PB0023

DATABASE

Click here to access PB0023 phyletic profile

PBID	Uniprot	Name	Gene	Alternative	Organism	Uniprot Description
PB0023	P12645	Bone morphogenetic protein 3	BMP3	BMP-3A	Homo_sapiens	Growth factor of the TGF-beta superfamily that plays an essential role in developmental process by inducing and patterning early skeletal formation and by negatively regulating bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification (PubMed:11138004, PubMed:15269709).

Domains

Gene Ontology

PF00019 (TGF_beta)

GO:0005102 (enables) signaling receptor binding GO:0005125 (enables) cytokine activity GO:0008083 (enables) growth factor activity GO:0070700 (enables) BMP receptor binding GO:0001501 (involved in) skeletal system development GO:0001503 (involved in) ossification GO:0001649 (involved in) osteoblast differentiation GO:0007267 (involved in) cell-cell signaling GO:0010862 (involved in) positive regulation of pathway-restricted SMAD protein phosphorylation GO:0030154 (involved in) cell differentiation GO:0051216 (involved in) cartilage development GO:0060395 (involved in) SMAD protein signal transduction GO:0005576 (located in) extracellular region GO:0005615 (located in) extracellular space GO:0070062 (located in) extracellular exosome

External Links	Description
Intact	Open source database system and analysis tools for molecular interaction data.
Protein Atlas	An open access resource for human proteins
InterPro (new pfam)	InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish) >sp|P12645|BMP3_HUMAN Bone morphogenetic protein 3 OS=Homo sapiens OX=9606 GN=BMP3 PE=1 SV=2 MAGASRLLFLWLGCFCVSLAQGERPKPPFPELRKAVPGDRTAGGGPDSELQPQDKVSEHM LRLYDRYSTVQAARTPGSLEGGSQPWRPRLLREGNTVRSFRAAAAETLERKGLYIFNLTS LTKSENILSATLYFCIGELGNISLSCPVSGGCSHHAQRKHIQIDLSAWTLKFSRNQSQLL GHLSVDMAKSHRDIMSWLSKDITQLLRKAKENEEFLIGFNITSKGRQLPKRRLPFPEPYI LVYANDAAISEPESVVSSLQGHRNFPTGTVPKWDSHIRAALSIERRKKRSTGVLLPLQNN ELPGAEYQYKKDEVWEERKPYKTLQAQAPEKSKNKKKQRKGPHRKSQTLQFDEQTLKKAR RKQWIEPRNCARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQ SIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR >tr|A2AVJ4|A2AVJ4_DANRE Bone morphogenetic protein 3 OS=Danio rerio OX=7955 GN=bmp3 PE=3 SV=1 MDRCQRLFVLLLGCGYLCCGYCAVLKTPVMGFSKDVQLGQKAEEPEKQQVKKSEQDTLSE HMQMLYAKYTSAGFPLKDGNTVRSFKGHLGTINNRQLQIFNLTSLTKSEDVLSATLHYYI GDLHNSSHRCSKHKSCAQHNLRRQAHVHLDVWSFSLVKNTTRTIGHFPINISTMHWDFIS WQWKDITRVVNQAKHHDQLLIGININSRGHQPWKKLLSDRSPYILVYANDSAISEPESVV STLQRHKSRLLPNLHMLESHNRNASAQHRSRRSTNILLPLQNNELPGPEYPYEIPTWDEA SPYDPMESKTVKRPRKKPRKNPRHKNPLLQFDEQTIKKARKKQWNEPRNCARRYLKVDFA DIGWSEWIISPKSFDAYYCSGSCQFPMPKSLKPSNHATIQSIVRAVGVVPGIPEPCCVPE KMSSLSILFFDEDKNVVLKVYPNMTVDSCACR
Selected proteins from model organisms >NP_001192.4 bone morphogenetic protein 3 preproprotein [Homo sapiens] MAGASRLLFLWLGCFCVSLAQGERPKPPFPELRKAVPGDRTAGGGPDSELQPQDKVSEHMLRLYDRYSTV QAARTPGSLEGGSQPWRPRLLREGNTVRSFRAAAAETLERKGLYIFNLTSLTKSENILSATLYFCIGELG NISLSCPVSGGCSHHAQRKHIQIDLSAWTLKFSRNQSQLLGHLSVDMAKSHRDIMSWLSKDITQLLRKAK ENEEFLIGFNITSKGRQLPKRRLPFPEPYILVYANDAAISEPESVVSSLQGHRNFPTGTVPKWDSHIRAA LSIERRKKRSTGVLLPLQNNELPGAEYQYKKDEVWEERKPYKTLQAQAPEKSKNKKKQRKGPHRKSQTLQ FDEQTLKKARRKQWIEPRNCARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQ SIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR >XP_031567165.1 bone morphogenetic protein 2-like [Actinia tenebrosa] MLVLRVWCLIFGIAFPFKVNSSPVDSTSSARASVEIKNSQAFLGVEKAILKSMGIKTRPRPRRGIKIPKYMKDLYHSHEE HPEWISTNFRFNKKWTSVNTVRAFHHLDDLPISHPDAPGRPRLKFDVSSLPKLEQVKSAELRLHKNGLWRHGGDPEMRVS VYQITHSRLPSSLENRTLIDSHIMNTANSGWESFDVRSAVEHWISNPSDKNNIEVHISTKNGHSLNISADDVIRNLSMDK EQWHDERPLLVVYTHDALTHHHVRKKRSASKSRSQKKRTRPQYCKRHPLYVDFSDVGWNDWIVAPPGYYAFFCNGECPYP ITKHLNATNHAIVQTVMNSVDPKVPNVCCVPTTLTPISMLYMDEYEKVVLKNYQDMVVEGCGCR >NP_504709.1 Protein dbl-1 [Caenorhabditis elegans] MNDSVRTTTTISSTKSLVHSFQLSAILHLFLLISFTPMSAAADQHASHATRRGLLRKLGLEHVPVQTGPSIDVPQHMWDI YDDDNDVDWVRHYYPKEIIEDNEGFLLSYNLSLAARNAHNEEVTKATLKLRLRRNNKARRSGNISIYFFEDDINNDRFQI ESRSVDNLTEWIDFDVTAAFLRRTNRISFFIDLPEDVEIEETQSSSLSSLPYARAQSAPLIVFSDLSEPSSVRRKRSAQT GNSERKNRKKGRKHHNTEAESNLCRRTDFYVDFDDLNWQDWIMAPKGYDAYQCQGSCPNPMPAQLNATNHAIIQSLLHSL RPDEVPPPCCVPTETSPLSILYMDVDKVIVIREYADMRVESCGCR >AAC47552.1 decapentaplegic protein [Drosophila melanogaster] MRAWLLLLAVLATFQTIVRVASTEDISQRFIAAIAPVAAHIPLASASGSGSGRSGSRSGGASTSTALAKAFNPFSEPASF SDSDKSHRSKTNKKPSKSDANRQFNEVHKPRTDQLENSKNMSKQLVNKPNHNKMAVKEQRSHHKKSHHHRSHQPKQASAS TESHQSSSIESIFVEEPTLVLDREVASINVPANAKAIIAEQGPSTYSKEALIKDKLKPDPSTLVEIEKSLLSLFNMKRPP KIDRSKIIIPEPMKKLYAEIMGHELDSVNIPKPGLLTKSANTVRSFTHKDSKIDDRFPHHHRFRLHFDVKSIPADEKLKA AELQLTRDALSQQVVASRSSANRTRYQVLVYDITRVGVRGQREPSYLLLDTKTVRLNSTDTVSLDVQPAVDRWLASPQRN YGLLVEVRTVRSLKPAPHHHVRLRRSADEAHERWQHKQPLLFTYTDDGRHKARSIRDVSGGEGGGKGGRNKRQPRRPTRR KNHDDTCRRHSLYVDFSDVGWDDWIVAPLGYDAYYCHGKCPFPLADHFNSTNHAVVQTLVNNMNPGKVPKACCVPTQLDS VAMLYLNDQSTVVLKNYQEMTVVGCGCR >XP_043304197.1 bone morphogenetic protein 3 [Cervus canadensis] MAGARGLLRLWLGCLCVSLAQGQRLRQPFPELRVAVPGDRAAGGGPESPVQPLDQLSEHMLRLYDRYSGGRAEAARTPGT SERGSSPLRPQLLREGNTVRSFRAGAAGTLENKELHIFNLTSLTKSENILSATLYFYIRELINISLSCPVSQECSHHAQR KHIHIDLSAWILKSSGNQSQLLGHLSVDGGKPHRDFVSWLSKDITQLLRKAKENDEFLIGFNITTKGHQLPKKMIPSPEP YILVYANDAAISEPESVVSSLQGHRNFPTGAVPKLDGHSRAALSIERRRRKRSAGVLLPLQNNELPGAEYQYKEDGVWEE RKPYKTLQTQPPDKSKNKKKQRKGPQQKSQTLQFDEQTLKKARRKQWIEPRNCARRYLKVDFADIGWSEWIISPKSFDAY YCSGACQFPMPKSLKPSNHATIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR >KAB0354394.1 hypothetical protein FD755_022932 [Muntiacus reevesi] MSCFCLLAIVESRTLENKELHIFNLTSLTKSESILSATLYFYIRELINISLSCPVSQECSHHAQRKHIHIDLSAWILKSS GNQSQLLGHLSVDGGKPHRDFVSWLSKDITQLLRKAKENDEFLIGFNITTKGHQLPKKMTPSPEPYILVYANDAAISEPE SVVSSLQGHRNFPTGAVPKLDGHSRAALSIDRRRRKRSAGVLLPLQNNELPGAEYQYKEDGVWEERKPYKTLQTQPPDKS KNKKKQRKGPQQKSQTLQFDEQTLKKARRKQWIEPRNCARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLK PSNHATIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR >KAB0344722.1 hypothetical protein FD754_021648 [Muntiacus muntjak] MSCFCLLAIVESRTLENKELHIFNLTSLTKSESILSATLYFYIRELINISLSCPVSQECSHHAQRKHIHIDLSAWILKSS GNQSQLLGHLSVDGGKPHRDFVSWLSKDVTQLLRKAKENDEFLIGFNITTKGHQLPKKMTPSPEPYILVYANDAAISEPE SVVSSLQGHRNFPTGAVPKLDGHSRAALSIDRRRRKRSAGVLLPLQNNELPGAEYQYKEDGVWEERKPYKTLQTQPPDKS KNKKKQRKGPQQKSQTLQFDEQTLKKARRKQWIEPRNCARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLK PSNHATIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR >OCU00369.1 hypothetical protein XELAEV_18006143mg [Xenopus laevis] MAECRPWLVLWVGCCGCLCLALGELLNDGLLAVGMGTGDAARQEEAALPLGDTVSEHMLRLYDKYRSGGGRAKESLRYRQ ALPDGNTVRSFRAMNGDEHKKCHYMFNLTSLTSSENILSATLHYYLGDLLNSSHRCPHSLFCTQHGHAKPEFTLYLTLWS FNALQNPTHVISNFLINVSASQRDHPLWQWKDITQAVRKAKEYGEAVLGFNLTIEYPNYRSIDILGLKPYILVYANDSAI SEPDSVVSSLHGPHTPLALKPNRKTEKAEQRKKRSTEILLPLQNNELPGAEYQYSVDEEGWEERKPYKNLQGRQNEKDKN KKKLRKGSRQKSQTLQFDEQTLKKARRKQWNEPRNCARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPS NHATIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFLDENKNVVLKVYPNMTVESCACR >KAF4018998.1 hypothetical protein G4228_010604 [Cervus hanglu yarkandensis] MARGPARTSLRPGSQQLPLLSLLLLLLLLRDADGSHTAAARPAPPAAADGLAGDKNPQRSPGDVVAAQNPGAQDMVAVHM LRLYEKYSRRGARPGGGNTVRSFRARLEVVNQKAVYFFNLTSMQDSEMILTATFHFYSEPLWPPAREVPCKQRAKNASCR LLPPGPPARQHLLFRSLSQNTATQGLLRGAMALPPPPRGLWQAKDISLIVKAARRDGELLLSAQLDSGEKDMGVPRLGPH APYILIYANDLAISEPNSVAVTLQRYDPFQAGDPEPGAAPNSSADPRVRRATQATGPLQNNELPGLDERPEHAPHAQHYH KHELWPSPFRALKPRPGRKDRRKKGQDVFMASSQVLDFDEKTMQKARKKQWDEPRVCSRRYLKVDFADIGWNEWIISPKS FDAYYCSGACEFPMPKMVRPSNHATIQSIVRAVGIVPGIPEPCCVPDKMSSLGVLFLDENRNVVLKVYPNMSVETCACR >OWK07582.1 GDF10 [Cervus elaphus hippelaphus] MARGPARTSLRPGSQQLPLLSLLLLLLLLRDADGSHTAAARPAPPAAADGLAGDKNPQRSPGDVVAAQNPGAQDMVAVHM LRLYEKYSRRGARPGGGNTVRSFRARLEVVNQKAVYFFNLTSMQDSEMILTATFHFYSEPLWPPAREVPCKQRAKNASCR LLPPGPPARQHLLFRSLSQNTATQGLLRGAMALPPPPRGLWQAKDISLIVKAARRDGELLLSAQLDSGEKDMGVPRLGPH APYILIYANDLAISEPNSVAVTLQRYDPFQAGDPEPGAAPNSSADPRVRRATQATGPLQNNELPGLDERPEHAPHAQHYH KHELWPSPFRALKPRPGRKDRRKKGQDVFMASSQVLDFDEKTMQKARKKQWDEPRMVRPSNHATIQSIVRAVGIVPGIPE PCCVPDKMSSLGVLFLDENRNVVLKVYPNMSVETCACR >XP_038062104.1 growth/differentiation factor 10-like isoform X2 [Patiria miniata] MEYRVHIVQLLILMSCLATVLCKELSSSVNRESIQRPYTKDGKLVDPSDPWSRKRYHAADVHPPKRIMKLMQQLSKNEDL LKERGNTVRSYLPNLRFACNEPTYVFSIKSHKTESLRSVELHFFASKPSNLIDSESTIDIHLHLITNTSSACQPIGVQQR PAKARGWQVIDVTAQIAHLLKPILESENSQITVGVSFRLQETGGSHDTSRERTTNEKIMSNHARPFLLVYAEDDDSSGNS VLQWTQEGAKTKTAPSETTHPMEARSPTQVRSHTRHARSVDGNVHSIMTNEFPEGSTNVAHQATFQHFNEQDSKRRKAKK RTSKKRKRVSKKQHRKAPLLDPSSSVVEDESEEQAAMNDDRDQNTVLPMSPNDGPCSRHAMFVSFDTIDWDGYVIAPTGF EAFYCTGACSFPLSKTDNPSNHATIQSVMSVAGIQAKIPPPCCVPEKLTSLSILFLDENDNVGLKSYKNMVVESCGCR >XP_039273812.1 uncharacterized protein LOC120347787 isoform X2 [Styela clava] MKGIRAHSIRSPAILFLICICVILFGTTYGELNTRKEGRRLHKDSNELSVSEHQNIRTSNATSRVSPIETSPISQINPST DANQRSVQRRKDRQRKKSKHGRREKGNKRNGRKRKDNELNRGGETDINEVLRNTMRHMFGFDHIPVTTLPPVDAKPRTAD VDLDLTDSHTDYVNKKDIKSSWLDQNGDMMPQPPDFMLELYRTYSRDNNLMMLHSISQGNTVRSFFPSPADPSERSKIRK AVTIKPVQANTGATDGSKQTTETQRYESPFPVFLFNLSSIPRPETLVRAEIRLDGMTRSAMLMNQHNIENTQNETSLQNL NIVVGVYKIDSNDCADGLDCSVSSKIFHRIGNTTALNFDAVASWSARNLLRLATQARDRNHFLIVRFENRPDESLSRQIR HTEKESAGDDLPLQFMISENERLKRSSNRAKDNLDSSGSSLKEQWFDVNFDHSPETPILIIYCNDSRTALVKDTPSLAPS IIWRRLENMTNLFKKRVRRSEPQDIAKDEVDNRIVDEYDENNHGSTRRMQKTTPQVVEKYDSETKSENRKGKNVTKIKNI ISNEKSGRKRRRNQKCNDGKKKGKRGCKKSSKGRKKQKKVPLHPSAVERDEDCGRKSMNVDFASIGWSDWIISPTTFEAY YCSGRCEISNMQQTGTTNHAIVQAIARLAGATVPEPCCAPDKLMPLSVLFFDENSNVVLRVYTNMSVETCACK >XP_030834960.1 bone morphogenetic protein 3-like [Strongylocentrotus purpuratus] MDTLLPESGVRRRRSAGSNDTKETLDENETLVSNEVVDVEPVDNNEYPLNPIGKTFPATTHTAFSFFAEQNMRRIKSNRR RARNQRKKDKSKNMMLDAEEKSRARKKKLNKPRPKHLDIGTPTEATNVCDRHSMNVDFQAIGWDDYVIAPATFQAFYCAG QCAYPIQKELHPSNHALIQSIMHLLGVQTGVPTPCCVPDKMEPLVLLYIEQDSTVTLKKYSDMVVESCGCH >CAE1274945.1 BMP2 [Sepia pharaonis] MSIIIFLSSQASIYLSIYLSIYLFIYLSICLSFCYQEIKRDILRHEQQTKQERSPGLQKAIRLLNEKERTEYQQQKHGSS WGLGFKRKRRSAPNSRQATESHERRNSTSGSSHGRNRRTLFRRKRRNCARYEMYVDFNAIGWSGWIISPKGYNAYHCSGP CPFPLGQSHRPTNHATVQSIVHALRAGKNVLTPCCVPDKLYSISLLYFDDQENVILKLYEDMVAASCGCH >tr|A2AVJ4|A2AVJ4_DANRE Bone morphogenetic protein 3 OS=Danio rerio OX=7955 GN=bmp3 PE=3 SV=1 MDRCQRLFVLLLGCGYLCCGYCAVLKTPVMGFSKDVQLGQKAEEPEKQQVKKSEQDTLSE