PB0014

DATABASE

Click here to access PB0014 phyletic profile

PBID	Uniprot	Name	Gene	Alternative	Organism	Uniprot Description
PB0014	P24158	Myeloblastin	PRTN3	ACPA, AGP7, C-ANCA, CANCA, MBN, MBT, NP-4, NP4, P29, PR-3, PR3, proteinase 3	Homo_sapiens	May play a role in neutrophil transendothelial migration, probably when associated with CD177 (PubMed:22266279).

Domains

Gene Ontology

PF00089 (Trypsin)

GO:0062023 (colocalizes with) collagen-containing extracellular matrix GO:0004252 (enables) serine-type endopeptidase activity GO:0005102 (enables) signaling receptor binding GO:0005515 (enables) protein binding GO:0008233 (enables) peptidase activity GO:0008236 (enables) serine-type peptidase activity GO:0016787 (enables) hydrolase activity GO:0019899 (enables) enzyme binding GO:0006508 (involved in) proteolysis GO:0006509 (involved in) membrane protein ectodomain proteolysis GO:0006909 (involved in) phagocytosis GO:0008284 (involved in) positive regulation of cell population proliferation GO:0019730 (involved in) antimicrobial humoral response GO:0030574 (involved in) collagen catabolic process GO:0043547 (involved in) positive regulation of GTPase activity GO:0045217 (involved in) cell-cell junction maintenance GO:0050765 (involved in) negative regulation of phagocytosis GO:0072672 (involved in) neutrophil extravasation GO:0097029 (involved in) mature conventional dendritic cell differentiation GO:0005615 (is active in) extracellular space GO:0005576 (located in) extracellular region GO:0005829 (located in) cytosol GO:0005886 (located in) plasma membrane GO:0016020 (located in) membrane GO:0035578 (located in) azurophil granule lumen GO:0043231 (located in) intracellular membrane-bounded organelle GO:0044853 (located in) plasma membrane raft GO:0045121 (located in) membrane raft GO:0070062 (located in) extracellular exosome

External Links	Description
Intact	Open source database system and analysis tools for molecular interaction data.
Protein Atlas	An open access resource for human proteins
InterPro (new pfam)	InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish) >sp|P24158|PRTN3_HUMAN Myeloblastin OS=Homo sapiens OX=9606 GN=PRTN3 PE=1 SV=3 MAHRPPSPALASVLLALLLSGAARAAEIVGGHEAQPHSRPYMASLQMRGNPGSHFCGGTL IHPSFVLTAAHCLRDIPQRLVNVVLGAHNVRTQEPTQQHFSVAQVFLNNYDAENKLNDVL LIQLSSPANLSASVATVQLPQQDQPVPHGTQCLAMGWGRVGAHDPPAQVLQELNVTVVTF FCRPHNICTFVPRRKAGICFGDSGGPLICDGIIQGIDSFVIWGCATRLFPDFFTRVALYV DWIRSTLRRVEAKGRP
Selected proteins from model organisms >NP_002768.3 myeloblastin precursor [Homo sapiens] MAHRPPSPALASVLLALLLSGAARAAEIVGGHEAQPHSRPYMASLQMRGNPGSHFCGGTLIHPSFVLTAA HCLRDIPQRLVNVVLGAHNVRTQEPTQQHFSVAQVFLNNYDAENKLNDVLLIQLSSPANLSASVATVQLP QQDQPVPHGTQCLAMGWGRVGAHDPPAQVLQELNVTVVTFFCRPHNICTFVPRRKAGICFGDSGGPLICD GIIQGIDSFVIWGCATRLFPDFFTRVALYVDWIRSTLRRVEAKGRP >XP_018099106.1 myeloblastin [Xenopus laevis] MEHFLLVTLALLWTSQVNGGSMQTQIVGGREASPNSHPYIASLQLRGRHFCGGSLIAPQFLMTAAHCMENTAPSVVTVVL GAHSLRENEETKQRFRVNQVFENGFNPLTLENDIVILKLDRPVSLNGKVQVVSLPNANEDVPAGTQCVTAGWGQLSTEGR IPDRLQELNVTVTSRNLCRPNNICTGVFMQRAGICFGDSGGPLVCNGVIQGITSFIIRTCGNGRSPDFFSRVALFRSFID NAINS >XP_031571314.1 chymotrypsinogen A-like [Actinia tenebrosa] MIFWAALLLVLPALIEGCGKRPAGTRVINGQDAAPHSWPWQISLRLDGYHICGGTLIRPDWVLTAAHCVNKNPDPKRYIV AVGAHRRLSITSVERFMKIKKVIMHSGYTDQQKLHDIALLQLRTPVTLSDKVNLACLPTTEAAVGAKCYITGWGRTSASS GSADTLQQAMLPVASHSDCKKKFTIVDRKAHICAGDAKSSASSGGCHGDSGGPLVCEERGRWVQHGIVSFGKRNCPTTFY TVFARVSSYLDWVNSKITGSTPSPPSPSPPPSPEPPLPPTTSPAGGCSDRSGPKACQYFKDRCSQDFVKKACQKTCGLC >XP_038051917.1 trypsin-like [Patiria miniata] MLKFLVLCALAASVYADCGVQVISPSLSKIVGGDEAVPGSWPWQVMLRKKYWGGDYQFCGGTLINDQWVVTAAHCFYNYG NINLYSAVVGAHDRDAVDATQSSVGLAQVFLHEDYNTRTLDNDITLLKLSSPVSLSDYVTPACLPQREVATGTDCVVTGW GDQETTVDDPALQQVVVPIISTAQCNKATWYGGDITDNMICAGYSQGGKDSCQGDSGGPFVCAASSGAYELVGVVSWGYG CADARNPGVYAKVLNYVDWINNIVANN >XP_039266389.1 trypsin-3-like [Styela clava] MFPSKFICWTVLCFLSVRNGECDKIVGGYEARPHSAPYIAHLDRYSSYFCCGTLIHESWVLSAAHCHYEPDQFKVIIGDH DRSIVEGTEQTIQAILALNHELYNPMITDNDVMMVKLEKPAIFNQYVQLALLPTSEIGSGIECLACGWGYTDYTSNTLPD RLQCVEVFTVSNTECNYMYGGEVKETMLCAESAGKDACNGDSGGPLMCGNLLHGVTSTGFGCAYPHFPGIYARVTEFTSW IQMVMEYN >NP_726740.1 uncharacterized protein Dmel_CG32808 [Drosophila melanogaster] MAVMAWLARLALFYTATFLLAGASGEDGKIVNGTTAGPGEFPFVVSLRRAKSGRHSCGATLLNPYWVLTAAHCVRGSSPE QLDLQYGSQMLARNSSQVARVAAIFVHPGYEPEDKYVNDIALLQLAQSVALSKFVQPVRLPEPRQVTPGNASAVLAGWGL NATGGVVQQHLQKVKLQVFSDTECSERHQTYLHDSQICAGLPEGGKGQCSGDSGGPLLLIGSDTQVGIVSWSIKPCARPP FPGVFTEVSAYVDWIVETVNSYSPPSSLWVGQLIVGRSPPSLSS >KAG6801689.1 chymotrypsin-2 [Apis mellifera caucasica] MIKKFFIFCALIALINALSWNYNPKIINGEDAKEGEIPYQVSLQNKFSSFHFCGGSILNENYVITAAHCVHGKFSEDIKV VAGTINLANPKYENDVNEIIVHEKYNVSDSWKNDIALLKVKTSFTLSNTISSVPLPSPNDIIKPNDLATVSGWGRLRQGG PTTIYLQRVNILIANQEYCELTYKKINYTVYESQICAYYPTSEKGSCNGDSGGPLTVNGKLVGLVSWAMGCALIDYPTVY TRVESYLDWIKENAV >CAE1324442.1 Plasminogen,Apolipoprotein(a),Chymotrypsinogen B2,Chymotrypsinogen A,Chymotrypsinogen 2,Chymotrypsinogen B [Sepia pharaonis] MRRIYFFHGICLVLFSFTSSFLSLSLSLSLSLSRSLFLSRFLSLSSSLRRRGRHLISRGSHKYTASSNMSQVDHEGNIIP KRKQSGSSTVMCEHYSAWATWSHCSRRCEQYRTRNCVEPRYCGNTTIKDKRFCKRRNKQCSILSFKVITPLRRAKEVQQI ITNAFYNKWTAWSPCSRDCKQKRKRQCRSRWKNVCGESYIQQTRKCRPVAGTCEKKYTLSVLVADEPAETKKGPTSNRHN KAITNCTAELAMPDKCGTRPSGSQRNYRIVGGYEVRRHSWPWQVAILTRAKKQYCGGTLISPQWVLTAAHCVRKRGRKRK VIVRMGEHDLHSRSGNEITLELEKDFPHPKFDFHTISNDIALLKLKRPVRRSFNVGFACLPTETNELHAGTICNIIGWGK VDGSHQDGAKILREAEVPVVDQGKCQKAFKYKITNNQICAGFKGGGVDSCGGDSGGPLICANHPNRTTQWANRNAVSVLD ADFSFSPSLFMH >XP_030844513.1 trypsin-2 [Strongylocentrotus purpuratus] MLKAIVLLSCVAAALADCGKPAVDPVNTFIVGGDAAMPGSWPWQVGIRKNYLVGQGGYHMCGATLIDNQWIVSAAHCFYR WKRLSDYTITLGSHDRDEVDSTQVNAKLGGIFVHEDYNSMTLDNDIAMLKLETPIDFNDAISEACVATSDYPADTMCVVT GWGDQEAAIDNAELQQVYVPIIDTKVCNRPSWYNGEITDNMFCAGYSSGGMDSCQGDSGGPFVCKNSAGAWELTGVVSWG YGCADPLNPGVYTRVTQYNDWISGIKRNN >NP_494910.2 Peptidase S1 domain-containing protein [Caenorhabditis elegans] MKVWIFLLLVGVINKVSTDNKNDVIEKVGCGLHSTNVELAQTRSAQEPADYVTLDHRLIGGSESSPHSWPWTVQLLSRLG HHRCGGSLIDPNFVLTAAHCFAKDRRPTSYSVRVGGHRSGSGSPHRVTAVSIHPWYNIGFPSSYDFAIMRIHPPVNTSTT ARPICLPSLPAVENRLCVVTGWGSTIEGSSLSAPTLREIHVPLLSTLFCSSLPNYIGRIHLPSMLCAGYSYGKIDSCQGD SGGPLMCARDGHWELTGVVSWGIGCARPGMPGVYGNVHSASTWINLEMNRLRI >NP_001019435.1 myeloblastin precursor [Rattus norvegicus] MAGIRPSLKGMHPFLLLALVFGGAVQASKIVGGHEARPHSRPYVASLQLSRSPGSHFCGGTLIHPRFVLTAAHCLQDISW QLVTVVLGAHDLLSSEPEQQKFTITQVFENNYNPEETLNDVLLLQLNRPASLGKQVAVASLPQQDQSLSQGTQCLAMGWG RLGTRAPTPRVLHELNVTVVTFLCREHNVCTLVPRRAAGICFGDSGGPLICNGILHGVDSFVIRECASLQFPDFFARVSM YVNWIHSVLRSAEP >KAB0359192.1 hypothetical protein FD754_003348 [Muntiacus muntjak] MSNPGVGQPQRPAECDYKRGWAHGQGGPLDHARKLQTPCPSLAPVLLAALLGGAAQAAEIVGGREAQPHSRPYMASLQLA SGSHFCGGTLVHPRFVLTAAHCLNNVNPQRVRVVLGAHRLLTAEPTQQRVGVSRLFKNSYDPQEKLNDVLLLQLDQPATL NTHVVVAQLPQQAQPLPHGTQCLAMGWGRLGTLEPPPQNVCTYVPRRSAGICSGDSGDPLICDGILQGVDSFVIRGCATG