:2000041 (involved in) negative regulation of planar cell polarity pathway involved in axis elongation GO:2000052 (involved in) positive regulation of non-canonical Wnt signaling pathway GO:2000054 (involved in) negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification GO:2000080 (involved in) negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation GO:2000270 (involved in) negative regulation of fibroblast apoptotic process GO:2000271 (involved in) positive regulation of fibroblast apoptotic process GO:2001238 (involved in) positive regulation of extrinsic apoptotic signaling pathway GO:0005615 (is active in) extracellular space GO:0005576 (located in) extracellular region GO:0005829 (located in) cytosol GO:0005886 (located in) plasma membrane GO:0009986 (located in) cell surface GO:0062023 (located in) collagen-containing extracellular matrix GO:0070062 (located in) extracellular exosome

External Links	Description
Intact	Open source database system and analysis tools for molecular interaction data.
Protein Atlas	An open access resource for human proteins
InterPro (new pfam)	InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish) >sp|Q8N474|SFRP1_HUMAN Secreted frizzled-related protein 1 OS=Homo sapiens OX=9606 GN=SFRP1 PE=1 SV=1 MGIGRSEGGRRGAALGVLLALGAALLAVGSASEYDYVSFQSDIGPYQSGRFYTKPPQCVD IPADLRLCHNVGYKKMVLPNLLEHETMAEVKQQASSWVPLLNKNCHAGTQVFLCSLFAPV CLDRPIYPCRWLCEAVRDSCEPVMQFFGFYWPEMLKCDKFPEGDVCIAMTPPNATEASKP QGTTVCPPCDNELKSEAIIEHLCASEFALRMKIKEVKKENGDKKIVPKKKKPLKLGPIKK KDLKKLVLYLKNGADCPCHQLDNLSHHFLIMGRKVKSQYLLTAIHKWDKKNKEFKNFMKK MKNHECPTFQSVFK >tr|A3KNP6|A3KNP6_DANRE Secreted frizzled-related protein 1 OS=Danio rerio OX=7955 GN=sfrp1b PE=2 SV=1 MKNLALKLWLSIAPFLCLPLLNALEDEDYIWPPDSSDKHPPCVDIPEDLRLCFNVGYGRM MLPNLLDHETIAEVKQQAVSWVPLVHKACHKGTQVLLCSLFAPVCLDRPLYPCRWFCEAV RDSCAPIMQAFGFPWPEMLRCDKFPLGEVCISSNATKSNETDLIAGGSSVCPACENEMKT DLILDQMCASEFAIKTKIKEVKIDNLDRKVILQKRRKLVRAGSMKKQDLKKLVLYLKSGA HCPCQQLENLENHYLIMGRSVGKQYVLTGIHKWDNSSKDFKKTIKKLKNHKCPSYDHVFK >tr|Q7T2K9|Q7T2K9_DANRE Secreted frizzled-related protein 1 OS=Danio rerio OX=7955 GN=sfrp1a PE=2 SV=1 MKSLASLSLWRIIILILPLVSLGQTFEYGWPDNYDKPPQCVDIPVDLRLCQGVGYHQMLL PNLLEHESMAEVKQQAGSWVPLLHKNCDPGTQLLLCSLFAPVCMERPIYPCRRLCENVRD GCSPIMAAFGFPWPHILTCDKFPQDDMCINTPNDTSTSEPNGHPPVCPPCDNEMKMDVIL DHMCASEFAIKTKIQEVKRENMDRKVTLQKKKRTIKMGTLKKKDLKKLTLYLKNGADCPC TQLDNTRNTYLIMGRKVDKQYLLTGIHKWDKSNREFKKTMKKLKSHKCPAYENVFK
Selected proteins from model organisms >NP_003003.3 secreted frizzled-related protein 1 precursor [Homo sapiens] MGIGRSEGGRRGAALGVLLALGAALLAVGSASEYDYVSFQSDIGPYQSGRFYTKPPQCVDIPADLRLCHN VGYKKMVLPNLLEHETMAEVKQQASSWVPLLNKNCHAGTQVFLCSLFAPVCLDRPIYPCRWLCEAVRDSC EPVMQFFGFYWPEMLKCDKFPEGDVCIAMTPPNATEASKPQGTTVCPPCDNELKSEAIIEHLCASEFALR MKIKEVKKENGDKKIVPKKKKPLKLGPIKKKDLKKLVLYLKNGADCPCHQLDNLSHHFLIMGRKVKSQYL LTAIHKWDKKNKEFKNFMKKMKNHECPTFQSVFK >KAF4026217.1 hypothetical protein G4228_018281 [Cervus hanglu yarkandensis] MGGGRWAAAGALLALAAGLLAAGSASEYDYVSFQSDIGAYQSGRFYTKPPQCVDIPADLRLCHNVGYKRMVLPNLLEHET MAEVKQQASSWVPLLNKNCHIGTQVFLCSLFAPVCLDRPIYPCRWLCEAVRDSCEPVMQFFGFYWPEMLKCDKFPEGDVC IAMTPPNATEASKPQGTTVCPPCDNELKSEAIIEHLCASEFALRMKIKEVKKENGDKKIVPKKKKPLKLGPIKKKELKKL VLYLKNGADCPCHQLDNLSHHFLIMGRKVKSQYLLTAIHKWDKKNKEFKNFMKKMKNHECPTFQSVFK >XP_006568530.1 frizzled-2 [Apis mellifera] MIPRYAIYVFSVAVFSVNALHTKDPLAHHGRCEPITINLCMNIPYNETIMPNLMNHQKQEDAGQEVHQFAPLVKMKCSPD LRFFLCTVYAPVCTIIDRAIPPCRSLCESARAGCERLMNSFGFAWPDNLDCSKLPENGGPELCVGHNETTPPEPSPPVYT PPRMPVAEFQPSWTGGPKTYGSGFMLGARDFGFVCPMQFKVPHELGYSLKVGDKVELNCGAPCDGMFFTERERRFSRIWV GTWASVCAASCFFTFLTFLIDTDRFRYPERPIIFLSVCYLMVALAYVIGWAAGNSIACREPFPPPLDMRIQMASTITQGT KHELCTVLFMVLYFFGMASSIWWVILTLTWFLAAGLKWGHEAIEANSQYFHLAAWAAPAIKTVTILAMGKVEGDILSGVC YVGLWNVEALRGFVLAPLCVYLILGTAFLLAGFVSLFRIRTVMKHDGTKTDKLEKLMIRIGIFSVLYIVPALIVIACLFY EQAYFDQWMLTWNMEMCSRPGPQSLYSMPCPVGERTRDVGRRPEFEVFMIKYLMAMIVGITSSFWVWSSKTLTSWRQFFN HIQGRRAEAYV >CAE1239454.1 FZD1_7 [Sepia pharaonis] MLKELRNFIIGFIFLCSILYHQGFLLAASQSSISRRVNNHQGLPTHGKCEPITIPLCKGIQYNMTILPNILNHQKQDDAG LEVHQFYPLVKVECSPYLRFFLCSMYAPVCTLLDHAIPPCQQMCQQAREGCEKLMNRFGFEWPESLRCEKFPRSGLCVGE NITDPTPPPTPHDRYNRPTQARPVGRDYFQPNTNSSGFHCPVEFRVPKTLDYRLKVGDSLERDCGAPCNDMFFTPDKRDF ARMWIGICSAVCMASTLFTVLTFLIDMTRFRYPERPIIFLSGCYFMVALAYVVGFALRDSVACNRPFDPPIHNLQSDKMV SIITQGTKKEGCTILFMMLYFFSMASSIWWVILTLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAIKTIAILAMGQVDG DVLSGVCFTGIFDVDALRGFVLAPLVVYLIIGTTFLLAGFVSLFRIRTIMKSDGTKTDKLEKLMVRIGIFSVLYTVPATI VIACLFYEQSFRDQWMVSWHSRVCITYFFPCPHTGDPTRPWPDFTVFMIKYLMTIIVGITSGVWIWTGKTLNSWKRFYCR FFMPRNQSAVV >CAA38459.1 frizzled [Drosophila melanogaster] MWRQILFILPTLIQGVQRYDQSPLDASPYYRSGGGLMASSGTELDGLPHHNRCEPITISICKNIPYNMTIMPNLIGHTKQ EEAGLEVHQFAPLVKIGCSDDLQLFLCSLYVPVCTILERPIPPCRSLCESARVCEKLMKTYNFNWPENLECSKFPVHGGE DLCVAENTTSSASTAATPTRSVAKVTTRKHQTGVERPHRNIGFVCPVQLKTPLGMGYELKVGGKDLHDCGAPCHAMFFPE RERTVLRYWVGSWAAVCVASCLFTVLTFLIDSSRFRYPERAIVFLAVCYLVVGCAYVAGLGAGDSVSCREPFPPPVKLGR LQMMSTITQGHRQTTSCTVLFMALYFCCMAAFAWWSCLAFAWFLAAGLKWGHEAIENKSHLFHLVAWAVPALQTISVLAL AKVEGMYLWQFHTIN >KYO28472.1 secreted frizzled-related protein 1 [Alligator mississippiensis] MCRAAHVPHAMGSGKNSAVLPSEYDYVSYQSDLGAYQSGRFYPKPHQCVPIPADLRLCHSVGYDKMVLPNLLDHETMAEV KHQASSWVPLLNKNCHMGTQVFLCALFAPVCLDRPVYPCRWLCEAVRDACEPVMQFFGFYWPDMLKCDQFPQDDVCIAMT TPNATEVARPKGSGVCPPCDNEMKSEAIIEHLCASEFALKMTIKEVKRENGDRKIIPKKRKALKMGPIRKKNLKKLVLYL KNGAGCPCHQLDNLNHYFLIMGRQVKSQYLLTAIYKWDKKNKEFKQFMKKMKSPDCPTFPSVFK >XP_030273955.1 secreted frizzled-related protein 1-like [Sparus aurata] MISASESVWRMIRLAVTVALISACAASEYEYLSWKSDMYNGGRSYGKPPQCVDIPEDLRLCHNVGYNQMLLPNVLEHETM AEVKQQASSWVPLVHKNCHPGTQVFLCSLFAPVCLERPIFPCRWLCEAVRDGCTPIMEAFGFPWPEMLTCDKFPQDDVCI AMTQPNATEAPMPTGYSPICPPCDNEMKTDAMLEHMCASEFAFKTKIKEVKRENMDRKVILQKRKKMLKPGNLKKKDMKT LVMYLKNGADCPCQQLDNLANQYLIMGRKVDKQYLLTGIHKWDKSSKEFKKAIKKLKTYKCPAFENVF >NP_001098307.1 secreted frizzled-related protein 1 precursor [Oryzias latipes] MGSASVLFRRWTQLVLLLAVTCGASEYEYTWAAGSYNGGRGYGKAPQCVDIPDDLRLCHTVGYTQMLLPNLLEHETMAEV KQQASSWVPLVHKNCHKDTQVFLCALFAPVCMERPIYPCRWLCETVRDSCSPIMEAFGFPWPEMLTCDKFPQDGVCIAVT QPNATEATWPSGHSPACPPCDNEIKNDAMLENICASEFALKAKIKEVKQENMDRKVILQRRKRMVKQGNLKKRDLKKLTL YLKNGANCPCQQLENLENQYLIMGRKVDKQFLLTGIHKWDKSSKEFKKIMKKLKNYKCPAFENVFK >NP_001080957.1 secreted frizzled-related protein 1 L homeolog precursor [Xenopus laevis] MNGENGIWPLLLFWVTPGILSQVPQASEYDYVSFQPDLGRQYQSGRFYSRPAQCLEIPQDMTLCHGVGYNKMVLPNLLDS ETMAEVKYQASSWVPLLSKKCHPSTQVFLCSLFAPLCLDRPVYPCRRLCESVRDACEPVMQYFGFHWPEMLRCEQYPTEE DVCIAVHLPNATQAPRSRKTEVCPQCDSEIKADSLYEHMCASDFALKVSIREVRKENGDRKLLLRKEKALKKGPIQKKDW AELVLYLKNGANCPCHQLDQLKGQFLVLGPKAKAQHLLTAIHKWDKTNREFNRFMRKVKKSKCPIPLTAPH >XP_015799833.1 PREDICTED: secreted frizzled-related protein 5 [Nothobranchius furzeri] MALGQKSPRLALTQGFFSLALGLLLFSLLLFTIVDADEYDYYNWQADNFHNGRFYTKQPQCVDIPADLRLCHNVGYKKMR LPNLLDHETMPEVKQQASSWVPLLAKRCHADTQVFLCSLFAPVCLDRPIYPCRSLCEAVRDSCAPVMETYGFPWPEMLNC DKFPIDNDLCIPMQFAANHVTQPPVSNVCPPCDNEMKADNIMEHYCASDFALKMKIKEVKKEKGDRKLIAAQKKKKVLKQ GVLRKKDLKKLTLYIKNGANCPCSQLENLGSNFLIMGRKVDQQLLLMSIHKWDKKSKELKFAIKYMKSHQCPTYHSVFQ >KAB0348761.1 hypothetical protein FD754_013618 [Muntiacus muntjak] MGGGRWAAAGALLALAAGLLAAGSASEYDYVSFQSDIGAYQSGRFYTKPPQCVDIPADLRLCHNVGYKRMVLPNLLEHET MAEVKQQASSWVPLLNKNCHIGTQVFLCSLFAPVCLDRPVYPCRWLCEAVRDSCEPVMQFFGFYWPEMLKCDKFPEGDVC IAMTPPNATEASKPQGPCRVHLRGDAAGTWSRLSPWYPHPRPPPEAGVVEGRETKTHAVFLESFTPWLPSPLAPPKSALG TICPPPSIPGVLR >KAB0383808.1 hypothetical protein FD755_005725 [Muntiacus reevesi] MRAAAGGARAAALALLLGALHGAPARGEEYDYYGWQTEPLHGRSYSKPPQCLDIPADLPLCHTVGYKRMRLPNLLEHESL AEVKQQASSWLPLLAKRCHSDTQVFLCSLFAPVCLDRPIYPCRSLCEAVRAGCAPLMEAYGFPWPEMLHCHKFPLDNDLC IAVQFGHLPATAPPVTKICAQCEMEHSADGLMEQMCSSDFVVKMRIKEIKIENGDRKLIGAQKKKKLLKPGPLKRKDTKR LVLHMKNGAGCPCPQLDNLAGSFLVMGRRVDGQLLLMAVYRWDKKNKEMKFAVKFMFSYPCSLYYPFFYGAAEPH >XP_039270710.1 secreted frizzled-related protein 1-like isoform X2 [Styela clava] MTIGSIVIVLLNALLCSANTFGAFTGVDTASPFAKNFVCEPIPHSLKLCRNIAYNQMRLPNLLGHETMDEVKQQAASWVP LLNKRCHKDLQRLLCSLFSPVCIEDSPEPIYPCQSLCQAVKGACEPVMQKVGYPWPDMLSCDKFRDNDMCVPQECHHNCS SYAEPESTPICPACGNELDAETILNLYCAVEFVLKVKIRSVKTSRKDLKLMADKRKRVIYQEGSLKRKDLRKLTLLIRGG KSCTCPHLEPQGKGKKKKKDFYLVMGGKVGRKLLVSAIYRWPKKLKMLRRLSKKFTPDLCS >XP_781087.2 secreted frizzled-related protein 5 isoform X2 [Strongylocentrotus purpuratus] MIERVLVVLLAFAASSPGVWGQETETDMAMLGVNSRTYPLDLSGRPKETDCVDIPEDLSLCQNIGYTRMRMPNLLEHDSL DEVRNQAKSWVPLLLQRCHEGTQLFLCTLFAPVCLEVDRPIYPCRSLCEEVQAGCGPLMESNCFPWPAMLQCDKFPEDND LCIRLNMRNQNGTVEAQPFEMSAAMQEAYMMHFTQCHDDSLEDTLLRKFCNSDFVLKVKIKTIRESKDGKKYIGDPNPEK LEVLKQGSLKTKDLQRLTFYVREGANCQCDMLERSGNYLLVMGHRDSKKNRKLFMTFVHSWEKTRDFRRAIKGFENPDMC ENLETATEGRREEIAPQDAEPHEMTPADEVLLASQTNTPVNDGVYTTHQVMADETPSPKTNTRRERKRGKRTRDRPRKNR ERENREMPVRRARSKWD >XP_043340126.1 secreted frizzled-related protein 2 [Cervus canadensis] MPQGPGSLLLIVLASHCCLGFARGLFFGQPDFSYKRSNCKPIPANLQLCHGIEYQNMRLPNLLGHETMKEVLEQAGAWIP