HMQMLYAKYTSAGFPLKDGNTVRSFKGHLGTINNRQLQIFNLTSLTKSEDVLSATLHYYI GDLHNSSHRCSKHKSCAQHNLRRQAHVHLDVWSFSLVKNTTRTIGHFPINISTMHWDFIS WQWKDITRVVNQAKHHDQLLIGININSRGHQPWKKLLSDRSPYILVYANDSAISEPESVV STLQRHKSRLLPNLHMLESHNRNASAQHRSRRSTNILLPLQNNELPGPEYPYEIPTWDEA SPYDPMESKTVKRPRKKPRKNPRHKNPLLQFDEQTIKKARKKQWNEPRNCARRYLKVDFA DIGWSEWIISPKSFDAYYCSGSCQFPMPKSLKPSNHATIQSIVRAVGVVPGIPEPCCVPE KMSSLSILFFDEDKNVVLKVYPNMTVDSCACR >KAG6798905.1 bone morphogenetic protein 10 [Apis mellifera caucasica] MMTDSGFRFLLFAILLYLLSPSFEHFAHSHPSRAIDEDDDNANGEREEDVNERWPRLDEASNEQDARRNEILEKLQQVLG IRSYLERERTGRRKVPPQFMVELYNNVADPSGVTRGRNPYNAKVVRSFIERDTTTSRFYFFNITGLEVNESVLEAELHLY RKRTPLKALHPSILASPYYLIRVYQVLDEKSLDVPDLHRLLNVRYVGAHASGWQIFNVKQAVLAWLNGEPNLGLLVTATT LFEDRANVEFSRRNEYHHSKQPILVLFDDDGKDRRGDGNDEIEQVFHDEEEEKGDWRNSDAEQDPRGKGELEGNKNKTGS FERQKRTRMREHEEGETTRGAQHLADDGSGRRRRETNVKKLHGISSSLEEETFGGSYLTSMDIYERAMRRERIMGGRAGQ RSFWSEKIREKRSAKSRASVRQNVTECSRHELYVDFKEIGLSSSIIAPLGYSAFHCKGICESPLSQDQQPTNHATIQGIV HKMGLVKGVERPCCVPTKLLGTTILFYDDNENVILKVYQDMIADRCGCR >NP_058801.1 bone morphogenetic protein 3 precursor [Rattus norvegicus] MAGARGLLCLWLGCFCLNLAQGQRPNLHLPGLRGTESSDRMTGGGPSPDLRPHDKVSEHMLWLYDRYSGS NRAQATRTPGSQLPGPQPLRGGNTVRSFRAAAAGTLQRKGLHTFNLTSLTKSENILSATLYFYIGELVNT SVNCPESQGCSHDSQRQHIQIDLSAWTLQSNQSQLLGHLSVDTAKPYRDSMSWLSKDITQLLRKAKQDEE FLIGFNITSRAHELPKRMLLFPEPYILVYANDAAICEPESVVSSLQRHRDFTAGTVPRLDSHVREALSVE RRKKRSTGILLPLQNNELPGAEYQYKEAGVWEERKPYKSLQTQPPEKSRSKKKQRKGPHQKGQTLQFDEQ TLKKARRKQWIEPRNCARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVR AVGVVSGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVDSCACR >NP_775580.1 bone morphogenetic protein 3 isoform 2 preproprotein [Mus musculus] MAGARGLLCLWLGYFCLNLAQGQRPNLHLPGLRETEPSDRATGGSPSPDLRPHDKVSEHMLWLYDRYSGS SRVQATRTPGSQLPGPQPLRGGNTVRSFRAAAAGTPQTKGLHTFNLTSLTKSENILSATLYFYVGELVNI SLSCPEPQGCSHHTQRQHIQIDLSAWILKSNQSQLLGHLSVDVVRPYRDSVSWLSKDITQLLRKAKQNEE FLIGFNITSRAHELPKRMLFFPEPYILVYANDAAISEPESVVSSLQRHRDFTAGTGPRLDSHVREALSVE RRKKRSTGILLPLQNNELPGAEYQYKEEGAWEERKPYKSLQTQPPEKSRNKKKQRKGSHQKGQTLQFDEQ TLKKARRKQWVEPRNCARRYLKVDFADIGWSEWIISPKSFDAFYCSGACQFPMPKSLKPSNHATIQSIVR AVGVVSGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVDSCACR >XP_015131733.2 bone morphogenetic protein 3 isoform X1 [Gallus gallus] MQISPVCSMRSLQEEKTSFLLFGYCSLEACFISARLQAELLPIPQQKFSVMRETCDLRALEKKLCWEGTS NGRAAAGHLSKHPAWRAQRSSMEGVSVVSSSAGFPNASWREQITAQFPGRPGSQELYVFNLTSLTKSENI LSASLHYYIGDLLDADWNCSQSGGCSHRGHRKPEIQIHLSVWTFPSVGNQTRGLGHFLINISSSYSDVLS WQWKDITQVLHKAKQSNELLIGVKMDSTSRHLWRRAPFHYEPYILIYANDSAISEPENVVSSLQGHHNPL ARVFPRPENHMRSSLGKRRRKRSTNVLLPLQNNELPGAEYQYNEDERWEDRKPYKTFQPRLADRAKSKKK QRKNHHQKSQTLQFDEQTLKKARRKQWNEPRYCARRYLKVDFADIGWSEWIISPKSFDAYYCSGECQFPI PKALKPSNHATIQSIVRAVGVVPGIPEPCCVPDKMSSLSILFFDENKNVVLKVYPNMTVESCACR >XP_001144027.1 bone morphogenetic protein 3 [Pan troglodytes] MAGASRLLFLWLGCFCVNLAQGERPKPPFPELRKAVPGDRTAGGGPDSELQPQDKVSEHMLRLYDRYSTV QAAWTPGSLEGGSQPWRPRPLREGNTVRSFRAAAAETLERKGLYIFNLTSLTKSENILSATLYFCIGELG NISLSCPVSGGCSHHAQRKHIQIDLSAWTLKFSRNQSQLLGHLSVDMAKSHRDIMSWLSKDITQFLRKAK ENEEFLIGFNITSKGHQLPKRRLPFPEPYILVYANDAAISETESVVSSLQGHRNFPTGTVPKWDSHIRAA LSIERRKKRSTGVLLPLQNNELPGAEYQYKKDEVWEERKPYKTLQTQPPEKSKNKKKQRKGPHQKSQTLQ FDEQTLKKARRKQWIEPRNCARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQ SIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR >NP_001179197.1 bone morphogenetic protein 3 precursor [Bos taurus] MAGARGLLHLWLSCLCVSLAQGQRLRQPFPELRVAVPADRAAGGGPESPLQPLDQVSEHMLRLYDRYSGG RTEEARTPGNSERGSPSLRPQPLREGNTVRSFRAGAAGMLENKELHIFNLTSLTKSENILSATLYFYIRE LINISLSCPVSQECSHHAQRKHIQIDLSAWILKSSGNQSQLLGHLSVDGGKPHRDFVSWLSKDITQLLRK AKENEEFLIGFNITTKGHQLPKKMTPSPEPYILVYANDAAISEPESVVSSLQGHRNFPTGAVPKLDSQSR SAPSIERRRRKRSTGVLLPLQNNELPGAEYQYKEDEVWEERKPYKTLQTQPPDKSKNKKKQRKGPQQKSQ TLQFDEQTLKKARRKQWIEPRNCARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHA TIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR >XP_002717136.1 PREDICTED: bone morphogenetic protein 3 [Oryctolagus cuniculus] MAWARGLLCLWLSCVCVSLARTERPRQPFPELRKAGPGDRAAGGGPGPELQPHDKVSEHMLRLYDRYSGG GRVQAPRTPGSRERGSQPAHPQPLREGNTVRSFRAGAAGAVESKGLHIFNLTSLTKSENILSATLYFYSG ELVNTNLSCPVSQGCSHHAKRKPVQIVLSAWILKSDRNQSQPLGHLSVDVAKSHRDVTPWLSKDITQLLR KAKEKEEFLIGFNITSKAHQLPKRMLLSPEPYILVYANDAAISEPESVVSSLQGHRNFPTGSVPKLDRHI RAALSVERRKKRSTGVLLPLQNNELPGAEYQYKEEGVWEERKPYKTLQTQPPEKSKNKKKQRKGPHQKSQ TLQFDEQTLKKARRKQWLEPRDCARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHA TIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR >XP_002814965.1 bone morphogenetic protein 3 [Pongo abelii] MAGASRLLFLWLGCFCVSLAQGERPKPPFSELRKAVPGDRTAGGGPDTELQPQDKVSEHMLRLYDRYSTV QAARTPGSPEGGLQPWRPQPLREGNTVRSFRAAAAETLERKGLYIFNLTSLTKSENILSATLYFYIGELG NISLSCPVSGGCSHHAQRKHIQIDLSAWTLKFSRNPSQLLGHLSVDMAKSHRDIMSWLSKDITQFLRKAK GNEAFLIGFNVTSKGHQLPKRRLPFPEPYILVYANDAAISEPESVVSSLQGHQNFPTGTVPKWDSHIRAA LSIERRKKRSTGVLLPLQNNELPGAEYQYKKDEVWEERKPYKTLQTQPPEKSKNKKKQRKGPHQKSQTLQ FDEQTLKKARRKQWIEPRNCARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQ SIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR >NP_001193317.1 bone morphogenetic protein 3 precursor [Sus scrofa] MAAARALLPLWLGCLCGSLAQGLRRQQPFPELRDAVPGHRAAGGGPDPPLQPLDPLSEHMLRLYDSYSGG ASAEAARTPGSPEPGSPPLRPQPRREGNTVRSFRAGAAGTLENKELHVFNLTSLTKSENVLSATLYFYIG ELINATLSCPASRGCSHHAQRRHIQISLSAWVLQLSRNQSQLLGHLSVDVAKPHRDMASWLSKDITQLLR KAKENEEFLIGFNITSRGHQLPKKVIPFPEPYILVYANDAAISEPESVVASLQGHRNFPAGAVPKLDRHL RAALSTERRRKRSAGLLLPLQNNELPGAEYQYKEDGVWEERKPYKTLQTQPPEKSKNKKKQRKGPHQKSQ TLQFDEQTLKKARRRQWIEPRNCARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHA TIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR >XP_038299875.1 bone morphogenetic protein 3 [Canis lupus familiaris] MAGARGLLWLWLGCFCGSLARAERPKPGLPQLHGAGSGDRAAGGGSGPVLRPLDKVSEHMLRLYDRYSGG GGARAERARGASERGSQPARPQPLREGNTVRSFRGGAAGTLGSKGLHIFNLTSLTKSENILSATLYFYVG ELINISLSCPESRGCSHHAQRKHMQIDLSVSILKSDRNQSQLFGHLSVDVAKSHRDFGSWLSKDITQLLR KAKENEEFLIGFNITSKGHQLPKKRLPFPEPYILVYANDAAISEPESVVSSLQGHRNFATGTMPKLASHI RAALSIERRKKRSAGVLLPLQNNELPGAEYQYREDGVWEEKKPYKTLQTQAPEKTKNKKKQRKGLHQKSQ TLQFDEQTLKKARRKQWIEPRNCARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHA TIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR >XP_003832318.1 bone morphogenetic protein 3 [Pan paniscus] MAGASRLLFLWLGCFCVNLAQGERPKPPFPELRKAVPGDRTAGGGPDSELQPQDKVSEHMLRLYDRYSTV QAAWTPGSLEGGSQPWRPRPLREGNTVRSFRAAAAETLERKGLYIFNLTSLTKSENILSATLYFCIGELG NISLSCPVSGGCSHHAQRKHIQIDLSAWTLKFSRNQSQLLGHLSVDMAKSHRDIMSWLSKDITQFLRKAK ENEEFLIGFNITSKGHQLPKRRLPFPEPYILVYANDAAISEPESVVSSLQGHRNFPTGTVPKWDSHIRAA LSIERRKKRSTGVLLPLQNNELPGAEYQYKKDEVWEERKPYKTLQTQPPEKSKNKKKQRKGPHQKSQTLQ FDEQTLKKARRKQWIEPRNCARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQ SIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR >XP_006931098.2 bone morphogenetic protein 3 [Felis catus] MAGALRLLCLWLGCFCVSLARGEGLTRTVPEPHRAVPGDRTAGGGPGPVLQPHDKVSEHMLRLYDRYSGG GRAEAERAQRSSERGSQPLRPPPLREGNTVRSFRAGASGTLGSKGLHIFNLTSLTKSENILSATLYFYIG ELINISLSCPASRGCSPHAQRKHVLIDLSAWILKSDRNQSQHLGHLSVDVAKSHRDLGSWLSKDITQLLR RAKENEEFLIGFNITSKGHQLPKKMLPFPEPYILVYANDAAISEPESVVSSLQRHRNFPIGAVPRPDGHI KAALSTERRRKRSAGVLLPLQNNELPGAEYQYREDGVWEERKPYKTLQTQAPEKTKNKKKQRKGPPQKSQ TLQFDEQTLKKARRKQWIEPRNCARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHA TIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR >XP_027826928.1 bone morphogenetic protein 3 [Ovis aries] MAGARGLLHLWLSCLCVSLAQGQRLRQPFPELRVAVPADRAAGGGPESPLQPLDQLSEHMLRLYDRYSGG GAEEARTPGNSERGSPSLRPQPLREGNTVRSFRAGAAGMLENKELHIFNLTSLTKSENILSATLYFYIRE LINISLSCPVSQECSHHAQRKHIQIDLSAWILKSSGNQSQLLGHLSVDGGKPHGDFVSWLSKDITQLLRK AKENEEFLIGFNITTKGHQLPKKMTPSPEPYILVYANDAAISEPESVVSSLQGHRNFPTGAVPKLDSHSR AALSMERRRRKRSTGVLLPLQNNELPGAEYQYKEDRVWEERKPYKTLQTQPPDKSKSKKKQRKGPQQKSQ TLQFDEQTLKKARRKQWIEPRNCARRYLRVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHA TIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR >XP_004038932.1 bone morphogenetic protein 3 [Gorilla gorilla gorilla] MARASRLLFLWLGCFCVSLAQGERPKPPFPELRKAVPGDRTAGGGPDSELQPQDKVSEHMLRLYDRYSTV QAARTPGSLEGGSQPWRPQPLREGNTVRSFRAAAAETLERKGLYIFNLTSLTKSENILSATLYFYIGELG NISLSCPVSGGCSHHAQRKHIQIDLSAWTLKFSRNQSQLLGHLSVDMAKSHRDIMSWLSKDITQFLRKAK ENEEFLIGFNITSKGHQLPKRRLPFPEPYILVYANDAAISQPESVVSSLQGHRNFPTGTVPKWDSHIRAA LSTERRKKRSTGVLLPLQNNELPGAEYQYKKDEVWEERKPYKTLQTQPPEKSKNKKKQRKGPHQKSQTLQ FDEQTLKKARRKQWIEPRNCARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQ SIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR >XP_004073050.1 bone morphogenetic protein 3 [Oryzias latipes] MAFYSQSVVVLLYGWSFLCLGYCTMLKANSSPQRRKVDFTHSVDKRDTVKGERDLLLQDTMTKHMQMLYA KYNRAGFPFRDGNTVRSFKAHWGTINEKHLQIFNLTSLTKSEDVLSATLHYYIGDLQNSTWGCSRSKSCG RHALLRHNHIHMVIWSFASIDNKMRSLGHLRINVSTLYRDFISWQWKDITRVVNQAKHHEELLIGIDVAS QGPQPWKKLLSDRSPYILVYANDSAISEPESVVATLQRHGSGPNKGQMPHRPQKVGAQERNNTEHLQPRH RRSVNVLLPLQNNELPGSEYPYETTGWDETSPHEPFKKKQSRRPRKKTRKNQQQKMPLLQFDEQTIKKAR KKQWNEPRTCARRYLKVDFADIGWNDWIISPKSFDAYYCSGSCQFPMPKALKPSNHASIQSIVRAVGVVP GVPEPCCVPEKMSSLSILFFDEDQKVVLKVYPNMTVDSCACR >XP_005498604.1 bone morphogenetic protein 3 isoform X2 [Columba livia] MAALTRWVLCLCLGWGCLCLPPGDVLKARWVELQRRGSRGGRAAAPRPQDPSGLPRLHPRQGNTVRGFRP LGAGSPESQEMYVFNLTSLTKSENILSASVYYYIGGLLNAQWNCSQPRRCSHHRPRKPEIQIHLSVWTFP SFGNQTRSLGHFLINVSAAYQDGLSWQWKDITQLLYEAKESNELLISIKMDLTSHHPWKRAASHYEPYIL IYANDSAISEPESVVSSLQGHRNPLAMVIPKPQNHVRSSFGKRRRKRSTNVLLPLQNNELPGAEYQYNEE DRWEDRKPYKTFQPQLAETAKSKKKQRKNHHRKSQTLQFDEQTLKAARRKQWNEPRYCARRYLKVDFADI GWSEWIISPKSFDAYYCSGECQFPIPKALKPSNHATIQSIVRAVGVIPGIPEPCCVPDKMSSLSILFFDE NKNVVLKVYPNMTVESCACR >XP_005682010.3 PREDICTED: LOW QUALITY PROTEIN: bone morphogenetic protein 3 [Capra hircus] MAGARGLLHLWLSCLCVSLAQGQRLRQPFPELRVAVPADRAAGGGPESPLQPLDQLSEHMLRLYDRYSGG GAEEAPTPGTXERGSPSLRPQPLREGNTVRSFRAGAAGMLENKELHIFNLTSLTKSENILSATLYFYIRE LINISLSCPVSQECSHHAQRKHIQIDLSAWILKSSGNQSQLLGHLSVDGGKPHGDFVSWLSKDITQLLRK AKENEEFLIGFNITTKGHQLPKKMTPSPEPYILVYANDAAISEPESVVSSLQGHRNFPTGAVPKLDSHSR AALSMERRRRKRSTGVLLPLQNNELPGAEYQYKEDRVWEERKPYKTLQTQPPDKSKSKKKQRKGPQQKSQ TLQFDEQTLKKARRKQWIEPRNCARRYLRVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHA TIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR >XP_025057757.1 bone morphogenetic protein 3 isoform X1 [Alligator