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PBID | Uniprot | Name | Gene | Alternative | Organism | Uniprot Description |
PB0026 | Q08431 | Milk fat globule EGF and factor V/VIII domain containing | MFGE8 | BA46, EDIL1, HMFG, HsT19888, MFG-E8, MFGM, OAcGD3S, SED1, SPAG10, hP47, Lactadherin | Homo_sapiens | Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction. |
Domains | Gene Ontology |
PF00008 (EGF) PF00754 (2_F5_F8_type_C) |
GO:0001786 (enables) phosphatidylserine binding
GO:0005178 (enables) integrin binding GO:0005201 (enables) extracellular matrix structural constituent GO:0008429 (enables) phosphatidylethanolamine binding GO:0001525 (involved in) angiogenesis GO:0006910 (involved in) phagocytosis, recognition GO:0006911 (involved in) phagocytosis, engulfment GO:0007155 (involved in) cell adhesion GO:0007338 (involved in) single fertilization GO:0043277 (involved in) apoptotic cell clearance GO:0050766 (involved in) positive regulation of phagocytosis GO:0002080 (located in) acrosomal membrane GO:0005576 (located in) extracellular region GO:0005615 (located in) extracellular space GO:0005788 (located in) endoplasmic reticulum lumen GO:0009897 (located in) external side of plasma membrane GO:0016020 (located in) membrane GO:0019897 (located in) extrinsic component of plasma membrane GO:0031410 (located in) cytoplasmic vesicle GO:0062023 (located in) collagen-containing extracellular matrix GO:0070062 (located in) extracellular exosome GO:1903561 (located in) extracellular vesicle |
External Links | Description |
Intact | Open source database system and analysis tools for molecular interaction data. |
Protein Atlas | An open access resource for human proteins |
InterPro (new pfam) | InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. |