PBID | Uniprot | Name | Gene | Alternative | Organism | Uniprot Description |
PB0019 | P02452 | Collagen type I alpha 1 chain | COL1A1 | CAFYD, EDSARTH1, EDSC, OI1, OI2, OI3, OI4, Collagen alpha-1(I) chain | Homo_sapiens | Type I collagen is a member of group I collagen (fibrillar forming collagen). |
Domains | Gene Ontology |
PF00093 (VWC) PF01391 (11_Collagen) PF01410 (COLFI) |
GO:0002020 (enables) protease binding
GO:0005201 (enables) extracellular matrix structural constituent GO:0005515 (enables) protein binding GO:0030020 (enables) extracellular matrix structural constituent conferring tensile strength GO:0042802 (enables) identical protein binding GO:0046872 (enables) metal ion binding GO:0048407 (enables) platelet-derived growth factor binding GO:0001501 (involved in) skeletal system development GO:0001503 (involved in) ossification GO:0001568 (involved in) blood vessel development GO:0001649 (involved in) osteoblast differentiation GO:0001957 (involved in) intramembranous ossification GO:0001958 (involved in) endochondral ossification GO:0007584 (involved in) response to nutrient GO:0007601 (involved in) visual perception GO:0007605 (involved in) sensory perception of sound GO:0009410 (involved in) response to xenobiotic stimulus GO:0009612 (involved in) response to mechanical stimulus GO:0010718 (involved in) positive regulation of epithelial to mesenchymal transition GO:0010812 (involved in) negative regulation of cell-substrate adhesion GO:0015031 (involved in) protein transport GO:0030198 (involved in) extracellular matrix organization GO:0030199 (involved in) collagen fibril organization GO:0030335 (involved in) positive regulation of cell migration GO:0031667 (involved in) response to nutrient levels GO:0031960 (involved in) response to corticosteroid GO:0032355 (involved in) response to estradiol GO:0032964 (involved in) collagen biosynthetic process GO:0034504 (involved in) protein localization to nucleus GO:0034505 (involved in) tooth mineralization GO:0038063 (involved in) collagen-activated tyrosine kinase receptor signaling pathway GO:0042060 (involved in) wound healing GO:0042542 (involved in) response to hydrogen peroxide GO:0043434 (involved in) response to peptide hormone GO:0043588 (involved in) skin development GO:0043589 (involved in) skin morphogenesis GO:0044344 (involved in) cellular response to fibroblast growth factor stimulus GO:0044691 (involved in) tooth eruption GO:0045893 (involved in) positive regulation of transcription, DNA-templated GO:0048545 (involved in) response to steroid hormone GO:0048705 (involved in) skeletal system morphogenesis GO:0048706 (involved in) embryonic skeletal system development GO:0051591 (involved in) response to cAMP GO:0055093 (involved in) response to hyperoxia GO:0060325 (involved in) face morphogenesis GO:0060346 (involved in) bone trabecula formation GO:0060351 (involved in) cartilage development involved in endochondral bone morphogenesis GO:0071230 (involved in) cellular response to amino acid stimulus GO:0071260 (involved in) cellular response to mechanical stimulus GO:0071300 (involved in) cellular response to retinoic acid GO:0071306 (involved in) cellular response to vitamin E GO:0071356 (involved in) cellular response to tumor necrosis factor GO:0071364 (involved in) cellular response to epidermal growth factor stimulus GO:0071560 (involved in) cellular response to transforming growth factor beta stimulus GO:0090263 (involved in) positive regulation of canonical Wnt signaling pathway GO:1902617 (involved in) response to fluoride GO:1902618 (involved in) cellular response to fluoride GO:0005615 (is active in) extracellular space GO:0005737 (is active in) cytoplasm GO:0031012 (is active in) extracellular matrix GO:0005576 (located in) extracellular region GO:0005783 (located in) endoplasmic reticulum GO:0005788 (located in) endoplasmic reticulum lumen GO:0005794 (located in) Golgi apparatus GO:0030141 (located in) secretory granule GO:0062023 (located in) collagen-containing extracellular matrix GO:0005581 (part of) collagen trimer GO:0005584 (part of) collagen type I trimer |
External Links | Description |
Intact | Open source database system and analysis tools for molecular interaction data. |
Protein Atlas | An open access resource for human proteins |
InterPro (new pfam) | InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. |