PB0013

DATABASE

Click here to access PB0013 phyletic profile

PBID	Uniprot	Name	Gene	Alternative	Organism	Uniprot Description
PB0013	P08311	Cathepsin G	CTSG	CG, CATG	Homo_sapiens	Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe-CH2Cl and phenylmethylsulfonyl fluoride.

Domains

Gene Ontology

PF00089 (Trypsin)

GO:0062023 (colocalizes with) collagen-containing extracellular matrix GO:0004252 (enables) serine-type endopeptidase activity GO:0005515 (enables) protein binding GO:0008201 (enables) heparin binding GO:0008233 (enables) peptidase activity GO:0008236 (enables) serine-type peptidase activity GO:0016787 (enables) hydrolase activity GO:0089720 (enables) caspase binding GO:0002003 (involved in) angiotensin maturation GO:0006468 (involved in) protein phosphorylation GO:0006508 (involved in) proteolysis GO:0006955 (involved in) immune response GO:0016485 (involved in) protein processing GO:0019221 (involved in) cytokine-mediated signaling pathway GO:0019731 (involved in) antibacterial humoral response GO:0022617 (involved in) extracellular matrix disassembly GO:0032496 (involved in) response to lipopolysaccharide GO:0035590 (involved in) purinergic nucleotide receptor signaling pathway GO:0042742 (involved in) defense response to bacterium GO:0044267 (involved in) cellular protein metabolic process GO:0050778 (involved in) positive regulation of immune response GO:0050829 (involved in) defense response to Gram-negative bacterium GO:0050830 (involved in) defense response to Gram-positive bacterium GO:0050832 (involved in) defense response to fungus GO:0070946 (involved in) neutrophil-mediated killing of gram-positive bacterium GO:0071222 (involved in) cellular response to lipopolysaccharide GO:0098786 (involved in) biofilm matrix disassembly GO:1901731 (involved in) positive regulation of platelet aggregation GO:0005737 (is active in) cytoplasm GO:0043231 (is active in) intracellular membrane-bounded organelle GO:0005576 (located in) extracellular region GO:0005615 (located in) extracellular space GO:0005634 (located in) nucleus GO:0005829 (located in) cytosol GO:0005886 (located in) plasma membrane GO:0009986 (located in) cell surface GO:0010494 (located in) cytoplasmic stress granule GO:0016020 (located in) membrane GO:0030141 (located in) secretory granule GO:0035578 (located in) azurophil granule lumen GO:0070062 (located in) extracellular exosome

External Links	Description
Intact	Open source database system and analysis tools for molecular interaction data.
Protein Atlas	An open access resource for human proteins
InterPro (new pfam)	InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish) >sp|P08311|CATG_HUMAN Cathepsin G OS=Homo sapiens OX=9606 GN=CTSG PE=1 SV=2 MQPLLLLLAFLLPTGAEAGEIIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVL TAAHCWGSNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRRVRR NRNVNPVALPRAQEGLRPGTLCTVAGWGRVSMRRGTDTLREVQLRVQRDRQCLRIFGSYD PRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGKSSGVPPEVFTRVSSFLPWIRT TMRSFKLLDQMETPL