QYPDFFARVSLYVDWINSVLSSVGGEDSP >XP_003981686.1 neutrophil elastase [Felis catus] MTPSRRSAGPALAPVLLAMLLGGPALASEIVGGRPARPHAWPFMVSLQLRGGHFCGGTLIAPNFVMSAAHCVDGLNFRSV VAVLGAHDLRRREPTRQMFTIQRVFENGFDPQRLLNDIVILQLNGSATINSNVRVARLPAQNQGVGSGVQCLAMGWGQLG TTQPPPNILQELNVTVVTTLCPRSNVCTLVPRRQAGICFGDSGGPLVCNGLIQGIDSFIRGSCGSGFYPDAFAPVAQFAN WIDSIIRRQDDRPSVHPRDPASRTL >NP_001003378.1 neutrophil elastase precursor [Canis lupus familiaris] MTARRVPAGPALGPLLLLATLLPGPALASEIVGGRPAQPHAWPFMVSLQRRGGHFCGGTLIAPNFVMSAAHCVDGLNFRS VVVVLGAHDLGERESTRQLFAVQRVFENGFDPVRLVNDIVLLQLNGSATINANVQVARLPAQNQGVGNGVQCLAMGWGQL GTAQPPPRILQELNVTVVTTLCRRSNVCTLVPRRRAGICFGDSGGPLVCNGLIQGIDSFIRGSCASGFFPDAFAPVAQFV DWINSIIRRPPALPPARPGQQDPERGAARAPPPAPHRPRPTQ >KAB0387936.1 hypothetical protein FD755_002892 [Muntiacus reevesi] MTALRLLAVLASLLATSRAGSAPLVDIVGGRKARPQELPFLASIQKQGRHFCGGALIHPNFVLTAASCFQSRNAGIATVV LGAYDLRRREQSRQTFSIRSVSENGYDPQQNLNDVLLLQLDRQANLTNSVAPVPLPEQNATVEAGTRCQVAGWGTRRRRG RLSRVPRVLNVTVTPANQCRPNNVCTGVLTRRGGICQGDGGTPLVCNGLAHGVASWSRGPCGRGTDFFARVALFRNWIDS VINQPS >XP_043345889.1 mast cell protease 3-like [Cervus canadensis] MVLFLLLVALLLSPTGEAGKIIGGHEAKPHSRPYMAFLRFKISGKPHMCGGFLVREDFVLTAAHCLGSSIDVTLGAHNIR EQERTQQVIPVMRAFPHPHYNDKTFVNDIMLLQLARKADMTDAVSPISLPRSFEKLKPGMMCSVAGWGRLDVDIPPADKL QEVDLEVQKDEKCIARFKDYIPIMQICAGDPNKRKSSFSGDSGGPLVCDGVAQGIVSYGEVYGTPPNVYTRVSSFLTWIQ KTMRQYKQQGSA >AXK15893.1 granzyme B [Sparus aurata] MIHAYRIILLLQLLSPTGASESGIVNGKVSKPHSRPYMASLQYDGQHSCGGILIREDFVLTAAHCEDSNQPVTMTVVLGA HNIIKKEKSQQRIKVAKYIKHPKFNGNYDYDIMLLKLEKKATLNKFVKTIGLPKKKGKIPANIKCTVAGWGRTGQDKPAS DVLKENTEKLQLNSKCEKKWQTVFDDDSMICTTFTREAGGICQGDSGGPLICNTKPQGITAFTDKNDCNNPEWPHVFTKV NAFIPWIKKVLKENRNVA >XP_040178020.1 serine protease 57-like [Rana temporaria] MKYLVLLATTLCLLNLSEAYRIVGGREAKAHSRPYMVSLQIKSQSFCGGALIDPKWVLTAAHCMEDTPVDMVRVVLGAHN LNQPDDCVQVSPVQESFQHPGYNPNSLQNDLQLLKLNTSANITPYVKTIKLASADTDVLPGTSCSVAGWGYVSDFGTLPR ALMETDVNVITLAACNVSWKQSIFDTMVCTASQGLRIKGFCSGDSGGPLICEDRVEGVVSFSGFRCGNPITPDVYTRVSS FMSWIKSVINRA >XP_004086989.3 granzyme E [Oryzias latipes] MKGACSFLCVLLMVSTAGASEGGIFGGRVAKPHSRPYMASLQFQGQHSCGGILIRDDYVLTSAHCKNDVQPMTVVLGAHD ISKKEKTQQHFKVQKYNQHPDYKCEQANDIMLIKLETKAKLNKYVKPIELSKKNGDIRANIKCAVAGWGKTAVDKPASNV LKEATEETQFKAECNNIWKEHFNSTQMICTKFSRKTGGICQGDSGGPLICNTKPLGLAAFTKQDNCNDPKFPHVFIKINF YLPWIKKIMTE >XP_002717971.1 PREDICTED: chymase-like [Oryctolagus cuniculus] MQAVLLLLVFLVPPEAAAEEIIGGTESKPHSRPYMAHLKIITKQGTFAYCGGFLISREFVMTAAHCKGRHITVTLGAHDV VKKESTWQKIDVVKQFVHPNYNSYTKLNDIMLLKLRWPAMLTFAVGTVPLPSRRTFSLPGTICQAAGWGQTGVTDPLSNT LREVNLRLMDDEVCNHFLFYDHGLQMCVGDPRMAGSAFKGDSGGPLLCAGVAQGIVSYTNQNAQPTVIFTQIFSYMPWIK KVLKGQVATEAWPA >XP_015822591.1 PREDICTED: trypsin-3-like [Nothobranchius furzeri] MNLPQVFTALFIFCFSACSQADDVRIVGGQEVEPYSIKYQASLQTEKGQHYCGATLVAQQWVVSAAHCWRPNTMMRVVLS EHNLLVVEGFEQNFNVSKIFLQNYNYRNYDNDIMLIKLSQPAVLNANVVPVNLPDSTTPPLRGDVCTVSGWGVTQVYSYE LSPVLRAVDVREISVCNWYYWGRITSNMLCAGSPFGGKDSCQGDSGGPLVCNGNFEGIVSWGISCANPYYPGVYTKVRQY VDWINWLINADV >XP_006270497.2 PREDICTED: mast cell protease 1A [Alligator mississippiensis] MLLLLLFPVTFLLPAGTGAGKIIGGREARPHSRPYMAFLNGQRGEKKYMCGGSLVHEHFVLTAAHCSGDQITVLLGAHNI HKKEESWQEIKVHRQIPHPRYKKKTREKDIMLLQLERKANLSEQVGIIRLPQPGEAVKPGSVCGVAGWGQTNVTFGESSN VLLEIDLEVLGDTICEDHYNCYYDPRTMLCVGDFKGNKSSFQGDSGGPLVCDRVVQGIISWGPNNAAPPEVYTKVSRFIA WIKNELAKLKKPLDIPGFFS >XP_004055076.1 chymase [Gorilla gorilla gorilla] MLLLPLPLLLFLFCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNFVLTAAHCAGRSITVTLGAHN ITEEEDTWQKLEVIKQFRHSKYNTSTLHHDIMLLKLKEKASLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSD TLQEVKLRLMDPQACSHFRDFDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWI NQILQAN >XP_014382175.2 mast cell protease 1A-like [Alligator sinensis] MPMFSSVLKGPRKESAEGKPTVGSPLLKVPEKKRERLRGKIIGGREARPHSRPYMAFLDGQRGEKKYMCGGSLVHEHFVL TAAHCSGDQITVLLGAHNIHKKEESWQEIKVHRQIPHPKYKKKTREKDIMLLQLEHKANLSEQVGIIRLPQPGEAVKPGS VCGVAGWGQTNVIFGDSSNVLLEIDLQVLGDTICEDHYSCYYDPRTMLCVGDFKGNKSSFQGDSGGPLVCDRVVQGIISW GPNNAAPPEVYTKVSRFIVWIKNELAKLKKPLDIPGFFS >KAF4008330.1 hypothetical protein G4228_020050 [Cervus hanglu yarkandensis] MRPLLLLVVFLLFPRARAGQIIGGREARPHSRPYMAFILIRAPGGLKVCGGFLVREDFVMTAAHCLGSQMNVILGAHNVR TLEGTQQRVPVLRPIPHPGYSPQSHSNDIMLLQLANRVQRNRFVRPVPLPQTRNRLRPGTRCTVAGWGLTGLNTRTDTLQ YVQLRVQRDRLCSRRFRSYNGRTQICVGDPRQRKSAFLGDSGGPLVCNNVAQGIVSYGDRMGTPPAVFTRISSFLPWIRR TMRRFKEWRPE >NP_989788.1 granzyme A precursor [Gallus gallus] MGVFFTLSTSAAIVLLILPGDLCVDIIGGHEVAPHSRPFMAMLKGKEFCGGALIKPSWVLTAAHCNLKGGRVILGAHSRT KREEEEQVIEIAEEIRYPDYCPERKEHDIMLLKLKKRAKINSAVKVIPLPTSGDDLKQGTICSVAGWGQISKRGNKMSDT LREVNVTVISRRICNDKKHYRKEPRITDNMICAGSKRGDKDSCRGDSGGPLICNNVMKGITSFGKSPCGDPGGPGVYTRI TDKYLKWIRKTIGGDLLTGF >XP_003213299.1 serine protease 57 [Meleagris gallopavo] MLAALLILSLGVSALSPAGAHSSWVIGGKAVVPHSRPFIASIQMDGQHFCGGFLVWPKWVMTAAHCPVPRRNPSVRVVLG AHSLEQPEESQQEFGVEESIAHPLYNHRTVDNDIRLLKLNHTATLNAFVKRIRLPRPRIDLKPGTLCSVVGWGDISNYGE RPIQLMEANTTIVKRSLCRTLWKGRVSGNMLCGASRNATLQGVCAGDSGGPLVFKGKVYGVVSFSGERCGDRRYPDIYTR ISNYIDWVHHVVLSHRQPHGQKKHKPGPEEAGGDQGAAGWGRPGLPRPSPAPRALMFNGN >OWK11991.1 PRSS57 [Cervus elaphus hippelaphus] MGLGVGDWGRLLLTVTAALTLPMKPPGSWGAQIIGGHEVTPHSRPYMASVKFQGQHHCGGFLLRARWVVSAAHCFSGRDP GTGLVVLGAHALRTVEATQQVFSISAVITHPDYQPTTHNSDICLLQLNSSATLGPAVGLLGLPQRGARPPRAGTRCKVVG WGSVSDFEELPPGLMEAEVRVLGLDACNSSWKGQLSPAMLCTHSGDRRRRGFCSADSGGPLVCKNRAYGLVSFSGLWCGD PKTPDVYTQVSTFVTWIWDVIWHGPQPRTTGGQQALSEPQQHRVHHRDGKRYK >XP_005505199.2 cathepsin G [Columba livia] MLFLLLTSAFLLVSWAEAGRIIGGQEARPHSRRYMAYVSIGSRSGTSNCGGFLIHPYAVLSAAHCVAGKTGVNITVTLGA HNIKKEELSQQKFHIGRWVIHPNYSGDTLANDIMLLKLKPNAKLTKQVNRVPLPRHNEHIKQGTRCKVAGWGWTSTTRDK TSVLMEVDLKVQSEDICEKSFKKNYLRESMICCGDEDGKKSTSRGDSGGPLVCNGKAHGIVSYGHKNRIFPKVFTRVSYF EPWIRKELRKFALQDLPDSPSSY >XP_003201075.3 granzyme-like protein 1 [Danio rerio] MTIITISLLLLVSLVPHLTFTARVGIVDGTEAEPHSRPYMVSLQKKSRHICGGFLIHQQFVLTAAHCWKGDPLTVVVGAH DLRMTDSSNSFKVTSYVQHPNFDLNTLKNDIMLLKLNKKVTLSNNVGLISLPKYGEDVKADTACSVAGWGRLSRKGPKPD RLREAETVIVNDAECQRRWRQTYVASEMICVYGPGGTCKGDSGGPLVCGDTAVGITSFSDPYLCNSRLLPNTYTRISAYL SWIYHLTGNV >NP_035308.2 myeloblastin precursor [Mus musculus] MAGSYPSPKGIHPFLLLALVVGGAVQASKIVGGHEARPHSRPYVASLQLSRFPGSHFCGGTLIHPRFVLT AAHCLQDISWQLVTVVLGAHDLLSSEPEQQKFTISQVFQNNYNPEENLNDVLLLQLNRTASLGKEVAVAS LPQQDQTLSQGTQCLAMGWGRLGTQAPTPRVLQELNVTVVTFLCREHNVCTLVPRRAAGICFGDSGGPLI CNGILHGVDSFVIRECASLQFPDFFARVSMYVDWIQNVLRGAEP >XP_024207540.1 myeloblastin [Pan troglodytes] MAHRPPSPALASVLLALLLSGAARAAEIVGGHEAQPHSRPYMASLQMRGNPGSHFCGGTLIHPSFVLTAA HCLQDIPQRLVNVVLGAHNVRTQEPTQQHFSVAQVFLNNYDAENKLNDVLLIQVGGQGREGSEGHGQRAP GPPFLQPAFIEHPLYTGPRPRPLQPGSGGTGGGRPLLGHQATPPPRLSPARASPQGGQAGADSK >XP_002689189.2 myeloblastin [Bos taurus] MPGSCRRPSPSLAPVLLAVLLGGAAQAVEIVGGREAQPHSRPYVASLQLASGSHFCGGTLVHPSFVLTAA HCLNNLNPQRVRVVLGAHRLQTPEPTQQRLGISRLFENNYNPQEKLNDVLLLQLDQPATLNTHVAVAQLP QQAQPLPHGTQCLAMGWGRLGTLEPLPQVLQELNVTVVTFLCRPQNVCTYVPRRSAGICFGDSGGPLICN