LVMKQCHPDTKKFLCSLFAPVCLDDLDETIQPCHSLCVQVKDRCAPVMSAFGFPWPDMLECDRFPQDNDLCIPLASSDHL LPATEEAPKVCEACKTKNEDDNDIMETLCKNDFALKIKVKEITYINRDTKIILETKSKTIYKLNGVSERDLKKSVLWLKD SLQCTCEEMNDINAPYLVMGQKLGGELVITSVKRWQKGQREFKRISRSIRKLQC >XP_038052835.1 secreted frizzled-related protein 5-like isoform X2 [Patiria miniata] MIGSVVVVMAACLAQMTAGFAMDLSGRITKPTCVDIPVDLALCQNIGYNRMRMPNLLDHDSIFEVKDQSQGWIPLLMVNC DNDTQLFLCSLFSPVCLDRPIYPCRSLCRKVRQNCEPIMLRNCFPWPSMLECDRFPEDNGLCIQSEMRQRNATDQPTQSS GSMIPSGIGMSGMVAAVGSLFTQCHDDADAASIVEYFCNADFVLKMKLKEVKETDEGMRYVGDPTPGKFAVIKQGSLKQK DLAKMRFWTREGANCGCDMLRPRKENFLVMGHRDGKKLYMTYVHIWTKSRELRNANKQFAQPCPGDGVESSELPATKKPR KDRGGKKGRPDRRERPGRDGAAETTTQAVTERKLTREERRQLREQMRETKRENRRNKE >NP_500977.2 Secreted frizzled-related protein 1 [Caenorhabditis elegans] MMLFPVLYILFAFSVTNGYLEDSWAMFSSERPVGPKCVDIPSNLSICNGIEYTQMRLPNILEHETVSEAIHASKDWESLL RLNCHPDTQRFLCSLFAPVCLMQMDRLILPCKSLCMAVKQGCENRMANYGFPWPEMLSCEKFEDDDMCIKPMQPAKPPAG SSTTCTACSQVATYENLVDQFCRSHLVLKAKVIRDSPTHIRVRNGRSLKKGERRRGVSDVEIRLSSESDGSCPCNIPVKN QNEKLLVMASRQPDGKYLANLVLPWQKEKNFKRAIHQFQRLNCQSLGREIRESASRRPHYYEMRRHNTGRYQMF >XP_031565722.1 secreted frizzled-related protein 1-like [Actinia tenebrosa] MDFLRCLLLLAGVFHVALCYRTRSHHCVDITSNTAPLCANLSLGYDKMMLPNFLRHDTAMEVRRELAQWSPLVGSGCHPY LKHFLCSVFAPVCMLELIPPCRSLCSMVQNSCEPLMRRHNYTWPSMLDCRKYPENSMCVKIETPTPIPTTTVCEEDGSNV PLDELQKKFCDSDFAMRARVSEKKMKDGYLILKATAIKSLKGSLKRDQLQRLRIPNMESRNCGYVNKRKQFLILGTKRGR RMIVTYLMKWKDFRNMRRKIKEKACRKM >NP_038862.2 secreted frizzled-related protein 1 precursor [Mus musculus] MGVGRSARGRGGAASGVLLALAAALLAAGSASEYDYVSFQSDIGSYQSGRFYTKPPQCVDIPVDLRLCHN VGYKKMVLPNLLEHETMAEVKQQASSWVPLLNKNCHMGTQVFLCSLFAPVCLDRPIYPCRWLCEAVRDSC EPVMQFFGFYWPEMLKCDKFPEGDVCIAMTPPNTTEASKPQGTTVCPPCDNELKSEAIIEHLCASEFALR MKIKEVKKENGDKKIVPKKKKPLKLGPIKKKELKRLVLFLKNGADCPCHQLDNLSHNFLIMGRKVKSQYL LTAIHKWDKKNKEFKNFMKRMKNHECPTFQSVFK >NP_001263641.2 secreted frizzled-related protein 1 precursor [Rattus norvegicus] MGVGRNARGRGGAASGVLLALAAALLAAGSASEYDYVSFQSDIGSYQSGRFYTKPPQCVDIPVDLRLCHN VGYKKMVLPNLLEHETMAEVKQQASSWVPLLNKNCHMGTQVFLCSLFAPVCLDRPIYPCRWLCEAVRDSC EPVMQFFGFYWPEMLKCDKFPEGDVCIAMTPPNATEASKPQGTTVCPPCDNELKSEAIIEHLCASEFALR MKIKEVKKENGDKKIVPKKKKPLKLGPIKKKELKRLVLFLKNGADCPCHQLDNLSHNFLIMGRKVKSQYL LTAIHKWDKKNKEFKNFMKKMKNHECPTFQSVFK >NP_776885.1 secreted frizzled-related protein 1 precursor [Bos taurus] MGGGRWAAAGALLALAAGLLAAGSASEYDYVSFQSDIGAYQSGRFYTKPPQCVDIPADLRLCHNVGYKRM VLPNLLEHETMAEVKQQASSWVPLLNKNCHIGTQVFLCSLFAPVCLDRPIYPCRWLCEAVRDSCEPVMQF FGFYWPEMLKCDKFPEGDVCIAMTPPNATEASKPQGTTVCPPCDNELKSEAIIEHLCASEFALRMKIKEV KKENGDKKIVPKKKKPLKLGPIKKKELKKLVLYLKNGADCPCHQLDNLSHHFLIMGRKVKSQYLLTAIHK WDKKNKEFKTFMKKMKNHECPTFQSVFK >NP_989884.2 secreted frizzled-related protein 1 precursor [Gallus gallus] MGRVRGALRALLSLAAGLLACGGASEYDYVSYQSDLGPYPGGRFYTKPHQCVAIPADLRLCHSVGYDKMV LPNLLDHETMAEVKHQASSWVPLLNKNCHMGTQVFLCSLFAPVCLDRPVYPCRWLCEAVRDSCEPVMQFF GFFWPEMLKCDQFPQDDVCIAMTTPNATEVSRPKGTTVCPPCDNEMKSEAIVEHLCASEFALKMTIKEVK KENGDKVIIPRKRKALKLGPIRKKNLKKLVLLLKNGADCPCHQLDNLGHHFLIMGRQVKTQHLLTAIYKW DKKNKEFKKFMKKVKAPDCPTFPSVFK >XP_003639612.2 secreted frizzled-related protein 1 [Canis lupus familiaris] MGSGRGAGGRRWAARGVLLALAAGLLAASSASEYDYVSFQSDIGSYQSGRFYTKPPQCVDIPADLRLCHN VGYKKMVLPNLLEHETMAEVKQQASSWVPLLNKNCHIGTQVFLCSLFAPVCLDRPIYPCRWLCEAVRDSC EPVMQFFGFYWPEMLKCDKFPEGDVCIAMTPPNATEASKPQGTTVCPPCDNELKSEAIIEHLCASEFALR MKIKEVKKENGDKKIVPKKKKPLKLGPIKKKELKKLVLYLKNGADCPCHQLDNLSHHFLIMGRKVKSQYL LTAIHKWDKKNKEFKNFMKKMKNHECPTFQSVFK >XP_001138037.1 secreted frizzled-related protein 1 [Pan troglodytes] MGSGRSVGGRRGAALGVLLALGAALLAVGSASEYDYVSFQSDIGPYQSGRFYTKPPQCVDIPADLRLCHN VGYKKMVLPNLLEHETMAEVKQQASSWVPLLNKNCHAGTQVFLCSLFAPVCLDRPIYPCRWLCEAVRDSC EPVMQFFGFYWPEMLKCDKFPEGDVCIAMTPPNATEASKPQGTTVCPPCDNELKSEAIIEHLCASEFALR MKIKEVKKENGDKKIVPKKKKPLKLGPIKKKDLKKLVLYLKNGADCPCHQLDNLSHHFLIMGRKVKSQYL LTAIHKWDKKNKEFKNFMKKMKNHECPTFQSVFK >XP_024106845.1 secreted frizzled-related protein 1 [Pongo abelii] MGSGRSVGGRRGAALGVLLALGAALLAVGSASEYDYVSFQSDIGPYQSGRFYTKPPQCVDIPADLRLCHN VGYKKMVLPNLLEHETMAEVKQQASSWVPLLNKNCHAGTQVFLCSLFAPVCLDRPIYPCRWLCEAVRDSC EPVMQFFGFYWPEMLKCDKFPEGDVCIAMTPPNATEASKPQGTTVCPPCDNELKSEAIIEHLCASEFALR MKIKEVKKENGDKKIVPKKKKPLKLGPIKKKDLKKLVLYLKNGADCPCHQLDNLSHHFLIMGRKVKSQYL LTAIHKWDKKNKEFKNFMKKMKNHECPTFQSVFK >XP_019478198.1 secreted frizzled-related protein 1 [Meleagris gallopavo] MVLPNLLDHETMAEVKHQASSWVPLLNKNCHMGTQVFLCSLFAPVCLDRPVYPCRWLCEAVRDSCEPVMQ FFGFFWPEMLKCDQFPQDDVCIAMTAPNATEVSRPKGTTVCPPCDNEMKSEAIVEHLCASEFALKMTIKE VKKENGDKVIIPRKRKALKLGPIRKKNLKKLVLLLKNGADCPCHQLDNLGHHFLIMGRQVKTQHLLTAIY KWDKKNKEFKKFMKKVKAPDCPTFPSVFK >XP_003359916.2 secreted frizzled-related protein 1 [Sus scrofa] MGGGRWAAAGVLLALAAGLLAAGSASEYDYVSFQSDIGSYQSGRFYTKPPQCVDIPVDLRLCHNVGYKKM VLPNLLEHETMAEVKQQASSWVPLLNKNCHIGTQVFLCSLFAPVCLDRPIYPCRWLCEAVRDSCEPVMQF FGFYWPEMLKCDKFPEGDVCIAMTPPNATEASKPQGTPVCPPCDNELKSEAIIEHLCASEFALRMKIKEV KKENGDKKIVPKKKKPLKLGPIKKKELKKLVLYLKNGADCPCHQLDNLSHHFLIMGRKVKGQYLLTAIHK WDKKNKEFKNFMKKMKNHECPTFQSVFK >XP_034821881.1 secreted frizzled-related protein 1 [Pan paniscus] MGSGRSVGGRRGAALGVLLALGAALLAVGSASEYDYVSFQSDIGPYQSGRFYTKPPQCVDIPADLRLCHN VGYKKMVLPNLLEHETMAEVKQQASSWVPLLNKNCHAGTQVFLCSLFAPVCLDRPIYPCRWLCEAVRDSC EPVMQFFGFYWPEMLKCDKFPEGDVCIAMTPPNATEASKPQGTTVCPPCDNELKSEAIIEHLCASEFALR MKIKEVKKENGDKKIVPKKKKPLKLGPIKKKDLKKLVLYLKNGADCPCHQLDNLSHHFLIMGRKVKSQYL LTAIHKWDKKNKEFKNFMKKMKNHECPTFQSVFK >XP_011279807.1 secreted frizzled-related protein 1 isoform X1 [Felis catus] MGSGRGAGGRRWAAPGVLLALAAGLLAAGSASEYDYVSFQSDIGSYQSGRFYTKPPQCVDIPVDLRLCHN VGYKKMVLPNLLEHETMAEVKQQASSWVPLLNKNCHIGTQVFLCSLFAPVCLDRPIYPCRWLCEAVRDSC EPVMQFFGFYWPEMLKCDKFPEGDVCIAMTPPNATEASKPQGTTVCPPCDNELKSEAIIEHLCASEFALR MKIKEVKKENGDKKIVPKKKKPLKLGPIKKKELKKLVLYLKNGADCPCHQLDNLSHHFLIMGRKVKSQYL LTAIHKWDKKNKEFKNFMKKMKNHECPTFQSVFK >XP_027818279.1 secreted frizzled-related protein 1 [Ovis aries] MGGGRWAAAGALLALAAGLLAAGSASEYDYVSFQSDIGAYQSGRFYTKPPQCVDIPADLRLCHNVGYKRM VLPNLLEHETMAEVKQQASSWVPLLNKNCHIGTQVFLCSLFAPVCLDRPIYPCRWLCEAVRDSCEPVMQF FGFYWPEMLKCDKFPEGDVCIAMTPPNATEASKPQGTTVCPPCDNELKSEAIIEHLCASEFALRMKIKEV KKENGDKKIVPKKKKPLKLGPIKKKELKKLVLYLKNGADCPCHQLDNLSHHFLIMGRKVKSQYLLTAIHK WDKKNKEFKNFMKKMKNHECPTFQSVFK >XP_018887508.1 secreted frizzled-related protein 1 [Gorilla gorilla gorilla] MGSGRSVGGRRGAVLGVLLALGAALLAVGSASEYDYVSFQSDIGPYQSGRFYTKPPQCVDIPADLRLCHN VGYKKMVLPNLLEHETMAEVKQQASSWVPLLNKNCHAGTQVFLCSLFAPVCLDRPIYPCRWLCEAVRDSC EPVMQFFGFYWPEMLKCDKFPEGDVCIAMTPPNATEASKPQGTTVCPPCDNELKSEAIIEHLCASEFVTL HRKRILNQHSQLQEKEELQAPAKSASVLYTEEDRGSHVDNQSRFVESE >XP_017897532.1 PREDICTED: secreted frizzled-related protein 1 [Capra hircus] MGGGRWAAAGALLALAAGLLAAGSASEYDYVSFQSDIGAYQSGRFYTKPPQCVDIPADLRLCHNVGYKRM VLPNLLEHETMAEVKQQASSWVPLLNKNCHIGTQVFLCSLFAPVCLDRPIYPCRWLCEAVRDSCEPVMQF FGFYWPEMLKCDKFPEGDVCIAMTPPNATEASKPQGTTVCPPCDNELKSEAIIEHLCASEFALRMKIKEV KKENGDKKIVPKKKKPLKLGPIKKKELKKLVLYLKNGADCPCHQLDNLSHHFLIMGRKVKSQYLLTAIHK WDKKNKEFKNFMKKMKNHECPTFQSVFK >tr|A3KNP6|A3KNP6_DANRE Secreted frizzled-related protein 1 OS=Danio rerio OX=7955 GN=sfrp1b PE=2 SV=1 MKNLALKLWLSIAPFLCLPLLNALEDEDYIWPPDSSDKHPPCVDIPEDLRLCFNVGYGRM MLPNLLDHETIAEVKQQAVSWVPLVHKACHKGTQVLLCSLFAPVCLDRPLYPCRWFCEAV RDSCAPIMQAFGFPWPEMLRCDKFPLGEVCISSNATKSNETDLIAGGSSVCPACENEMKT DLILDQMCASEFAIKTKIKEVKIDNLDRKVILQKRRKLVRAGSMKKQDLKKLVLYLKSGA HCPCQQLENLENHYLIMGRSVGKQYVLTGIHKWDNSSKDFKKTIKKLKNHKCPSYDHVFK >tr|Q7T2K9|Q7T2K9_DANRE Secreted frizzled-related protein 1 OS=Danio rerio OX=7955 GN=sfrp1a PE=2 SV=1 MKSLASLSLWRIIILILPLVSLGQTFEYGWPDNYDKPPQCVDIPVDLRLCQGVGYHQMLL PNLLEHESMAEVKQQAGSWVPLLHKNCDPGTQLLLCSLFAPVCMERPIYPCRRLCENVRD GCSPIMAAFGFPWPHILTCDKFPQDDMCINTPNDTSTSEPNGHPPVCPPCDNEMKMDVIL DHMCASEFAIKTKIQEVKRENMDRKVTLQKKKRTIKMGTLKKKDLKKLTLYLKNGADCPC TQLDNTRNTYLIMGRKVDKQYLLTGIHKWDKSNREFKKTMKKLKSHKCPAYENVFK >XP_006023123.1 secreted frizzled-related protein 1 [Alligator sinensis] MSRFCGSQLDLRILQVSGHQVPSAPGPVQSFAATCHVEARCIQAPLSFSEYDYVSYQSDLGAYQSGRFYP KPHQCVPIPADLRLCHSVGYDKMVLPNLLDHETMAEVKHQASSWVPLLNKNCHMGTQVFLCALFAPVCLD RPVYPCRWLCEAVRDACEPVMQFFGFYWPDMLKCDQFPQDDVCIAMTTPNATEVARPKGSGVCPPCDNEM KSEAIIEHLCASEFALKMTIKEVKRENGDRKIIPKKRKALKMGPIRKKNLKKLVLYLKNGAGCPCHQLDN LNHYFLIMGRQVKSQYLLTAIYKWDKKNKEFKQFMKKMKSPDCPTFPSVFK >XP_017205875.1 PREDICTED: secreted frizzled-related protein 1 isoform X1 [Oryctolagus cuniculus] MGGGAAPGALLLALAAGLLLAAGSASEYDYVSFQSDVGPYPSGRFYSKPPQCVDIPADLRLCHTVGYKKM VLPNLLEHETMAEVKQQASSWVPLLNKNCHIGTQVFLCALFAPVCLDRPVHPCRWLCEAVRDACEPVMQF FGFHWPEMLRCDKFPEGEVCITMTPPNATEAAKPQGTTVCPPCDNELKSEAIIEHLCASEFGERMFPAAP HPGVGTPQPVLPALRMKIKEVKKENGDKKIVPKKKKPLKLGPIKKKELKKLVLYLKNGADCPCHQLDNLS HHFLIMGRKVKSQYLLTAIHKWDKRNKEFKNFMKRMKNHECPTFQSVFK >XP_020732018.1 secreted frizzled-related protein 1 [Odocoileus virginianus texanus] MTCPVIPVPSQHCEPLPLSTSRFLNVLLPGVFVPSQSLSTGKSGEKAAGRFAPYCGPSALIDACLPRGLE MLGPEHNKKPTIVLPKSTPLCAPFPSTLPRDCRSAIIRLSHLETRLPFIASKQPDSTFPRVFAGAELHRP GMERQTSLATAFLSPGPPERSRRPALIGRRGTAGALLALAAGLLAAGSASEYDYVSFQSDIGAYQSGRFY TKPPQCVDIPADLRLCHNVGYKRMVLPNLLEHETMAEVKQQASSWVPLLNKNCHIGTQVFLCSLFAPVCL DRPIYPCRWLCEAVRDSCEPVMQFFGFYWPEMLKCDKFPEGDVCIAMTPPNATEASKPQGTTVCPPCDNE LKSEAIIEHLCASEFALRMKIKEVKKENGDKKIVPKKKKPLKLGPIKKKELKKLVLYLKNGADCPCHQLD NLSQHFLIMGRKVKSQYLLTAIHKWDKKNKEFKNFMKKMKNHECPTFQSVFK >XP_040197630.1 LOW QUALITY PROTEIN: secreted frizzled-related protein 1 [Rana temporaria] MTQSLTMTQSMTTAKHNHGLKHDHNLKLDLDLKHDHDLKHDHGLKLDNDLLLHDIEHDLKLDHDKLDHHL NIDHDSKHDHDLKLEHKHHGLKLDSDLKLDIERDFKHDYDFKHDLKHDHGLKLDLDLLWPWPLLLLWISX GLFSKEVQPNEYDYVGFQPEMVRNYQXGRFYSRTPQCEDIPQDLALCHGVGYNKMVLPNLLDQETMVEAK YQASSWVPLLSKNCHPGTQVFLCSLFAPVCLEQPLYPCRWLCEEVRDACEPVMQYXGFSWPEMLRCEQFP REDVCIASPNATQAPHPRRSEVCPQCDSEIKADSLYEHMCASEFALKVSVREVKKESGDRKLILKKKKAL NKGPIQRKEWGDLVLYLKNGANCPCPQLEQLNGQFLVLGRKVKNQHILTAIHKWDKANREFNRFMRRVKK TKCPKPHSVFM