Selected proteins from model organisms >NP_001902.1 cathepsin G preproprotein [Homo sapiens] MQPLLLLLAFLLPTGAEAGEIIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVLTAAHCWGSNI NVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRRVRRNRNVNPVALPRAQEGLRPGT LCTVAGWGRVSMRRGTDTLREVQLRVQRDRQCLRIFGSYDPRRQICVGDRRERKAAFKGDSGGPLLCNNV AHGIVSYGKSSGVPPEVFTRVSSFLPWIRTTMRSFKLLDQMETPL >XP_039266389.1 trypsin-3-like [Styela clava] MFPSKFICWTVLCFLSVRNGECDKIVGGYEARPHSAPYIAHLDRYSSYFCCGTLIHESWVLSAAHCHYEPDQFKVIIGDH DRSIVEGTEQTIQAILALNHELYNPMITDNDVMMVKLEKPAIFNQYVQLALLPTSEIGSGIECLACGWGYTDYTSNTLPD RLQCVEVFTVSNTECNYMYGGEVKETMLCAESAGKDACNGDSGGPLMCGNLLHGVTSTGFGCAYPHFPGIYARVTEFTSW IQMVMEYN >XP_031571314.1 chymotrypsinogen A-like [Actinia tenebrosa] MIFWAALLLVLPALIEGCGKRPAGTRVINGQDAAPHSWPWQISLRLDGYHICGGTLIRPDWVLTAAHCVNKNPDPKRYIV AVGAHRRLSITSVERFMKIKKVIMHSGYTDQQKLHDIALLQLRTPVTLSDKVNLACLPTTEAAVGAKCYITGWGRTSASS GSADTLQQAMLPVASHSDCKKKFTIVDRKAHICAGDAKSSASSGGCHGDSGGPLVCEERGRWVQHGIVSFGKRNCPTTFY TVFARVSSYLDWVNSKITGSTPSPPSPSPPPSPEPPLPPTTSPAGGCSDRSGPKACQYFKDRCSQDFVKKACQKTCGLC >XP_030844513.1 trypsin-2 [Strongylocentrotus purpuratus] MLKAIVLLSCVAAALADCGKPAVDPVNTFIVGGDAAMPGSWPWQVGIRKNYLVGQGGYHMCGATLIDNQWIVSAAHCFYR WKRLSDYTITLGSHDRDEVDSTQVNAKLGGIFVHEDYNSMTLDNDIAMLKLETPIDFNDAISEACVATSDYPADTMCVVT GWGDQEAAIDNAELQQVYVPIIDTKVCNRPSWYNGEITDNMFCAGYSSGGMDSCQGDSGGPFVCKNSAGAWELTGVVSWG YGCADPLNPGVYTRVTQYNDWISGIKRNN >XP_016768428.1 trypsin-7 [Apis mellifera] MWRVLLLLSTVLYITHCLQPRIIGGHNASIIEYPYQVSIHYMGKHHCGGSIISENWLLTAAHCIYGLIPVNFKIRAGSIY NNNGIEYNIKNIIMHEKYNIYTFDYDVALIMLSTPIKISPTTKPIALAQSTTSVEIGKNAVVTGWGYLSVNSNSMSDILQ VLTLPIVDQNVCKTIFSGINTVTENMICAGSLTGKDTCKGDSGGPLVYNNVQIGIVSWGLKCALPNYPGVYTRVSAIRDW IKKKTGV >XP_038051917.1 trypsin-like [Patiria miniata] MLKFLVLCALAASVYADCGVQVISPSLSKIVGGDEAVPGSWPWQVMLRKKYWGGDYQFCGGTLINDQWVVTAAHCFYNYG NINLYSAVVGAHDRDAVDATQSSVGLAQVFLHEDYNTRTLDNDITLLKLSSPVSLSDYVTPACLPQREVATGTDCVVTGW GDQETTVDDPALQQVVVPIISTAQCNKATWYGGDITDNMICAGYSQGGKDSCQGDSGGPFVCAASSGAYELVGVVSWGYG CADARNPGVYAKVLNYVDWINNIVANN >CAE1324442.1 Plasminogen,Apolipoprotein(a),Chymotrypsinogen B2,Chymotrypsinogen A,Chymotrypsinogen 2,Chymotrypsinogen B [Sepia pharaonis] MRRIYFFHGICLVLFSFTSSFLSLSLSLSLSLSRSLFLSRFLSLSSSLRRRGRHLISRGSHKYTASSNMSQVDHEGNIIP KRKQSGSSTVMCEHYSAWATWSHCSRRCEQYRTRNCVEPRYCGNTTIKDKRFCKRRNKQCSILSFKVITPLRRAKEVQQI ITNAFYNKWTAWSPCSRDCKQKRKRQCRSRWKNVCGESYIQQTRKCRPVAGTCEKKYTLSVLVADEPAETKKGPTSNRHN KAITNCTAELAMPDKCGTRPSGSQRNYRIVGGYEVRRHSWPWQVAILTRAKKQYCGGTLISPQWVLTAAHCVRKRGRKRK VIVRMGEHDLHSRSGNEITLELEKDFPHPKFDFHTISNDIALLKLKRPVRRSFNVGFACLPTETNELHAGTICNIIGWGK VDGSHQDGAKILREAEVPVVDQGKCQKAFKYKITNNQICAGFKGGGVDSCGGDSGGPLICANHPNRTTQWANRNAVSVLD ADFSFSPSLFMH >NP_727055.1 uncharacterized protein Dmel_CG32755 [Drosophila melanogaster] MDHLWMCLLIVATHSGITQSQIGQPTATASPFVILPKIVGGYTVTIDQVPFQVSVRRRSIHERHYGLGHVCGGAVISQRV VCSAAHCYAINTSVPLVYRDPELYVVVAGSSAIDRTDRFTQEYLVQRIVGHKDYNGSTLENDIALLFLNGFIPWESPGVR AIPLAIKAPEEGTTCLIHGWGKVTMKEKSASLQQAPVPILNKELCQVIYKLPASQMCAGFLQGGIDACQGDSGGPLICDG RLAGIISWGVGCADPGYPGVYTNVSHFLKWIRRANASLDYSEYRQIPPLNLASRRSVSSSCLGIGVLALAMSLRL >NP_494910.2 Peptidase