GVLHGVDSFVIRGCATGQYPDFFARVSLYVDWINSVLSSVGGKDSP >XP_002828407.1 myeloblastin [Pongo abelii] MAHRPPSPALASVLLALLLSGAARAAEIVGGHEAQPHSRPYMASLQVRGSLGSHFCGGTLIHPRFVLTAA HCLRDIPQHLVNVVLGAHNVRTQEPTQQHFSVAQVFLNNYDAENKLNDVLLIQLSSPANLSASVATVQLP QQDQPVPHGTQCLAMGWGRVGTHDPPAQVLQELNVTVVTFLCRPHNICTFVPRRSAGICFGDSGGPLICD GVIQGIDSFVIWGCATRHFPDFFARVALYVDWIRSTLRRVEAEGRP >XP_027826496.1 myeloblastin [Ovis aries] MPGSCRSPSPSLAPVLLAMLLGGAARAAEIVGGREAQPHSRPYMASLQLASGSHFCGGTLVHPSFVLTAA HCLNNLNPQRVSVVLGAHRLQTPEPTQQRLGISRLFENNYDPQEKLNDVLLLQLDQPATLNTHVAVAQLP QQAQPLPHGTQCLAMGWGRLGTLEPLPQVLQELNVTVVTFLCRPQNVCTYVPRRSAGICFGDSGGPLICD GVLHGVDSFVIRGCATGQYPDFFARVSLYVDWINSVLSSVRGKDSP >XP_034801396.1 myeloblastin [Pan paniscus] MAHRPPSPALASVLLALLLSGAARAAEIVGGHEAQPHSRPYMASLQMRGNPGSHFCGGTLIHPSFVLTAA HCLQDIPQRLVNVVLGAHNVRTQEPTQQHFSVAQVFLNNYDAENKLNDVLLIQLSSPANLSDSVATVQLP QQDQPVPHGTQCLAMGWGRVGTHDPPAQVLQELNVTVVTFFCRPHNICTLVPRRRAGICFGDSGGPLICD GIIQGIDSFVIWGCATRLFPDFFARVALYVDWIRSTLRRVEAEGRL >XP_013850254.1 myeloblastin [Sus scrofa] MTRSCRPSSPALAPVLLALLLGGAARAVEIVGGQEAQPHSRPYVASLQLPWPPNSHFCGGTLIHPSFVLT AAHCLNTMNPTRVNVVLGAHNLQTPEPTQQIFRIARLFENNYDPQQKLNDVLLLQLDRPATLNTQVAVAQ LPQQDQLLPHGTRCLAMGWGRLGTLEPQPRVLQELNVTVVTFLCRPQNVCTFVPQRSAGICFGDSGGPLI CDGVLQGVDSFVIRGCATGQFPDFFARVALYVNWIHSVLRSVGGEDGPGAPNQNPHRR >XP_017905989.1 PREDICTED: myeloblastin [Capra hircus] MPGSCRSPGPSLAPVLLAVLLGGAARAAEIVGGREAQPHSRPYMASLQLASGSHFCGGTLVHPSFVLTAA HCLNNLNPQRVSVVLGAHRLQTPEPTQQRLSISRLFENNYDPQEKLNDVLLLQLDQPAILNTHVAVAQLP QQAQPLPHGTQCLAMGWGRLGTLEPLPQVLQELNVTVVTFLCRPQNVCTYVPRRSAGICFGDSGGPLICD GVLHGVDSFVIRGCATGQYPDFFARVSLYVDWINSVLSSVRGKDSP >XP_020746008.1 myeloblastin [Odocoileus virginianus texanus] MPGNCRSPCPSLAPVLLAVLLGGAAQAAEIVGGREAQPHSRPYMASLQLASGSHFCGGTLVHPRFVLTAA HCLNNVNPQRVRVVLGAHRLLTAEPTQQRLGISRLFENNYDPQEKLNDVLLLQLDQPATLNTHVAVAQLP QQAQPLPHGTQCLAMGWGRLGTLKPLPQVLQELNVTVVTFLCRPQNVCTYVPRRSAGICFGDSGGPLICD GILQGVDSFVIRGCATGQYPDFFARVSLYVDWIHSVLSSVGGEDSP
Mafft alignment of selected proteins >NP_002768.3 myeloblastin precursor [Homo sapiens] M--------------------AH------------RPPSPALAS-VLLALL--------- -------------------------LSGAAR----------------------------- ---------------------A-------------------------------------- ------------------------------------------------------------ ----------------------------------------------AEIVGGHEAQPHSR PYMASLQMRG---NPGSHFCGGTLIHPSFVLTAAHCLRD-IPQRLVNVVLGAHNVRTQEP TQQHFSVAQVFLN-NYD-AENKLNDVLLIQLSSPANLSASVATVQLPQQD---------- -------QPVPHGTQCLAMGWGRVGAH-DPPAQVLQELNVTVVT-FFCR----------- --PHNICTFVPRRK--AGICFGDSGGPLICDGI-----IQGIDSFVIWG-CATRLFPDFF TRVA-LYVDWIRSTLRRVEAKGRP------------------------------------ ----------------------------- >XP_018099106.1 myeloblastin [Xenopus laevis] M----------------------------------EHFLLVTLA-LLWTSQ--------- -------------------------VNGGSM----------------------------- ---------------------Q-------------------------------------- ------------------------------------------------------------ ----------------------------------------------TQIVGGREASPNSH PYIASLQL------RGRHFCGGSLIAPQFLMTAAHCMEN-TAPSVVTVVLGAHSLRENEE TKQRFRVNQVFEN-GFN-PLTLENDIVILKLDRPVSLNGKVQVVSLPNAN---------- -------EDVPAGTQCVTAGWGQLSTE-GRIPDRLQELNVTVTSRNLCR----------- --PNNICTGVFMQR--AGICFGDSGGPLVCNGV-----IQGITSFIIRT-CGNGRSPDFF SRVA-LFRSFIDNAINS------------------------------------------- ----------------------------- >XP_031571314.1 chymotrypsinogen A-like [Actinia tenebrosa] M-----------------------------------IFWAALLL-VLPALIEG------- -------------------------CGKRPA----------------------------- ---------------------G-------------------------------------- ------------------------------------------------------------ ----------------------------------------------TRVINGQDAAPHSW PWQISLRL------DGYHICGGTLIRPDWVLTAAHCVNKNPDPKRYIVAVGAHRRLSITS VERFMKIKKVIMHSGYT-DQQKLHDIALLQLRTPVTLSDKVNLACLPTTE---------- ---------AAVGAKCYITGWGRTSAS-SGSADTLQQAMLPVASHSDCKK--KFTI---V DRKAHICAGDAKSSASSGGCHGDSGGPLVCEER-GRWVQHGIVSFGKRN-C-PTTFYTVF ARVS-SYLDWVNSKITGSTPSPPSPSPPPSPEPPL----------P--PTTSPAGGCSDR SGPKACQYFKDRCSQDFVKKACQKTCGLC >XP_038051917.1 trypsin-like [Patiria miniata] M---------------------------------------LKFL-VLCALA--------- -------------------------ASVYAD----------------------------- ---------------------CG------------------------------------- ------------------------------------------------------------ --------------------------------------VQVISPSLSKIVGGDEAVPGSW PWQVMLRKKYW--GGDYQFCGGTLINDQWVVTAAHCFYNYGNINLYSAVVGAHDRDAVDA TQSSVGLAQVFLHEDYN-TRTLDNDITLLKLSSPVSLSDYVTPACLPQRE---------- ---------VATGTDCVVTGWGDQETT--VDDPALQQVVVPIISTAQCNKATWYGGD--I -TDNMICAGYSQGG--KDSCQGDSGGPFVCAASSGAYELVGVVSWGYG--CADARNPGVY AKVL-NYVDWINNIVANN------------------------------------------ ----------------------------- >XP_039266389.1 trypsin-3-like [Styela clava] M-----------------------------------FPSKFICW-TVLCFL--------- -------------------------SVRNGE----------------------------- ---------------------C-------------------------------------- ------------------------------------------------------------ ----------------------------------------------DKIVGGYEARPHSA PYIAHLDR------YSSYFCCGTLIHESWVLSAAHCHYE---PDQFKVIIGDHDRSIVEG TEQTIQAILALNHELYN-PMITDNDVMMVKLEKPAIFNQYVQLALLPTSE---------- ---------IGSGIECLACGWGYTDYTSNTLPDRLQCVEVFTVSNTECNY--MYGGE--V -KETMLCA--ESAG--KDACNGDSGGPLMCGNL-----LHGVTSTGFG--CAYPHFPGIY ARVT-EFTSWIQMVMEYN------------------------------------------ ----------------------------- >NP_726740.1 uncharacterized protein Dmel_CG32808 [Drosophila melanogaster] M------------------------------AVMAWLARLALFY-TATFLL--------- -------------------------AGASGE----------------------------- ---------------------D-------------------------------------- ------------------------------------------------------------ ----------------------------------------------GKIVNGTTAGPGEF PFVVSLRRA----KSGRHSCGATLLNPYWVLTAAHCVRG-SSPEQLDLQYGSQMLA--RN SSQVARVAAIFVHPGYEPEDKYVNDIALLQLAQSVALSKFVQPVRLPEPR---------- -------QVTPGNASAVLAGWGLNATG-GVVQQHLQKVKLQVFSDTECSE--RHQTY--L -HDSQICAGLPEGG--KGQCSGDSGGPLLLIGS---DTQVGIVSWSIKP-CARPPFPGVF TEVS-AYVDWIVETVNSYSPPSSLWVGQLIVGRS-----------P--PSLS-------- ----------------------------S >KAG6801689.1 chymotrypsin-2 [Apis mellifera caucasica] M-----------------------------------IKKFFIFC-ALIALIN-------- -------------------------ALSWNY----------------------------- ---------------------N-------------------------------------- ------------------------------------------------------------ ----------------------------------------------PKIINGEDAKEGEI PYQVSLQNKF----SSFHFCGGSILNENYVITAAHCVHG-KFSEDIKVVAGTINLANPKY EN---DVNEIIVHEKYNVSDSWKNDIALLKVKTSFTLSNTISSVPLPSPN---------- -------DIIKPNDLATVSGWGRLRQG-GPTTIYLQRVNILIANQEYCEL--TYKKINYT