Mafft alignment of selected proteins >NP_003003.3 secreted frizzled-related protein 1 precursor [Homo sapiens] -------------------------------------MGIGR------------------ ----------SEGG---------------------------------------------- ------------------------------------------------------------ ---------------RRGAALGVLLALGAA-LLA-------------VGSASEYDYVSFQ SDI-GPYQ---SGRFYTKPPQCVDIPADLR-LCHN--VGYKKMVLPNLLEHETMAEVKQQ ASSWVPLLNKNCHAGTQVFLCSLFAPVCL---DRPIYPCRWLCEAVRDSCEPVMQFFGFY WPEMLKCDKFP-EG--DVCIAMTPP-----NATEASKPQG-T----------------TV CPPCDNELK--SEA-IIEHLCASEF---------------------ALRMKIK------- EVKKENGDKKIV---------PKKKKPL-------------------------KLGPIKK KDLK-------------KLVLYLKNGADCPCH-QLD--------NLSHHFLIMG---RKV KS------------------------QYLLTAIHKWDKKNKEFKNFMKKMKN-HEC---- ---------------------------------------------------PTFQSVFK- ------------------------------------------------------------ ------------------------------------------------------------ -------------- >KAF4026217.1 hypothetical protein G4228_018281 [Cervus hanglu yarkandensis] ------------------------------------------------------------ -----------MGG---------------------------------------------- ------------------------------------------------------------ ---------------GRWAAAGALLALAAG-LLA-------------AGSASEYDYVSFQ SDI-GAYQ---SGRFYTKPPQCVDIPADLR-LCHN--VGYKRMVLPNLLEHETMAEVKQQ ASSWVPLLNKNCHIGTQVFLCSLFAPVCL---DRPIYPCRWLCEAVRDSCEPVMQFFGFY WPEMLKCDKFP-EG--DVCIAMTPP-----NATEASKPQG-T----------------TV CPPCDNELK--SEA-IIEHLCASEF---------------------ALRMKIK------- EVKKENGDKKIV---------PKKKKPL-------------------------KLGPIKK KELK-------------KLVLYLKNGADCPCH-QLD--------NLSHHFLIMG---RKV KS------------------------QYLLTAIHKWDKKNKEFKNFMKKMKN-HEC---- ---------------------------------------------------PTFQSVFK- ------------------------------------------------------------ ------------------------------------------------------------ -------------- >XP_006568530.1 frizzled-2 [Apis mellifera] -------------------------------------M---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------IPRYAIYVFSVA-VFS-------------V------------ ----NALH---TKDPLAHHGRCE--PITIN-LCMN--IPYNETIMPNLMNHQKQEDAGQE VHQFAPLVKMKCSPDLRFFLCTVYAPVCTI-IDRAIPPCRSLCESARAGCERLMNSFGFA WPDNLDCSKLPENGGPELCVGHNETTPPEPSPPVYTPPRMPV---------------AEF QPSWTGGPKTYGSG-FMLGARDFGF---------------------VCPMQFKVPHELGY SLKVGDKVELNCGAPCDGMFFTERERRFSRIWVGTWASVCAASCFFTFLTFLIDTDRFRY PERPIIFLSVCYLMVALAYVIGWAAGNSIACREPFPPPLD--MRIQMASTITQG---TKH ELCTVLFMVLYFFGMASSIWWVILTLTWFLAAGLKWGHEAIEANSQYFHLAA-WAAP--A IKTVTILAMGKVEGDILSGVCYVGLWNVEALRGFVLAPLCVYLILGTAFLLAGFVSLFRI RTVMKHDGTKTDKLEKLMIRIGIFSVLYIVPALIVIACLFYEQAYFDQWMLTWNMEMCSR PGPQSLYSMPCP-VGERTRDVGRRPEFEVFMIKYLMAMIVGITSSFWVWSSKTLTSWRQF FNHI-QGRRAEAYV >CAE1239454.1 FZD1_7 [Sepia pharaonis] -------------------------------------M---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------LKELRNFIIGFIFLCS-------------ILYHQGFLLAASQ SSISRRVN---NHQGLPTHGKCE--PITIP-LCKG--IQYNMTILPNILNHQKQDDAGLE VHQFYPLVKVECSPYLRFFLCSMYAPVCTL-LDHAIPPCQQMCQQAREGCEKLMNRFGFE WPESLRCEKFPRSG---LCVGENITDP--------TPPPTPH---------------DRY NRPTQARPV--GRDYFQPNTNSSGF---------------------HCPVEFRVPKTLDY RLKVGDSLERDCGAPCNDMFFTPDKRDFARMWIGICSAVCMASTLFTVLTFLIDMTRFRY PERPIIFLSGCYFMVALAYVVGFALRDSVACNRPFDPPIHNLQSDKMVSIITQG---TKK EGCTILFMMLYFFSMASSIWWVILTLTWFLAAGMKWGHEAIEANSQYFHLAA-WAVP--A IKTIAILAMGQVDGDVLSGVCFTGIFDVDALRGFVLAPLVVYLIIGTTFLLAGFVSLFRI RTIMKSDGTKTDKLEKLMVRIGIFSVLYTVPATIVIACLFYEQSFRDQWMVSWHSRVCIT ------YFFPCPHTGDPTRP---WPDFTVFMIKYLMTIIVGITSGVWIWTGKTLNSWKRF YCRFFMPRNQSAVV >CAA38459.1 frizzled [Drosophila melanogaster] -------------------------------------M---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------WRQILFILPTL-IQGVQRYDQSPLDASPYYRSGGGLMASSG TEL----------DGLPHHNRCE--PITIS-ICKN--IPYNMTIMPNLIGHTKQEEAGLE VHQFAPLVKIGCSDDLQLFLCSLYVPVCTI-LERPIPPCRSLCESARV-CEKLMKTYNFN WPENLECSKFPVHGGEDLCVAENTTS----SASTAATPTRSV------------------ -AKVTTRKH--QTG-VERPHRNIGF---------------------VCPVQLKTPLGMGY ELKVGGKDLHDCGAPCHAMFFPERERTVLRYWVGSWAAVCVASCLFTVLTFLIDSSRFRY PERAIVFLAVCYLVVGCAYVAGLGAGDSVSCREPFPPPVK-LGRLQMMSTITQGH--RQT TSCTVLFMALYFCCMAAFAWWSCLAFAWFLAAGLKWGHEAIENKSHLFHLVA-WAVP--A LQTISVLALAKVEG---------------------------------------------- ------------------------------------------------------------ ---------------------------------------------MYLWQFHTIN----- -------------- >KYO28472.1 secreted frizzled-related protein 1 [Alligator mississippiensis] -------------------------------------MCR-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------AAHVPHAMGSG-KNS-------------AVLPSEYDYVSYQ SDL-GAYQ---SGRFYPKPHQCVPIPADLR-LCHS--VGYDKMVLPNLLDHETMAEVKHQ ASSWVPLLNKNCHMGTQVFLCALFAPVCL---DRPVYPCRWLCEAVRDACEPVMQFFGFY WPDMLKCDQFP-QD--DVCIAMTTP-----NATEVARPKG-S----------------GV CPPCDNEMK--SEA-IIEHLCASEF---------------------ALKMTIK------- EVKRENGDRKII---------PKKRKAL-------------------------KMGPIRK KNLK-------------KLVLYLKNGAGCPCH-QLD--------NLNHYFLIMG---RQV KS------------------------QYLLTAIYKWDKKNKEFKQFMKKMKS-PDC---- ---------------------------------------------------PTFPSVFK- ------------------------------------------------------------ ------------------------------------------------------------ -------------- >XP_030273955.1 secreted frizzled-related protein 1-like [Sparus aurata] -------------------------------------MISAS------------------ -----------ESV---------------------------------------------- ------------------------------------------------------------ -------------------WRMIRLAVTVA-LIS-------------ACAASEYEYLSWK SDM---YN---GGRSYGKPPQCVDIPEDLR-LCHN--VGYNQMLLPNVLEHETMAEVKQQ ASSWVPLVHKNCHPGTQVFLCSLFAPVCL---ERPIFPCRWLCEAVRDGCTPIMEAFGFP WPEMLTCDKFP-QD--DVCIAMTQP-----NATEAPMPTGYS----------------PI CPPCDNEMK--TDA-MLEHMCASEF---------------------AFKTKIK------- EVKRENMDRKVI--------LQKRKKML-------------------------KPGNLKK KDMK-------------TLVMYLKNGADCPCQ-QLD--------NLANQYLIMG---RKV DK------------------------QYLLTGIHKWDKSSKEFKKAIKKLKT-YKC---- ---------------------------------------------------PAFENVF-- ------------------------------------------------------------ ------------------------------------------------------------ -------------- >NP_001098307.1 secreted frizzled-related protein 1 precursor [Oryzias latipes] -------------------------------------MGSAS------------------ -----------VLF---------------------------------------------- ------------------------------------------------------------ ---------------RRWTQLVLLLAVTCG--------------------ASEYEY-TWA A---GSYN---GGRGYGKAPQCVDIPDDLR-LCHT--VGYTQMLLPNLLEHETMAEVKQQ ASSWVPLVHKNCHKDTQVFLCALFAPVCM---ERPIYPCRWLCETVRDSCSPIMEAFGFP WPEMLTCDKFP-QD--GVCIAVTQP-----NATEATWPSGHS----------------PA CPPCDNEIK--NDA-MLENICASEF---------------------ALKAKIK------- EVKQENMDRKVI--------LQRRKRMV-------------------------KQGNLKK RDLK-------------KLTLYLKNGANCPCQ-QLE--------NLENQYLIMG---RKV DK------------------------QFLLTGIHKWDKSSKEFKKIMKKLKN-YKC---- ---------------------------------------------------PAFENVFK- ------------------------------------------------------------ ------------------------------------------------------------ -------------- >NP_001080957.1 secreted frizzled-related protein 1 L homeolog precursor [Xenopus laevis] -------------------------------------MNG-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------ENGIWPLLLFWVTPG-ILSQ------------VPQASEYDYVSFQ PDLGRQYQ---SGRFYSRPAQCLEIPQDMT-LCHG--VGYNKMVLPNLLDSETMAEVKYQ ASSWVPLLSKKCHPSTQVFLCSLFAPLCL---DRPVYPCRRLCESVRDACEPVMQYFGFH WPEMLRCEQYPTEE--DVCIAVHLP-----NATQAPRSRK-T----------------EV CPQCDSEIK--ADS-LYEHMCASDF---------------------ALKVSIR------- EVRKENGDRKLL---------LRKEKAL-------------------------KKGPIQK KDWA-------------ELVLYLKNGANCPCH-QLD--------QLKGQFLVLG---PKA KA------------------------QHLLTAIHKWDKTNREFNRFMRKVKK-SKC---- ---------------------------------------------------PIPLTAPH- ------------------------------------------------------------ ------------------------------------------------------------ -------------- >XP_015799833.1 PREDICTED: secreted frizzled-related protein 5 [Nothobranchius furzeri] -------------------------------------MALGQKSPRL------------- ----------ALTQ---------------------------------------------- ------------------------------------------------------------ ---------------GFFSLALGLLLFSLL-LFT-------------IVDADEYDYYNWQ AD---NFH---NGRFYTKQPQCVDIPADLR-LCHN--VGYKKMRLPNLLDHETMPEVKQQ ASSWVPLLAKRCHADTQVFLCSLFAPVCL---DRPIYPCRSLCEAVRDSCAPVMETYGFP WPEMLNCDKFPIDN--DLCIPMQFA------ANHVTQPPV-S----------------NV CPPCDNEMK--ADN-IMEHYCASDF---------------------ALKMKIK------- EVKKEKGDRKLIA-------AQKKKKVL-------------------------KQGVLRK KDLK-------------KLTLYIKNGANCPCS-QLE--------NLGSNFLIMG---RKV DQ------------------------QLLLMSIHKWDKKSKELKFAIKYMKS-HQC---- ---------------------------------------------------PTYHSVFQ- ------------------------------------------------------------ ------------------------------------------------------------ -------------- >KAB0348761.1 hypothetical protein FD754_013618 [Muntiacus muntjak] -------------------------------------MGG-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------GRWAAAGALLALAAG-LLA-------------AGSASEYDYVSFQ SDI-GAYQ---SGRFYTKPPQCVDIPADLR-LCHN--VGYKRMVLPNLLEHETMAEVKQQ ASSWVPLLNKNCHIGTQVFLCSLFAPVCL---DRPVYPCRWLCEAVRDSCEPVMQFFGFY WPEMLKCDKFP-EG--DVCIAMTPP-----NATEASKPQG-------------------- --PCRVHLR--GDA-AGTWSRLSPW----------------------------------- --------------------YPHPRPPP-------------------------EAGVVEG RETK-------------THAVFLESFTP-----WLP-------SPLAPPKSALG------ -----------------------------------------------------TICP--- -------------------------------------P-------------PSIPGVLR- ------------------------------------------------------------ ------------------------------------------------------------ -------------- >KAB0383808.1 hypothetical protein FD755_005725 [Muntiacus reevesi] -------------------------------------MRAAA------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------GGARAAALALLLGAL-HGA-------------PARGEEYDYYGWQ TEP-------LHGRSYSKPPQCLDIPADLP-LCHT--VGYKRMRLPNLLEHESLAEVKQQ ASSWLPLLAKRCHSDTQVFLCSLFAPVCL---DRPIYPCRSLCEAVRAGCAPLMEAYGFP WPEMLHCHKFPLDN--DLCIAVQFG------HLPATAPPV-T----------------KI CAQCEMEHS--ADG-LMEQMCSSDF---------------------VVKMRIK------- EIKIENGDRKLIG-------AQKKKKLL-------------------------KPGPLKR KDTK-------------RLVLHMKNGAGCPCP-QLD--------NLAGSFLVMG---RRV DG------------------------QLLLMAVYRWDKKNKEMKFAVKFMFS-YPC---- ---------------------------------------------------SLYYPFFY- ---GAAE----------------------------------------------------- --PH-------------------------------------------------------- -------------- >XP_039270710.1 secreted frizzled-related protein 1-like isoform X2 [Styela clava] -------------------------------------M---------------------- ------------------------------------------------------------ -------------T---------------------------------------------- ------------------IGSIVIVLLNAL-LCSANTF---------------------- ----GAFTGVDTASPFAKNFVCEPIPHSLK-LCRN--IAYNQMRLPNLLGHETMDEVKQQ AASWVPLLNKRCHKDLQRLLCSLFSPVCIEDSPEPIYPCQSLCQAVKGACEPVMQKVGYP WPDMLSCDKFR-DN--DMCVPQECHH----NCSSYAEPES-T----------------PI CPACGNELD--AET-ILNLYCAVEF---------------------VLKVKIR------- SVKTSRKDLKLM--------ADKRKRVIY------------------------QEGSLKR KDLR-------------KLTLLIRGGKSCTCP-HLEPQGK-GKKKKKDFYLVMG---GKV GR------------------------KLLVSAIYRWPKKLKMLRRLSKKFTP-DLCS--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------- >XP_781087.2 secreted frizzled-related protein 5 isoform X2 [Strongylocentrotus purpuratus] -------------------------------------M---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------IERVLVVLLAFA-ASSPGV----------WGQETETDMAMLG VNS-RTYPLDLSGR--PKETDCVDIPEDLS-LCQN--IGYTRMRMPNLLEHDSLDEVRNQ AKSWVPLLLQRCHEGTQLFLCTLFAPVCLE-VDRPIYPCRSLCEEVQAGCGPLMESNCFP WPAMLQCDKFPEDN--DLCIRLNMRNQ---NGTVEAQPFEMS--------AAMQEAYMMH FTQCHDDSL--EDT-LLRKFCNSDF---------------------VLKVKIK------- TIRESKDGKKYIGDP-----NPEKLEVL-------------------------KQGSLKT KDLQ-------------RLTFYVREGANCQCD-MLE--------RSGNYLLVMGHRDSKK NR------------------------KLFMTFVHSWEK-TRDFRRAIKGFENPDMCE--N LET----ATEGRREEIAP----------QDAEPHEMTP-ADEVLLASQTNTPVNDGVYTT HQVMADE-TPSPKTNTRRERK--------------------------------------- -------------RGKRTRDRPRKNRER---------------ENREMPVRRARSKWD-- -------------- >XP_043340126.1 secreted frizzled-related protein 2 [Cervus canadensis] -------------------------------------M---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------PQGPGSLLLIVLASH-CCLGFAR---------------------- ----GLFFGQPDFS--YKRSNCKPIPANLQ-LCHG--IEYQNMRLPNLLGHETMKEVLEQ AGAWIPLVMKQCHPDTKKFLCSLFAPVCLDDLDETIQPCHSLCVQVKDRCAPVMSAFGFP WPDMLECDRFPQDN--DLCIPLASS-----DHLLPATEEA-P----------------KV CEACKTKNE--DDNDIMETLCKNDF---------------------ALKIKVK------- EITYINRDTKII--------LETKSKTIY------------------------KLNGVSE RDLK-------------KSVLWLKDSLQCTCE-EMN--------DINAPYLVMG---QKL GG------------------------ELVITSVKRWQKGQREFKRISRSIRK-LQC---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------- >XP_038052835.1 secreted frizzled-related protein 5-like isoform X2 [Patiria miniata] -------------------------------------M---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------IGSVVVVMAACLAQMT-------------------------- ----AGFAMDLSGR--ITKPTCVDIPVDLA-LCQN--IGYNRMRMPNLLDHDSIFEVKDQ SQGWIPLLMVNCDNDTQLFLCSLFSPVCL---DRPIYPCRSLCRKVRQNCEPIMLRNCFP WPSMLECDRFPEDN--GLCIQSEMRQR---NATDQPTQSSGSMIPSGIGMSGMVAAVGSL FTQCHDDAD--AAS-IVEYFCNADF---------------------VLKMKLK------- EVKETDEGMRYVGDP-----TPGKFAVI-------------------------KQGSLKQ KDLA-------------KMRFWTREGANCGCD-MLR--------PRKENFLVMG---HRD GK------------------------KLYMTYVHIWTK-SRELRNANKQFAQ--PCPGDG VESSELPATKKPRKDRGG----------KKGRP-------------DRRERPGRDGAAET TTQAVTE-RKLTREERRQLRE--------------------------------------- -------------QMRETKRENRRNKE--------------------------------- -------------- >NP_500977.2 Secreted frizzled-related protein 1 [Caenorhabditis elegans] -------------------------------------M---------------------- ------------------------------------------------------------ -------------M---------------------------------------------- ------------------LFPVLYILFAFS-VTNGYLE---------------------- ----DSWAMFSSER--PVGPKCVDIPSNLS-ICNG--IEYTQMRLPNILEHETVSEAIHA SKDWESLLRLNCHPDTQRFLCSLFAPVCLMQMDRLILPCKSLCMAVKQGCENRMANYGFP WPEMLSCEKFE-DD--DMCIKPMQP---------AKPPAGSS----------------TT CTACSQVAT--YEN-LVDQFCRSHL---------------------VLKAKVI------- ----RDSPTHIR---------VRNGRSL-------------------------KKGE-RR RGVSDV-----------EIRLSSESDGSCPCNIPVK--------NQNEKLLVMAS--RQP DG------------------------KYLANLVLPWQK-EKNFKRAIHQFQR-LNCQSLG REIRE-----------------------------------------SASRRPHYYEMRRH NT---------------------------------------------------------- ---------------------GRYQMF--------------------------------- -------------- >XP_031565722.1 secreted frizzled-related protein 1-like [Actinia tenebrosa] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------MDFLRCLLLLA-------------------------- ----GVFHVALCYR--TRSHHCVDITSNTAPLCANLSLGYDKMMLPNFLRHDTAMEVRRE LAQWSPLVGSGCHPYLKHFLCSVFAPVCM---LELIPPCRSLCSMVQNSCEPLMRRHNYT WPSMLDCRKYP-EN--SMCVKIETP-----------TPIPTT----------------TV CEEDGSNVP--LDE-LQKKFCDSDF---------------------AMRARVS------- EKKMKDGYLILK---------ATAIKSL--------------------------KGSLKR DQLQ-------------RLRIPNMESRNC----GYV--------NKRKQFLILG---TKR GR------------------------RMIVTYLMKW----KDFRNMRRKIKE-KAC---- --------------------------------------------------RKM------- ------------------------------------------------------------ ------------------------------------------------------------ -------------- >NP_038862.2 secreted frizzled-related protein 1 precursor [Mus musculus] -------------------------------------MGVGR------------------ ----------SARG---------------------------------------------- ------------------------------------------------------------ ---------------RGGAASGVLLALAAA-LLA-------------AGSASEYDYVSFQ SDI-GSYQ---SGRFYTKPPQCVDIPVDLR-LCHN--VGYKKMVLPNLLEHETMAEVKQQ ASSWVPLLNKNCHMGTQVFLCSLFAPVCL---DRPIYPCRWLCEAVRDSCEPVMQFFGFY WPEMLKCDKFP-EG--DVCIAMTPP-----NTTEASKPQG-T----------------TV CPPCDNELK--SEA-IIEHLCASEF---------------------ALRMKIK------- EVKKENGDKKIV---------PKKKKPL-------------------------KLGPIKK KELK-------------RLVLFLKNGADCPCH-QLD--------NLSHNFLIMG---RKV KS------------------------QYLLTAIHKWDKKNKEFKNFMKRMKN-HEC---- ---------------------------------------------------PTFQSVFK- ------------------------------------------------------------ ------------------------------------------------------------ -------------- >NP_001263641.2 secreted frizzled-related protein 1 precursor [Rattus