S1 domain-containing protein [Caenorhabditis elegans] MKVWIFLLLVGVINKVSTDNKNDVIEKVGCGLHSTNVELAQTRSAQEPADYVTLDHRLIGGSESSPHSWPWTVQLLSRLG HHRCGGSLIDPNFVLTAAHCFAKDRRPTSYSVRVGGHRSGSGSPHRVTAVSIHPWYNIGFPSSYDFAIMRIHPPVNTSTT ARPICLPSLPAVENRLCVVTGWGSTIEGSSLSAPTLREIHVPLLSTLFCSSLPNYIGRIHLPSMLCAGYSYGKIDSCQGD SGGPLMCARDGHWELTGVVSWGIGCARPGMPGVYGNVHSASTWINLEMNRLRI >XP_006252103.1 cathepsin G isoform X1 [Rattus norvegicus] MQPLLFLLIFVLFQEDEAGKIIGGREARPNSHPYMAFLLIQSPEGLSACGGFLVREDFVLTAGHCFGSSINVTLGAHNIR RQEGTQQHITVLRAIRHPDYNPPPVIQNDIMLLQLRSRARRSRAVKPVALPQATKRVQPGALCTVAGWGLVSQRRGTNVL QEVKLRVQTDQTCANRFQFYNSQTQICVGNPRERKSAFKGDSGGPLVCNNVAQGIVSYGSSSGNPPAVFTRIQSFMPWIK RTMRRLSSSKEDSKLDSKQGPGHPSKFKSNETLTRQKLSLLKEDN >XP_017921433.1 PREDICTED: cathepsin G-like isoform X1 [Capra hircus] MRPLLLLMAFLLSRKAQAGQIIGGREARPHSRPYMAFLQIQTPVGRKACGGFLVREDFVMTAAHCLGSQINVILGAHNIR TLESTQQHIPVLRSIPHPGHTQQNKRNDIMLLQLANRVQRNRFVRPVPLPQTRNRLRPGTQCTVAGWGLTGLNTRTDTLQ CVQLRVQRDRVCSRRFMLYNGRTQICVGDPRQRKSAFQGDSGGPLVCSNVAQGIVSYGDRVGTPPAVFTRISSFLPWIRR TMRRFQEWTPE >XP_014957329.3 cathepsin G-like [Ovis aries] MRPLLLLMAFLLSPRARAGQIIGGREARPHSRPYMAFLQIQTPAGRKACGGFLVREDFVMTAAHCLGSQINVILGAHNIR TLESTQQHIPVLRSIPHPGHTQQNKRNDIMLLQLANRVQRNRFVRPVPLPQTQNRLRPGTQCTAAGWGLTGLNTRTDTLQ YVQLRVQRGRVCSRRFMLYDGRTQICVGDPRQRKSAFQGDSGGPLVCSNVAQGIVSYGDRVGTPPAVFTRISSFLPWIRR TMRRLPRADTRVTSHETDSPALGQSPAPGQFPEP >XP_001926799.2 cathepsin G [Sus scrofa] MGPQRLAGGSTGSNRLGSPPGNMQPLLLLVALLLPPGARAGEIIGGQEARPHSRPYMAYMHFQSAQGQKTCGGFLVRKDF VMTAAHCFGRQTVVILGAHNIRRFERTQQRISVLRAIPHPRYNPYNHLNDIMLLQLANRTRQNRFVRPVALPRTQARLSP GARCTVAGWGLVSLSRRTDTLQEVQLTVQRDGECHRRFDHYNGRIQMCVGDPRERKSAFLGDSGGPLVCGRVAQGIVSYG NRQGTPPAVFTRVSSFLPWIRRTMSRFQQRGQAEIPL >XP_002696688.2 cathepsin G isoform X1 [Bos taurus] MKLITAAGEWDCGCLSPHPHPQTPTFTFASSPRGSKSGRRKQGQQLLGSLAGKMWPLLLLVAFLLSPRARAGQIIGGREA RPHSRPYMAYIQIRSPVGIKVCGGFLVREDFVMTAAHCLGSQINVILGAHNIRTLESTQQRIPVLRSIPHPGYSQQNKRN DIMLLQLANRAQRNRFVRPVPLPQTQNRLRPGTQCTVAGWGLIGLNMRTDTLQCVQLRVQRDRVCRRRFMLYYGRTQICV GDPRQRKSAFLGDSGGPLVCSNVAQGVVSYGDRMGTPPAVFTRISSFLPWIRRTMRRFQEWRPE >KAB0338566.1 hypothetical protein FD754_024485 [Muntiacus muntjak] MVLLLLLAALLLYPTGEAGKIIGGHEAKPHSRPYMAYLQIQTPENIQFCGGFLVREDFVLTAAHCLGSSISVTLGAHNIK KQERTQQITAVRRAIPHPRYNDKTVTNDIMLLQLTRKAKVTTAVSPISLPRDWDAVNPGMLCSVAGWGRLDVDMYCPNKL QEIQLKVQRAEKCTSCYKYYRTTTQICAGDARKRKSSFKGDSGGPLVCNGVAQGIVSYGKEDGTPPQVFTRISSFLPWIQ KTMKQYELQGPD >KAF4008330.1 hypothetical protein G4228_020050 [Cervus hanglu yarkandensis] MRPLLLLVVFLLFPRARAGQIIGGREARPHSRPYMAFILIRAPGGLKVCGGFLVREDFVMTAAHCLGSQMNVILGAHNVR TLEGTQQRVPVLRPIPHPGYSPQSHSNDIMLLQLANRVQRNRFVRPVPLPQTRNRLRPGTRCTVAGWGLTGLNTRTDTLQ YVQLRVQRDRLCSRRFRSYNGRTQICVGDPRQRKSAFLGDSGGPLVCNNVAQGIVSYGDRMGTPPAVFTRISSFLPWIRR TMRRFKEWRPE >KAB0369106.1 hypothetical protein FD755_019111 [Muntiacus reevesi] MALLLLLAALLLSPTGEAGKIIGGHEAKPHSRPYMAYLQIHTAENILICGGFLVREDFVLTAAHCLGSSINVTLGAHNIK KQERTQQVIAVRRAIPHPRYNDKTVTNDIMLLQLTRRAKVTTAVSPISLPRDWDAVNPGMLCSVAGWGRLDVDMYCPNKL QEVQLEVQRAKKCTSRYKYYRTTTQICAGDTRKRKSSFKGDSGGPLVCNGVAQGIVSYGTKDGTPPQVFTKISSFLPWIQ KTMKQYKLQGPD >XP_043290367.1 mast cell protease 