VYESQICAYYPTSE--KGSCNGDSGGPLTVNGK-----LVGLVSWAMG--CALIDYPTVY TRVE-SYLDWIKENA--------------------------------------------- ----------------------------V >CAE1324442.1 Plasminogen,Apolipoprotein(a),Chymotrypsinogen B2,Chymotrypsinogen A,Chymotrypsinogen 2,Chymotrypsinogen B [Sepia pharaonis] MRRIYF----FHGIC----------------LVLFSFTSSFLSLSLSLSLSLSRSLFLSR FLSLSSSLRRRGRHLISRGSHKYTASSNMSQVDHEGNIIPKRKQSGSSTVMCEHYSAWAT WSHCSRRCEQYRTRNCVEPRYCGNTTIKDKRFCKRRNKQCSILSFKVITPLRRAKEVQQI ITNAFYNKWTAWSPCSRDCKQKRKRQCRSRWKNVCGESYIQQTRKCRPVAGTCEKKYTLS VLVADEPAETKKGPTSNRHNKAITNCTAELAMPDKCGTRPSGSQRNYRIVGGYEVRRHSW PWQVAILT-----RAKKQYCGGTLISPQWVLTAAHCVRKRGRKRKVIVRMGEHDLHSRSG NEITLELEKDFPHPKFD-FHTISNDIALLKLKRPVRRSFNVGFACLPTET---------- -------NELHAGTICNIIGWGKVDGSHQDGAKILREAEVPVVDQGKCQK--AFKYK--I -TNNQICAGFKGGG--VDSCGGDSGGPLICANH-----PNRTTQWANRN-AVSVLDADFS FSPS-LFMH--------------------------------------------------- ----------------------------- >XP_030844513.1 trypsin-2 [Strongylocentrotus purpuratus] M---------------------------------------LKAI-VLLSCV--------- -------------------------AAALAD----------------------------- ---------------------CG------------------------------------- ------------------------------------------------------------ --------------------------------------KPAVDPVNTFIVGGDAAMPGSW PWQVGIRKNYLVGQGGYHMCGATLIDNQWIVSAAHCFYRWKRLSDYTITLGSHDRDEVDS TQVNAKLGGIFVHEDYN-SMTLDNDIAMLKLETPIDFNDAISEACVATSD---------- ---------YPADTMCVVTGWGDQEAA--IDNAELQQVYVPIIDTKVCNRPSWYNGE--I -TDNMFCAGYSSGG--MDSCQGDSGGPFVCKNSAGAWELTGVVSWGYG--CADPLNPGVY TRVT-QYNDWISGIKRNN------------------------------------------ ----------------------------- >NP_494910.2 Peptidase S1 domain-containing protein [Caenorhabditis elegans] M-------------------------------------KVWIFL-LLVGVINK------- -------------------------VSTDNK----NDVIEKVG----------------- ---------------------CG------------------------------------- ------------------------------------------------------------ ----------------------LHSTNVELAQTRSAQEPADYVTLDHRLIGGSESSPHSW PWTVQLLS-----RLGHHRCGGSLIDPNFVLTAAHCFAKDRRPTSYSVRVGGHR----SG SGSPHRVTAVSIHPWYNIGFPSSYDFAIMRIHPPVNTSTTARPICLPSLP---------- ---------AVENRLCVVTGWGSTIEGSSLSAPTLREIHVPLLSTLFCSSLPNYIGR--I HLPSMLCAGYSYGK--IDSCQGDSGGPLMCARD-GHWELTGVVSWGIG--CARPGMPGVY GNVH-SASTWINLEMNRLR----------------------------------------- ----------------------------I >NP_001019435.1 myeloblastin precursor [Rattus norvegicus] M----------AGI---------------------RPSLKGMHPFLLLALV--------- -------------------------FGGAVQ----------------------------- ---------------------A-------------------------------------- ------------------------------------------------------------ ----------------------------------------------SKIVGGHEARPHSR PYVASLQLSR---SPGSHFCGGTLIHPRFVLTAAHCLQD-ISWQLVTVVLGAHDLLSSEP EQQKFTITQVFEN-NYN-PEETLNDVLLLQLNRPASLGKQVAVASLPQQD---------- -------QSLSQGTQCLAMGWGRLGTR-APTPRVLHELNVTVVT-FLCR----------- --EHNVCTLVPRRA--AGICFGDSGGPLICNGI-----LHGVDSFVIRE-CASLQFPDFF ARVS-MYVNWIHSVLRSAEP---------------------------------------- ----------------------------- >KAB0359192.1 hypothetical protein FD754_003348 [Muntiacus muntjak] MSNPGVGQPQRPAECDYKRGWAHGQGGPLDHARKLQTPCPSLAP-VLLAAL--------- -------------------------LGGAAQ----------------------------- ---------------------A-------------------------------------- ------------------------------------------------------------ ----------------------------------------------AEIVGGREAQPHSR PYMASLQL-----ASGSHFCGGTLVHPRFVLTAAHCLNN-VNPQRVRVVLGAHRLLTAEP TQQRVGVSRLFKN-SYD-PQEKLNDVLLLQLDQPATLNTHVVVAQLPQQA---------- -------QPLPHGTQCLAMGWGRLGTL-EPP----------------------------- --PQNVCTYVPRRS--AGICSGDSGDPLICDGI-----LQGVDSFVIRG-CATGQYPDFF ARVS-LYVDWINSVLSSVGGEDSP------------------------------------ ----------------------------- >XP_003981686.1 neutrophil elastase [Felis catus] M----------TPSR--------------------RSAGPALAP-VLLAML--------- -------------------------LGGPAL----------------------------- ---------------------A-------------------------------------- ------------------------------------------------------------ ----------------------------------------------SEIVGGRPARPHAW PFMVSLQL------RGGHFCGGTLIAPNFVMSAAHCVDG-LNFRSVVAVLGAHDLRRREP TRQMFTIQRVFEN-GFD-PQRLLNDIVILQLNGSATINSNVRVARLPAQN---------- -------QGVGSGVQCLAMGWGQLGTT-QPPPNILQELNVTVVT-TLCP----------- --RSNVCTLVPRRQ--AGICFGDSGGPLVCNGL-----IQGIDSFIRGS-CGSGFYPDAF APVA-QFANWIDSIIRRQDDRPSVHP--RDPAS--------------------------- --------------------------RTL >NP_001003378.1 neutrophil elastase precursor [Canis lupus familiaris] M----------TARR--------------------VPAGPALGPLLLLATL--------- -------------------------LPGPAL----------------------------- ---------------------A-------------------------------------- ------------------------------------------------------------ ----------------------------------------------SEIVGGRPAQPHAW PFMVSLQR------RGGHFCGGTLIAPNFVMSAAHCVDG-LNFRSVVVVLGAHDLGERES TRQLFAVQRVFEN-GFD-PVRLVNDIVLLQLNGSATINANVQVARLPAQN---------- -------QGVGNGVQCLAMGWGQLGTA-QPPPRILQELNVTVVT-TLCR----------- --RSNVCTLVPRRR--AGICFGDSGGPLVCNGL-----IQGIDSFIRGS-CASGFFPDAF APVA-QFVDWINSIIRRPPALPPARPGQQDPERGAAR------APP--PAPHR------- --PR----------------------PTQ >KAB0387936.1 hypothetical protein FD755_002892 [Muntiacus reevesi] M---------------------------------TALRLLAVLA-SLLATS--------- -------------------------RAGSAP----------------------------- ---------------------L-------------------------------------- ------------------------------------------------------------ ----------------------------------------------VDIVGGRKARPQEL PFLASIQK------QGRHFCGGALIHPNFVLTAASCFQS-RNAGIATVVLGAYDLRRREQ SRQTFSIRSVSEN-GYD-PQQNLNDVLLLQLDRQANLTNSVAPVPLPEQN---------- -------ATVEAGTRCQVAGWGTRRRR-GRLSRVPRVLNVTVTPANQCR----------- --PNNVCTGVLTRR--GGICQGDGGTPLVCNGL-----AHGVASWSRGP-CGRG--TDFF ARVA-LFRNWIDSVINQPS----------------------------------------- ----------------------------- >XP_043345889.1 mast cell protease 3-like [Cervus canadensis] M---------------------------------------VLFL-LLVALL--------- -------------------------LSPTGE----------------------------- ---------------------A-------------------------------------- ------------------------------------------------------------ ----------------------------------------------GKIIGGHEAKPHSR PYMAFLRFKI---SGKPHMCGGFLVREDFVLTAAHCL-----GSSIDVTLGAHNIREQER TQQVIPVMRAFPHPHYN-DKTFVNDIMLLQLARKADMTDAVSPISLPRSF---------- -------EKLKPGMMCSVAGWGRLDVD-IPPADKLQEVDLEVQKDEKCIA--RFKD---Y IPIMQICAGDPNKR--KSSFSGDSGGPLVCDGV-----AQGIVSYGEV----YGTPPNVY TRVS-SFLTWIQKTMRQYKQQGS------------------------------------- ----------------------------A >AXK15893.1 granzyme B [Sparus aurata] M------------------------------------IHAYRII-LLLQLL--------- -------------------------SPTGAS----------------------------- ---------------------E-------------------------------------- ------------------------------------------------------------ ----------------------------------------------SGIVNGKVSKPHSR PYMASLQY------DGQHSCGGILIREDFVLTAAHCEDS-NQPVTMTVVLGAHNIIKKEK SQQRIKVAKYIKHPKFN--GNYDYDIMLLKLEKKATLNKFVKTIGLPKKK---------- -------GKIPANIKCTVAGWGRTGQD-KPASDVLKENTEKLQLNSKCEK--KWQTV--F DDDSMICTTFTREA--GGICQGDSGGPLICNTK-----PQGITAFTDKNDCNNPEWPHVF TKVN-AFIPWIKKVLKENRNVA-------------------------------------- ----------------------------- >XP_040178020.1 serine protease 57-like [Rana temporaria] M--------------------------------------KYLVL-LATTLC--------- -------------------------LLNLSE----------------------------- ---------------------A-------------------------------------- ------------------------------------------------------------ ----------------------------------------------YRIVGGREAKAHSR PYMVSLQI------KSQSFCGGALIDPKWVLTAAHCMED-TPVDMVRVVLGAHNLNQPDD CVQVSPVQESFQHPGYN-PNSLQNDLQLLKLNTSANITPYVKTIKLASAD---------- -------TDVLPGTSCSVAGWGYVSDF-GTLPRALMETDVNVITLAACNV--SWKQS--I -FDTMVCTASQGLR-IKGFCSGDSGGPLICEDR-----VEGVVSFSGFR-CGNPITPDVY TRVS-SFMSWIKSVINRA------------------------------------------ ----------------------------- >XP_004086989.3 granzyme E [Oryzias latipes] M------------------------------------KGACSFL-CVLLMV--------- -------------------------STAGAS----------------------------- ---------------------E-------------------------------------- ------------------------------------------------------------ ----------------------------------------------GGIFGGRVAKPHSR PYMASLQF------QGQHSCGGILIRDDYVLTSAHCKND---VQPMTVVLGAHDISKKEK TQQHFKVQKYNQHPDYK--CEQANDIMLIKLETKAKLNKYVKPIELSKKN---------- -------GDIRANIKCAVAGWGKTAVD-KPASNVLKEATEETQFKAECNN--IWKEH--F NSTQMICTKFSRKT--GGICQGDSGGPLICNTK-----PLGLAAFTKQDNCNDPKFPHVF IKIN-FYLPWIKKIMTE------------------------------------------- ----------------------------- >XP_002717971.1 PREDICTED: chymase-like [Oryctolagus cuniculus] M---------------------------------------QAVL-LLLVFL--------- -------------------------VPPEAA----------------------------- ---------------------A-------------------------------------- ------------------------------------------------------------ ----------------------------------------------EEIIGGTESKPHSR PYMAHLKIITK--QGTFAYCGGFLISREFVMTAAHCK-----GRHITVTLGAHDVVKKES TWQKIDVVKQFVHPNYN-SYTKLNDIMLLKLRWPAMLTFAVGTVPLPSRR---------- -------TFSLPGTICQAAGWGQTGVT-DPLSNTLREVNLRLMDDEVCN---HFLF---Y DHGLQMCVGDPRMA--GSAFKGDSGGPLLCAGV-----AQGIVSYTNQ----NAQPTVIF TQIF-SYMPWIKKVLKGQVATEAWP----------------------------------- ----------------------------A >XP_015822591.1 PREDICTED: trypsin-3-like [Nothobranchius furzeri] M----------------------------------NLPQVFTAL-FIFCFS--------- -------------------------ACSQAD----------------------------- ---------------------D-------------------------------------- ------------------------------------------------------------ ----------------------------------------------VRIVGGQEVEPYSI KYQASLQT-----EKGQHYCGATLVAQQWVVSAAHCWRP---NTMMRVVLSEHNLLVVEG FEQNFNVSKIFLQ-NYN-YRNYDNDIMLIKLSQPAVLNANVVPVNLPDST---------- -------TPPLRGDVCTVSGWGVTQVYSYELSPVLRAVDVREIS--VCNW--YYWGR--I -TSNMLCAGSPFGG--KDSCQGDSGGPLVCNGN-----FEGIVSWGIS--CANPYYPGVY TKVR-QYVDWINWLINADV----------------------------------------- ----------------------------- >XP_006270497.2 PREDICTED: mast cell protease 1A [Alligator mississippiensis] M--------------------------------------LLLLL-FPVTFL--------- -------------------------LPAGTG----------------------------- ---------------------A-------------------------------------- ------------------------------------------------------------ ----------------------------------------------GKIIGGREARPHSR PYMAFLNGQR---GEKKYMCGGSLVHEHFVLTAAHCS-----GDQITVLLGAHNIHKKEE SWQEIKVHRQIPHPRYK-KKTREKDIMLLQLERKANLSEQVGIIRLPQPG---------- -------EAVKPGSVCGVAGWGQTNVTFGESSNVLLEIDLEVLGDTICED--HYNCY--Y DPRTMLCVGDFKGN--KSSFQGDSGGPLVCDRV-----VQGIISWGPN----NAAPPEVY TKVS-RFIAWIKNELAKLKKPLDIPG---------------------------------- --------------------------FFS >XP_004055076.1 chymase [Gorilla gorilla gorilla] M--------------------------------------LLLPL-PLLLFL--------- -------------------------FCSRAE----------------------------- ---------------------A-------------------------------------- ------------------------------------------------------------ ----------------------------------------------GEIIGGTECKPHSR PYMAYLEIVTS--NGPSKFCGGFLIRRNFVLTAAHCA-----GRSITVTLGAHNITEEED TWQKLEVIKQFRHSKYN-TSTLHHDIMLLKLKEKASLTLAVGTLPFPSQF---------- -------NFVPPGRMCRVAGWGRTGVL-KPGSDTLQEVKLRLMDPQACS---HFRD---F DHNLQLCVGNPRKT--KSAFKGDSGGPLLCAGV-----AQGIVSYGRS----DAKPPAVF TRIS-HYRPWINQILQAN------------------------------------------ ----------------------------- >XP_014382175.2 mast cell protease 1A-like [Alligator sinensis] -----------------------------------------MPM-FSSVLK--------- -------------------------GPRKES----------------------------- ---------------------AEG------------------------------------ ----------------------------------------------KPTVG--------- --------------------------SPLLKVP-----EKKRERLRGKIIGGREARPHSR PYMAFLDGQR---GEKKYMCGGSLVHEHFVLTAAHCS-----GDQITVLLGAHNIHKKEE SWQEIKVHRQIPHPKYK-KKTREKDIMLLQLEHKANLSEQVGIIRLPQPG---------- -------EAVKPGSVCGVAGWGQTNVIFGDSSNVLLEIDLQVLGDTICED--HYSCY--Y DPRTMLCVGDFKGN--KSSFQGDSGGPLVCDRV-----VQGIISWGPN----NAAPPEVY TKVS-RFIVWIKNELAKLKKPLDIPG---------------------------------- --------------------------FFS >KAF4008330.1 hypothetical protein G4228_020050 [Cervus hanglu yarkandensis] M---------------------------------------RPLL-LLVVFL--------- -------------------------LFPRAR----------------------------- ---------------------A-------------------------------------- ------------------------------------------------------------ ----------------------------------------------GQIIGGREARPHSR PYMAFILIRA---PGGLKVCGGFLVREDFVMTAAHCL-----GSQMNVILGAHNVRTLEG TQQRVPVLRPIPHPGYS-PQSHSNDIMLLQLANRVQRNRFVRPVPLPQTR---------- -------NRLRPGTRCTVAGWGLTGLN--TRTDTLQYVQLRVQRDRLCSR--RFRS---Y NGRTQICVGDPRQR--KSAFLGDSGGPLVCNNV-----AQGIVSYGDR----MGTPPAVF TRIS-SFLPWIRRTMRRFKEWRP------------------------------------- ----------------------------E >NP_989788.1 granzyme A precursor [Gallus gallus] M----------------------------------GVFFTLSTS-AAIVLL--------- -------------------------ILPGDL----------------------------- ---------------------C-------------------------------------- ------------------------------------------------------------ ----------------------------------------------VDIIGGHEVAPHSR PFMAML--------KGKEFCGGALIKPSWVLTAAHCN-----LKGGRVILGAHSRTKREE EEQVIEIAEEIRYPDYC-PERKEHDIMLLKLKKRAKINSAVKVIPLPTSG---------- -------DDLKQGTICSVAGWGQISKRGNKMSDTLREVNVTVISRRICNDKKHYRKEPRI -TDNMICAGSKRGD--KDSCRGDSGGPLICNNV-----MKGITSFGKSP-CGDPGGPGVY