sinensis] MSWSCPQSRGCSRHGSRKPKIQIDLLVLSVPSRGNQTRTLGHFLINVSAAYRADVSWQWKDFTHVLCEAK QNDEFLIGVKMASTSHYLWRRMPSSYEPYILVYANDSAISEPDTVVSNFQGHQHSLSVGFPRQESHSKGS LTEQRRKRSTSVLLPLQNNELPGSEYQYNEGERWEERKSYKTLQPRLAERAKNKKKQRKNQHQKSQTLQF DEQTLKKARRKQWNEPRHCARRYLKVDFADIGWSEWIISPKSFDAYYCSGECQFPIPKALKPSNHATIQS IVRAVGVVPGIPEPCCVPDKMSSLSILFFDENKNVVLKVYPNMTVESCACR >XP_006269586.2 PREDICTED: bone morphogenetic protein 3 [Alligator mississippiensis] MAGAPRSLLCLCLGWSCLWLALGDALRAHVAELRRRAAAGAAGLPPLXXXKVSEHMLRLYDRYRAAPPHP HPHAPRAAPRQGNTVRGFRALPAGNPGNEELYVFNLTSLTKSENILSASFHYYIGDLLNMSWSCPQSRGC SRHGSRKPKIQIDLLVLSFPSRGNRTRTLGHFLINISAAYRADVSWQWKDFTHVLCEAKQNDEFLIGVKM ASTSHYLWRRMPSSYEPYILVYANDSAISEPDTVVSNFQGHQHSLSVGFPRQESHSKGSLTEQRRKRSTG VLLPLQNNELPGSEYQYNEGERWEERKSYKTLQPRLAERAKNKKKQRKNQHQKSQTLQFDEQTLKKARRK QWNEPRHCARRYLKVDFADIGWSEWIISPKSFDAYYCSGECQFPIPKALKPSNHATIQSIVRAVGVVPGI PEPCCVPDKMSSLSILFFDENKNVVLKVYPNMTVESCACR >XP_015815719.1 PREDICTED: bone morphogenetic protein 3 [Nothobranchius furzeri] MAVCPRFVLVLLYGGSYLCAGYCAMLKSDNFPQRRKVDFTHSVDKKHTAKEEQDARLQDTMTEHMQMLYA KYNRAGFPFRDGNTVRSFKAHWGTINKKELQIFNLTSLTKSEDVLSATLHYYITDLQNQSCSRSKSCARH GPRRHSHIHMVIWSFASVDNKMRSLGHFRINASTLSRDFISWQWKDITQVVNQAKHHDELLIGIDVASQG PQPWKKLLSDRSPYILVYANDSAISEPENVVASLQRSYSAGRGPSASHGFHKLREQNHTKQEQLRSRHKR SVNVLLPLQNNELPGPEYPYETPGWDETSPYEPLGTKQPRHPRKKTRKNQRQRLPLLQFDEQTIKKARKK QWNEPRNCARRYLKVDFADIGWSEWIISPKSFDAYYCSGSCQFPMPKALKPSNHATIQSIVRAVGVVPGI PEPCCIPEKMSSLSILFFDEDKNVVLKVYPNMTVDSCACR >XP_020759985.1 bone morphogenetic protein 3 [Odocoileus virginianus texanus] MAGARGLLRLWLGCLCVSLAQGQRLRQPFPELRVAVPGDRAAGGDPESPLQPLDQLSEHMLRLYDRYSGG RAEAARTPLTSERGSSPLRPQLLREGNTVRSFRAGAAGTLENKELHIFNLTSLTKSENILSATLYFYIRE LINISLSCPVSQECSHHAQRKHIHIDLSAWILKSSGNQSQLLGHLSVDGGKPHQDFVSWLSKDITQLLRK AKENDEFLIGFNITTKGHQLPKKMTPSPEPYILVYANDAAISEPESVVSSLQGHRNFPTGAVPKLEGHSR AALSIERRRRKRSAGVLLPLQNNELPGAEYQYKEDGVWEERKPYKTLQTQPPDKSKNKRKQRKGPQQKSQ TLQFDEQTLKKARRKQWIEPRNCARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHA TIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR >XP_030273663.1 bone morphogenetic protein 3 [Sparus aurata] MVCRFGDRHHFWKRARLCSNCYFFRCHLRFGSSMALYSRFVVVLLYGWTYLCVGYCAMLKTDNFPERRKV DFTHSVDKKQPTKDDQDLLLQDTMTEHMQMLYTKYNRAGFPFKDGNTVRSFKAHWGTINKKQLQIFNLTS LTKSEDVLSATLHYYIGDLQNSTQACSRPKSCGRHGPRRHSHIHMVIWSFASVDNKMRTLGHFRINVSTL YRDFISWQWKDITRVVNQAKNHDELLIGIDVTSQGPQPWKKLLSDRSPYILVYANDSAISEPESVVATLQ RHHPVGGEGSISHSFQKLGLNEQNDTEQERPQPRQKRSVNILLPLQNNELPGPEYPYETTGWDETSPYEP FENKQARRPRKKTRKNQRHKMPLLQFDEQTIKKARKKQWNEPRNCARRYLKVDFADIGWSEWIISPKSFD AYYCSGSCQFPMPKALKPSNHATIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDEDKNVVLKVYPNMT VDSCACR >XP_040181031.1 bone morphogenetic protein 3 [Rana temporaria] MATRGSAWLVLCWACSSCLCLGEVWKEGVLAIRSQAGAAEAVLPVGDTVSEHMLRLYDKYRGGGGGGGRR GRDSSRHQLTLKDGNTVRSFKPLTGSFEDINQHIFNLTSLTSSENILSATFHYYLGDILNISQRCQHSSS CSRRGHRKPELSIDLKVSSLTSLENQTRILGNFLINISTTYRDLPSWHWKDITQVLREAKQHGEALIAIN MTVDTANKRRKQLLGHKPYILVYANDSAISEPDTVVSNLHGQRASIVHKKQRKEGLIDHRSRRSTDILLP LQNNELPGAEYQYNEDEERWVEKKPYKTLQVRPAEKEKSNKKLRKSGRQKGQTLQFDEHTLKKARRKQWN EPRNCARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGVVPGIPEP CCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR
Mafft alignment of selected proteins >NP_001192.4 bone morphogenetic protein 3 preproprotein [Homo sapiens] ---------------------------------MA-GA-----SRLL-----------FL WLGC---------------FC--------------------------VSLAQGERPKP-- ------------------------------------------------------------ ------------------------------------------------------------ ----------PFPELRKAV----------------PGDRTAGGGP---DSELQPQDKVSE HMLRLYDRYS---TVQAARTPGSLEGGSQPWRPRLLREGNTVRSFRA------------- ---------------AAAETLERKG------LYIFNLTSLTK---SENILSATLYFCIGE LGNISLSCPVSGGCSHHAQRK-----HIQIDLSAWTLKFSRNQSQLLG---------HLS VDMAKSHRDI-MSWLSKDITQLLRK------AKENEEFLI-------------------- ---GFNI-----------------------TSKGRQLPKRRLP------FPEPYILVYAN DA--------AISEPESVVSSLQGHRN-----FPTGTVPK---WDSHIRAALSIE----- RRKKRST-GVLLPLQ-NNELP----GAE---------YQYKKD-EVWEERKPYKTLQAQA -------------------PEKSKNKKKQRKG--PHRKSQTLQFDEQTLKKARRKQWIEP RN--------------CARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKP SNHATIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR >XP_031567165.1 bone morphogenetic protein 2-like [Actinia tenebrosa] ---------------------------------ML-----------------------VL RVWC-------------------------------------------LIFGIAFPFKVNS SPVD-------------------------------------------------------- ------------------------------------------------------------ ----------STSSARASVEIKNSQA---FLGVEKAILKSMGIKT---RPRPRRGIKIPK YMKDLYHSHEEHPEWISTNFRFNK----------KWTSVNTVRAFHH------------- -LDDLPI---------SHPDAPGRP------RLKFDVSSLPK---LEQVKSAELRLHKNG LWRH--------------------GGDPEMRVSVYQITHSRLPSSLEN---------RTL IDSHIMNTAN-SGWESFDVRSAVEHWIS--NPSDKNNIEV----------------HIS- ------------------------------TKNGHS------------------------ ----------LNISADDVIRNLSMDK---------------------------------- --------------------------------------------EQWHDERPLLVVYTHD -------------------ALTHHHVRKKRSA--SKSRSQ--------------KKRTRP QY--------------CKRHPLYVDFSDVGWNDWIVAPPGYYAFFCNGECPYPITKHLNA TNHAIVQTVMNSVD--PKVPNVCCVPTTLTPISMLYMDEYEKVVLKNYQDMVVEGCGCR >NP_504709.1 Protein dbl-1 [Caenorhabditis elegans] ---------------------------------MN--------DSVR----------TTT TISS------------------------------------------TKSLVHSFQLSA-- ------------------------------------------------------------ -----------------------------------ILHLFLLI----------------- ----------SFTPMSAAADQHA------SHATRRGLLRKLGLEH--VPVQTGPSIDVPQ HMWDIYDDD---------------------------NDVDWVRHYYP------------- ----------------KEIIEDNEGF-----LLSYNLSLAARNAHNEEVTKATLKLRLRR NNKA----------------------RRSGNISIYFFEDDINNDR--------------- FQIESRSVDNLTEWIDFDVTAAFLR------RTNRISFFI-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------DLP---EDVE---------IEETQ--SSSLSSLPYARAQSAP LIVFS--------------DLSEPSSVRRKRS------AQTGNSERKNRKKGRKHHNTEA ES------------NLCRRTDFYVDFDDLNWQDWIMAPKGYDAYQCQGSCPNPMPAQLNA TNHAIIQSLLHSLRPD-EVPPPCCVPTETSPLSILYMDVDKVIVIREYADMRVESCGCR >AAC47552.1 decapentaplegic protein [Drosophila melanogaster] ---------------------------------MR-AWL--LLLAVLA------TFQTIV RVASTEDISQRFIAAIAPVAAHIPLASASGSGSGRSGSR---SGGASTSTALAKAFNPFS EPASFSDSDKSHRSKTNKKPSKSDANRQFNEVHKPRTDQLENSKNMSKQLVNKPNHNKMA VKEQRSHHKKSHHHRSHQPKQASASTESHQ--SSSIESIFVEEPTLVLDREVASINVPAN AKAIIAEQGPSTYSKEALIKDKLKPDPSTLVEIEKSLLSLFNMKR--PPKIDRSKIIIPE PMKKLYAEIMGH-ELDSVNIPKP---------GLLTKSANTVRSFTH------------- ----------------KDSKIDDRFPHHHRFRLHFDVKSIPA---DEKLKAAELQLTRDA LSQQVVASRSS-------------ANRTRYQVLVYDITRVGVRGQREPS--------YLL LDTKTVRLNS-TDTVSLDVQPAVDRWLA--SPQRNYGLLV-------------------- ------------------------------------------------------------ ------------------------------------------------------E----- VRTVRSL----KPAP-HHHVR----LRR---------SADEAH-ERWQHKQPLLFTYTDD -------------------GRHKARSIRDVSG--GEGGGKGGRNKRQPRRPTRRKN---- ------------HDDTCRRHSLYVDFSDVGWDDWIVAPLGYDAYYCHGKCPFPLADHFNS TNHAVVQTLVNNMNPG-KVPKACCVPTQLDSVAMLYLNDQSTVVLKNYQEMTVVGCGCR >XP_043304197.1 bone morphogenetic protein 3 [Cervus canadensis] ---------------------------------MA-GA-----RGLL-----------RL WLGC---------------LC--------------------------VSLAQGQRLRQ-- ------------------------------------------------------------ ------------------------------------------------------------ ----------PFPELRVAV----------------PGDRAAGGGP---ESPVQPLDQLSE HMLRLYDRYSGG-RAEAARTPGTSERGSSPLRPQLLREGNTVRSFRA------------- ---------------GAAGTLENKE------LHIFNLTSLTK---SENILSATLYFYIRE LINISLSCPVSQECSHHAQRK-----HIHIDLSAWILKSSGNQSQLLG---------HLS VDGGKPHRDF-VSWLSKDITQLLRK------AKENDEFLI-------------------- ---GFNI-----------------------TTKGHQLPKKMIP------SPEPYILVYAN DA--------AISEPESVVSSLQGHRN-----FPTGAVPK---LDGHSRAALSIER---- RRRKRSA-GVLLPLQ-NNELP----GAE---------YQYKED-GVWEERKPYKTLQTQP -------------------PDKSKNKKKQRKG--PQQKSQTLQFDEQTLKKARRKQWIEP RN--------------CARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKP SNHATIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR >KAB0354394.1 hypothetical protein FD755_022932 [Muntiacus reevesi] ---------------------------------MS------------------------- ---C---------------FCL-------------------------LAIVE-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------SRTLENKE------LHIFNLTSLTK---SESILSATLYFYIRE LINISLSCPVSQECSHHAQRK-----HIHIDLSAWILKSSGNQSQLLG---------HLS VDGGKPHRDF-VSWLSKDITQLLRK------AKENDEFLI-------------------- ---GFNI-----------------------TTKGHQLPKKMTP------SPEPYILVYAN DA--------AISEPESVVSSLQGHRN-----FPTGAVPK---LDGHSRAALSIDR---- RRRKRSA-GVLLPLQ-NNELP----GAE---------YQYKED-GVWEERKPYKTLQTQP -------------------PDKSKNKKKQRKG--PQQKSQTLQFDEQTLKKARRKQWIEP RN--------------CARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKP SNHATIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR >KAB0344722.1 hypothetical protein FD754_021648 [Muntiacus muntjak] ---------------------------------MS------------------------- ---C---------------FCL-------------------------LAIVE-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------SRTLENKE------LHIFNLTSLTK---SESILSATLYFYIRE LINISLSCPVSQECSHHAQRK-----HIHIDLSAWILKSSGNQSQLLG---------HLS VDGGKPHRDF-VSWLSKDVTQLLRK------AKENDEFLI-------------------- ---GFNI-----------------------TTKGHQLPKKMTP------SPEPYILVYAN DA--------AISEPESVVSSLQGHRN-----FPTGAVPK---LDGHSRAALSIDR---- RRRKRSA-GVLLPLQ-NNELP----GAE---------YQYKED-GVWEERKPYKTLQTQP -------------------PDKSKNKKKQRKG--PQQKSQTLQFDEQTLKKARRKQWIEP RN--------------CARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKP SNHATIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR >OCU00369.1 hypothetical protein XELAEV_18006143mg [Xenopus laevis] ---------------------------------MA-EC-----RPWL-----------VL WVGC--------------CGC--------------------------LCLALGELLND-- ------------------------------------------------------------ ------------------------------------------------------------ ----------GLLAVG-------------------MGTGDAARQE---EAALPLGDTVSE