norvegicus] -------------------------------------MGVGR------------------ ----------NARG---------------------------------------------- ------------------------------------------------------------ ---------------RGGAASGVLLALAAA-LLA-------------AGSASEYDYVSFQ SDI-GSYQ---SGRFYTKPPQCVDIPVDLR-LCHN--VGYKKMVLPNLLEHETMAEVKQQ ASSWVPLLNKNCHMGTQVFLCSLFAPVCL---DRPIYPCRWLCEAVRDSCEPVMQFFGFY WPEMLKCDKFP-EG--DVCIAMTPP-----NATEASKPQG-T----------------TV CPPCDNELK--SEA-IIEHLCASEF---------------------ALRMKIK------- EVKKENGDKKIV---------PKKKKPL-------------------------KLGPIKK KELK-------------RLVLFLKNGADCPCH-QLD--------NLSHNFLIMG---RKV KS------------------------QYLLTAIHKWDKKNKEFKNFMKKMKN-HEC---- ---------------------------------------------------PTFQSVFK- ------------------------------------------------------------ ------------------------------------------------------------ -------------- >NP_776885.1 secreted frizzled-related protein 1 precursor [Bos taurus] ------------------------------------------------------------ -----------MGG---------------------------------------------- ------------------------------------------------------------ ---------------GRWAAAGALLALAAG-LLA-------------AGSASEYDYVSFQ SDI-GAYQ---SGRFYTKPPQCVDIPADLR-LCHN--VGYKRMVLPNLLEHETMAEVKQQ ASSWVPLLNKNCHIGTQVFLCSLFAPVCL---DRPIYPCRWLCEAVRDSCEPVMQFFGFY WPEMLKCDKFP-EG--DVCIAMTPP-----NATEASKPQG-T----------------TV CPPCDNELK--SEA-IIEHLCASEF---------------------ALRMKIK------- EVKKENGDKKIV---------PKKKKPL-------------------------KLGPIKK KELK-------------KLVLYLKNGADCPCH-QLD--------NLSHHFLIMG---RKV KS------------------------QYLLTAIHKWDKKNKEFKTFMKKMKN-HEC---- ---------------------------------------------------PTFQSVFK- ------------------------------------------------------------ ------------------------------------------------------------ -------------- >NP_989884.2 secreted frizzled-related protein 1 precursor [Gallus gallus] -------------------------------------M---------------------- -------------G---------------------------------------------- ------------------------------------------------------------ ---------------RVRGALRALLSLAAG-LLA-------------CGGASEYDYVSYQ SDL-GPYP---GGRFYTKPHQCVAIPADLR-LCHS--VGYDKMVLPNLLDHETMAEVKHQ ASSWVPLLNKNCHMGTQVFLCSLFAPVCL---DRPVYPCRWLCEAVRDSCEPVMQFFGFF WPEMLKCDQFP-QD--DVCIAMTTP-----NATEVSRPKG-T----------------TV CPPCDNEMK--SEA-IVEHLCASEF---------------------ALKMTIK------- EVKKENGDKVII---------PRKRKAL-------------------------KLGPIRK KNLK-------------KLVLLLKNGADCPCH-QLD--------NLGHHFLIMG---RQV KT------------------------QHLLTAIYKWDKKNKEFKKFMKKVKA-PDC---- ---------------------------------------------------PTFPSVFK- ------------------------------------------------------------ ------------------------------------------------------------ -------------- >XP_003639612.2 secreted frizzled-related protein 1 [Canis lupus familiaris] -------------------------------------MGSGR------------------ ----------GAGG---------------------------------------------- ------------------------------------------------------------ ---------------RRWAARGVLLALAAG-LLA-------------ASSASEYDYVSFQ SDI-GSYQ---SGRFYTKPPQCVDIPADLR-LCHN--VGYKKMVLPNLLEHETMAEVKQQ ASSWVPLLNKNCHIGTQVFLCSLFAPVCL---DRPIYPCRWLCEAVRDSCEPVMQFFGFY WPEMLKCDKFP-EG--DVCIAMTPP-----NATEASKPQG-T----------------TV CPPCDNELK--SEA-IIEHLCASEF---------------------ALRMKIK------- EVKKENGDKKIV---------PKKKKPL-------------------------KLGPIKK KELK-------------KLVLYLKNGADCPCH-QLD--------NLSHHFLIMG---RKV KS------------------------QYLLTAIHKWDKKNKEFKNFMKKMKN-HEC---- ---------------------------------------------------PTFQSVFK- ------------------------------------------------------------ ------------------------------------------------------------ -------------- >XP_001138037.1 secreted frizzled-related protein 1 [Pan troglodytes] -------------------------------------MGSGR------------------ ----------SVGG---------------------------------------------- ------------------------------------------------------------ ---------------RRGAALGVLLALGAA-LLA-------------VGSASEYDYVSFQ SDI-GPYQ---SGRFYTKPPQCVDIPADLR-LCHN--VGYKKMVLPNLLEHETMAEVKQQ ASSWVPLLNKNCHAGTQVFLCSLFAPVCL---DRPIYPCRWLCEAVRDSCEPVMQFFGFY WPEMLKCDKFP-EG--DVCIAMTPP-----NATEASKPQG-T----------------TV CPPCDNELK--SEA-IIEHLCASEF---------------------ALRMKIK------- EVKKENGDKKIV---------PKKKKPL-------------------------KLGPIKK KDLK-------------KLVLYLKNGADCPCH-QLD--------NLSHHFLIMG---RKV KS------------------------QYLLTAIHKWDKKNKEFKNFMKKMKN-HEC---- ---------------------------------------------------PTFQSVFK- ------------------------------------------------------------ ------------------------------------------------------------ -------------- >XP_024106845.1 secreted frizzled-related protein 1 [Pongo abelii] -------------------------------------MGSGR------------------ ----------SVGG---------------------------------------------- ------------------------------------------------------------ ---------------RRGAALGVLLALGAA-LLA-------------VGSASEYDYVSFQ SDI-GPYQ---SGRFYTKPPQCVDIPADLR-LCHN--VGYKKMVLPNLLEHETMAEVKQQ ASSWVPLLNKNCHAGTQVFLCSLFAPVCL---DRPIYPCRWLCEAVRDSCEPVMQFFGFY WPEMLKCDKFP-EG--DVCIAMTPP-----NATEASKPQG-T----------------TV CPPCDNELK--SEA-IIEHLCASEF---------------------ALRMKIK------- EVKKENGDKKIV---------PKKKKPL-------------------------KLGPIKK KDLK-------------KLVLYLKNGADCPCH-QLD--------NLSHHFLIMG---RKV KS------------------------QYLLTAIHKWDKKNKEFKNFMKKMKN-HEC---- ---------------------------------------------------PTFQSVFK- ------------------------------------------------------------ ------------------------------------------------------------ -------------- >XP_019478198.1 secreted frizzled-related protein 1 [Meleagris gallopavo] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------MVLPNLLDHETMAEVKHQ ASSWVPLLNKNCHMGTQVFLCSLFAPVCL---DRPVYPCRWLCEAVRDSCEPVMQFFGFF WPEMLKCDQFP-QD--DVCIAMTAP-----NATEVSRPKG-T----------------TV CPPCDNEMK--SEA-IVEHLCASEF---------------------ALKMTIK------- EVKKENGDKVII---------PRKRKAL-------------------------KLGPIRK KNLK-------------KLVLLLKNGADCPCH-QLD--------NLGHHFLIMG---RQV KT------------------------QHLLTAIYKWDKKNKEFKKFMKKVKA-PDC---- ---------------------------------------------------PTFPSVFK- ------------------------------------------------------------ ------------------------------------------------------------ -------------- >XP_003359916.2 secreted frizzled-related protein 1 [Sus scrofa] ------------------------------------------------------------ -----------MGG---------------------------------------------- ------------------------------------------------------------ ---------------GRWAAAGVLLALAAG-LLA-------------AGSASEYDYVSFQ SDI-GSYQ---SGRFYTKPPQCVDIPVDLR-LCHN--VGYKKMVLPNLLEHETMAEVKQQ ASSWVPLLNKNCHIGTQVFLCSLFAPVCL---DRPIYPCRWLCEAVRDSCEPVMQFFGFY WPEMLKCDKFP-EG--DVCIAMTPP-----NATEASKPQG-T----------------PV CPPCDNELK--SEA-IIEHLCASEF---------------------ALRMKIK------- EVKKENGDKKIV---------PKKKKPL-------------------------KLGPIKK KELK-------------KLVLYLKNGADCPCH-QLD--------NLSHHFLIMG---RKV KG------------------------QYLLTAIHKWDKKNKEFKNFMKKMKN-HEC---- ---------------------------------------------------PTFQSVFK- ------------------------------------------------------------ ------------------------------------------------------------ -------------- >XP_034821881.1 secreted frizzled-related protein 1 [Pan paniscus] -------------------------------------MGSGR------------------ ----------SVGG---------------------------------------------- ------------------------------------------------------------ ---------------RRGAALGVLLALGAA-LLA-------------VGSASEYDYVSFQ SDI-GPYQ---SGRFYTKPPQCVDIPADLR-LCHN--VGYKKMVLPNLLEHETMAEVKQQ ASSWVPLLNKNCHAGTQVFLCSLFAPVCL---DRPIYPCRWLCEAVRDSCEPVMQFFGFY WPEMLKCDKFP-EG--DVCIAMTPP-----NATEASKPQG-T----------------TV CPPCDNELK--SEA-IIEHLCASEF---------------------ALRMKIK------- EVKKENGDKKIV---------PKKKKPL-------------------------KLGPIKK KDLK-------------KLVLYLKNGADCPCH-QLD--------NLSHHFLIMG---RKV KS------------------------QYLLTAIHKWDKKNKEFKNFMKKMKN-HEC---- ---------------------------------------------------PTFQSVFK- ------------------------------------------------------------ ------------------------------------------------------------ -------------- >XP_011279807.1 secreted frizzled-related protein 1 isoform X1 [Felis catus] -------------------------------------MGSGR------------------ ----------GAGG---------------------------------------------- ------------------------------------------------------------ ---------------RRWAAPGVLLALAAG-LLA-------------AGSASEYDYVSFQ SDI-GSYQ---SGRFYTKPPQCVDIPVDLR-LCHN--VGYKKMVLPNLLEHETMAEVKQQ ASSWVPLLNKNCHIGTQVFLCSLFAPVCL---DRPIYPCRWLCEAVRDSCEPVMQFFGFY WPEMLKCDKFP-EG--DVCIAMTPP-----NATEASKPQG-T----------------TV