TRITDKYLKWIRKTIGGDLLTG-------------------------------------- ----------------------------F >XP_003213299.1 serine protease 57 [Meleagris gallopavo] M-----------------------------------LAALLILS-LGVSAL--------- -------------------------SPAGAH----------------------------- ---------------------S-------------------------------------- ------------------------------------------------------------ ----------------------------------------------SWVIGGKAVVPHSR PFIASIQM------DGQHFCGGFLVWPKWVMTAAHCPVP-RRNPSVRVVLGAHSLEQPEE SQQEFGVEESIAHPLYN-HRTVDNDIRLLKLNHTATLNAFVKRIRLPRPR---------- -------IDLKPGTLCSVVGWGDISNY-GERPIQLMEANTTIVKRSLCRT--LWKGR--V -SGNMLCGASRNAT-LQGVCAGDSGGPLVFKGK-----VYGVVSFSGER-CGDRRYPDIY TRIS-NYIDWVHHVVLSHRQPHGQKKHKPGPEEAGGDQGAAGWGRPGLPRPSPA------ --PRALMF------------------NGN >OWK11991.1 PRSS57 [Cervus elaphus hippelaphus] M---------GLGVGD------------------WGRLLLTVTA-ALTLPM--------- -------------------------KPPGSW----------------------------- ---------------------G-------------------------------------- ------------------------------------------------------------ ----------------------------------------------AQIIGGHEVTPHSR PYMASVKF------QGQHHCGGFLLRARWVVSAAHCFSG-RDPGTGLVVLGAHALRTVEA TQQVFSISAVITHPDYQ-PTTHNSDICLLQLNSSATLGPAVGLLGLPQRG---------- ------ARPPRAGTRCKVVGWGSVSDF-EELPPGLMEAEVRVLGLDACNS--SWKGQ--L -SPAMLCTHSGDRR-RRGFCSADSGGPLVCKNR-----AYGLVSFSGLW-CGDPKTPDVY TQVS-TFVTWIWDVIWHGPQPRTTGGQQALSE----------------PQQHRV---HHR DGKRY-----------------------K >XP_005505199.2 cathepsin G [Columba livia] M---------------------------------------LFLL-LTSAFL--------- -------------------------LVSWAE----------------------------- ---------------------A-------------------------------------- ------------------------------------------------------------ ----------------------------------------------GRIIGGQEARPHSR RYMAYVSIGS---RSGTSNCGGFLIHPYAVLSAAHCVAG-KTGVNITVTLGAHNIKKEEL SQQKFHIGRWVIHPNYS-GDTLANDIMLLKLKPNAKLTKQVNRVPLPRHN---------- -------EHIKQGTRCKVAGWGWTSTT-RDKTSVLMEVDLKVQSEDICEK--SFKKN--Y LRESMICCGDEDGK--KSTSRGDSGGPLVCNGK-----AHGIVSYGHK----NRIFPKVF TRVS-YFEPWIRKELRKFALQDLPDSPSS------------------------------- ----------------------------Y >XP_003201075.3 granzyme-like protein 1 [Danio rerio] M-----------------------------------TIITISLL-LLVSLVP-------- -------------------------HLTFTA----------------------------- ---------------------R-------------------------------------- ------------------------------------------------------------ ----------------------------------------------VGIVDGTEAEPHSR PYMVSLQK------KSRHICGGFLIHQQFVLTAAHCWKG----DPLTVVVGAHDLRMTDS SN-SFKVTSYVQHPNFD-LNTLKNDIMLLKLNKKVTLSNNVGLISLPKYG---------- -------EDVKADTACSVAGWGRLSRK-GPKPDRLREAETVIVNDAECQR--RWRQT--Y VASEMICVYGP-----GGTCKGDSGGPLVCGDT-----AVGITSFSDPYLCNSRLLPNTY TRIS-AYLSWIYHLTGNV------------------------------------------ ----------------------------- >NP_035308.2 myeloblastin precursor [Mus musculus] M----------AGS---------------------YPSPKGIHPFLLLALV--------- -------------------------VGGAVQ----------------------------- ---------------------A-------------------------------------- ------------------------------------------------------------ ----------------------------------------------SKIVGGHEARPHSR PYVASLQLSR---FPGSHFCGGTLIHPRFVLTAAHCLQD-ISWQLVTVVLGAHDLLSSEP EQQKFTISQVFQN-NYN-PEENLNDVLLLQLNRTASLGKEVAVASLPQQD---------- -------QTLSQGTQCLAMGWGRLGTQ-APTPRVLQELNVTVVT-FLCR----------- --EHNVCTLVPRRA--AGICFGDSGGPLICNGI-----LHGVDSFVIRE-CASLQFPDFF ARVS-MYVDWIQNVLRGAEP---------------------------------------- ----------------------------- >XP_024207540.1 myeloblastin [Pan troglodytes] M--------------------AH------------RPPSPALAS-VLLALL--------- -------------------------LSGAAR----------------------------- ---------------------A-------------------------------------- ------------------------------------------------------------ ----------------------------------------------AEIVGGHEAQPHSR PYMASLQMRG---NPGSHFCGGTLIHPSFVLTAAHCLQD-IPQRLVNVVLGAHNVRTQEP TQQHFSVAQVFLN-NYD-AENKLNDVLLIQVGGQGREGSEGHGQRAPGPPFLQPAFIEHP LYTGPRPRPLQPGSGGTGGGRPLLGHQ-ATPPPRLSPARASPQ----------------- ----------------GGQAGADSK----------------------------------- ------------------------------------------------------------ ----------------------------- >XP_002689189.2 myeloblastin [Bos taurus] M----------PGSC--------------------RRPSPSLAP-VLLAVL--------- -------------------------LGGAAQ----------------------------- ---------------------A-------------------------------------- ------------------------------------------------------------ ----------------------------------------------VEIVGGREAQPHSR PYVASLQL-----ASGSHFCGGTLVHPSFVLTAAHCLNN-LNPQRVRVVLGAHRLQTPEP TQQRLGISRLFEN-NYN-PQEKLNDVLLLQLDQPATLNTHVAVAQLPQQA---------- -------QPLPHGTQCLAMGWGRLGTL-EPLPQVLQELNVTVVT-FLCR----------- --PQNVCTYVPRRS--AGICFGDSGGPLICNGV-----LHGVDSFVIRG-CATGQYPDFF ARVS-LYVDWINSVLSSVGGKDSP------------------------------------ ----------------------------- >XP_002828407.1 myeloblastin [Pongo abelii] M--------------------AH------------RPPSPALAS-VLLALL--------- -------------------------LSGAAR----------------------------- ---------------------A-------------------------------------- ------------------------------------------------------------ ----------------------------------------------AEIVGGHEAQPHSR PYMASLQVRG---SLGSHFCGGTLIHPRFVLTAAHCLRD-IPQHLVNVVLGAHNVRTQEP TQQHFSVAQVFLN-NYD-AENKLNDVLLIQLSSPANLSASVATVQLPQQD---------- -------QPVPHGTQCLAMGWGRVGTH-DPPAQVLQELNVTVVT-FLCR----------- --PHNICTFVPRRS--AGICFGDSGGPLICDGV-----IQGIDSFVIWG-CATRHFPDFF ARVA-LYVDWIRSTLRRVEAEGRP------------------------------------ ----------------------------- >XP_027826496.1 myeloblastin [Ovis aries] M----------PGSC--------------------RSPSPSLAP-VLLAML--------- -------------------------LGGAAR----------------------------- ---------------------A-------------------------------------- ------------------------------------------------------------ ----------------------------------------------AEIVGGREAQPHSR PYMASLQL-----ASGSHFCGGTLVHPSFVLTAAHCLNN-LNPQRVSVVLGAHRLQTPEP TQQRLGISRLFEN-NYD-PQEKLNDVLLLQLDQPATLNTHVAVAQLPQQA---------- -------QPLPHGTQCLAMGWGRLGTL-EPLPQVLQELNVTVVT-FLCR----------- --PQNVCTYVPRRS--AGICFGDSGGPLICDGV-----LHGVDSFVIRG-CATGQYPDFF ARVS-LYVDWINSVLSSVRGKDSP------------------------------------ ----------------------------- >XP_034801396.1 myeloblastin [Pan paniscus] M--------------------AH------------RPPSPALAS-VLLALL--------- -------------------------LSGAAR----------------------------- ---------------------A-------------------------------------- ------------------------------------------------------------ ----------------------------------------------AEIVGGHEAQPHSR PYMASLQMRG---NPGSHFCGGTLIHPSFVLTAAHCLQD-IPQRLVNVVLGAHNVRTQEP