HMLRLYDKYRSGGG----RAKESLRY------RQALPDGNTVRSFRA------------- ----------------MNGDEHKKC------HYMFNLTSLTS---SENILSATLHYYLGD LLNSSHRCPHSLFCTQHGHAK----PEFTLYLTLWSFNALQNPTHVIS---------NFL INVSASQRDH-PLWQWKDITQAVRK------AKEYGEAVL-------------------- ---GFNL-----------------------TIEYPNYRSIDIL------GLKPYILVYAN DS--------AISEPDSVVSSLHGPHT-----PLAL---------KPNRKTEKAE----- QRKKRST-EILLPLQ-NNELP----GAE---------YQYSVDEEGWEERKPYKNLQGRQ -------------------NEKDKNKKKLRKG--SRQKSQTLQFDEQTLKKARRKQWNEP RN--------------CARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKP SNHATIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFLDENKNVVLKVYPNMTVESCACR >KAF4018998.1 hypothetical protein G4228_010604 [Cervus hanglu yarkandensis] ---------------------------------MA-RGP--ARTSLRPGSQQLPLLSLLL LLLL-------------------------------------------LRDADGSHTAA-- ------------------------------------------------------------ ------------------------------------------------------------ ----------ARPAPPAAADG---------LAGDKNPQRSPGDVV--AAQNPGAQDMVAV HMLRLYEKYSRRGA--------------------RPGGGNTVRSFRA------------- ----------------RLEVVNQKA------VYFFNLTSMQD---SEMILTATFHFYSEP LWPPAREVPCKQRAKNASCRLLPPGPPARQHLL---FRSLSQNTATQG---------LLR GAMALPPPPR-GLWQAKDISLIVKA------ARRDGELLL-------------------- ---SAQL-----------------------DSGEKDMGVPRLG------PHAPYILIYAN DL--------AISEPNSVAVTLQRYDP-----FQAGD------PEPGAAPNSSAD----- PRVRRAT-QATGPLQ-NNELP----GLDERPEHAPHAQHYHKH-ELWP--SPFRALKPRP -------------------GRKDRRKKGQDVF---MASSQVLDFDEKTMQKARKKQWDEP RV--------------CSRRYLKVDFADIGWNEWIISPKSFDAYYCSGACEFPMPKMVRP SNHATIQSIVRAVGIVPGIPEPCCVPDKMSSLGVLFLDENRNVVLKVYPNMSVETCACR >OWK07582.1 GDF10 [Cervus elaphus hippelaphus] ---------------------------------MA-RGP--ARTSLRPGSQQLPLLSLLL LLLL-------------------------------------------LRDADGSHTAA-- ------------------------------------------------------------ ------------------------------------------------------------ ----------ARPAPPAAADG---------LAGDKNPQRSPGDVV--AAQNPGAQDMVAV HMLRLYEKYSRRGA--------------------RPGGGNTVRSFRA------------- ----------------RLEVVNQKA------VYFFNLTSMQD---SEMILTATFHFYSEP LWPPAREVPCKQRAKNASCRLLPPGPPARQHLL---FRSLSQNTATQG---------LLR GAMALPPPPR-GLWQAKDISLIVKA------ARRDGELLL-------------------- ---SAQL-----------------------DSGEKDMGVPRLG------PHAPYILIYAN DL--------AISEPNSVAVTLQRYDP-----FQAGD------PEPGAAPNSSAD----- PRVRRAT-QATGPLQ-NNELP----GLDERPEHAPHAQHYHKH-ELWP--SPFRALKPRP -------------------GRKDRRKKGQDVF---MASSQVLDFDEKTMQKARKKQWDEP R-------------------------------------------------------MVRP SNHATIQSIVRAVGIVPGIPEPCCVPDKMSSLGVLFLDENRNVVLKVYPNMSVETCACR >XP_038062104.1 growth/differentiation factor 10-like isoform X2 [Patiria miniata] ---------------------------------ME------YRVHIV---------QLLI LMSC-------------------------------------------LATVLCKELSS-- -----------------------SVNRESIQR---------------------------- ------------------------------------------------------------ ----------PYTKDGKLVDPSDPWS---------------------RKRYHAADVHPPK RIMKLMQQLSKNEDL-------------------LKERGNTVRSYLP------------- ----------------NLRFACNEP------TYVFSIKS-HK---TESLRSVELHFFASK PSNLIDS-------------------ESTIDIHLHLITNTSSACQPIG------------ --VQQRPAKA-RGWQVIDVTAQIAHLLKPILESENSQITV-------------------- ---GVSFRLQ-----------ETGGSHD--TSRERTTNEKIMS-----NHARPFLLVYAE DD--------DSSGNSVLQWTQEGAKTKT---APSETTHP---MEARSPTQVRSH----- TRHARSVDGNVHSIM-TNEFP---EGSTNVA-HQAT-FQHFNE-QDSKRRKAKKRTSKKR K------------------RVSKKQHRKAPLLDPSSSVVEDESEEQAAMNDDRDQNTVLP MS-----P----NDGPCSRHAMFVSFDTIDWDGYVIAPTGFEAFYCTGACSFPLSKTDNP SNHATIQSVMSVAGIQAKIPPPCCVPEKLTSLSILFLDENDNVGLKSYKNMVVESCGCR >XP_039273812.1 uncharacterized protein LOC120347787 isoform X2 [Styela clava] ---------------------------------MK--GI--RAHSIR--------SPAIL FLIC---------------ICVILFGTTYGELNTRKEGRRLHKDSNELSVSEHQNIRTSN ATSRVSPIETSPISQIN---PSTDANQRSVQRRKDR--QRKKSKHGRREKGNKRNGRK-- --------------RKDNELNRGGETDINEVLRNTMRHMFGFDH------------IP-- ----VT-TLPPVDAKPRTADVDLDLTDSHTDYVNKKDIKSSWL-----DQNGDMMPQPPD FMLELYRTYSRDNNLMMLH---------------SISQGNTVRSFFPSPADPSERSKIRK AVTIKPVQANTGATDGSKQTTETQRYESPFPVFLFNLSSIPR---PETLVRAEIRLDGMT RSAMLMNQHNIENTQNETSLQ-------NLNIVVGVYKIDSNDCADGLDCSVSSKIFHRI GNTTALNFDAVASWSARNLLRLATQ------ARDRNHFLIVRFENRPDESLSRQIRHTEK ESAGDDLPLQFMISENERLKRSSNRAKDNLDSSGSSLKEQWFDVNFDHSPETPILIIYCN DSRTALVKDTPSLAPSIIWRRLENMTN-----LFKKRVRR---SEPQDIAKDEVDNRIVD EYDENNH-GSTRRMQ--KTTP----QVV---------EKYDSE-TKSENRKGKNVTKIKN I------------------ISNEKSGRKRRRNQKCNDGKKKGKRGCKKSSKGRKKQKKVP LH-----PSAVERDEDCGRKSMNVDFASIGWSDWIISPTTFEAYYCSGRCEISNMQQTGT TNHAIVQAIARLAGAT--VPEPCCAPDKLMPLSVLFFDENSNVVLRVYTNMSVETCACK >XP_030834960.1 bone morphogenetic protein 3-like [Strongylocentrotus purpuratus] ---------------------------------MD------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------TLLPESGVRRRRS------------- -----------------AGSNDTKE-------------TLDE---NETLVSNEV------ ------------------------------------------------------------ ----------------VDVE---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PVD-NNEYPLNPIGKT---------FPATTH-------TAFSFFAEQN -------------------MRRIKSNRRRARNQRKKDKSKNMMLDAEEKSRARKKKLNKP RPKHLDIGTPTEATNVCDRHSMNVDFQAIGWDDYVIAPATFQAFYCAGQCAYPIQKELHP SNHALIQSIMHLLGVQTGVPTPCCVPDKMEPLVLLYIEQDSTVTLKKYSDMVVESCGCH >CAE1274945.1 BMP2 [Sepia pharaonis] ---------------------------------MS----------------------III FLSS-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------QASIYLSIY------------------------- -------------------------------------LSI-------------------- -----------------------------------------------------YLFIYLS IC--------LSFCYQEIKRDILRHEQQ-------------------------------- TKQERSP-GLQKAIRLLNEKE----RTE---------YQQQKH-GSSWGLGFKRKRRSAP -------------------NSRQATESHERRN--STSGSSHGR-NRRTLFRRKRRN---- ----------------CARYEMYVDFNAIGWSGWIISPKGYNAYHCSGPCPFPLGQSHRP TNHATVQSIVHALRAGKNVLTPCCVPDKLYSISLLYFDDQENVILKLYEDMVAASCGCH >tr|A2AVJ4|A2AVJ4_DANRE Bone morphogenetic protein 3 OS=Danio rerio OX=7955 GN=bmp3 PE=3 SV=1 ---------------------------------MD-RC-----QRLF-----------VL LLGC---------------GY--------------------------LCCGYCAVLKT-- ------------------------------------------------------------ ------------------------------------------------------------ ----------PVMGFSKDVQ------------LGQKAEE--PEKQ---QVKKSEQDTLSE HMQMLYAKYTSAGF--------------------PLKDGNTVRSFKG------------- ----------------HLGTINNRQ------LQIFNLTSLTK---SEDVLSATLHYYIGD LHNSSHRCSKHKSCAQHNLRR-----QAHVHLDVWSFSLVKNTTRTIG---------HFP INISTMHWDF-ISWQWKDITRVVNQ------AKHHDQLLI-------------------- ---GINI-----------------------NSRGHQPWKKLLS------DRSPYILVYAN DS--------AISEPESVVSTLQRHKS-----RLLPNLHM---LESHNRNA-SAQ----- HRSRRST-NILLPLQ-NNELP----GPE---------YPYEI--PTWDEASPYDPMESKT -------------------VKRP--RKKPRKN--PRHKNPLLQFDEQTIKKARKKQWNEP RN--------------CARRYLKVDFADIGWSEWIISPKSFDAYYCSGSCQFPMPKSLKP SNHATIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDEDKNVVLKVYPNMTVDSCACR >KAG6798905.1 bone morphogenetic protein 10 [Apis mellifera caucasica] M--------------------------------MTDSGF----RFLL--------FAILL YLLS--------------PSF--------------------------EHFAHSHPSRAID E-------------------DDDNANG--------------------------------- ------------------------------------------------------------ ------EREEDVNERWPRLDEASNEQDARRNEILEKLQQVLGIRSYLERERTGRRKVPPQ FMVELYNNVADPSGVTRGR---------------NPYNAKVVRSFIE------------- ------------------RDTTTSR------FYFFNITGLEV---NESVLEAELHLYRKR TPLKALH----------------PSILASPYYLIRVYQVLDEKSLDVPD-------LHRL LNVRYVGAHA-SGWQIFNVKQAVLAWLN---GEPNLGLLV-------------------- --TATTL-FE--------------------DRANVEFSRRNEY----HHSKQPILVLFDD DGKDR--RGDGNDEIEQVFHDEEEEKG-----DWRNSDAE---QDPRGKGELEGN----- KNKTGSF-ERQKRTR-MREHE---EGETTRG------AQHLAD-DGSGRRRRETNVKKLH GISSSLEEETFGGSYLTSMDIYERAMRRERIM--GGRAGQRSFWSEKIREKRSAKSRASV RQ----------NVTECSRHELYVDFKEIGLSSSIIAPLGYSAFHCKGICESPLSQDQQP TNHATIQGIVHKMGLVKGVERPCCVPTKLLGTTILFYDDNENVILKVYQDMIADRCGCR >NP_058801.1 bone morphogenetic protein 3 precursor [Rattus norvegicus] ---------------------------------MA-GA-----RGLL-----------CL WLGC---------------FC--------------------------LNLAQGQRPNL-- ------------------------------------------------------------ ------------------------------------------------------------ ----------HLPGLRGTE----------------SSDRMTGGGP---SPDLRPHDKVSE HMLWLYDRYSGSNRAQATRTPGSQLPG-----PQPLRGGNTVRSFRA------------- ---------------AAAGTLQRKG------LHTFNLTSLTK---SENILSATLYFYIGE LVNTSVNCPESQGCSHDSQRQ-----HIQIDLSAWTLQS--NQSQLLG---------HLS VDTAKPYRDS-MSWLSKDITQLLRK------AKQDEEFLI-------------------- ---GFNI-----------------------TSRAHELPKRMLL------FPEPYILVYAN DA--------AICEPESVVSSLQRHRD-----FTAGTVPR---LDSHVREALSVE----- RRKKRST-GILLPLQ-NNELP----GAE---------YQYKEA-GVWEERKPYKSLQTQP -------------------PEKSRSKKKQRKG--PHQKGQTLQFDEQTLKKARRKQWIEP RN--------------CARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKP SNHATIQSIVRAVGVVSGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVDSCACR >NP_775580.1 bone morphogenetic protein 3 isoform 2 preproprotein [Mus musculus] ---------------------------------MA-GA-----RGLL-----------CL WLGY---------------FC--------------------------LNLAQGQRPNL-- ------------------------------------------------------------ ------------------------------------------------------------ ----------HLPGLRETE----------------PSDRATGGSP---SPDLRPHDKVSE HMLWLYDRYSGSSRVQATRTPGSQLPG-----PQPLRGGNTVRSFRA------------- ---------------AAAGTPQTKG------LHTFNLTSLTK---SENILSATLYFYVGE LVNISLSCPEPQGCSHHTQRQ-----HIQIDLSAWILKS--NQSQLLG---------HLS VDVVRPYRDS-VSWLSKDITQLLRK------AKQNEEFLI-------------------- ---GFNI-----------------------TSRAHELPKRMLF------FPEPYILVYAN DA--------AISEPESVVSSLQRHRD-----FTAGTGPR---LDSHVREALSVE----- RRKKRST-GILLPLQ-NNELP----GAE---------YQYKEE-GAWEERKPYKSLQTQP -------------------PEKSRNKKKQRKG--SHQKGQTLQFDEQTLKKARRKQWVEP RN--------------CARRYLKVDFADIGWSEWIISPKSFDAFYCSGACQFPMPKSLKP SNHATIQSIVRAVGVVSGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVDSCACR >XP_015131733.2 bone morphogenetic protein 3 isoform X1 [Gallus gallus] ---------------------------------MQ-ISPVCSMRSLQ------EEKTSFL