CPPCDNELK--SEA-IIEHLCASEF---------------------ALRMKIK------- EVKKENGDKKIV---------PKKKKPL-------------------------KLGPIKK KELK-------------KLVLYLKNGADCPCH-QLD--------NLSHHFLIMG---RKV KS------------------------QYLLTAIHKWDKKNKEFKNFMKKMKN-HEC---- ---------------------------------------------------PTFQSVFK- ------------------------------------------------------------ ------------------------------------------------------------ -------------- >XP_027818279.1 secreted frizzled-related protein 1 [Ovis aries] ------------------------------------------------------------ -----------MGG---------------------------------------------- ------------------------------------------------------------ ---------------GRWAAAGALLALAAG-LLA-------------AGSASEYDYVSFQ SDI-GAYQ---SGRFYTKPPQCVDIPADLR-LCHN--VGYKRMVLPNLLEHETMAEVKQQ ASSWVPLLNKNCHIGTQVFLCSLFAPVCL---DRPIYPCRWLCEAVRDSCEPVMQFFGFY WPEMLKCDKFP-EG--DVCIAMTPP-----NATEASKPQG-T----------------TV CPPCDNELK--SEA-IIEHLCASEF---------------------ALRMKIK------- EVKKENGDKKIV---------PKKKKPL-------------------------KLGPIKK KELK-------------KLVLYLKNGADCPCH-QLD--------NLSHHFLIMG---RKV KS------------------------QYLLTAIHKWDKKNKEFKNFMKKMKN-HEC---- ---------------------------------------------------PTFQSVFK- ------------------------------------------------------------ ------------------------------------------------------------ -------------- >XP_018887508.1 secreted frizzled-related protein 1 [Gorilla gorilla gorilla] -------------------------------------MGSGR------------------ ----------SVGG---------------------------------------------- ------------------------------------------------------------ ---------------RRGAVLGVLLALGAA-LLA-------------VGSASEYDYVSFQ SDI-GPYQ---SGRFYTKPPQCVDIPADLR-LCHN--VGYKKMVLPNLLEHETMAEVKQQ ASSWVPLLNKNCHAGTQVFLCSLFAPVCL---DRPIYPCRWLCEAVRDSCEPVMQFFGFY WPEMLKCDKFP-EG--DVCIAMTPP-----NATEASKPQG-T----------------TV CPPCDNELK--SEA-IIEHLCASEF------------------------VTLH------- --------RKRI--------LNQHSQLQ-------------------------EKEELQA PAKS-------------ASVLYTEEDRGS----HVD--------NQS----------RFV ES---------------------------------------------------------- ------------------------------------------------------------ ------E----------------------------------------------------- ------------------------------------------------------------ -------------- >XP_017897532.1 PREDICTED: secreted frizzled-related protein 1 [Capra hircus] ------------------------------------------------------------ -----------MGG---------------------------------------------- ------------------------------------------------------------ ---------------GRWAAAGALLALAAG-LLA-------------AGSASEYDYVSFQ SDI-GAYQ---SGRFYTKPPQCVDIPADLR-LCHN--VGYKRMVLPNLLEHETMAEVKQQ ASSWVPLLNKNCHIGTQVFLCSLFAPVCL---DRPIYPCRWLCEAVRDSCEPVMQFFGFY WPEMLKCDKFP-EG--DVCIAMTPP-----NATEASKPQG-T----------------TV CPPCDNELK--SEA-IIEHLCASEF---------------------ALRMKIK------- EVKKENGDKKIV---------PKKKKPL-------------------------KLGPIKK KELK-------------KLVLYLKNGADCPCH-QLD--------NLSHHFLIMG---RKV KS------------------------QYLLTAIHKWDKKNKEFKNFMKKMKN-HEC---- ---------------------------------------------------PTFQSVFK- ------------------------------------------------------------ ------------------------------------------------------------ -------------- >tr|A3KNP6|A3KNP6_DANRE Secreted frizzled-related protein 1 OS=Danio rerio OX=7955 GN=sfrp1b PE=2 SV=1 -------------------------------------MKNLA------------------ -----------LKL---------------------------------------------- ------------------------------------------------------------ -------------------WLSIAPFLCLP-LLN-------------ALEDEDY---IWP PDS------------SDKHPPCVDIPEDLR-LCFN--VGYGRMMLPNLLDHETIAEVKQQ AVSWVPLVHKACHKGTQVLLCSLFAPVCL---DRPLYPCRWFCEAVRDSCAPIMQAFGFP WPEMLRCDKFP-LG--EVCISSNAT-----KSNETDLIAGGS----------------SV CPACENEMK--TDL-ILDQMCASEF---------------------AIKTKIK------- EVKIDNLDRKVI--------LQKRRKLV-------------------------RAGSMKK QDLK-------------KLVLYLKSGAHCPCQ-QLE--------NLENHYLIMG---RSV GK------------------------QYVLTGIHKWDNSSKDFKKTIKKLKN-HKC---- ---------------------------------------------------PSYDHVFK- ------------------------------------------------------------ ------------------------------------------------------------ -------------- >tr|Q7T2K9|Q7T2K9_DANRE Secreted frizzled-related protein 1 OS=Danio rerio OX=7955 GN=sfrp1a PE=2 SV=1 -------------------------------------MKSLA------------------ ----------SLSL---------------------------------------------- ------------------------------------------------------------ ---------------------WRIIILILP-LVS-------------LGQTFEY---GWP D-------------NYDKPPQCVDIPVDLR-LCQG--VGYHQMLLPNLLEHESMAEVKQQ AGSWVPLLHKNCDPGTQLLLCSLFAPVCM---ERPIYPCRRLCENVRDGCSPIMAAFGFP WPHILTCDKFP-QD--DMCI--NTP-----NDTSTSEPNGHP----------------PV CPPCDNEMK--MDV-ILDHMCASEF---------------------AIKTKIQ------- EVKRENMDRKVT--------LQKKKRTI-------------------------KMGTLKK KDLK-------------KLTLYLKNGADCPCT-QLD--------NTRNTYLIMG---RKV DK------------------------QYLLTGIHKWDKSNREFKKTMKKLKS-HKC---- ---------------------------------------------------PAYENVFK- ------------------------------------------------------------ ------------------------------------------------------------ -------------- >XP_006023123.1 secreted frizzled-related protein 1 [Alligator sinensis] -------------------------------------MSRFCGSQ-----------LDLR ILQVSGHQVPSAPG---------------------------------------------- ------------------------------------------------------------ ---------------PVQSFAATCHVEARC-IQA-------------PLSFSEYDYVSYQ SDL-GAYQ---SGRFYPKPHQCVPIPADLR-LCHS--VGYDKMVLPNLLDHETMAEVKHQ ASSWVPLLNKNCHMGTQVFLCALFAPVCL---DRPVYPCRWLCEAVRDACEPVMQFFGFY WPDMLKCDQFP-QD--DVCIAMTTP-----NATEVARPKG-S----------------GV CPPCDNEMK--SEA-IIEHLCASEF---------------------ALKMTIK------- EVKRENGDRKII---------PKKRKAL-------------------------KMGPIRK KNLK-------------KLVLYLKNGAGCPCH-QLD--------NLNHYFLIMG---RQV KS------------------------QYLLTAIYKWDKKNKEFKQFMKKMKS-PDC---- ---------------------------------------------------PTFPSVFK- ------------------------------------------------------------ ------------------------------------------------------------ -------------- >XP_017205875.1 PREDICTED: secreted frizzled-related protein 1 isoform X1 [Oryctolagus cuniculus] -------------------------------------MGGGA------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------APGALLLALAAGLLLA-------------AGSASEYDYVSFQ SDV-GPYP---SGRFYSKPPQCVDIPADLR-LCHT--VGYKKMVLPNLLEHETMAEVKQQ ASSWVPLLNKNCHIGTQVFLCALFAPVCL---DRPVHPCRWLCEAVRDACEPVMQFFGFH WPEMLRCDKFP-EG--EVCITMTPP-----NATEAAKPQG-T----------------TV CPPCDNELK--SEA-IIEHLCASEFGERMFPAAPHPGVGTPQPVLPALRMKIK------- EVKKENGDKKIV---------PKKKKPL-------------------------KLGPIKK KELK-------------KLVLYLKNGADCPCH-QLD--------NLSHHFLIMG---RKV KS------------------------QYLLTAIHKWDKRNKEFKNFMKRMKN-HEC---- ---------------------------------------------------PTFQSVFK- ------------------------------------------------------------ ------------------------------------------------------------ -------------- >XP_020732018.1 secreted frizzled-related protein 1 [Odocoileus virginianus texanus] MTCPVIPVPSQHCEPLPLSTSRFLNVLLPGVFVPSQSLSTGKSGE--------------- ----------KAAGRFAPYCGPSALIDACLPRGLEMLGPEHNKKPTIVLPKSTPLCAPFP STLPRDCRSAIIRLSHLETRLPFIASKQPDSTFPRVFAGAELH---RPGMERQTSLATAF LSPGPPERSRRPALIGRRGTAGALLALAAG-LLA-------------AGSASEYDYVSFQ SDI-GAYQ---SGRFYTKPPQCVDIPADLR-LCHN--VGYKRMVLPNLLEHETMAEVKQQ ASSWVPLLNKNCHIGTQVFLCSLFAPVCL---DRPIYPCRWLCEAVRDSCEPVMQFFGFY WPEMLKCDKFP-EG--DVCIAMTPP-----NATEASKPQG-T----------------TV CPPCDNELK--SEA-IIEHLCASEF---------------------ALRMKIK------- EVKKENGDKKIV---------PKKKKPL-------------------------KLGPIKK KELK-------------KLVLYLKNGADCPCH-QLD--------NLSQHFLIMG---RKV KS------------------------QYLLTAIHKWDKKNKEFKNFMKKMKN-HEC---- ---------------------------------------------------PTFQSVFK- ------------------------------------------------------------ ------------------------------------------------------------ -------------- >XP_040197630.1 LOW QUALITY PROTEIN: secreted frizzled-related protein 1 [Rana temporaria] MT-----------QSLTM----------------TQSMTTAKHNHGLKHDHNLKLDLDLK HDHDLKHD-HGLKLD----------------NDLLLHDIEHDLK---------------- --LDHD------KLDH-HLNIDHDSKHDHDLKLEHKHHGLKLDSDLKLDIERDFKHDYDF KHDLKHDHGLKLDLDLLWPWPLLLLWISXG-LFSK------------EVQPNEYDYVGFQ PEMVRNYQ---XGRFYSRTPQCEDIPQDLA-LCHG--VGYNKMVLPNLLDQETMVEAKYQ ASSWVPLLSKNCHPGTQVFLCSLFAPVCL---EQPLYPCRWLCEEVRDACEPVMQYXGFS WPEMLRCEQFP-RE--DVCIA--SP-----NATQAPHPRR-S----------------EV CPQCDSEIK--ADS-LYEHMCASEF---------------------ALKVSVR------- EVKKESGDRKLI---------LKKKKAL-------------------------NKGPIQR KEWG-------------DLVLYLKNGANCPCP-QLE--------QLNGQFLVLG---RKV KN------------------------QHILTAIHKWDKANREFNRFMRRVKK-TKC---- ---------------------------------------------------PKPHSVFM- ------------------------------------------------------------ ------------------------------------------------------------ --------------