TQQHFSVAQVFLN-NYD-AENKLNDVLLIQLSSPANLSDSVATVQLPQQD---------- -------QPVPHGTQCLAMGWGRVGTH-DPPAQVLQELNVTVVT-FFCR----------- --PHNICTLVPRRR--AGICFGDSGGPLICDGI-----IQGIDSFVIWG-CATRLFPDFF ARVA-LYVDWIRSTLRRVEAEGRL------------------------------------ ----------------------------- >XP_013850254.1 myeloblastin [Sus scrofa] M----------TRSC--------------------RPSSPALAP-VLLALL--------- -------------------------LGGAAR----------------------------- ---------------------A-------------------------------------- ------------------------------------------------------------ ----------------------------------------------VEIVGGQEAQPHSR PYVASLQLPW---PPNSHFCGGTLIHPSFVLTAAHCLNT-MNPTRVNVVLGAHNLQTPEP TQQIFRIARLFEN-NYD-PQQKLNDVLLLQLDRPATLNTQVAVAQLPQQD---------- -------QLLPHGTRCLAMGWGRLGTL-EPQPRVLQELNVTVVT-FLCR----------- --PQNVCTFVPQRS--AGICFGDSGGPLICDGV-----LQGVDSFVIRG-CATGQFPDFF ARVA-LYVNWIHSVLRSVGGEDGPGAPNQNPHRR-------------------------- ----------------------------- >XP_017905989.1 PREDICTED: myeloblastin [Capra hircus] M----------PGSC--------------------RSPGPSLAP-VLLAVL--------- -------------------------LGGAAR----------------------------- ---------------------A-------------------------------------- ------------------------------------------------------------ ----------------------------------------------AEIVGGREAQPHSR PYMASLQL-----ASGSHFCGGTLVHPSFVLTAAHCLNN-LNPQRVSVVLGAHRLQTPEP TQQRLSISRLFEN-NYD-PQEKLNDVLLLQLDQPAILNTHVAVAQLPQQA---------- -------QPLPHGTQCLAMGWGRLGTL-EPLPQVLQELNVTVVT-FLCR----------- --PQNVCTYVPRRS--AGICFGDSGGPLICDGV-----LHGVDSFVIRG-CATGQYPDFF ARVS-LYVDWINSVLSSVRGKDSP------------------------------------ ----------------------------- >XP_020746008.1 myeloblastin [Odocoileus virginianus texanus] M----------PGNC--------------------RSPCPSLAP-VLLAVL--------- -------------------------LGGAAQ----------------------------- ---------------------A-------------------------------------- ------------------------------------------------------------ ----------------------------------------------AEIVGGREAQPHSR PYMASLQL-----ASGSHFCGGTLVHPRFVLTAAHCLNN-VNPQRVRVVLGAHRLLTAEP TQQRLGISRLFEN-NYD-PQEKLNDVLLLQLDQPATLNTHVAVAQLPQQA---------- -------QPLPHGTQCLAMGWGRLGTL-KPLPQVLQELNVTVVT-FLCR----------- --PQNVCTYVPRRS--AGICFGDSGGPLICDGI-----LQGVDSFVIRG-CATGQYPDFF ARVS-LYVDWIHSVLSSVGGEDSP------------------------------------ -----------------------------
BMGE Cleaned alignment of selected proteins >NP_002768.3 myeloblastin precursor [Homo sapiens] VLLALLEIVGGHEAQPHSRPYMASLQSHFCGGTLIHSFVLTAAHCLNVVLGAHNVLN-NYDLNDVLLIQLSPANLSHGTQCLAMGWGRVGVLQELNNICTFVAGICFGDSGGPLICDGIQGIDSFVFPDFFTRVALYVDWIR >XP_018099106.1 myeloblastin [Xenopus laevis] LLWTSQQIVGGREASPNSHPYIASLQRHFCGGSLIAQFLMTAAHCMTVVLGAHSLEN-GFNENDIVILKLDPVSLNAGTQCVTAGWGQLSRLQELNNICTGVAGICFGDSGGPLVCNGVQGITSFISPDFFSRVALFRSFID >XP_031571314.1 chymotrypsinogen A-like [Actinia tenebrosa] VLPALIRVINGQDAAPHSWPWQISLRYHICGGTLIRDWVLTAAHCVIVAVGAHRRMHSGYTLHDIALLQLRPVTLSVGAKCYITGWGRTSTLQQAMHICAGDSGGCHGDSGGPLVCEERHGIVSFGFYTVFARVSSYLDWVN >XP_038051917.1 trypsin-like [Patiria miniata] VLCALAKIVGGDEAVPGSWPWQVMLRYQFCGGTLINQWVVTAAHCFSAVVGAHDRLHEDYNDNDITLLKLSPVSLSTGTDCVVTGWGDQEALQQVVMICAGYKDSCQGDSGGPFVCAASVGVVSWGNPGVYAKVLNYVDWIN >XP_039266389.1 trypsin-3-like [Styela clava] TVLCFLKIVGGYEARPHSAPYIAHLDSYFCCGTLIHSWVLSAAHCHKVIIGDHDRNHELYNDNDVMMVKLEPAIFNSGIECLACGWGYTDRLQCVEMLCA--KDACNGDSGGPLMCGNLHGVTSTGFPGIYARVTEFTSWIQ >NP_726740.1 uncharacterized protein Dmel_CG32808 [Drosophila melanogaster] TATFLLKIVNGTTAGPGEFPFVVSLRRHSCGATLLNYWVLTAAHCVDLQYGSQMLVHPGYEVNDIALLQLASVALSGNASAVLAGWGLNAHLQKVKQICAGLKGQCSGDSGGPLLLIGSVGIVSWSFPGVFTEVSAYVDWIV >KAG6801689.1 chymotrypsin-2 [Apis mellifera caucasica] ALIALIKIINGEDAKEGEIPYQVSLQFHFCGGSILNNYVITAAHCVKVVAGTINLVHEKYNKNDIALLKVKSFTLSPNDLATVSGWGRLRYLQRVNQICAYYKGSCNGDSGGPLTVNGKVGLVSWAYPTVYTRVESYLDWIK >CAE1324442.1 Plasminogen,Apolipoprotein(a),Chymotrypsinogen B2,Chymotrypsinogen A,Chymotrypsinogen 2,Chymotrypsinogen B [Sepia pharaonis] LSLSLSRIVGGYEVRRHSWPWQVAILKQYCGGTLISQWVLTAAHCVIVRMGEHDLPHPKFDSNDIALLKLKPVRRSAGTICNIIGWGKVDILREAEQICAGFVDSCGGDSGGPLICANHNRTTQWADADFSFSPSLFMH--- >XP_030844513.1 trypsin-2 [Strongylocentrotus purpuratus] VLLSCVFIVGGDAAMPGSWPWQVGIRYHMCGATLIDQWIVSAAHCFTITLGSHDRVHEDYNDNDIAMLKLEPIDFNADTMCVVTGWGDQEELQQVYMFCAGYMDSCQGDSGGPFVCKNSTGVVSWGNPGVYTRVTQYNDWIS >NP_494910.2 Peptidase S1 domain-containing protein [Caenorhabditis elegans] LLVGVIRLIGGSESSPHSWPWTVQLLHHRCGGSLIDNFVLTAAHCFSVRVGGHR-IHPWYNSYDFAIMRIHPVNTSENRLCVVTGWGSTITLREIHMLCAGYIDSCQGDSGGPLMCARDTGVVSWGMPGVYGNVHSASTWIN >NP_001019435.1 myeloblastin precursor [Rattus norvegicus] LLLALVKIVGGHEARPHSRPYVASLQSHFCGGTLIHRFVLTAAHCLTVVLGAHDLEN-NYNLNDVLLLQLNPASLGQGTQCLAMGWGRLGVLHELNNVCTLVAGICFGDSGGPLICNGIHGVDSFVFPDFFARVSMYVNWIH >KAB0359192.1 hypothetical protein FD754_003348 [Muntiacus muntjak] VLLAALEIVGGREAQPHSRPYMASLQSHFCGGTLVHRFVLTAAHCLRVVLGAHRLKN-SYDLNDVLLLQLDPATLNHGTQCLAMGWGRLG------NVCTYVAGICSGDSGDPLICDGIQGVDSFVYPDFFARVSLYVDWIN >XP_003981686.1 neutrophil elastase [Felis catus] VLLAMLEIVGGRPARPHAWPFMVSLQGHFCGGTLIANFVMSAAHCVVAVLGAHDLEN-GFDLNDIVILQLNSATINSGVQCLAMGWGQLGILQELNNVCTLVAGICFGDSGGPLVCNGLQGIDSFIYPDAFAPVAQFANWID >NP_001003378.1 neutrophil elastase precursor [Canis lupus familiaris] LLLATLEIVGGRPAQPHAWPFMVSLQGHFCGGTLIANFVMSAAHCVVVVLGAHDLEN-GFDVNDIVLLQLNSATINNGVQCLAMGWGQLGILQELNNVCTLVAGICFGDSGGPLVCNGLQGIDSFIFPDAFAPVAQFVDWIN >KAB0387936.1 hypothetical protein FD755_002892 [Muntiacus reevesi] SLLATSDIVGGRKARPQELPFLASIQRHFCGGALIHNFVLTAASCFTVVLGAYDLEN-GYDLNDVLLLQLDQANLTAGTRCQVAGWGTRRVPRVLNNVCTGVGGICQGDGGTPLVCNGLHGVASWS-TDFFARVALFRNWID >XP_043345889.1 mast cell protease 3-like [Cervus canadensis] LLVALLKIIGGHEAKPHSRPYMAFLRPHMCGGFLVRDFVLTAAHCLDVTLGAHNIPHPHYNVNDIMLLQLAKADMTPGMMCSVAGWGRLDKLQEVDQICAGDKSSFSGDSGGPLVCDGVQGIVSYGPPNVYTRVSSFLTWIQ >AXK15893.1 granzyme B [Sparus aurata] LLLQLLGIVNGKVSKPHSRPYMASLQQHSCGGILIRDFVLTAAHCETVVLGAHNIKHPKFNDYDIMLLKLEKATLNANIKCTVAGWGRTGVLKENTMICTTFGGICQGDSGGPLICNTKQGITAFTWPHVFTKVNAFIPWIK >XP_040178020.1 serine protease 57-like [Rana temporaria] LATTLCRIVGGREAKAHSRPYMVSLQQSFCGGALIDKWVLTAAHCMRVVLGAHNLQHPGYNQNDLQLLKLNSANITPGTSCSVAGWGYVSALMETDMVCTASKGFCSGDSGGPLICEDREGVVSFSTPDVYTRVSSFMSWIK >XP_004086989.3 granzyme E [Oryzias latipes] CVLLMVGIFGGRVAKPHSRPYMASLQQHSCGGILIRDYVLTSAHCKTVVLGAHDIQHPDYKANDIMLIKLEKAKLNANIKCAVAGWGKTAVLKEATMICTKFGGICQGDSGGPLICNTKLGLAAFTFPHVFIKINFYLPWIK >XP_002717971.1 PREDICTED: chymase-like [Oryctolagus cuniculus] LLLVFLEIIGGTESKPHSRPYMAHLKFAYCGGFLISEFVMTAAHCKTVTLGAHDVVHPNYNLNDIMLLKLRPAMLTPGTICQAAGWGQTGTLREVNQMCVGDGSAFKGDSGGPLLCAGVQGIVSYTPTVIFTQIFSYMPWIK >XP_015822591.1 PREDICTED: trypsin-3-like [Nothobranchius furzeri] FIFCFSRIVGGQEVEPYSIKYQASLQQHYCGATLVAQWVVSAAHCWRVVLSEHNLLQ-NYNDNDIMLIKLSPAVLNRGDVCTVSGWGVTQVLRAVDMLCAGSKDSCQGDSGGPLVCNGNEGIVSWGYPGVYTKVRQYVDWIN >XP_006270497.2 