1A-like [Cervus canadensis] MVLLLLLAALLLSPTGEAGKIIGGHEAKPHSRPYMAYLQIHTAENILFCGGFLVREDFVLTAAHCLGSSISITLGAHNIK KQERTQQIIAVKRAIPHPRYNNKTVTNDIMLLQLTRKAKVTTAVSPISLPRDWDTVNPGMLCSVAGWGRLDVDMYCPNKL QEVQLEVQRAKKCTSRYKYYRTTTQICAGDPGERKGSFQGDSGGPLVCNGVAQGIVSYGTKDGTPPQVFTRISSFLPWIQ KTMKQYELQGQD >XP_020728783.1 cathepsin G-like isoform X3 [Odocoileus virginianus texanus] MRPLLLLVAFLLFPRVWAGQIIGGREARPHSYPYMAFIQIRTPVRRKVCGGFLVREDFVMTAAHCLGSQMNVILGAHNIR TLEGTQQRIPVVRPIPHPGYSPLQSHSNDIMLLQLANRVQRNRFVRPVPLPQTQNRLRPGTRCTVAGWGLTGPNTRTDTL QCVQLRVQRDGVCRRRFVSYNGRTQICVGDPRQRKSAFVGDSGGPLVCNNVAQGIVSYGDRMGTPPAVFTRISSFLPWIR RTMRRFKEWRPE >XP_006932885.1 granzyme B(G,H) [Felis catus] MQPLLLLLAFFLPSRAKAGEIIGGHEAKPHSRPYMAHLWIQNREVCSKCGGFLIQEKFVLTAAHCWGSSINVTLGAHNIK KQEKTQQIIPVRRAIPHPDYNPKNYSNDIMLLQLVKKAKLTAAVRPLGLPKGKDRVRPGQVCSVAGWGRVATGRYPDTLQ EVELIVQEDQECKSRFPNYYNHKTQLCMGDPKEKKSSFQGDSGGPLLCNNVAQGIVSYGLKDRASPRAYTKVTSFLPWIK KTMRGLFLQEPDYLL >XP_002718156.1 PREDICTED: granzyme H [Oryctolagus cuniculus] MQPLLLLLAFFLPPWAEAGEIIGGHEAKPHSRPYMAYLQYWKDNRKRTCGGFLVREDFVLTAAHCHGSSINVTLGAHNIK QQERTQQVIPVRRAIPHKDYKQKGYINDIMLLQLERKAKKTKAVQPISLPRGKAQVKPGQVCQVAGWGQDASGTLATTLQ EVELTVQQDQECESLFRGYYSRATEICVGDPETKKSSFKGDSGGPLVCNNVAQGIVSYGPKERNPPPVVYTKISSFLPWI KKTMKTR >OWK08743.1 GZMB [Cervus elaphus hippelaphus] MQPLLLLVAFLLTPRAKAGEIIGGHEAKPHSRPYMAYLQFWVKDDEMKCGGFLVRQDFVLTAAHCNGSSISVTLGAHNIK QRERTQQVIRVRRAIPHPDYNPEDISNDIMLLKLERKAKQTSAVKPVSLPRAMPQVKPGQTCSVAGWGKDSMTTYPETLQ EVKLIVQEDWKCESHLGKYYNHTTQLCVGDPKTKNTSFQGDSGGPLMCGNVAQGIVSYGRKDGSTPRACTKLSSFLPWIK KTMKSL >XP_006270497.2 PREDICTED: mast cell protease 1A [Alligator mississippiensis] MLLLLLFPVTFLLPAGTGAGKIIGGREARPHSRPYMAFLNGQRGEKKYMCGGSLVHEHFVLTAAHCSGDQITVLLGAHNI HKKEESWQEIKVHRQIPHPRYKKKTREKDIMLLQLERKANLSEQVGIIRLPQPGEAVKPGSVCGVAGWGQTNVTFGESSN VLLEIDLEVLGDTICEDHYNCYYDPRTMLCVGDFKGNKSSFQGDSGGPLVCDRVVQGIISWGPNNAAPPEVYTKVSRFIA WIKNELAKLKKPLDIPGFFS >XP_005505199.2 cathepsin G [Columba livia] MLFLLLTSAFLLVSWAEAGRIIGGQEARPHSRRYMAYVSIGSRSGTSNCGGFLIHPYAVLSAAHCVAGKTGVNITVTLGA HNIKKEELSQQKFHIGRWVIHPNYSGDTLANDIMLLKLKPNAKLTKQVNRVPLPRHNEHIKQGTRCKVAGWGWTSTTRDK TSVLMEVDLKVQSEDICEKSFKKNYLRESMICCGDEDGKKSTSRGDSGGPLVCNGKAHGIVSYGHKNRIFPKVFTRVSYF EPWIRKELRKFALQDLPDSPSSY >XP_014382706.2 mast cell protease 1A-like [Alligator sinensis] MVSASLSRLKAKLSHGDGIVTTSHDRSSDEIIGGREAKKYSRPYMAYTIIKTSENEELACGGFLIQEDVVVTAAHCNTEP RHLSKMSVILGAHNIRKPEPNSQQIKVRHWIPHPKYNRTTLRYDIMLLQLKHKARLNHRVQTIPLPAWKKNVKPGTMCSV AGWGRIHLWSNKTSDVLLEVDLMVQKDRICKKTFSGYSRKVQMCVGDSSGKKSTFKGDSGGPLVCNGAAYGIVSYGPHGT TFPDVFAKVSSFIPWIKKELKKMHS >XP_040548520.1 mast cell protease 1A [Gallus gallus] MRRPHCPLLLALLLLLSCLRADGSALRGQIIGGHEAKPHSHPYMAYLKLRMSACGGFLVAPDWVMTAAHCLEGNITVILG AHDIHEPEQSQQVRGVLKYYPHPAYNPNTVANDIMLLKLTAKVKLNKYVRTIALPKTSSDLPTGTSCTIAGWGLIDEDER TSKLFETEVSIYSRRKCILFYPHLDNSMVCAGSFHEMKDSSQGDSGGPLVCNKVAQGVVSFGYDSPPGVYARIANYLPWI KKVMKK >XP_010723125.1 mast cell protease 1A-like isoform X1 [Meleagris gallopavo] MRRPHCPLLLALLLLLSCPRADGSALRGQIIGGHEAEPHSHPYMAYLKLERSACGGFLVASDWVMTAAHCLSGNITVVLG AHEIFQPEQSQQVRGVLRYHPHPAYNPKTFANDIMLLKLTAKAKLNKYVRTIALPKTSSYLLTGTSCTIAGWGLIDEDEI