LFGY-----------CSLEACFI------------------------SARLQAELLPIPQ Q----------------------------------------------------------- ------------------------------------------------------------ ----------KFSVMRETCD------------LRALEKKLCWEGT---SNGRAAAGHLSK HPAWRAQRSSMEGV---SVVSSSAGFP-----NASWREQITAQ----------------- ----------------FPGRPGSQE------LYVFNLTSLTK---SENILSASLHYYIGD LLDADWNCSQSGGCSHRGHRK----PEIQIHLSVWTFPSVGNQTRGLG---------HFL INISSSYSDV-LSWQWKDITQVLHK------AKQSNELLI-------------------- ---GVKM-----------------------DSTSRHLWRRAPF------HYEPYILIYAN DS--------AISEPENVVSSLQGHHN-----PLARVFPR---PENHMRSS-LGK----- RRRKRST-NVLLPLQ-NNELP----GAE---------YQYNED-ERWEDRKPYKTFQPRL -------------------ADRAKSKKKQRKN--HHQKSQTLQFDEQTLKKARRKQWNEP RY--------------CARRYLKVDFADIGWSEWIISPKSFDAYYCSGECQFPIPKALKP SNHATIQSIVRAVGVVPGIPEPCCVPDKMSSLSILFFDENKNVVLKVYPNMTVESCACR >XP_001144027.1 bone morphogenetic protein 3 [Pan troglodytes] ---------------------------------MA-GA-----SRLL-----------FL WLGC---------------FC--------------------------VNLAQGERPKP-- ------------------------------------------------------------ ------------------------------------------------------------ ----------PFPELRKAV----------------PGDRTAGGGP---DSELQPQDKVSE HMLRLYDRYS---TVQAAWTPGSLEGGSQPWRPRPLREGNTVRSFRA------------- ---------------AAAETLERKG------LYIFNLTSLTK---SENILSATLYFCIGE LGNISLSCPVSGGCSHHAQRK-----HIQIDLSAWTLKFSRNQSQLLG---------HLS VDMAKSHRDI-MSWLSKDITQFLRK------AKENEEFLI-------------------- ---GFNI-----------------------TSKGHQLPKRRLP------FPEPYILVYAN DA--------AISETESVVSSLQGHRN-----FPTGTVPK---WDSHIRAALSIE----- RRKKRST-GVLLPLQ-NNELP----GAE---------YQYKKD-EVWEERKPYKTLQTQP -------------------PEKSKNKKKQRKG--PHQKSQTLQFDEQTLKKARRKQWIEP RN--------------CARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKP SNHATIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR >NP_001179197.1 bone morphogenetic protein 3 precursor [Bos taurus] ---------------------------------MA-GA-----RGLL-----------HL WLSC---------------LC--------------------------VSLAQGQRLRQ-- ------------------------------------------------------------ ------------------------------------------------------------ ----------PFPELRVAV----------------PADRAAGGGP---ESPLQPLDQVSE HMLRLYDRYSGG-RTEEARTPGNSERGSPSLRPQPLREGNTVRSFRA------------- ---------------GAAGMLENKE------LHIFNLTSLTK---SENILSATLYFYIRE LINISLSCPVSQECSHHAQRK-----HIQIDLSAWILKSSGNQSQLLG---------HLS VDGGKPHRDF-VSWLSKDITQLLRK------AKENEEFLI-------------------- ---GFNI-----------------------TTKGHQLPKKMTP------SPEPYILVYAN DA--------AISEPESVVSSLQGHRN-----FPTGAVPK---LDSQSRSAPSIER---- RRRKRST-GVLLPLQ-NNELP----GAE---------YQYKED-EVWEERKPYKTLQTQP -------------------PDKSKNKKKQRKG--PQQKSQTLQFDEQTLKKARRKQWIEP RN--------------CARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKP SNHATIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR >XP_002717136.1 PREDICTED: bone morphogenetic protein 3 [Oryctolagus cuniculus] ---------------------------------MA-WA-----RGLL-----------CL WLSC---------------VC--------------------------VSLARTERPRQ-- ------------------------------------------------------------ ------------------------------------------------------------ ----------PFPELRKAG----------------PGDRAAGGGP---GPELQPHDKVSE HMLRLYDRYSGGGRVQAPRTPGSRERGSQPAHPQPLREGNTVRSFRA------------- ---------------GAAGAVESKG------LHIFNLTSLTK---SENILSATLYFYSGE LVNTNLSCPVSQGCSHHAKRK-----PVQIVLSAWILKSDRNQSQPLG---------HLS VDVAKSHRDV-TPWLSKDITQLLRK------AKEKEEFLI-------------------- ---GFNI-----------------------TSKAHQLPKRMLL------SPEPYILVYAN DA--------AISEPESVVSSLQGHRN-----FPTGSVPK---LDRHIRAALSVE----- RRKKRST-GVLLPLQ-NNELP----GAE---------YQYKEE-GVWEERKPYKTLQTQP -------------------PEKSKNKKKQRKG--PHQKSQTLQFDEQTLKKARRKQWLEP RD--------------CARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKP SNHATIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR >XP_002814965.1 bone morphogenetic protein 3 [Pongo abelii] ---------------------------------MA-GA-----SRLL-----------FL WLGC---------------FC--------------------------VSLAQGERPKP-- ------------------------------------------------------------ ------------------------------------------------------------ ----------PFSELRKAV----------------PGDRTAGGGP---DTELQPQDKVSE HMLRLYDRYS---TVQAARTPGSPEGGLQPWRPQPLREGNTVRSFRA------------- ---------------AAAETLERKG------LYIFNLTSLTK---SENILSATLYFYIGE LGNISLSCPVSGGCSHHAQRK-----HIQIDLSAWTLKFSRNPSQLLG---------HLS VDMAKSHRDI-MSWLSKDITQFLRK------AKGNEAFLI-------------------- ---GFNV-----------------------TSKGHQLPKRRLP------FPEPYILVYAN DA--------AISEPESVVSSLQGHQN-----FPTGTVPK---WDSHIRAALSIE----- RRKKRST-GVLLPLQ-NNELP----GAE---------YQYKKD-EVWEERKPYKTLQTQP -------------------PEKSKNKKKQRKG--PHQKSQTLQFDEQTLKKARRKQWIEP RN--------------CARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKP SNHATIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR >NP_001193317.1 bone morphogenetic protein 3 precursor [Sus scrofa] ---------------------------------MA-AA-----RALL-----------PL WLGC---------------LC--------------------------GSLAQGLRRQQ-- ------------------------------------------------------------ ------------------------------------------------------------ ----------PFPELRDAV----------------PGHRAAGGGP---DPPLQPLDPLSE HMLRLYDSYSGGASAEAARTPGSPEPGSPPLRPQPRREGNTVRSFRA------------- ---------------GAAGTLENKE------LHVFNLTSLTK---SENVLSATLYFYIGE LINATLSCPASRGCSHHAQRR-----HIQISLSAWVLQLSRNQSQLLG---------HLS VDVAKPHRDM-ASWLSKDITQLLRK------AKENEEFLI-------------------- ---GFNI-----------------------TSRGHQLPKKVIP------FPEPYILVYAN DA--------AISEPESVVASLQGHRN-----FPAGAVPK---LDRHLRAALSTE----- RRRKRSA-GLLLPLQ-NNELP----GAE---------YQYKED-GVWEERKPYKTLQTQP -------------------PEKSKNKKKQRKG--PHQKSQTLQFDEQTLKKARRRQWIEP RN--------------CARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKP SNHATIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR >XP_038299875.1 bone morphogenetic protein 3 [Canis lupus familiaris] ---------------------------------MA-GA-----RGLL-----------WL WLGC---------------FC--------------------------GSLARAERPKP-- ------------------------------------------------------------ ------------------------------------------------------------ ----------GLPQLHGAG----------------SGDRAAGGGS---GPVLRPLDKVSE HMLRLYDRYSGGGGARAERARGASERGSQPARPQPLREGNTVRSFRG------------- ---------------GAAGTLGSKG------LHIFNLTSLTK---SENILSATLYFYVGE LINISLSCPESRGCSHHAQRK-----HMQIDLSVSILKSDRNQSQLFG---------HLS VDVAKSHRDF-GSWLSKDITQLLRK------AKENEEFLI-------------------- ---GFNI-----------------------TSKGHQLPKKRLP------FPEPYILVYAN DA--------AISEPESVVSSLQGHRN-----FATGTMPK---LASHIRAALSIE----- RRKKRSA-GVLLPLQ-NNELP----GAE---------YQYRED-GVWEEKKPYKTLQTQA -------------------PEKTKNKKKQRKG--LHQKSQTLQFDEQTLKKARRKQWIEP RN--------------CARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKP SNHATIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR >XP_003832318.1 bone morphogenetic protein 3 [Pan paniscus] ---------------------------------MA-GA-----SRLL-----------FL WLGC---------------FC--------------------------VNLAQGERPKP-- ------------------------------------------------------------ ------------------------------------------------------------ ----------PFPELRKAV----------------PGDRTAGGGP---DSELQPQDKVSE HMLRLYDRYS---TVQAAWTPGSLEGGSQPWRPRPLREGNTVRSFRA------------- ---------------AAAETLERKG------LYIFNLTSLTK---SENILSATLYFCIGE LGNISLSCPVSGGCSHHAQRK-----HIQIDLSAWTLKFSRNQSQLLG---------HLS VDMAKSHRDI-MSWLSKDITQFLRK------AKENEEFLI-------------------- ---GFNI-----------------------TSKGHQLPKRRLP------FPEPYILVYAN DA--------AISEPESVVSSLQGHRN-----FPTGTVPK---WDSHIRAALSIE----- RRKKRST-GVLLPLQ-NNELP----GAE---------YQYKKD-EVWEERKPYKTLQTQP -------------------PEKSKNKKKQRKG--PHQKSQTLQFDEQTLKKARRKQWIEP RN--------------CARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKP SNHATIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR >XP_006931098.2 bone morphogenetic protein 3 [Felis catus] ---------------------------------MA-GA-----LRLL-----------CL WLGC---------------FC--------------------------VSLARGEGLTR-- ------------------------------------------------------------ ------------------------------------------------------------ ----------TVPEPHRAV----------------PGDRTAGGGP---GPVLQPHDKVSE HMLRLYDRYSGGGRAEAERAQRSSERGSQPLRPPPLREGNTVRSFRA------------- ---------------GASGTLGSKG------LHIFNLTSLTK---SENILSATLYFYIGE LINISLSCPASRGCSPHAQRK-----HVLIDLSAWILKSDRNQSQHLG---------HLS VDVAKSHRDL-GSWLSKDITQLLRR------AKENEEFLI-------------------- ---GFNI-----------------------TSKGHQLPKKMLP------FPEPYILVYAN DA--------AISEPESVVSSLQRHRN-----FPIGAVPR---PDGHIKAALSTE----- RRRKRSA-GVLLPLQ-NNELP----GAE---------YQYRED-GVWEERKPYKTLQTQA -------------------PEKTKNKKKQRKG--PPQKSQTLQFDEQTLKKARRKQWIEP RN--------------CARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKP SNHATIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR >XP_027826928.1 bone morphogenetic protein 3 [Ovis aries] ---------------------------------MA-GA-----RGLL-----------HL WLSC---------------LC--------------------------VSLAQGQRLRQ-- ------------------------------------------------------------ ------------------------------------------------------------ ----------PFPELRVAV----------------PADRAAGGGP---ESPLQPLDQLSE HMLRLYDRYSGG-GAEEARTPGNSERGSPSLRPQPLREGNTVRSFRA------------- ---------------GAAGMLENKE------LHIFNLTSLTK---SENILSATLYFYIRE LINISLSCPVSQECSHHAQRK-----HIQIDLSAWILKSSGNQSQLLG---------HLS VDGGKPHGDF-VSWLSKDITQLLRK------AKENEEFLI-------------------- ---GFNI-----------------------TTKGHQLPKKMTP------SPEPYILVYAN DA--------AISEPESVVSSLQGHRN-----FPTGAVPK---LDSHSRAALSMER---- RRRKRST-GVLLPLQ-NNELP----GAE---------YQYKED-RVWEERKPYKTLQTQP -------------------PDKSKSKKKQRKG--PQQKSQTLQFDEQTLKKARRKQWIEP RN--------------CARRYLRVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKP SNHATIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR >XP_004038932.1 bone morphogenetic protein 3 [Gorilla gorilla gorilla] ---------------------------------MA-RA-----SRLL-----------FL WLGC---------------FC--------------------------VSLAQGERPKP-- ------------------------------------------------------------ ------------------------------------------------------------ ----------PFPELRKAV----------------PGDRTAGGGP---DSELQPQDKVSE HMLRLYDRYS---TVQAARTPGSLEGGSQPWRPQPLREGNTVRSFRA------------- ---------------AAAETLERKG------LYIFNLTSLTK---SENILSATLYFYIGE LGNISLSCPVSGGCSHHAQRK-----HIQIDLSAWTLKFSRNQSQLLG---------HLS VDMAKSHRDI-MSWLSKDITQFLRK------AKENEEFLI-------------------- ---GFNI-----------------------TSKGHQLPKRRLP------FPEPYILVYAN DA--------AISQPESVVSSLQGHRN-----FPTGTVPK---WDSHIRAALSTE----- RRKKRST-GVLLPLQ-NNELP----GAE---------YQYKKD-EVWEERKPYKTLQTQP -------------------PEKSKNKKKQRKG--PHQKSQTLQFDEQTLKKARRKQWIEP RN--------------CARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKP SNHATIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR >XP_004073050.1 bone morphogenetic protein 3 [Oryzias latipes] ---------------------------------MA-FYS----QSVV-----------VL LYGW---------------SF--------------------------LCLGYCTMLKA-- ------------------------------------------------------------ ------------------------------------------------------------ ----------NSSPQRRKVD------------FTHSVDKRDTVKG---ERDLLLQDTMTK HMQMLYAKYNRAGF--------------------PFRDGNTVRSFKA------------- ----------------HWGTINEKH------LQIFNLTSLTK---SEDVLSATLHYYIGD LQNSTWGCSRSKSCGRHALLR-----HNHIHMVIWSFASIDNKMRSLG---------HLR INVSTLYRDF-ISWQWKDITRVVNQ------AKHHEELLI-------------------- ---GIDV-----------------------ASQGPQPWKKLLS------DRSPYILVYAN DS--------AISEPESVVATLQRHGSGPNKGQMPHRPQK--VGAQERNNTEHLQ----- PRHRRSV-NVLLPLQ-NNELP----GSE---------YPYET--TGWDETSPHEPFKKKQ -------------------SRRP--RKKTRKN--QQQKMPLLQFDEQTIKKARKKQWNEP RT--------------CARRYLKVDFADIGWNDWIISPKSFDAYYCSGSCQFPMPKALKP SNHASIQSIVRAVGVVPGVPEPCCVPEKMSSLSILFFDEDQKVVLKVYPNMTVDSCACR >XP_005498604.1 bone morphogenetic protein 3 isoform X2 [Columba livia] ---------------------------------MA-ALT----RWVL-----------CL CLGW---------------GC--------------------------LCLPPGDVLKA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ RWVELQRRGSRGGRAAAPRPQDPSGLP-----RLHPRQGNTVRGFRP------------- ---------------LGAGSPESQE------MYVFNLTSLTK---SENILSASVYYYIGG LLNAQWNCSQPRRCSHHRPRK----PEIQIHLSVWTFPSFGNQTRSLG---------HFL INVSAAYQDG-LSWQWKDITQLLYE------AKESNELLI-------------------- ---SIKM-----------------------DLTSHHPWKRAAS------HYEPYILIYAN DS--------AISEPESVVSSLQGHRN-----PLAMVIPK---PQNHVRSS-FGK----- RRRKRST-NVLLPLQ-NNELP----GAE---------YQYNEE-DRWEDRKPYKTFQPQL -------------------AETAKSKKKQRKN--HHRKSQTLQFDEQTLKAARRKQWNEP RY--------------CARRYLKVDFADIGWSEWIISPKSFDAYYCSGECQFPIPKALKP SNHATIQSIVRAVGVIPGIPEPCCVPDKMSSLSILFFDENKNVVLKVYPNMTVESCACR >XP_005682010.3 PREDICTED: LOW QUALITY PROTEIN: bone morphogenetic protein 3 [Capra hircus] ---------------------------------MA-GA-----RGLL-----------HL WLSC---------------LC--------------------------VSLAQGQRLRQ-- ------------------------------------------------------------ ------------------------------------------------------------ ----------PFPELRVAV----------------PADRAAGGGP---ESPLQPLDQLSE HMLRLYDRYSGG-GAEEAPTPGTXERGSPSLRPQPLREGNTVRSFRA------------- ---------------GAAGMLENKE------LHIFNLTSLTK---SENILSATLYFYIRE LINISLSCPVSQECSHHAQRK-----HIQIDLSAWILKSSGNQSQLLG---------HLS VDGGKPHGDF-VSWLSKDITQLLRK------AKENEEFLI-------------------- ---GFNI-----------------------TTKGHQLPKKMTP------SPEPYILVYAN DA--------AISEPESVVSSLQGHRN-----FPTGAVPK---LDSHSRAALSMER---- RRRKRST-GVLLPLQ-NNELP----GAE---------YQYKED-RVWEERKPYKTLQTQP -------------------PDKSKSKKKQRKG--PQQKSQTLQFDEQTLKKARRKQWIEP RN--------------CARRYLRVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKP SNHATIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR >XP_025057757.1 bone morphogenetic protein 3 isoform X1 [Alligator sinensis] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---MSWSCPQSRGCSRHGSRK----PKIQIDLLVLSVPSRGNQTRTLG---------HFL INVSAAYRAD-VSWQWKDFTHVLCE------AKQNDEFLI-------------------- ---GVKM-----------------------ASTSHYLWRRMPS------SYEPYILVYAN DS--------AISEPDTVVSNFQGHQH-----SLSVGFPR---QESHSKGS-LTE----- QRRKRST-SVLLPLQ-NNELP----GSE---------YQYNEG-ERWEERKSYKTLQPRL -------------------AERAKNKKKQRKN--QHQKSQTLQFDEQTLKKARRKQWNEP RH--------------CARRYLKVDFADIGWSEWIISPKSFDAYYCSGECQFPIPKALKP SNHATIQSIVRAVGVVPGIPEPCCVPDKMSSLSILFFDENKNVVLKVYPNMTVESCACR >XP_006269586.2 PREDICTED: bone morphogenetic protein 3 [Alligator mississippiensis] ---------------------------------MA-GAP----RSLL-----------CL CLGW---------------SC--------------------------LWLALGDALRA-- ------------------------------------------------------------ ------------------------------------------------------------ ----------HVAELRR---------------------RAAAGAA---GLPPLXXXKVSE HMLRLYDRYRAA----PPHPHPHA--P-----RAAPRQGNTVRGFRA------------- ---------------LPAGNPGNEE------LYVFNLTSLTK---SENILSASFHYYIGD LLNMSWSCPQSRGCSRHGSRK----PKIQIDLLVLSFPSRGNRTRTLG---------HFL INISAAYRAD-VSWQWKDFTHVLCE------AKQNDEFLI-------------------- ---GVKM-----------------------ASTSHYLWRRMPS------SYEPYILVYAN DS--------AISEPDTVVSNFQGHQH-----SLSVGFPR---QESHSKGS-LTE----- QRRKRST-GVLLPLQ-NNELP----GSE---------YQYNEG-ERWEERKSYKTLQPRL -------------------AERAKNKKKQRKN--QHQKSQTLQFDEQTLKKARRKQWNEP RH--------------CARRYLKVDFADIGWSEWIISPKSFDAYYCSGECQFPIPKALKP SNHATIQSIVRAVGVVPGIPEPCCVPDKMSSLSILFFDENKNVVLKVYPNMTVESCACR >XP_015815719.1 PREDICTED: bone morphogenetic protein 3 [Nothobranchius furzeri] ---------------------------------MA-VCP----RFVL-----------VL LYGG---------------SY--------------------------LCAGYCAMLKS-- ------------------------------------------------------------ ------------------------------------------------------------ ----------DNFPQRRKVD------------FTHSVDKKHTAKE---EQDARLQDTMTE HMQMLYAKYNRAGF--------------------PFRDGNTVRSFKA------------- ----------------HWGTINKKE------LQIFNLTSLTK---SEDVLSATLHYYITD LQN--QSCSRSKSCARHGPRR-----HSHIHMVIWSFASVDNKMRSLG---------HFR INASTLSRDF-ISWQWKDITQVVNQ------AKHHDELLI-------------------- ---GIDV-----------------------ASQGPQPWKKLLS------DRSPYILVYAN DS--------AISEPENVVASLQRSYSAGRGPSASHGFHK--LREQNHTKQEQLR----- SRHKRSV-NVLLPLQ-NNELP----GPE---------YPYET--PGWDETSPYEPLGTKQ -------------------PRHP--RKKTRKN--QRQRLPLLQFDEQTIKKARKKQWNEP RN--------------CARRYLKVDFADIGWSEWIISPKSFDAYYCSGSCQFPMPKALKP SNHATIQSIVRAVGVVPGIPEPCCIPEKMSSLSILFFDEDKNVVLKVYPNMTVDSCACR >XP_020759985.1 bone morphogenetic protein 3 [Odocoileus virginianus texanus] ---------------------------------MA-GA-----RGLL-----------RL WLGC---------------LC--------------------------VSLAQGQRLRQ-- ------------------------------------------------------------ ------------------------------------------------------------ ----------PFPELRVAV----------------PGDRAAGGDP---ESPLQPLDQLSE HMLRLYDRYSGG-RAEAARTPLTSERGSSPLRPQLLREGNTVRSFRA------------- ---------------GAAGTLENKE------LHIFNLTSLTK---SENILSATLYFYIRE LINISLSCPVSQECSHHAQRK-----HIHIDLSAWILKSSGNQSQLLG---------HLS VDGGKPHQDF-VSWLSKDITQLLRK------AKENDEFLI-------------------- ---GFNI-----------------------TTKGHQLPKKMTP------SPEPYILVYAN DA--------AISEPESVVSSLQGHRN-----FPTGAVPK---LEGHSRAALSIER---- RRRKRSA-GVLLPLQ-NNELP----GAE---------YQYKED-GVWEERKPYKTLQTQP -------------------PDKSKNKRKQRKG--PQQKSQTLQFDEQTLKKARRKQWIEP RN--------------CARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKP SNHATIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR >XP_030273663.1 bone morphogenetic protein 3 [Sparus aurata] MVCRFGDRHHFWKRARLCSNCYFFRCHLRFGSSMA-LYS----RFVV-----------VL LYGW---------------TY--------------------------LCVGYCAMLKT-- ------------------------------------------------------------ ------------------------------------------------------------ ----------DNFPERRKVD------------FTHSVDKKQPTKD---DQDLLLQDTMTE HMQMLYTKYNRAGF--------------------PFKDGNTVRSFKA------------- ----------------HWGTINKKQ------LQIFNLTSLTK---SEDVLSATLHYYIGD LQNSTQACSRPKSCGRHGPRR-----HSHIHMVIWSFASVDNKMRTLG---------HFR INVSTLYRDF-ISWQWKDITRVVNQ------AKNHDELLI-------------------- ---GIDV-----------------------TSQGPQPWKKLLS------DRSPYILVYAN DS--------AISEPESVVATLQRHHPVGGEGSISHSFQKLGLNEQNDTEQERPQ----- PRQKRSV-NILLPLQ-NNELP----GPE---------YPYET--TGWDETSPYEPFENKQ -------------------ARRP--RKKTRKN--QRHKMPLLQFDEQTIKKARKKQWNEP RN--------------CARRYLKVDFADIGWSEWIISPKSFDAYYCSGSCQFPMPKALKP SNHATIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDEDKNVVLKVYPNMTVDSCACR >XP_040181031.1 bone morphogenetic protein 3 [Rana temporaria] ---------------------------------MATRG-----SAWL-----------VL CWAC--------------SSC--------------------------LCL--GEVWKE-- ------------------------------------------------------------ ------------------------------------------------------------ ----------GV-----------------------LAIRSQAGAA---EAVLPVGDTVSE HMLRLYDKYRGGGGGGGRRGRDSSRH------QLTLKDGNTVRSFKP------------- ----------------LTGSFEDIN------QHIFNLTSLTS---SENILSATFHYYLGD ILNISQRCQHSSSCSRRGHRK----PELSIDLKVSSLTSLENQTRILG---------NFL INISTTYRDL-PSWHWKDITQVLRE------AKQHGEALI-------------------- ---AINM-----------------------TVDTANKRRKQLL------GHKPYILVYAN DS--------AISEPDTVVSNLHGQRA-----SIVH---------KKQRKEGLID----- HRSRRST-DILLPLQ-NNELP----GAE---------YQYNEDEERWVEKKPYKTLQVRP -------------------AEKEKSNKKLRKS--GRQKGQTLQFDEHTLKKARRKQWNEP RN--------------CARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKP SNHATIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR
BMGE Cleaned alignment of selected proteins >NP_001192.4 bone morphogenetic protein 3 preproprotein [Homo sapiens] FLWLGCVSLAQELRKAVGDRTAGGGPQDKVSEHMLRLYDRYS---TARTPGSLEGGPRLLREGNTVRSFRAAAAETLYIFNLTSLTKSENILSATLYFCIGELGNISLSCPVSGGCSHHAQRKQIDLSAWTLKRNQSQLLGHLSVDMASWLSKDITQLLRKAKENEEFLITSKGRQLPKRRLPFPEPYILVYANDAAISEPESVVSSLQGHRNFPTGTVPKAALSIERRKKRSTGVLLPLQNNELPYQYKKDEVWEERKPYKTLQSKNKKKQRKGKSQTLQFDEQTLKKARRKQWIEPRNCARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR >XP_031567165.1 bone morphogenetic protein 2-like [Actinia tenebrosa] VLRVWCLIFGISARASVILKSMGIKTGIKIPKYMKDLYHSHEEHPETNFRFNK-----KWTSVNTVRAFHH-SHPDRLKFDVSSLPKLEQVKSAELRLHKNGLWRH-----------------EMRVSVYQITRLPSSLENRTLIDSHGWESFDVRSAVEHPSDKNNIEVTKNGHS--------------------LNISADDVIRNLSMDK----------------------------------------EQWHDERPLLVVYHHHVRKKRSARSQ--------------KKRTRPQYCKRHPLYVDFSDVGWNDWIVAPPGYYAFFCNGECPYPITKHLNATNHAIVQTVMNSVD--PKVPNVCCVPTTLTPISMLYMDEYEKVVLKNYQDMVVEGCGCR >NP_504709.1 Protein dbl-1 [Caenorhabditis elegans] TTTISSKSLVHPMSAAALLRKLGLEHSIDVPQHMWDIYDDD-------------------NDVDWVRHYYP-KEIILLSYNLSLAARNEEVTKATLKLRLRRNNKA-----------------SGNISIYFFEINNDR------FQIEEWIDFDVTAAFLRRTNRISFFI-------------------------------------------------------------------------DLPIEETQ-SSSLSSLPYARAQEPSSVRRKRS-AQTGNSERKNRKKGRKHHNTEAESCRRTDFYVDFDDLNWQDWIMAPKGYDAYQCQGSCPNPMPAQLNATNHAIIQSLLHSLRPD-EVPPPCCVPTETSPLSILYMDVDKVIVIREYADMRVESCGCR >AAC47552.1 decapentaplegic protein [Drosophila melanogaster] IVRVASTSTALSKEALILLSLFNMKRKIIIPEPMKKLYAEIMGH-EVNIPKP----GLLTKSANTVRSFTH-KDSKRLHFDVKSIPADEKLKAAELQLTRDALSQQVVASRSS----------RYQVLVYDITGVRGQREPYLLLDTKDTVSLDVQPAVDRPQRNYGLLV--------------------------------------------------------EVRTVRSL---KPAPHHHVRSADEAHERWQHKQPLLFTYKARSIRDVSGGGKGGRNKRQPRRPTRRKN------CRRHSLYVDFSDVGWDDWIVAPLGYDAYYCHGKCPFPLADHFNSTNHAVVQTLVNNMNPG-KVPKACCVPTQLDSVAMLYLNDQSTVVLKNYQEMTVVGCGCR >XP_043304197.1 bone morphogenetic protein 3 [Cervus canadensis] RLWLGCVSLAQELRVAVGDRAAGGGPLDQLSEHMLRLYDRYSGG-RARTPGTSERGPQLLREGNTVRSFRAGAAGTLHIFNLTSLTKSENILSATLYFYIRELINISLSCPVSQECSHHAQRKHIDLSAWILKGNQSQLLGHLSVDGGSWLSKDITQLLRKAKENDEFLITTKGHQLPKKMIPSPEPYILVYANDAAISEPESVVSSLQGHRNFPTGAVPKAALSIERRRKRSAGVLLPLQNNELPYQYKEDGVWEERKPYKTLQSKNKKKQRKGKSQTLQFDEQTLKKARRKQWIEPRNCARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR >KAB0354394.1 hypothetical protein FD755_022932 [Muntiacus reevesi] -----CLAIVE--------------------------------------------------------------SRTLHIFNLTSLTKSESILSATLYFYIRELINISLSCPVSQECSHHAQRKHIDLSAWILKGNQSQLLGHLSVDGGSWLSKDITQLLRKAKENDEFLITTKGHQLPKKMTPSPEPYILVYANDAAISEPESVVSSLQGHRNFPTGAVPKAALSIDRRRKRSAGVLLPLQNNELPYQYKEDGVWEERKPYKTLQSKNKKKQRKGKSQTLQFDEQTLKKARRKQWIEPRNCARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR >KAB0344722.1 hypothetical protein FD754_021648 [Muntiacus muntjak] -----CLAIVE--------------------------------------------------------------SRTLHIFNLTSLTKSESILSATLYFYIRELINISLSCPVSQECSHHAQRKHIDLSAWILKGNQSQLLGHLSVDGGSWLSKDVTQLLRKAKENDEFLITTKGHQLPKKMTPSPEPYILVYANDAAISEPESVVSSLQGHRNFPTGAVPKAALSIDRRRKRSAGVLLPLQNNELPYQYKEDGVWEERKPYKTLQSKNKKKQRKGKSQTLQFDEQTLKKARRKQWIEPRNCARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR >OCU00369.1 hypothetical protein XELAEV_18006143mg [Xenopus laevis] VLWVGCLCLALAVG---GTGDAARQEGDTVSEHMLRLYDKYRSGGG-RAKESLRY-RQALPDGNTVRSFRA-MNGDHYMFNLTSLTSSENILSATLHYYLGDLLNSSHRCPHSLFCTQHGHAKTLYLTLWSFNQNPTHVISNFLINVSLWQWKDITQAVRKAKEYGEAVLTIEYPNYRSIDILGLKPYILVYANDSAISEPDSVVSSLHGPHTPLAL----KTEKAEQRKKRSTEILLPLQNNELPYQYSVDEGWEERKPYKNLQDKNKKKLRKGKSQTLQFDEQTLKKARRKQWNEPRNCARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFLDENKNVVLKVYPNMTVESCACR >KAF4018998.1 hypothetical protein G4228_010604 [Cervus hanglu yarkandensis] LLLLLLLRDADAPPAAAPQRSPGDVVQDMVAVHMLRLYEKYSRRGA------------RPGGGNTVRSFRA-RLEVVYFFNLTSMQDSEMILTATFHFYSEPLWPPAREVPCKQRAKNASCRLRQHLL---FRSQNTATQGLLRGAMALWQAKDISLIVKAARRDGELLLDSGEKDMGVPRLGPHAPYILIYANDLAISEPNSVAVTLQRYDPFQAGD---PNSSADPRVRRATQATGPLQNNELPQHYHKHELWP--SPFRALKDRRKKGQDVFSSQVLDFDEKTMQKARKKQWDEPRVCSRRYLKVDFADIGWNEWIISPKSFDAYYCSGACEFPMPKMVRPSNHATIQSIVRAVGIVPGIPEPCCVPDKMSSLGVLFLDENRNVVLKVYPNMSVETCACR >OWK07582.1 GDF10 [Cervus elaphus hippelaphus] LLLLLLLRDADAPPAAAPQRSPGDVVQDMVAVHMLRLYEKYSRRGA------------RPGGGNTVRSFRA-RLEVVYFFNLTSMQDSEMILTATFHFYSEPLWPPAREVPCKQRAKNASCRLRQHLL---FRSQNTATQGLLRGAMALWQAKDISLIVKAARRDGELLLDSGEKDMGVPRLGPHAPYILIYANDLAISEPNSVAVTLQRYDPFQAGD---PNSSADPRVRRATQATGPLQNNELPQHYHKHELWP--SPFRALKDRRKKGQDVFSSQVLDFDEKTMQKARKKQWDEPR-----------------------------------------MVRPSNHATIQSIVRAVGIVPGIPEPCCVPDKMSSLGVLFLDENRNVVLKVYPNMSVETCACR >XP_038062104.1 growth/differentiation factor 10-like isoform X2 [Patiria miniata] LILMSCLATVLKDGKLV---------DVHPPKRIMKLMQQLSKNED------------LKERGNTVRSYLP-NLRFTYVFSIKS-HKTESLRSVELHFFASKPSNLIDS--------------TIDIHLHLITSSACQPIG-----VQGWQVIDVTAQIAHESENSQITVTSRERTTNEKIMSHARPFLLVYAEDDDSSGNSVLQWTQEGAKTAPSETTHPTQVRSHTRHARSVGNVHSIMTNEFPFQHFNEQDSKRRKAKKRTSKKQHRKAPLLVVEDESEEQAAMNDDRDQNTVLPMSCSRHAMFVSFDTIDWDGYVIAPTGFEAFYCTGACSFPLSKTDNPSNHATIQSVMSVAGIQAKIPPPCCVPEKLTSLSILFLDENDNVGLKSYKNMVVESCGCR >XP_039273812.1 uncharacterized protein LOC120347787 isoform X2 [Styela clava] ILFLICLSVSEAKPRTADIKSSWL--MPQPPDFMLELYRTYSRDNNLH----------SISQGNTVRSFFPGSKQTVFLFNLSSIPRPETLVRAEIRLDGMTRSAMLMNQHNIENTQNETSLQNLNIVVGVYKSNDCADGLHRIGNTTSWSARNLLRLATQARDRNHFLIDSSGSSLKEQWFDPETPILIIYCNDSPSLAPSIIWRRLENMTNLFKKRVRRAKDEVDEYDENNHGSTRRMQ-KTTPEKYDSETKSENRKGKNVTKEKSGRKRRRNGKKKGKRGCKKSSKGRKKQKKVPLHCGRKSMNVDFASIGWSDWIISPTTFEAYYCSGRCEISNMQQTGTTNHAIVQAIARLAGAT--VPEPCCAPDKLMPLSVLFFDENSNVVLRVYTNMSVETCACK >XP_030834960.1 bone morphogenetic protein 3-like [Strongylocentrotus purpuratus] ----------------------------------------------------------TLLPESGVRRRRS--AGS-------TLDENETLVSNEV--------------------------------------------------------VDVE----------------------------------------------------------------------------------PVDNNEYPFPATTH------TAFSFFAIKSNRRRARNKSKNMMLDAEEKSRARKKKLNKPRPCDRHSMNVDFQAIGWDDYVIAPATFQAFYCAGQCAYPIQKELHPSNHALIQSIMHLLGVQTGVPTPCCVPDKMEPLVLLYIEQDSTVTLKKYSDMVVESCGCH >CAE1274945.1 BMP2 [Sepia pharaonis] IIFLSS---------------------------------------------------------------------------------------------------------------------SIYLSIY-------------------------------------LSI-----------------YLFIYLSICLSFCYQEIKRDILRHEQ--------------TKQERSPGLQKAIRLNEKEYQQQKHGSSWGLGFKRKRRQATESHERRNGSSHGR-NRRTLFRRKRRN------CARYEMYVDFNAIGWSGWIISPKGYNAYHCSGPCPFPLGQSHRPTNHATVQSIVHALRAGKNVLTPCCVPDKLYSISLLYFDDQENVILKLYEDMVAASCGCH >tr|A2AVJ4|A2AVJ4_DANRE Bone morphogenetic protein 3 OS=Danio rerio OX=7955 GN=bmp3 PE=3 SV=1 VLLLGCLCCGYGFSKDVAEE--PEKQQDTLSEHMQMLYAKYTSAGF------------PLKDGNTVRSFKG-HLGTLQIFNLTSLTKSEDVLSATLHYYIGDLHNSSHRCSKHKSCAQHNLRRHVHLDVWSFSKNTTRTIGHFPINISSWQWKDITRVVNQAKHHDQLLINSRGHQPWKKLLSDRSPYILVYANDSAISEPESVVSTLQRHKSRLLPNLHMNA-SAQHRSRRSTNILLPLQNNELPYPYEI-PTWDEASPYDPMEP--RKKPRKNKNPLLQFDEQTIKKARKKQWNEPRNCARRYLKVDFADIGWSEWIISPKSFDAYYCSGSCQFPMPKSLKPSNHATIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDEDKNVVLKVYPNMTVDSCACR >KAG6798905.1 bone morphogenetic protein 10 [Apis mellifera caucasica] LLYLLSEHFAHERWPRLLQQVLGIRSRKVPPQFMVELYNNVADPSGGR----------NPYNAKVVRSFIE---RDFYFFNITGLEVNESVLEAELHLYRKRTPLKALH--------------SPYYLIRVYQDEKSLDVPHRLLNVRGWQIFNVKQAVLAGEPNLGLLVDRANVEFSRRNEYSKQPILVLFDDDGGNDEIEQVFHDEEEEKGDWRNSDAEGELEGNKNKTGSFERQKRTRMREHEAQHLADDGSGRRRRETNVKERAMRRERIMAGQRSFWSEKIREKRSAKSRASVRQCSRHELYVDFKEIGLSSSIIAPLGYSAFHCKGICESPLSQDQQPTNHATIQGIVHKMGLVKGVERPCCVPTKLLGTTILFYDDNENVILKVYQDMIADRCGCR >NP_058801.1 bone morphogenetic protein 3 precursor [Rattus norvegicus] CLWLGCLNLAQGLRGTESDRMTGGGPHDKVSEHMLWLYDRYSGSNRTRTPGSQLPGPQPLRGGNTVRSFRAAAAGTLHTFNLTSLTKSENILSATLYFYIGELVNTSVNCPESQGCSHDSQRQQIDLSAWTLQ-NQSQLLGHLSVDTASWLSKDITQLLRKAKQDEEFLITSRAHELPKRMLLFPEPYILVYANDAAICEPESVVSSLQRHRDFTAGTVPREALSVERRKKRSTGILLPLQNNELPYQYKEAGVWEERKPYKSLQSRSKKKQRKGKGQTLQFDEQTLKKARRKQWIEPRNCARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGVVSGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVDSCACR >NP_775580.1 bone morphogenetic protein 3 isoform 2 preproprotein [Mus musculus] CLWLGYLNLAQGLRETESDRATGGSPHDKVSEHMLWLYDRYSGSSRTRTPGSQLPGPQPLRGGNTVRSFRAAAAGTLHTFNLTSLTKSENILSATLYFYVGELVNISLSCPEPQGCSHHTQRQQIDLSAWILK-NQSQLLGHLSVDVVSWLSKDITQLLRKAKQNEEFLITSRAHELPKRMLFFPEPYILVYANDAAISEPESVVSSLQRHRDFTAGTGPREALSVERRKKRSTGILLPLQNNELPYQYKEEGAWEERKPYKSLQSRNKKKQRKGKGQTLQFDEQTLKKARRKQWVEPRNCARRYLKVDFADIGWSEWIISPKSFDAFYCSGACQFPMPKSLKPSNHATIQSIVRAVGVVSGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVDSCACR >XP_015131733.2 bone morphogenetic protein 3 isoform X1 [Gallus gallus] FLLFGYSARLQVMRETCEKKLCWEGTAGHLSKHPAWRAQRSSMEGVSVVSSSAGFPNASWREQITAQ-----FPGRLYVFNLTSLTKSENILSASLHYYIGDLLDADWNCSQSGGCSHRGHRKQIHLSVWTFPGNQTRGLGHFLINISSWQWKDITQVLHKAKQSNELLIDSTSRHLWRRAPFHYEPYILIYANDSAISEPENVVSSLQGHHNPLARVFPRSS-LGKRRRKRSTNVLLPLQNNELPYQYNEDERWEDRKPYKTFQAKSKKKQRKNKSQTLQFDEQTLKKARRKQWNEPRYCARRYLKVDFADIGWSEWIISPKSFDAYYCSGECQFPIPKALKPSNHATIQSIVRAVGVVPGIPEPCCVPDKMSSLSILFFDENKNVVLKVYPNMTVESCACR >XP_001144027.1 bone morphogenetic protein 3 [Pan troglodytes] FLWLGCVNLAQELRKAVGDRTAGGGPQDKVSEHMLRLYDRYS---TAWTPGSLEGGPRPLREGNTVRSFRAAAAETLYIFNLTSLTKSENILSATLYFCIGELGNISLSCPVSGGCSHHAQRKQIDLSAWTLKRNQSQLLGHLSVDMASWLSKDITQFLRKAKENEEFLITSKGHQLPKRRLPFPEPYILVYANDAAISETESVVSSLQGHRNFPTGTVPKAALSIERRKKRSTGVLLPLQNNELPYQYKKDEVWEERKPYKTLQSKNKKKQRKGKSQTLQFDEQTLKKARRKQWIEPRNCARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR >NP_001179197.1 bone morphogenetic protein 3 precursor [Bos taurus] HLWLSCVSLAQELRVAVADRAAGGGPLDQVSEHMLRLYDRYSGG-RARTPGNSERGPQPLREGNTVRSFRAGAAGMLHIFNLTSLTKSENILSATLYFYIRELINISLSCPVSQECSHHAQRKQIDLSAWILKGNQSQLLGHLSVDGGSWLSKDITQLLRKAKENEEFLITTKGHQLPKKMTPSPEPYILVYANDAAISEPESVVSSLQGHRNFPTGAVPKSAPSIERRRKRSTGVLLPLQNNELPYQYKEDEVWEERKPYKTLQSKNKKKQRKGKSQTLQFDEQTLKKARRKQWIEPRNCARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR >XP_002717136.1 PREDICTED: bone morphogenetic protein 3 [Oryctolagus cuniculus] CLWLSCVSLARELRKAGGDRAAGGGPHDKVSEHMLRLYDRYSGGGRPRTPGSRERGPQPLREGNTVRSFRAGAAGALHIFNLTSLTKSENILSATLYFYSGELVNTNLSCPVSQGCSHHAKRKQIVLSAWILKRNQSQPLGHLSVDVAPWLSKDITQLLRKAKEKEEFLITSKAHQLPKRMLLSPEPYILVYANDAAISEPESVVSSLQGHRNFPTGSVPKAALSVERRKKRSTGVLLPLQNNELPYQYKEEGVWEERKPYKTLQSKNKKKQRKGKSQTLQFDEQTLKKARRKQWLEPRDCARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR >XP_002814965.1 bone morphogenetic protein 3 [Pongo abelii] FLWLGCVSLAQELRKAVGDRTAGGGPQDKVSEHMLRLYDRYS---TARTPGSPEGGPQPLREGNTVRSFRAAAAETLYIFNLTSLTKSENILSATLYFYIGELGNISLSCPVSGGCSHHAQRKQIDLSAWTLKRNPSQLLGHLSVDMASWLSKDITQFLRKAKGNEAFLITSKGHQLPKRRLPFPEPYILVYANDAAISEPESVVSSLQGHQNFPTGTVPKAALSIERRKKRSTGVLLPLQNNELPYQYKKDEVWEERKPYKTLQSKNKKKQRKGKSQTLQFDEQTLKKARRKQWIEPRNCARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR >NP_001193317.1 bone morphogenetic protein 3 precursor [Sus