PREDICTED: mast cell protease 1A [Alligator mississippiensis] FPVTFLKIIGGREARPHSRPYMAFLNKYMCGGSLVHHFVLTAAHCSTVLLGAHNIPHPRYKEKDIMLLQLEKANLSPGSVCGVAGWGQTNVLLEIDMLCVGDKSSFQGDSGGPLVCDRVQGIISWGPPEVYTKVSRFIAWIK >XP_004055076.1 chymase [Gorilla gorilla gorilla] PLLLFLEIIGGTECKPHSRPYMAYLESKFCGGFLIRNFVLTAAHCATVTLGAHNIRHSKYNHHDIMLLKLKKASLTPGRMCRVAGWGRTGTLQEVKQLCVGNKSAFKGDSGGPLLCAGVQGIVSYGPPAVFTRISHYRPWIN >XP_014382175.2 mast cell protease 1A-like [Alligator sinensis] FSSVLKKIIGGREARPHSRPYMAFLDKYMCGGSLVHHFVLTAAHCSTVLLGAHNIPHPKYKEKDIMLLQLEKANLSPGSVCGVAGWGQTNVLLEIDMLCVGDKSSFQGDSGGPLVCDRVQGIISWGPPEVYTKVSRFIVWIK >KAF4008330.1 hypothetical protein G4228_020050 [Cervus hanglu yarkandensis] LLVVFLQIIGGREARPHSRPYMAFILLKVCGGFLVRDFVMTAAHCLNVILGAHNVPHPGYSSNDIMLLQLARVQRNPGTRCTVAGWGLTGTLQYVQQICVGDKSAFLGDSGGPLVCNNVQGIVSYGPPAVFTRISSFLPWIR >NP_989788.1 granzyme A precursor [Gallus gallus] AAIVLLDIIGGHEVAPHSRPFMAML-KEFCGGALIKSWVLTAAHCNRVILGAHSRRYPDYCEHDIMLLKLKRAKINQGTICSVAGWGQISTLREVNMICAGSKDSCRGDSGGPLICNNVKGITSFGGPGVYTRITKYLKWIR >XP_003213299.1 serine protease 57 [Meleagris gallopavo] LGVSALWVIGGKAVVPHSRPFIASIQQHFCGGFLVWKWVMTAAHCPRVVLGAHSLAHPLYNDNDIRLLKLNTATLNPGTLCSVVGWGDISQLMEANMLCGASQGVCAGDSGGPLVFKGKYGVVSFSYPDIYTRISNYIDWVH >OWK11991.1 PRSS57 [Cervus elaphus hippelaphus] ALTLPMQIIGGHEVTPHSRPYMASVKQHHCGGFLLRRWVVSAAHCFLVVLGAHALTHPDYQNSDICLLQLNSATLGAGTRCKVVGWGSVSGLMEAEMLCTHSRGFCSADSGGPLVCKNRYGLVSFSTPDVYTQVSTFVTWIW >XP_005505199.2 cathepsin G [Columba livia] LTSAFLRIIGGQEARPHSRRYMAYVSTSNCGGFLIHYAVLSAAHCVTVTLGAHNIIHPNYSANDIMLLKLKNAKLTQGTRCKVAGWGWTSVLMEVDMICCGDKSTSRGDSGGPLVCNGKHGIVSYGFPKVFTRVSYFEPWIR >XP_003201075.3 granzyme-like protein 1 [Danio rerio] LLVSLVGIVDGTEAEPHSRPYMVSLQRHICGGFLIHQFVLTAAHCWTVVVGAHDLQHPNFDKNDIMLLKLNKVTLSADTACSVAGWGRLSRLREAEMICVYGGGTCKGDSGGPLVCGDTVGITSFSLPNTYTRISAYLSWIY >NP_035308.2 myeloblastin precursor [Mus musculus] LLLALVKIVGGHEARPHSRPYVASLQSHFCGGTLIHRFVLTAAHCLTVVLGAHDLQN-NYNLNDVLLLQLNTASLGQGTQCLAMGWGRLGVLQELNNVCTLVAGICFGDSGGPLICNGIHGVDSFVFPDFFARVSMYVDWIQ >XP_024207540.1 myeloblastin [Pan troglodytes] VLLALLEIVGGHEAQPHSRPYMASLQSHFCGGTLIHSFVLTAAHCLNVVLGAHNVLN-NYDLNDVLLIQVGQGREGPGSGGTGGGRPLLGRLSPAR------GGQAGADSK------------------------------- >XP_002689189.2 myeloblastin [Bos taurus] VLLAVLEIVGGREAQPHSRPYVASLQSHFCGGTLVHSFVLTAAHCLRVVLGAHRLEN-NYNLNDVLLLQLDPATLNHGTQCLAMGWGRLGVLQELNNVCTYVAGICFGDSGGPLICNGVHGVDSFVYPDFFARVSLYVDWIN >XP_002828407.1 myeloblastin [Pongo abelii] VLLALLEIVGGHEAQPHSRPYMASLQSHFCGGTLIHRFVLTAAHCLNVVLGAHNVLN-NYDLNDVLLIQLSPANLSHGTQCLAMGWGRVGVLQELNNICTFVAGICFGDSGGPLICDGVQGIDSFVFPDFFARVALYVDWIR >XP_027826496.1 myeloblastin [Ovis aries] VLLAMLEIVGGREAQPHSRPYMASLQSHFCGGTLVHSFVLTAAHCLSVVLGAHRLEN-NYDLNDVLLLQLDPATLNHGTQCLAMGWGRLGVLQELNNVCTYVAGICFGDSGGPLICDGVHGVDSFVYPDFFARVSLYVDWIN >XP_034801396.1 myeloblastin [Pan paniscus] VLLALLEIVGGHEAQPHSRPYMASLQSHFCGGTLIHSFVLTAAHCLNVVLGAHNVLN-NYDLNDVLLIQLSPANLSHGTQCLAMGWGRVGVLQELNNICTLVAGICFGDSGGPLICDGIQGIDSFVFPDFFARVALYVDWIR >XP_013850254.1 myeloblastin [Sus scrofa] VLLALLEIVGGQEAQPHSRPYVASLQSHFCGGTLIHSFVLTAAHCLNVVLGAHNLEN-NYDLNDVLLLQLDPATLNHGTRCLAMGWGRLGVLQELNNVCTFVAGICFGDSGGPLICDGVQGVDSFVFPDFFARVALYVNWIH >XP_017905989.1 PREDICTED: myeloblastin [Capra hircus] VLLAVLEIVGGREAQPHSRPYMASLQSHFCGGTLVHSFVLTAAHCLSVVLGAHRLEN-NYDLNDVLLLQLDPAILNHGTQCLAMGWGRLGVLQELNNVCTYVAGICFGDSGGPLICDGVHGVDSFVYPDFFARVSLYVDWIN >XP_020746008.1 myeloblastin [Odocoileus virginianus texanus] VLLAVLEIVGGREAQPHSRPYMASLQSHFCGGTLVHRFVLTAAHCLRVVLGAHRLEN-NYDLNDVLLLQLDPATLNHGTQCLAMGWGRLGVLQELNNVCTYVAGICFGDSGGPLICDGIQGVDSFVYPDFFARVSLYVDWIH
PhyML tree of selected proteins (XP_006270497_2_PREDICTED__mast_cell_protease_1A__Alligator_mississippiensis_:0.00000001,XP_014382175_2_mast_cell_protease_1A_like__Alligator_sinensis_:0.06135022,((XP_043345889_1_mast_cell_protease_3_like__Cervus_canadensis_:0.1590528,(KAF4008330_1_hypothetical_protein_G4228_020050__Cervus_hanglu_yarkandensis_:0.22677954,(XP_004055076_1_chymase__Gorilla_gorilla_gorilla_:0.16309775,XP_002717971_1_PREDICTED__chymase_like__Oryctolagus_cuniculus_:0.27445394):0.16122746):0.0980063):0.04567258,(XP_005505199_2_cathepsin_G__Columba_livia_:0.3660831,(((NP_989788_1_granzyme_A_precursor__Gallus_gallus_:0.43092828,XP_039266389_1_trypsin_3_like__Styela_clava_:0.72009617):0.09208924,(XP_015822591_1_PREDICTED__trypsin_3_like__Nothobranchius_furzeri_:0.41010706,((NP_494910_2_Peptidase_S1_domain_containing_protein__Caenorhabditis_elegans_:0.6452582,CAE1324442_1_Plasminogen_Apolipoprotein_a__Chymotrypsinogen_B2_Chymotrypsinogen_A_Chymotrypsinogen_2_Chymotrypsinogen_B__Sepia_pharaonis_:0.85168116):0.09456717,((XP_038051917_1_trypsin_like__Patiria_miniata_:0.15307077,XP_030844513_1_trypsin_2__Strongylocentrotus_purpuratus_:0.33388666):0.24254945,(XP_031571314_1_chymotrypsinogen_A_like__Actinia_tenebrosa_:0.5236188,(NP_726740_1_uncharacterized_protein_Dmel_CG32808__Drosophila_melanogaster_:0.71273524,KAG6801689_1_chymotrypsin_2__Apis_mellifera_caucasica_:0.41659977):0.19060029):0.08151253):0.01962552):0.16696886):0.08091427):0.06959136,((XP_040178020_1_serine_protease_57_like__Rana_temporaria_:0.25030297,(XP_003213299_1_serine_protease_57__Meleagris_gallopavo_:0.35015488,OWK11991_1_PRSS57__Cervus_elaphus_hippelaphus_:0.41815801):0.11704532):0.1082229,(XP_003201075_3_granzyme_like_protein_1__Danio_rerio_:0.36779467,((XP_004086989_3_granzyme_E__Oryzias_latipes_:0.21950826,AXK15893_1_granzyme_B__Sparus_aurata_:0.08574545):0.2820865,(XP_018099106_1_myeloblastin__Xenopus_laevis_:0.26409676,(KAB0387936_1_hypothetical_protein_FD755_002892__Muntiacus_reevesi_:0.4460117,((XP_003981686_1_neutrophil_elastase__Felis_catus_:0.054153,NP_001003378_1_neutrophil_elastase_precursor__Canis_lupus_familiaris_:0.02361505):0.23163994,(((XP_013850254_1_myeloblastin__Sus_scrofa_:0.01461647,(NP_001019435_1_myeloblastin_precursor__Rattus_norvegicus_:0.00763195,NP_035308_2_myeloblastin_precursor__Mus_musculus_:0.0265343):0.14006834):0.01328781,(XP_024207540_1_myeloblastin__Pan_troglodytes_:0.43178718,(XP_002828407_1_myeloblastin__Pongo_abelii_:0.00810758,(NP_002768_3_myeloblastin_precursor__Homo_sapiens_:0.00678163,XP_034801396_1_myeloblastin__Pan_paniscus_:0.00676857):0.00536647):0.00882357):0.07071313):0.02648134,(XP_027826496_1_myeloblastin__Ovis_aries_:0.00000001,(XP_017905989_1_PREDICTED__myeloblastin__Capra_hircus_:0.00689784,(XP_002689189_2_myeloblastin__Bos_taurus_:0.02080923,(KAB0359192_1_hypothetical_protein_FD754_003348__Muntiacus_muntjak_:0.03815386,XP_020746008_1_myeloblastin__Odocoileus_virginianus_texanus_:0.00674488):0.02119558):0.0069927):0.00689508):0.04567706):0.07589452):0.09982637):0.07286977):0.28249932):0.04026599):0.07572747):0.06973295):0.15057825):0.08081453):0.30992419);
BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)