BMGE Cleaned alignment of selected proteins >NP_003003.3 secreted frizzled-related protein 1 precursor [Homo sapiens] MGIGRLGVLLALGAAVGSASEYDYVSFQSDISGRFYTKPPQCVDIPADLRVGYKKMVLPNLLEHETMAEVKQQASSWVPLLNKNCHAGTQVFLCSLFAPVCLDRPIYPCRWLCEAVRDSCEPVMQFFGFYWPEMLKCDKFPDVCIAMNATEASKPQGTVCPPCDNELKIIEHLCASEFALRMKIKEVKKENGDKKIVPKKKKPLKLGPIKKKDLKKLVLYLKNGADCPCHFLIMGRKVKSQYLLTAIHKWDKKNKEFKNFMKKMKNPTFQSVFK >KAF4026217.1 hypothetical protein G4228_018281 [Cervus hanglu yarkandensis] -----AGALLALAAGAGSASEYDYVSFQSDISGRFYTKPPQCVDIPADLRVGYKRMVLPNLLEHETMAEVKQQASSWVPLLNKNCHIGTQVFLCSLFAPVCLDRPIYPCRWLCEAVRDSCEPVMQFFGFYWPEMLKCDKFPDVCIAMNATEASKPQGTVCPPCDNELKIIEHLCASEFALRMKIKEVKKENGDKKIVPKKKKPLKLGPIKKKELKKLVLYLKNGADCPCHFLIMGRKVKSQYLLTAIHKWDKKNKEFKNFMKKMKNPTFQSVFK >XP_006568530.1 frizzled-2 [Apis mellifera] M----RYAIYVFSVAV---------------TKDPLAHHGRCE--PITINIPYNETIMPNLMNHQKQEDAGQEVHQFAPLVKMKCSPDLRFFLCTVYAPVCTDRAIPPCRSLCESARAGCERLMNSFGFAWPDNLDCSKLPELCVGHSPPVYTPPRMEFQPSWTGGPKFMLGARDFGFVCPMQFKSLKVGDKVELNCTERERRFDTDRFRYPERPAYVIGWAAGNSIACRTITQGTKHELTWFLAAGLKWGHEAIEANSQYFHLAAAGFVSLFR >CAE1239454.1 FZD1_7 [Sepia pharaonis] M----ELRNFIIGFIILYHQGFLLAASQSSINHQGLPTHGKCE--PITIPIQYNMTILPNILNHQKQDDAGLEVHQFYPLVKVECSPYLRFFLCSMYAPVCTDHAIPPCQQMCQQAREGCEKLMNRFGFEWPESLRCEKFP-LCVGE-----TPPPTRYNRPTQARPVFQPNTNSSGFHCPVEFRRLKVGDSLERDCTPDKRDFDMTRFRYPERPAYVVGFALRDSVACNIITQGTKKEGTWFLAAGMKWGHEAIEANSQYFHLAAAGFVSLFR >CAA38459.1 frizzled [Drosophila melanogaster] M----RQILFILPTLYYRSGGGLMASSGTEL--DGLPHHNRCE--PITISIPYNMTIMPNLIGHTKQEEAGLEVHQFAPLVKIGCSDDLQLFLCSLYVPVCTERPIPPCRSLCESARV-CEKLMKTYNFNWPENLECSKFPDLCVAESASTAATPTR---AKVTTRKHVERPHRNIGFVCPVQLKELKVGGKDLHDCPERERTVDSSRFRYPERAAYVAGLGAGDSVSCRTITQGRQTTSAWFLAAGLKWGHEAIENKSHLFHLVA-------- >KYO28472.1 secreted frizzled-related protein 1 [Alligator mississippiensis] MCR--AHVPHAMGSGAVLPSEYDYVSYQSDLSGRFYPKPHQCVPIPADLRVGYDKMVLPNLLDHETMAEVKHQASSWVPLLNKNCHMGTQVFLCALFAPVCLDRPVYPCRWLCEAVRDACEPVMQFFGFYWPDMLKCDQFPDVCIAMNATEVARPKGGVCPPCDNEMKIIEHLCASEFALKMTIKEVKRENGDRKIIPKKRKALKMGPIRKKNLKKLVLYLKNGAGCPCHFLIMGRQVKSQYLLTAIYKWDKKNKEFKQFMKKMKSPTFPSVFK >XP_030273955.1 secreted frizzled-related protein 1-like [Sparus aurata] MISASRMIRLAVTVAACAASEYEYLSWKSDMGGRSYGKPPQCVDIPEDLRVGYNQMLLPNVLEHETMAEVKQQASSWVPLVHKNCHPGTQVFLCSLFAPVCLERPIFPCRWLCEAVRDGCTPIMEAFGFPWPEMLTCDKFPDVCIAMNATEAPMPTGPICPPCDNEMKMLEHMCASEFAFKTKIKEVKRENMDRKVIQKRKKMLKPGNLKKKDMKTLVMYLKNGADCPCQYLIMGRKVDKQYLLTGIHKWDKSSKEFKKAIKKLKTPAFENVF- >NP_001098307.1 secreted frizzled-related protein 1 precursor [Oryzias latipes] MGSASLVLLLAVTCG---ASEYEY-TWAA--GGRGYGKAPQCVDIPDDLRVGYTQMLLPNLLEHETMAEVKQQASSWVPLVHKNCHKDTQVFLCALFAPVCMERPIYPCRWLCETVRDSCSPIMEAFGFPWPEMLTCDKFPGVCIAVNATEATWPSGPACPPCDNEIKMLENICASEFALKAKIKEVKQENMDRKVIQRRKRMVKQGNLKKRDLKKLTLYLKNGANCPCQYLIMGRKVDKQFLLTGIHKWDKSSKEFKKIMKKLKNPAFENVFK >NP_001080957.1 secreted frizzled-related protein 1 L homeolog precursor [Xenopus laevis] MNG--PLLLFWVTPGVPQASEYDYVSFQPDLSGRFYSRPAQCLEIPQDMTVGYNKMVLPNLLDSETMAEVKYQASSWVPLLSKKCHPSTQVFLCSLFAPLCLDRPVYPCRRLCESVRDACEPVMQYFGFHWPEMLRCEQYPDVCIAVNATQAPRSRKEVCPQCDSEIKLYEHMCASDFALKVSIREVRKENGDRKLLLRKEKALKKGPIQKKDWAELVLYLKNGANCPCHFLVLGPKAKAQHLLTAIHKWDKTNREFNRFMRKVKKPIPLTAPH >XP_015799833.1 PREDICTED: secreted frizzled-related protein 5 [Nothobranchius furzeri] MALGQALGLLLFSLLIVDADEYDYYNWQAD-NGRFYTKQPQCVDIPADLRVGYKKMRLPNLLDHETMPEVKQQASSWVPLLAKRCHADTQVFLCSLFAPVCLDRPIYPCRSLCEAVRDSCAPVMETYGFPWPEMLNCDKFPDLCIPM-ANHVTQPPVNVCPPCDNEMKIMEHYCASDFALKMKIKEVKKEKGDRKLIQKKKKVLKQGVLRKKDLKKLTLYIKNGANCPCSFLIMGRKVDQQLLLMSIHKWDKKSKELKFAIKYMKSPTYHSVFQ >KAB0348761.1 hypothetical protein FD754_013618 [Muntiacus muntjak] MGG--AGALLALAAGAGSASEYDYVSFQSDISGRFYTKPPQCVDIPADLRVGYKRMVLPNLLEHETMAEVKQQASSWVPLLNKNCHIGTQVFLCSLFAPVCLDRPVYPCRWLCEAVRDSCEPVMQFFGFYWPEMLKCDKFPDVCIAMNATEASKPQG----PCRVHLRAGTWSRLSPW-------------------PHPRPPPEAGVVEGRETKTHAVFLESFTP----KSALG-------------------------------PSIPGVLR >KAB0383808.1 hypothetical protein FD755_005725 [Muntiacus reevesi] MRAAAAALALLLGALPARGEEYDYYGWQTEPHGRSYSKPPQCLDIPADLPVGYKRMRLPNLLEHESLAEVKQQASSWLPLLAKRCHSDTQVFLCSLFAPVCLDRPIYPCRSLCEAVRAGCAPLMEAYGFPWPEMLHCHKFPDLCIAV-HLPATAPPVKICAQCEMEHSLMEQMCSSDFVVKMRIKEIKIENGDRKLIQKKKKLLKPGPLKRKDTKRLVLHMKNGAGCPCPFLVMGRRVDGQLLLMAVYRWDKKNKEMKFAVKFMFSSLYYPFFY >XP_039270710.1 secreted frizzled-related protein 1-like isoform X2 [Styela clava] M----SIVIVLLNAL----------------TASPFAKNFVCEPIPHSLKIAYNQMRLPNLLGHETMDEVKQQAASWVPLLNKRCHKDLQRLLCSLFSPVCIPEPIYPCQSLCQAVKGACEPVMQKVGYPWPDMLSCDKFRDMCVPQNCSSYAEPESPICPACGNELDILNLYCAVEFVLKVKIRSVKTSRKDLKLMDKRKRVIQEGSLKRKDLRKLTLLIRGGKSCTCPYLVMGGKVGRKLLVSAIYRWPKKLKMLRRLSKKFTP-------- >XP_781087.2 secreted frizzled-related protein 5 isoform X2 [Strongylocentrotus purpuratus] M----RVLVVLLAFAWGQETETDMAMLGVNSSGR--PKETDCVDIPEDLSIGYTRMRMPNLLEHDSLDEVRNQAKSWVPLLLQRCHEGTQLFLCTLFAPVCLDRPIYPCRSLCEEVQAGCGPLMESNCFPWPAMLQCDKFPDLCIRLNGTVEAQPFEMHFTQCHDDSLLLRKFCNSDFVLKVKIKTIRESKDGKKYIPEKLEVLKQGSLKTKDLQRLTFYVREGANCQCDLLVMGSKKNRKLFMTFVHSWEK-TRDFRRAIKGFENPVNDGVYT >XP_043340126.1 secreted frizzled-related protein 2 [Cervus canadensis] M----SLLLIVLASH----------------DFS--YKRSNCKPIPANLQIEYQNMRLPNLLGHETMKEVLEQAGAWIPLVMKQCHPDTKKFLCSLFAPVCLDETIQPCHSLCVQVKDRCAPVMSAFGFPWPDMLECDRFPDLCIPLDHLLPATEEAKVCEACKTKNEIMETLCKNDFALKIKVKEITYINRDTKIIETKSKTIKLNGVSERDLKKSVLWLKDSLQCTCEYLVMGQKLGGELVITSVKRWQKGQREFKRISRSIRK-------- >XP_038052835.1 secreted frizzled-related protein 5-like isoform X2 [Patiria miniata] M----SVVVVMAACL----------------SGR--ITKPTCVDIPVDLAIGYNRMRMPNLLDHDSIFEVKDQSQGWIPLLMVNCDNDTQLFLCSLFSPVCLDRPIYPCRSLCRKVRQNCEPIMLRNCFPWPSMLECDRFPGLCIQSNATDQPTQSSSLFTQCHDDADIVEYFCNADFVLKMKLKEVKETDEGMRYVPGKFAVIKQGSLKQKDLAKMRFWTREGANCGCDFLVMGHRDGKKLYMTYVHIWTK-SRELRNANKQFAQPGRDGAAE >NP_500977.2 Secreted frizzled-related protein 1 [Caenorhabditis elegans] M----PVLYILFAFS----------------SER--PVGPKCVDIPSNLSIEYTQMRLPNILEHETVSEAIHASKDWESLLRLNCHPDTQRFLCSLFAPVCLDRLILPCKSLCMAVKQGCENRMANYGFPWPEMLSCEKFEDMCIKP----AKPPAGTTCTACSQVATLVDQFCRSHLVLKAKVI----RDSPTHIRVRNGRSLKKGE-RRRGVSEIRLSSESDGSCPCNLLVMARQPDGKYLANLVLPWQK-EKNFKRAIHQFQRPHYYEMRR >XP_031565722.1 secreted frizzled-related protein 1-like [Actinia tenebrosa] --------MDFLRCL----------------CYR--TRSHHCVDITSNTALGYDKMMLPNFLRHDTAMEVRRELAQWSPLVGSGCHPYLKHFLCSVFAPVCMLELIPPCRSLCSMVQNSCEPLMRRHNYTWPSMLDCRKYPSMCVKI------TPIPTVCEEDGSNVPLQKKFCDSDFAMRARVSEKKMKDGYLILKATAIKSL-KGSLKRDQLQRLRIPNMESRNC---FLILGTKRGRRMIVTYLMKW----KDFRNMRRKIKEKM------ >NP_038862.2 secreted frizzled-related protein 1 precursor [Mus musculus] MGVGRSGVLLALAAAAGSASEYDYVSFQSDISGRFYTKPPQCVDIPVDLRVGYKKMVLPNLLEHETMAEVKQQASSWVPLLNKNCHMGTQVFLCSLFAPVCLDRPIYPCRWLCEAVRDSCEPVMQFFGFYWPEMLKCDKFPDVCIAMNTTEASKPQGTVCPPCDNELKIIEHLCASEFALRMKIKEVKKENGDKKIVPKKKKPLKLGPIKKKELKRLVLFLKNGADCPCHFLIMGRKVKSQYLLTAIHKWDKKNKEFKNFMKRMKNPTFQSVFK >NP_001263641.2 secreted frizzled-related protein 1 precursor [Rattus norvegicus] MGVGRSGVLLALAAAAGSASEYDYVSFQSDISGRFYTKPPQCVDIPVDLRVGYKKMVLPNLLEHETMAEVKQQASSWVPLLNKNCHMGTQVFLCSLFAPVCLDRPIYPCRWLCEAVRDSCEPVMQFFGFYWPEMLKCDKFPDVCIAMNATEASKPQGTVCPPCDNELKIIEHLCASEFALRMKIKEVKKENGDKKIVPKKKKPLKLGPIKKKELKRLVLFLKNGADCPCHFLIMGRKVKSQYLLTAIHKWDKKNKEFKNFMKKMKNPTFQSVFK >NP_776885.1 secreted frizzled-related protein 1 precursor [Bos taurus] -----AGALLALAAGAGSASEYDYVSFQSDISGRFYTKPPQCVDIPADLRVGYKRMVLPNLLEHETMAEVKQQASSWVPLLNKNCHIGTQVFLCSLFAPVCLDRPIYPCRWLCEAVRDSCEPVMQFFGFYWPEMLKCDKFPDVCIAMNATEASKPQGTVCPPCDNELKIIEHLCASEFALRMKIKEVKKENGDKKIVPKKKKPLKLGPIKKKELKKLVLYLKNGADCPCHFLIMGRKVKSQYLLTAIHKWDKKNKEFKTFMKKMKNPTFQSVFK >NP_989884.2 secreted frizzled-related protein 1 precursor [Gallus gallus] M----LRALLSLAAGCGGASEYDYVSYQSDLGGRFYTKPHQCVAIPADLRVGYDKMVLPNLLDHETMAEVKHQASSWVPLLNKNCHMGTQVFLCSLFAPVCLDRPVYPCRWLCEAVRDSCEPVMQFFGFFWPEMLKCDQFPDVCIAMNATEVSRPKGTVCPPCDNEMKIVEHLCASEFALKMTIKEVKKENGDKVIIPRKRKALKLGPIRKKNLKKLVLLLKNGADCPCHFLIMGRQVKTQHLLTAIYKWDKKNKEFKKFMKKVKAPTFPSVFK >XP_003639612.2 secreted frizzled-related protein 1 [Canis lupus familiaris] MGSGRRGVLLALAAGASSASEYDYVSFQSDISGRFYTKPPQCVDIPADLRVGYKKMVLPNLLEHETMAEVKQQASSWVPLLNKNCHIGTQVFLCSLFAPVCLDRPIYPCRWLCEAVRDSCEPVMQFFGFYWPEMLKCDKFPDVCIAMNATEASKPQGTVCPPCDNELKIIEHLCASEFALRMKIKEVKKENGDKKIVPKKKKPLKLGPIKKKELKKLVLYLKNGADCPCHFLIMGRKVKSQYLLTAIHKWDKKNKEFKNFMKKMKNPTFQSVFK >XP_001138037.1 secreted frizzled-related protein 1 [Pan troglodytes] MGSGRLGVLLALGAAVGSASEYDYVSFQSDISGRFYTKPPQCVDIPADLRVGYKKMVLPNLLEHETMAEVKQQASSWVPLLNKNCHAGTQVFLCSLFAPVCLDRPIYPCRWLCEAVRDSCEPVMQFFGFYWPEMLKCDKFPDVCIAMNATEASKPQGTVCPPCDNELKIIEHLCASEFALRMKIKEVKKENGDKKIVPKKKKPLKLGPIKKKDLKKLVLYLKNGADCPCHFLIMGRKVKSQYLLTAIHKWDKKNKEFKNFMKKMKNPTFQSVFK >XP_024106845.1 secreted frizzled-related protein 1 [Pongo