scrofa] PLWLGCGSLAQELRDAVGHRAAGGGPLDPLSEHMLRLYDSYSGGASARTPGSPEPGPQPRREGNTVRSFRAGAAGTLHVFNLTSLTKSENVLSATLYFYIGELINATLSCPASRGCSHHAQRRQISLSAWVLQRNQSQLLGHLSVDVASWLSKDITQLLRKAKENEEFLITSRGHQLPKKVIPFPEPYILVYANDAAISEPESVVASLQGHRNFPAGAVPKAALSTERRRKRSAGLLLPLQNNELPYQYKEDGVWEERKPYKTLQSKNKKKQRKGKSQTLQFDEQTLKKARRRQWIEPRNCARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR >XP_038299875.1 bone morphogenetic protein 3 [Canis lupus familiaris] WLWLGCGSLARQLHGAGGDRAAGGGSLDKVSEHMLRLYDRYSGGGGERARGASERGPQPLREGNTVRSFRGGAAGTLHIFNLTSLTKSENILSATLYFYVGELINISLSCPESRGCSHHAQRKQIDLSVSILKRNQSQLFGHLSVDVASWLSKDITQLLRKAKENEEFLITSKGHQLPKKRLPFPEPYILVYANDAAISEPESVVSSLQGHRNFATGTMPKAALSIERRKKRSAGVLLPLQNNELPYQYREDGVWEEKKPYKTLQTKNKKKQRKGKSQTLQFDEQTLKKARRKQWIEPRNCARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR >XP_003832318.1 bone morphogenetic protein 3 [Pan paniscus] FLWLGCVNLAQELRKAVGDRTAGGGPQDKVSEHMLRLYDRYS---TAWTPGSLEGGPRPLREGNTVRSFRAAAAETLYIFNLTSLTKSENILSATLYFCIGELGNISLSCPVSGGCSHHAQRKQIDLSAWTLKRNQSQLLGHLSVDMASWLSKDITQFLRKAKENEEFLITSKGHQLPKRRLPFPEPYILVYANDAAISEPESVVSSLQGHRNFPTGTVPKAALSIERRKKRSTGVLLPLQNNELPYQYKKDEVWEERKPYKTLQSKNKKKQRKGKSQTLQFDEQTLKKARRKQWIEPRNCARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR >XP_006931098.2 bone morphogenetic protein 3 [Felis catus] CLWLGCVSLAREPHRAVGDRTAGGGPHDKVSEHMLRLYDRYSGGGRERAQRSSERGPPPLREGNTVRSFRAGASGTLHIFNLTSLTKSENILSATLYFYIGELINISLSCPASRGCSPHAQRKLIDLSAWILKRNQSQHLGHLSVDVASWLSKDITQLLRRAKENEEFLITSKGHQLPKKMLPFPEPYILVYANDAAISEPESVVSSLQRHRNFPIGAVPRAALSTERRRKRSAGVLLPLQNNELPYQYREDGVWEERKPYKTLQTKNKKKQRKGKSQTLQFDEQTLKKARRKQWIEPRNCARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR >XP_027826928.1 bone morphogenetic protein 3 [Ovis aries] HLWLSCVSLAQELRVAVADRAAGGGPLDQLSEHMLRLYDRYSGG-GARTPGNSERGPQPLREGNTVRSFRAGAAGMLHIFNLTSLTKSENILSATLYFYIRELINISLSCPVSQECSHHAQRKQIDLSAWILKGNQSQLLGHLSVDGGSWLSKDITQLLRKAKENEEFLITTKGHQLPKKMTPSPEPYILVYANDAAISEPESVVSSLQGHRNFPTGAVPKAALSMERRRKRSTGVLLPLQNNELPYQYKEDRVWEERKPYKTLQSKSKKKQRKGKSQTLQFDEQTLKKARRKQWIEPRNCARRYLRVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR >XP_004038932.1 bone morphogenetic protein 3 [Gorilla gorilla gorilla] FLWLGCVSLAQELRKAVGDRTAGGGPQDKVSEHMLRLYDRYS---TARTPGSLEGGPQPLREGNTVRSFRAAAAETLYIFNLTSLTKSENILSATLYFYIGELGNISLSCPVSGGCSHHAQRKQIDLSAWTLKRNQSQLLGHLSVDMASWLSKDITQFLRKAKENEEFLITSKGHQLPKRRLPFPEPYILVYANDAAISQPESVVSSLQGHRNFPTGTVPKAALSTERRKKRSTGVLLPLQNNELPYQYKKDEVWEERKPYKTLQSKNKKKQRKGKSQTLQFDEQTLKKARRKQWIEPRNCARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR >XP_004073050.1 bone morphogenetic protein 3 [Oryzias latipes] VLLYGWLCLGYPQRRKVVDKRDTVKGQDTMTKHMQMLYAKYNRAGF------------PFRDGNTVRSFKA-HWGTLQIFNLTSLTKSEDVLSATLHYYIGDLQNSTWGCSRSKSCGRHALLRHIHMVIWSFADNKMRSLGHLRINVSSWQWKDITRVVNQAKHHEELLIASQGPQPWKKLLSDRSPYILVYANDSAISEPESVVATLQRHGSQMPHRPQKNTEHLQPRHRRSVNVLLPLQNNELPYPYET-TGWDETSPHEPFKP--RKKTRKNKMPLLQFDEQTIKKARKKQWNEPRTCARRYLKVDFADIGWNDWIISPKSFDAYYCSGSCQFPMPKALKPSNHASIQSIVRAVGVVPGVPEPCCVPEKMSSLSILFFDEDQKVVLKVYPNMTVDSCACR >XP_005498604.1 bone morphogenetic protein 3 isoform X2 [Columba livia] CLCLGWLCLPP---------------------RWVELQRRGSRGGRPRPQDPSGLPRLHPRQGNTVRGFRPLGAGSMYVFNLTSLTKSENILSASVYYYIGGLLNAQWNCSQPRRCSHHRPRKQIHLSVWTFPGNQTRSLGHFLINVSSWQWKDITQLLYEAKESNELLIDLTSHHPWKRAASHYEPYILIYANDSAISEPESVVSSLQGHRNPLAMVIPKSS-FGKRRRKRSTNVLLPLQNNELPYQYNEEDRWEDRKPYKTFQAKSKKKQRKNKSQTLQFDEQTLKAARRKQWNEPRYCARRYLKVDFADIGWSEWIISPKSFDAYYCSGECQFPIPKALKPSNHATIQSIVRAVGVIPGIPEPCCVPDKMSSLSILFFDENKNVVLKVYPNMTVESCACR >XP_005682010.3 PREDICTED: LOW QUALITY PROTEIN: bone morphogenetic protein 3 [Capra hircus] HLWLSCVSLAQELRVAVADRAAGGGPLDQLSEHMLRLYDRYSGG-GAPTPGTXERGPQPLREGNTVRSFRAGAAGMLHIFNLTSLTKSENILSATLYFYIRELINISLSCPVSQECSHHAQRKQIDLSAWILKGNQSQLLGHLSVDGGSWLSKDITQLLRKAKENEEFLITTKGHQLPKKMTPSPEPYILVYANDAAISEPESVVSSLQGHRNFPTGAVPKAALSMERRRKRSTGVLLPLQNNELPYQYKEDRVWEERKPYKTLQSKSKKKQRKGKSQTLQFDEQTLKKARRKQWIEPRNCARRYLRVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR >XP_025057757.1 bone morphogenetic protein 3 isoform X1 [Alligator sinensis] ---------------------------------------------------------------------------------------------------------MSWSCPQSRGCSRHGSRKQIDLLVLSVPGNQTRTLGHFLINVSSWQWKDFTHVLCEAKQNDEFLIASTSHYLWRRMPSSYEPYILVYANDSAISEPDTVVSNFQGHQHSLSVGFPRGS-LTEQRRKRSTSVLLPLQNNELPYQYNEGERWEERKSYKTLQAKNKKKQRKNKSQTLQFDEQTLKKARRKQWNEPRHCARRYLKVDFADIGWSEWIISPKSFDAYYCSGECQFPIPKALKPSNHATIQSIVRAVGVVPGIPEPCCVPDKMSSLSILFFDENKNVVLKVYPNMTVESCACR >XP_006269586.2 PREDICTED: bone morphogenetic protein 3 [Alligator mississippiensis] CLCLGWLWLALELRR----RAAAGAAXXKVSEHMLRLYDRYRAA--PHPHPHA--PRAAPRQGNTVRGFRALPAGNLYVFNLTSLTKSENILSASFHYYIGDLLNMSWSCPQSRGCSRHGSRKQIDLLVLSFPGNRTRTLGHFLINISSWQWKDFTHVLCEAKQNDEFLIASTSHYLWRRMPSSYEPYILVYANDSAISEPDTVVSNFQGHQHSLSVGFPRGS-LTEQRRKRSTGVLLPLQNNELPYQYNEGERWEERKSYKTLQAKNKKKQRKNKSQTLQFDEQTLKKARRKQWNEPRHCARRYLKVDFADIGWSEWIISPKSFDAYYCSGECQFPIPKALKPSNHATIQSIVRAVGVVPGIPEPCCVPDKMSSLSILFFDENKNVVLKVYPNMTVESCACR >XP_015815719.1 PREDICTED: bone morphogenetic protein 3 [Nothobranchius furzeri] VLLYGGLCAGYPQRRKVVDKKHTAKEQDTMTEHMQMLYAKYNRAGF------------PFRDGNTVRSFKA-HWGTLQIFNLTSLTKSEDVLSATLHYYITDLQN--QSCSRSKSCARHGPRRHIHMVIWSFADNKMRSLGHFRINASSWQWKDITQVVNQAKHHDELLIASQGPQPWKKLLSDRSPYILVYANDSAISEPENVVASLQRSYSSASHGFHKKQEQLRSRHKRSVNVLLPLQNNELPYPYET-PGWDETSPYEPLGP--RKKTRKNRLPLLQFDEQTIKKARKKQWNEPRNCARRYLKVDFADIGWSEWIISPKSFDAYYCSGSCQFPMPKALKPSNHATIQSIVRAVGVVPGIPEPCCIPEKMSSLSILFFDEDKNVVLKVYPNMTVDSCACR >XP_020759985.1 bone morphogenetic protein 3 [Odocoileus virginianus texanus] RLWLGCVSLAQELRVAVGDRAAGGDPLDQLSEHMLRLYDRYSGG-RARTPLTSERGPQLLREGNTVRSFRAGAAGTLHIFNLTSLTKSENILSATLYFYIRELINISLSCPVSQECSHHAQRKHIDLSAWILKGNQSQLLGHLSVDGGSWLSKDITQLLRKAKENDEFLITTKGHQLPKKMTPSPEPYILVYANDAAISEPESVVSSLQGHRNFPTGAVPKAALSIERRRKRSAGVLLPLQNNELPYQYKEDGVWEERKPYKTLQSKNKRKQRKGKSQTLQFDEQTLKKARRKQWIEPRNCARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR >XP_030273663.1 bone morphogenetic protein 3 [Sparus aurata] VLLYGWLCVGYPERRKVVDKKQPTKDQDTMTEHMQMLYTKYNRAGF------------PFKDGNTVRSFKA-HWGTLQIFNLTSLTKSEDVLSATLHYYIGDLQNSTQACSRPKSCGRHGPRRHIHMVIWSFADNKMRTLGHFRINVSSWQWKDITRVVNQAKNHDELLITSQGPQPWKKLLSDRSPYILVYANDSAISEPESVVATLQRHHPSISHSFQKEQERPQPRQKRSVNILLPLQNNELPYPYET-TGWDETSPYEPFEP--RKKTRKNKMPLLQFDEQTIKKARKKQWNEPRNCARRYLKVDFADIGWSEWIISPKSFDAYYCSGSCQFPMPKALKPSNHATIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDEDKNVVLKVYPNMTVDSCACR >XP_040181031.1 bone morphogenetic protein 3 [Rana temporaria] VLCWACLCL--------AIRSQAGAAGDTVSEHMLRLYDKYRGGGGRRGRDSSRH-QLTLKDGNTVRSFKP-LTGSQHIFNLTSLTSSENILSATFHYYLGDILNISQRCQHSSSCSRRGHRKSIDLKVSSLTENQTRILGNFLINISSWHWKDITQVLREAKQHGEALITVDTANKRRKQLLGHKPYILVYANDSAISEPDTVVSNLHGQRASIVH----KEGLIDHRSRRSTDILLPLQNNELPYQYNEDERWVEKKPYKTLQEKSNKKLRKSKGQTLQFDEHTLKKARRKQWNEPRNCARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR
PhyML tree of selected proteins (((((((((XP_006931098_2_bone_morphogenetic_protein_3__Felis_catus_:0.046207,XP_038299875_1_bone_morphogenetic_protein_3__Canis_lupus_familiaris_:0.054912):0.012784,((((XP_020759985_1_bone_morphogenetic_protein_3__Odocoileus_virginianus_texanus_:0.008081,XP_043304197_1_bone_morphogenetic_protein_3__Cervus_canadensis_:0.002162):0.008474,((XP_005682010_3_PREDICTED__LOW_QUALITY_PROTEIN__bone_morphogenetic_protein_3__Capra_hircus_:0.004023,XP_027826928_1_bone_morphogenetic_protein_3__Ovis_aries_:0.001032):0.010403,NP_001179197_1_bone_morphogenetic_protein_3_precursor__Bos_taurus_:0.010399):0.015596):0.004612,(KAB0344722_1_hypothetical_protein_FD754_021648__Muntiacus_muntjak_:0.00312,KAB0354394_1_hypothetical_protein_FD755_022932__Muntiacus_reevesi_:-0.000172):0.015702):0.026597,NP_001193317_1_bone_morphogenetic_protein_3_precursor__Sus_scrofa_:0.078249):0.004424):0.010792,XP_002717136_1_PREDICTED__bone_morphogenetic_protein_3__Oryctolagus_cuniculus_:0.064671):0.004575,(XP_004038932_1_bone_morphogenetic_protein_3__Gorilla_gorilla_gorilla_:0.004004,(XP_002814965_1_bone_morphogenetic_protein_3__Pongo_abelii_:0.01351,((XP_003832318_1_bone_morphogenetic_protein_3__Pan_paniscus_:-0.00021,XP_001144027_1_bone_morphogenetic_protein_3__Pan_troglodytes_:0.002749):0.005948,NP_001192_4_bone_morphogenetic_protein_3_preproprotein__Homo_sapiens_:0.006889):0.004929):0.00101):0.042843):0.012714,(NP_775580_1_bone_morphogenetic_protein_3_isoform_2_preproprotein__Mus_musculus_:0.035646,NP_058801_1_bone_morphogenetic_protein_3_precursor__Rattus_norvegicus_:0.032039):0.08862):0.174367,((OWK07582_1_GDF10__Cervus_elaphus_hippelaphus_:0.186928,KAF4018998_1_hypothetical_protein_G4228_010604__Cervus_hanglu_yarkandensis_:-0.186928):1.015395,(((((KAG6798905_1_bone_morphogenetic_protein_10__Apis_mellifera_caucasica_:1.942172,CAE1274945_1_BMP2__Sepia_pharaonis_:0.447295):0.179378,((AAC47552_1_decapentaplegic_protein__Drosophila_melanogaster_:0.883978,XP_031567165_1_bone_morphogenetic_protein_2_like__Actinia_tenebrosa_:0.638466):0.582982,NP_504709_1_Protein_dbl_1__Caenorhabditis_elegans_:1.512568):0.181954):0.379142,XP_038062104_1_growth_differentiation_factor_10_like_isoform_X2__Patiria_miniata_:1.566839):0.14036,XP_039273812_1_uncharacterized_protein_LOC120347787_isoform_X2__Styela_clava_:1.54624):0.093021,XP_030834960_1_bone_morphogenetic_protein_3_like__Strongylocentrotus_purpuratus_:0.437236):0.763225):0.092492):0.041578,((XP_006269586_2_PREDICTED__bone_morphogenetic_protein_3__Alligator_mississippiensis_:0.068783,XP_025057757_1_bone_morphogenetic_protein_3_isoform_X1__Alligator_sinensis_:-0.055192):0.049805,(XP_005498604_1_bone_morphogenetic_protein_3_isoform_X2__Columba_livia_:0.096153,XP_015131733_2_bone_morphogenetic_protein_3_isoform_X1__Gallus_gallus_:0.177497):0.109229):0.094574):0.03328,((XP_030273663_1_bone_morphogenetic_protein_3__Sparus_aurata_:0.037678,(XP_004073050_1_bone_morphogenetic_protein_3__Oryzias_latipes_:0.08771,XP_015815719_1_PREDICTED__bone_morphogenetic_protein_3__Nothobranchius_furzeri_:0.059743):0.012077):0.112742,tr_A2AVJ4_A2AVJ4_DANRE_Bone_morphogenetic_protein_3_OS_Danio_rerio_OX_7955_GN_bmp3_PE_3_SV_1:0.112066):0.232654):0.101122,OCU00369_1_hypothetical_protein_XELAEV_18006143mg__Xenopus_laevis_:0.245555,XP_040181031_1_bone_morphogenetic_protein_3__Rana_temporaria_:0.154646);
BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)