ADRLFETKVSIYSRRKCILFYPHLDDGMVCAGSFHELKDSSQGDSGGPLVCNKVAQGIVSFGYNNPPGVYARIANYLHWI KKIMRT >XP_030284343.1 mast cell protease 4-like [Sparus aurata] MIHAYCIILLLQLLSPTGGSESGIVNGKVSKPHSRPYMASLQYDGQHSCGGILIREDFVLTAAHCKQSDTMTVVLGAHNI SKKEKSQQRINVTKYIKHPKYNGKYDYDIMLLKLKKNATLNKFVKTIGLPKKKGKIPANIKCTVAGWGRTGQDKPASDVL KENTEKLQFNSECKYIWQQYFDDDSMICTKFTRKAGGICQGDSGGPLICNSMPQGITAFTAGDDCNNPKYPHVFTKVNAF IPWIKEVLKGNRNVA >XP_018099449.2 mast cell protease 1A [Xenopus laevis] MRMDSVSFVFLAFFIQYTIADGIIKGKEVCPHSKPYMAFLNITSYDKQEVRCGGILISENFVLTAAHCKGSKIVVTLGAH NIDEREESQQKIDVCEQIQHPLYKNDDSKDIMLLKLRRKAVPNQHVLPIRLSQSGPKLKTGDLCNVAGWGRINKFNYRMA SKLQELDMKVVAPDECTKAFPNYNTKELICAQNFTEPKSSCWGDSGGPLFCDQYLHGLVYGGKGDCGGPRLFTSVFSYIK WINSSLKKPKCKIESY >NP_001108167.1 granzyme 3, tandem duplicate 4 [Danio rerio] MYYNNICIILISYSVIKTGGMESGIVGGREVKLHSRPYMASLQVQRKHNCGGILIKEDYVLTSAHCWKDTTNLEVVLGAH NISQRENSQQIIQVQKYIKHPNYQKKNHSFDIMLLKLKTKAVLNHFVNITNLPKHEPSILAPVECSIAGWGMQRPGEGAS NVLREVNLQLESNSYCKSKWQVYFNSKNMVCTASDGKKAFCQGDSGSPLFCNSELYGMAAYTYPNNCTFKEYPEVYMKVS AFLPWIKKNMK >XP_040191811.1 mast cell protease 1A-like [Rana temporaria] MTLLYYPKPDKIIGGDEVSPHSMPYMAFLKFDVTGNTYKRCGGILISEDVVLTAAHCNDTNMQVILGAHNIMSKENSWQV IKVCKMVPHHEHEKPGNDIMLLKLREKAVLNRYVLPLPINHTERKVKPGNVCSVAGWGRYKVYNNDEAPTLRKVDVKVVS AEICSKTFPKIDVKKFICAGDPQEEKYAYNGDSGGPLFCGKDLQGIVQGGDKPPTGLYTKVSSHVKWIKQTIRTMKCKKE V >XP_004086989.3 granzyme E [Oryzias latipes] MKGACSFLCVLLMVSTAGASEGGIFGGRVAKPHSRPYMASLQFQGQHSCGGILIRDDYVLTSAHCKNDVQPMTVVLGAHD ISKKEKTQQHFKVQKYNQHPDYKCEQANDIMLIKLETKAKLNKYVKPIELSKKNGDIRANIKCAVAGWGKTAVDKPASNV LKEATEETQFKAECNNIWKEHFNSTQMICTKFSRKTGGICQGDSGGPLICNTKPLGLAAFTKQDNCNDPKFPHVFIKINF YLPWIKKIMTE >XP_015797764.1 PREDICTED: trypsin-3-like [Nothobranchius furzeri] MKLFLLLISLGGAAALDDDRIVGGYECPKNSVPYQVSLFAGYNYCGGILLSDEWVLSAAHCKSKSDVEVRLGEHDIWEPE NTEQHIMSAEFIHHPDYNPRTQDSDIMLIRLSRTATLNSFVRPVALPSKCASAGSRCLVSGWGNIRPSDDASRYPDKLQC LDIPVLSDDTCFNSYPFQITDNMICAGFLEGGKDSCQGDSGGPLVCDGELQGVVSWGKGCALKNKPGVYTKVCNYVSWIK TTMASG >NP_031826.1 cathepsin G preproprotein [Mus musculus] MQPLLLLLTFILLQGDEAGKIIGGREARPHSYPYMAFLLIQSPEGLSACGGFLVREDFVLTAAHCLGSSI NVTLGAHNIQMRERTQQLITVLRAIRHPDYNPQNIRNDIMLLQLRRRARRSGSVKPVALPQASKKLQPGD LCTVAGWGRVSQSRGTNVLQEVQLRVQMDQMCANRFQFYNSQTQICVGNPRERKSAFRGDSGGPLVCSNV AQGIVSYGSNNGNPPAVFTKIQSFMPWIKRTMRRFAPRYQRPANSLSQAQT >XP_522810.1 cathepsin G [Pan troglodytes] MQPLLLLLAFLLPTGAEAGEIIGGQESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVLTAAHCWGSNI NVTLGAHNVQRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRRVRRNRNVNPVALPRAQEGLRPGT RCTVAGWGRVSLRRGTDTLREVQLRVQRDSQCLRIFDSYDPRRQICVGDRRERKSAFKGDSGGPLLCNNV AHGIVSYGKSSGVPPEVFTRVSSFLPWIRRTMRSFKLLDQMETPL >XP_024087523.1 cathepsin G [Pongo abelii] MQPLLLLLAFLLPTGAEAGEIIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVLTAGHCWGSDI NVTLGAHNVRRRESTQQHITVRRAIRHPQYNQQLIQNDIMLLQLSRRVRRNRNVNPVALPRAQEGLRPGT RCTVAGWGLVSMRRGTDTLREVQLRVQRDSQCRRIFPFYDPRTQICVGDRRERKGAFKGDSGGPLLCNNV AHGVVSYGKSSGVPPEVFTRVSSFLPWIRRTMRSFKLLDQMETPL >XP_003809162.1 cathepsin G [Pan