abelii] MGSGRLGVLLALGAAVGSASEYDYVSFQSDISGRFYTKPPQCVDIPADLRVGYKKMVLPNLLEHETMAEVKQQASSWVPLLNKNCHAGTQVFLCSLFAPVCLDRPIYPCRWLCEAVRDSCEPVMQFFGFYWPEMLKCDKFPDVCIAMNATEASKPQGTVCPPCDNELKIIEHLCASEFALRMKIKEVKKENGDKKIVPKKKKPLKLGPIKKKDLKKLVLYLKNGADCPCHFLIMGRKVKSQYLLTAIHKWDKKNKEFKNFMKKMKNPTFQSVFK >XP_019478198.1 secreted frizzled-related protein 1 [Meleagris gallopavo] -------------------------------------------------------MVLPNLLDHETMAEVKHQASSWVPLLNKNCHMGTQVFLCSLFAPVCLDRPVYPCRWLCEAVRDSCEPVMQFFGFFWPEMLKCDQFPDVCIAMNATEVSRPKGTVCPPCDNEMKIVEHLCASEFALKMTIKEVKKENGDKVIIPRKRKALKLGPIRKKNLKKLVLLLKNGADCPCHFLIMGRQVKTQHLLTAIYKWDKKNKEFKKFMKKVKAPTFPSVFK >XP_003359916.2 secreted frizzled-related protein 1 [Sus scrofa] -----AGVLLALAAGAGSASEYDYVSFQSDISGRFYTKPPQCVDIPVDLRVGYKKMVLPNLLEHETMAEVKQQASSWVPLLNKNCHIGTQVFLCSLFAPVCLDRPIYPCRWLCEAVRDSCEPVMQFFGFYWPEMLKCDKFPDVCIAMNATEASKPQGPVCPPCDNELKIIEHLCASEFALRMKIKEVKKENGDKKIVPKKKKPLKLGPIKKKELKKLVLYLKNGADCPCHFLIMGRKVKGQYLLTAIHKWDKKNKEFKNFMKKMKNPTFQSVFK >XP_034821881.1 secreted frizzled-related protein 1 [Pan paniscus] MGSGRLGVLLALGAAVGSASEYDYVSFQSDISGRFYTKPPQCVDIPADLRVGYKKMVLPNLLEHETMAEVKQQASSWVPLLNKNCHAGTQVFLCSLFAPVCLDRPIYPCRWLCEAVRDSCEPVMQFFGFYWPEMLKCDKFPDVCIAMNATEASKPQGTVCPPCDNELKIIEHLCASEFALRMKIKEVKKENGDKKIVPKKKKPLKLGPIKKKDLKKLVLYLKNGADCPCHFLIMGRKVKSQYLLTAIHKWDKKNKEFKNFMKKMKNPTFQSVFK >XP_011279807.1 secreted frizzled-related protein 1 isoform X1 [Felis catus] MGSGRPGVLLALAAGAGSASEYDYVSFQSDISGRFYTKPPQCVDIPVDLRVGYKKMVLPNLLEHETMAEVKQQASSWVPLLNKNCHIGTQVFLCSLFAPVCLDRPIYPCRWLCEAVRDSCEPVMQFFGFYWPEMLKCDKFPDVCIAMNATEASKPQGTVCPPCDNELKIIEHLCASEFALRMKIKEVKKENGDKKIVPKKKKPLKLGPIKKKELKKLVLYLKNGADCPCHFLIMGRKVKSQYLLTAIHKWDKKNKEFKNFMKKMKNPTFQSVFK >XP_027818279.1 secreted frizzled-related protein 1 [Ovis aries] -----AGALLALAAGAGSASEYDYVSFQSDISGRFYTKPPQCVDIPADLRVGYKRMVLPNLLEHETMAEVKQQASSWVPLLNKNCHIGTQVFLCSLFAPVCLDRPIYPCRWLCEAVRDSCEPVMQFFGFYWPEMLKCDKFPDVCIAMNATEASKPQGTVCPPCDNELKIIEHLCASEFALRMKIKEVKKENGDKKIVPKKKKPLKLGPIKKKELKKLVLYLKNGADCPCHFLIMGRKVKSQYLLTAIHKWDKKNKEFKNFMKKMKNPTFQSVFK >XP_018887508.1 secreted frizzled-related protein 1 [Gorilla gorilla gorilla] MGSGRLGVLLALGAAVGSASEYDYVSFQSDISGRFYTKPPQCVDIPADLRVGYKKMVLPNLLEHETMAEVKQQASSWVPLLNKNCHAGTQVFLCSLFAPVCLDRPIYPCRWLCEAVRDSCEPVMQFFGFYWPEMLKCDKFPDVCIAMNATEASKPQGTVCPPCDNELKIIEHLCASEF---VTLH--------RKRINQHSQLQEKEELQAPAKSASVLYTEEDRGS--------RFVES---------------------------------- >XP_017897532.1 PREDICTED: secreted frizzled-related protein 1 [Capra hircus] -----AGALLALAAGAGSASEYDYVSFQSDISGRFYTKPPQCVDIPADLRVGYKRMVLPNLLEHETMAEVKQQASSWVPLLNKNCHIGTQVFLCSLFAPVCLDRPIYPCRWLCEAVRDSCEPVMQFFGFYWPEMLKCDKFPDVCIAMNATEASKPQGTVCPPCDNELKIIEHLCASEFALRMKIKEVKKENGDKKIVPKKKKPLKLGPIKKKELKKLVLYLKNGADCPCHFLIMGRKVKSQYLLTAIHKWDKKNKEFKNFMKKMKNPTFQSVFK >tr|A3KNP6|A3KNP6_DANRE Secreted frizzled-related protein 1 OS=Danio rerio OX=7955 GN=sfrp1b PE=2 SV=1 MKNLALSIAPFLCLPALEDEDY---IWPPDS----SDKHPPCVDIPEDLRVGYGRMMLPNLLDHETIAEVKQQAVSWVPLVHKACHKGTQVLLCSLFAPVCLDRPLYPCRWFCEAVRDSCAPIMQAFGFPWPEMLRCDKFPEVCISSKSNETDLIAGSVCPACENEMKILDQMCASEFAIKTKIKEVKIDNLDRKVIQKRRKLVRAGSMKKQDLKKLVLYLKSGAHCPCQYLIMGRSVGKQYVLTGIHKWDNSSKDFKKTIKKLKNPSYDHVFK >tr|Q7T2K9|Q7T2K9_DANRE Secreted frizzled-related protein 1 OS=Danio rerio OX=7955 GN=sfrp1a PE=2 SV=1 MKSLA-WRIIILILPLGQTFEY---GWPD-----NYDKPPQCVDIPVDLRVGYHQMLLPNLLEHESMAEVKQQAGSWVPLLHKNCDPGTQLLLCSLFAPVCMERPIYPCRRLCENVRDGCSPIMAAFGFPWPHILTCDKFPDMCI--NDTSTSEPNGPVCPPCDNEMKILDHMCASEFAIKTKIQEVKRENMDRKVTQKKKRTIKMGTLKKKDLKKLTLYLKNGADCPCTYLIMGRKVDKQYLLTGIHKWDKSNREFKKTMKKLKSPAYENVFK >XP_006023123.1 secreted frizzled-related protein 1 [Alligator sinensis] MSRFCAATCHVEARCPLSFSEYDYVSYQSDLSGRFYPKPHQCVPIPADLRVGYDKMVLPNLLDHETMAEVKHQASSWVPLLNKNCHMGTQVFLCALFAPVCLDRPVYPCRWLCEAVRDACEPVMQFFGFYWPDMLKCDQFPDVCIAMNATEVARPKGGVCPPCDNEMKIIEHLCASEFALKMTIKEVKRENGDRKIIPKKRKALKMGPIRKKNLKKLVLYLKNGAGCPCHFLIMGRQVKSQYLLTAIYKWDKKNKEFKQFMKKMKSPTFPSVFK >XP_017205875.1 PREDICTED: secreted frizzled-related protein 1 isoform X1 [Oryctolagus cuniculus] MGGGAGALLLALAAGAGSASEYDYVSFQSDVSGRFYSKPPQCVDIPADLRVGYKKMVLPNLLEHETMAEVKQQASSWVPLLNKNCHIGTQVFLCALFAPVCLDRPVHPCRWLCEAVRDACEPVMQFFGFHWPEMLRCDKFPEVCITMNATEAAKPQGTVCPPCDNELKIIEHLCASEFALRMKIKEVKKENGDKKIVPKKKKPLKLGPIKKKELKKLVLYLKNGADCPCHFLIMGRKVKSQYLLTAIHKWDKRNKEFKNFMKRMKNPTFQSVFK >XP_020732018.1 secreted frizzled-related protein 1 [Odocoileus virginianus texanus] LSTGKAGALLALAAGAGSASEYDYVSFQSDISGRFYTKPPQCVDIPADLRVGYKRMVLPNLLEHETMAEVKQQASSWVPLLNKNCHIGTQVFLCSLFAPVCLDRPIYPCRWLCEAVRDSCEPVMQFFGFYWPEMLKCDKFPDVCIAMNATEASKPQGTVCPPCDNELKIIEHLCASEFALRMKIKEVKKENGDKKIVPKKKKPLKLGPIKKKELKKLVLYLKNGADCPCHFLIMGRKVKSQYLLTAIHKWDKKNKEFKNFMKKMKNPTFQSVFK >XP_040197630.1 LOW QUALITY PROTEIN: secreted frizzled-related protein 1 [Rana temporaria] MTTAKPLLLLWISXGEVQPNEYDYVGFQPEMXGRFYSRTPQCEDIPQDLAVGYNKMVLPNLLDQETMVEAKYQASSWVPLLSKNCHPGTQVFLCSLFAPVCLEQPLYPCRWLCEEVRDACEPVMQYXGFSWPEMLRCEQFPDVCIA-NATQAPHPRREVCPQCDSEIKLYEHMCASEFALKVSVREVKKESGDRKLILKKKKALNKGPIQRKEWGDLVLYLKNGANCPCPFLVLGRKVKNQHILTAIHKWDKANREFNRFMRRVKKPKPHSVFM
PhyML tree of selected proteins (XP_040197630_1_LOW_QUALITY_PROTEIN__secreted_frizzled_related_protein_1__Rana_temporaria_:0.15494586,NP_001080957_1_secreted_frizzled_related_protein_1_L_homeolog_precursor__Xenopus_laevis_:0.15550856,((((XP_018887508_1_secreted_frizzled_related_protein_1__Gorilla_gorilla_gorilla_:0.21485082,((XP_024106845_1_secreted_frizzled_related_protein_1__Pongo_abelii_:0.00000001,(XP_001138037_1_secreted_frizzled_related_protein_1__Pan_troglodytes_:0.00000001,XP_034821881_1_secreted_frizzled_related_protein_1__Pan_paniscus_:0.00000001):0.00000001):0.00000001,NP_003003_3_secreted_frizzled_related_protein_1_precursor__Homo_sapiens_:0.00399027):0.00000001):0.01586155,((XP_011279807_1_secreted_frizzled_related_protein_1_isoform_X1__Felis_catus_:0.00381749,(XP_003359916_2_secreted_frizzled_related_protein_1__Sus_scrofa_:0.00797982,(NP_001263641_2_secreted_frizzled_related_protein_1_precursor__Rattus_norvegicus_:0.00000001,NP_038862_2_secreted_frizzled_related_protein_1_precursor__Mus_musculus_:0.00757075):0.02438219):0.00000001):0.00381068,(XP_003639612_2_secreted_frizzled_related_protein_1__Canis_lupus_familiaris_:0.00767909,(XP_017205875_1_PREDICTED__secreted_frizzled_related_protein_1_isoform_X1__Oryctolagus_cuniculus_:0.07238735,(KAB0348761_1_hypothetical_protein_FD754_013618__Muntiacus_muntjak_:0.34992175,(NP_776885_1_secreted_frizzled_related_protein_1_precursor__Bos_taurus_:0.00393619,(XP_020732018_1_secreted_frizzled_related_protein_1__Odocoileus_virginianus_texanus_:0.00000001,(XP_027818279_1_secreted_frizzled_related_protein_1__Ovis_aries_:0.00000001,(KAF4026217_1_hypothetical_protein_G4228_018281__Cervus_hanglu_yarkandensis_:0.00000001,XP_017897532_1_PREDICTED__secreted_frizzled_related_protein_1__Capra_hircus_:0.00000001):0.00000001):0.00000001):0.00000001):0.01492132):0.00812195):0.00000001):0.00000001):0.00841505):0.0481357,(((XP_015799833_1_PREDICTED__secreted_frizzled_related_protein_5__Nothobranchius_furzeri_:0.10474684,KAB0383808_1_hypothetical_protein_FD755_005725__Muntiacus_reevesi_:0.46421625):0.10903476,((XP_043340126_1_secreted_frizzled_related_protein_2__Cervus_canadensis_:0.98015787,(XP_039270710_1_secreted_frizzled_related_protein_1_like_isoform_X2__Styela_clava_:0.55335585,(CAA38459_1_frizzled__Drosophila_melanogaster_:0.22466334,(CAE1239454_1_FZD1_7__Sepia_pharaonis_:0.51649018,XP_006568530_1_frizzled_2__Apis_mellifera_:0.24601827):0.36192664):2.50209604):0.13593795):0.17970769,((XP_038052835_1_secreted_frizzled_related_protein_5_like_isoform_X2__Patiria_miniata_:0.53398873,XP_781087_2_secreted_frizzled_related_protein_5_isoform_X2__Strongylocentrotus_purpuratus_:0.41173776):0.41091268,(NP_500977_2_Secreted_frizzled_related_protein_1__Caenorhabditis_elegans_:1.14265056,XP_031565722_1_secreted_frizzled_related_protein_1_like__Actinia_tenebrosa_:1.64192574):0.16086502):0.15174749):0.16171385):0.12697129,((NP_001098307_1_secreted_frizzled_related_protein_1_precursor__Oryzias_latipes_:0.15540913,XP_030273955_1_secreted_frizzled_related_protein_1_like__Sparus_aurata_:0.09148181):0.01825756,(tr_Q7T2K9_Q7T2K9_DANRE_Secreted_frizzled_related_protein_1_OS_Danio_rerio_OX_7955_GN_sfrp1a_PE_2_SV_1:0.22146662,tr_A3KNP6_A3KNP6_DANRE_Secreted_frizzled_related_protein_1_OS_Danio_rerio_OX_7955_GN_sfrp1b_PE_2_SV_1:0.38005516):0.07901556):0.18211303):0.10026108):0.02689872,((XP_006023123_1_secreted_frizzled_related_protein_1__Alligator_sinensis_:0.04222371,KYO28472_1_secreted_frizzled_related_protein_1__Alligator_mississippiensis_:0.01834829):0.07868053,(XP_019478198_1_secreted_frizzled_related_protein_1__Meleagris_gallopavo_:0.00000001,NP_989884_2_secreted_frizzled_related_protein_1_precursor__Gallus_gallus_:0.00000001):0.0731496):0.06955151):0.3179869);
BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)