paniscus] MQPLLLLLAFLLPTGAEAGEIIGGQESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVLTAAHCWGSNI NVTLGAHNVQRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRRVRRNRNVNPVALPRAQEGLRPGT RCTVAGWGRVSLRRGTDTLREVQLRVQRDSQCLRIFDSYDPRRQICVGDRRERKSAFKGDSGGPLLCNNV AHGIVSYGKSSGVPPEVFTRVSSFLPWIRRTMRSFKLLDQMETPL >XP_004055078.3 cathepsin G [Gorilla gorilla gorilla] MQPFLLLLAFLLTPGAGTEEIIGGHEAKPHSRPYMAFVQFLQVKSRKRCCGILVRKDFVLTAAHCQGSSI NVTLGAHNITEQERTQQLIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKWTTAVRPLRLPSSKAQVKPGQ VCSVAGWGYVSMGTLATTLQEVSLTVQKDWECERLFPENYSRATEICVGDPKKTQTSSKGDSGGPLVCKD VAQGILSYGNKKGTPPGVYIKVSHFLPWIKRTMKRLLGSLSGKMQPLLLLLAFLLSTGAEAGEIIGGRES RPHSRPYMAYLRIQSPAGQSRCGGFLVREDFVLTAAHCWGSNISVTLGAHNVQRRENTQQHITARRAIRH PQYNQRTIQNDIMLLQLSRRVRRNRNVNPVALPRAQEGLRPGTRCTVAGWGRVSLRRGTDTLREVQLRVQ RDSQCLRIFGSYDPRRQICVGDRRERKSAFKGDSGGPLLCNNVAHGIVSYGKSSGVPPEVFTRVSSFLPW IRRTMRSFKLLDQMETPL >XP_013971285.1 cathepsin G [Canis lupus familiaris] MPLFLFLVAFLLPPGAGAGDIIGGREARPHSRPYMAYLQIRSPNGGSSACGGFLVREDFVLTAAHCWGSR IAVTLGAHDVGRRERVQQRTTARRAIRHPRYNPQTTANDIMLLQLADRMRRTRQVRPVPLPRAQAGVRPG ATCTVAGWGRLGLNRRTNKLHEVQLTVQNNSRCSRRFNFFNGQTQICVGNPRAGKSAFLGDSGGPLVCNG VAQGIVSYGDRRGTPPAVFTRISAFMPWVRRTMRRFQQQCQP
Mafft alignment of selected proteins >NP_001902.1 cathepsin G preproprotein [Homo sapiens] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------MQPLLLLLAFL------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -LPTGAEAGEIIGGRESRPHSRPYMAYLQIQSPA-----GQS-RCGGFLVREDFVLTAAH CWG------------SNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQ-RT-IQNDIM LLQLSRRVRR-NRNVNPVALPRAQEGLRPGTLCTVAGWGRVSMRRG----TDTLREVQLR VQRDRQCLRI--F-GSYD--PRRQICVGDRRERKAA--FKGDSGGPLLCNN-----VAHG IVSYGK--SSGV--PPEVFTRVSSFLPWIRTTMRSFKLLDQ------------------M ETPL---------------------------------------- >XP_039266389.1 trypsin-3-like [Styela clava] MFPS-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------KFICWTVLCFL------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -SVRNGECDKIVGGYEARPHSAPYIAHLDRY--------SSY-FCCGTLIHESWVLSAAH CHYEP----------DQFKVIIGDHDRSIVEGTEQTIQAILALNHELYNP-MI-TDNDVM MVKLEKPAIF-NQYVQLALLPT--SEIGSGIECLACGWGYTDYTSNT--LPDRLQCVEVF TVSNTECNYM--Y-GGEV--KETMLCAE--SAGKDA--CNGDSGGPLMCGN-----LLHG VTSTGF--GCAYPHFPGIYARVTEFTSWIQMVMEYN------------------------ -------------------------------------------- >XP_031571314.1 chymotrypsinogen A-like [Actinia tenebrosa] MIFW-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AALLLVLPALIEG---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -CGKRPAGTRVINGQDAAPHSWPWQISLRLD--------GYH-ICGGTLIRPDWVLTAAH CVNKN-------PDPKRYIVAVGAHRRLSITSVERFMKIKKVIMHSGYTD-QQ-KLHDIA LLQLRTPVTL-SDKVNLACLPT--TEAAVGAKCYITGWGRTSASSG---SADTLQQAMLP VASHSDCKKK--F-TIVD--RKAHICAGDAKSSASSGGCHGDSGGPLVCEER-GRWVQHG IVSFGK--RNCPTTFYTVFARVSSYLDWVNSKITGSTPSPPSPSPPPSPE---------P PLPPTTSPAGGCSDRSGPKACQYFKDRCSQDFVKKACQKTCGLC >XP_030844513.1 trypsin-2 [Strongylocentrotus purpuratus] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------MLKAIVLLSCVAAALAD------------------------------ ------------------------------------------------------------ ------------------------------------CG---------------------- ------------------------------------------------------------ KPAVDPVNTFIVGGDAAMPGSWPWQVGIRKNYLVGQ--GGYH-MCGATLIDNQWIVSAAH CFYRW-------KRLSDYTITLGSHDRDEVDSTQVNAKLGGIFVHEDYNS-MT-LDNDIA MLKLETPIDF-NDAISEACVAT--SDYPADTMCVVTGWGDQEAAID----NAELQQVYVP IIDTKVCNRPSWY-NGEI--TDNMFCAGYSSGGMDS--CQGDSGGPFVCKNSAGAWELTG VVSWGY--GCADPLNPGVYTRVTQYNDWISGIKRNN------------------------ -------------------------------------------- >XP_016768428.1 trypsin-7 [Apis mellifera] M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------WRVLLLLSTVL------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -YITHCLQPRIIGGHNASIIEYPYQVSIHYM--------GKH-HCGGSIISENWLLTAAH CIY------------GLIPVNFKIRAGSIYNNNGIEYNIKNIIMHEKYNI-YT-FDYDVA LIMLSTPIKI-SPTTKPIALAQSTTSVEIGKNAVVTGWGYLSVNSNS--MSDILQVLTLP IVDQNVCKTI--F-SGINTVTENMICAGSL-TGKDT--CKGDSGGPLVYNN-----VQIG IVSWGL--KCALPNYPGVYTRVSAIRDWIKKKTGV------------------------- -------------------------------------------- >XP_038051917.1 trypsin-like [Patiria miniata] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------MLKFLVLCALAASVYAD------------------------------ ------------------------------------------------------------ ------------------------------------CG---------------------- ------------------------------------------------------------ VQVISPSLSKIVGGDEAVPGSWPWQVMLRKKYWG----GDYQ-FCGGTLINDQWVVTAAH CFYNY-------GNINLYSAVVGAHDRDAVDATQSSVGLAQVFLHEDYNT-RT-LDNDIT LLKLSSPVSL-SDYVTPACLPQ--REVATGTDCVVTGWGDQETTVD----DPALQQVVVP IISTAQCNKATWY-GGDI--TDNMICAGYSQGGKDS--CQGDSGGPFVCAASSGAYELVG VVSWGY--GCADARNPGVYAKVLNYVDWINNIVANN------------------------ -------------------------------------------- >CAE1324442.1 Plasminogen,Apolipoprotein(a),Chymotrypsinogen B2,Chymotrypsinogen A,Chymotrypsinogen 2,Chymotrypsinogen B [Sepia pharaonis] MRRIY------------------------------------------------------- ------------------------------------------------------------ ----------------------FFHGI------------------------CLVLFS--- ----------------------------------------------------------FT SSFLSLSLSLSLSLSRSLFLSRFLSLSSSLRRRGRHLISRGSHKYTASSNMSQVDHEGNI IPKRKQSGSSTVMCEHYSAWATWSHCSRRCEQYRTRNCVEPRYCGNTTIKDKRFCKRRNK QCSILSFKVITPLRRAKEVQQIITNAFYNKWTAWSPCSRDCKQKRKRQCRSRWKNVCGES YIQQTRKCRPVAGTCEKKYTLSVLVADEPAETKKGPTSNRHNKAITNCTAELAMPDKCGT RPSGSQRNYRIVGGYEVRRHSWPWQVAILTRA-------KKQ-YCGGTLISPQWVLTAAH CVRKR-------GRKRKVIVRMGEHDLHSRSGNEITLELEKDFPHPKFDF-HT-ISNDIA LLKLKRPVRR-SFNVGFACLPTETNELHAGTICNIIGWGKVDGSHQD--GAKILREAEVP VVDQGKCQKA--F-KYKI--TNNQICAGFKGGGVDS--CGGDSGGPLICAN-----HPNR TTQWAN--RNAV----SVLDADFSFSPSLFMH---------------------------- -------------------------------------------- >NP_727055.1 uncharacterized protein Dmel_CG32755 [Drosophila melanogaster] MDH--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------LWMCLLIVATHSGITQSQI---------------------------- ------------------------------------------------------------ ---------------------------------GQPTA---------------------- ------------------------------------------------------------ TASPFVILPKIVGGYTVTIDQVPFQVSVRRRSIHERHYGLGH-VCGGAVISQRVVCSAAH CYAINTSVPLVYRDPELYVVVAGSSAIDRTDRFTQEYLVQRIVGHKDYNG-ST-LENDIA LLFLNGFIPWESPGVRAIPLAI--KAPEEGTTCLIHGWGKVTMKEK----SASLQQAPVP ILNKELCQVI--Y-KL----PASQMCAGFLQGGIDA--CQGDSGGPLICDG-----RLAG IISWGV--GCADPGYPGVYTNVSHFLKWIRRANASLDYSEY------------------R QIPPLNLA----SRRSVSSSC--------LGIGVLALAMSLRL- >NP_494910.2 Peptidase S1 domain-containing protein [Caenorhabditis elegans] MK---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------VWIFLLLVGVINKVSTDNK---------------------------- ------------------------------------------------------------ ----------------------------NDVIEKVGCG---------------------- --------------------------------------------LHSTNVELAQTRSAQE PADYVTLDHRLIGGSESSPHSWPWTVQLLSRL-------GHH-RCGGSLIDPNFVLTAAH CFAKD-------RRPTSYSVRVGGH----RSGSGSPHRVTAVSIHPWYNIGFP-SSYDFA IMRIHPPVNT-STTARPICLPS--LPAVENRLCVVTGWGSTIEGSSL--SAPTLREIHVP LLSTLFCSSLPNYIGRIH--LPSMLCAGYSYGKIDS--CQGDSGGPLMCARD-GHWELTG VVSWGI--GCARPGMPGVYGNVHSASTWINLEMNRLRI---------------------- -------------------------------------------- >XP_006252103.1 cathepsin G isoform X1 [Rattus norvegicus] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------MQPLLFLLIFV------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -LFQEDEAGKIIGGREARPNSHPYMAFLLIQSPE-----GLS-ACGGFLVREDFVLTAGH CFG------------SSINVTLGAHNIRRQEGTQQHITVLRAIRHPDYNP-PPVIQNDIM LLQLRSRARR-SRAVKPVALPQATKRVQPGALCTVAGWGLVSQRRG----TNVLQEVKLR VQTDQTCANR--F-QFYN--SQTQICVGNPRERKSA--FKGDSGGPLVCNN-----VAQG IVSYGS--SSGN--PPAVFTRIQSFMPWIKRTMRRLSSSKEDSKLDSKQGP--G-HP-SK FKSNETLT----RQKLS--------------LLKEDN------- >XP_017921433.1 PREDICTED: cathepsin G-like isoform X1 [Capra hircus] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------MRPLLLLMAFL------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -LSRKAQAGQIIGGREARPHSRPYMAFLQIQTPV-----GRK-ACGGFLVREDFVMTAAH CLG------------SQINVILGAHNIRTLESTQQHIPVLRSIPHPGHTQ-QN-KRNDIM LLQLANRVQR-NRFVRPVPLPQTRNRLRPGTQCTVAGWGLTGLNTR----TDTLQCVQLR VQRDRVCSRR--F-MLYN--GRTQICVGDPRQRKSA--FQGDSGGPLVCSN-----VAQG IVSYGD--RVGT--PPAVFTRISSFLPWIRRTMRRFQEWT-------------------- --PE---------------------------------------- >XP_014957329.3 cathepsin G-like [Ovis aries] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------MRPLLLLMAFL------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -LSPRARAGQIIGGREARPHSRPYMAFLQIQTPA-----GRK-ACGGFLVREDFVMTAAH CLG------------SQINVILGAHNIRTLESTQQHIPVLRSIPHPGHTQ-QN-KRNDIM LLQLANRVQR-NRFVRPVPLPQTQNRLRPGTQCTAAGWGLTGLNTR----TDTLQYVQLR VQRGRVCSRR--F-MLYD--GRTQICVGDPRQRKSA--FQGDSGGPLVCSN-----VAQG IVSYGD--RVGT--PPAVFTRISSFLPWIRRTMRRLPRADTRVTSHETDSPALGQSPAPG QFPEP--------------------------------------- >XP_001926799.2 cathepsin G [Sus scrofa] MGPQRL------------------------------------------------------ ------------------------------------------------------------ ------------------------AG---------------------------------- -----------------------------------------------------------G STGSNRLGSPPGNMQPLLLLVALL------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -LPPGARAGEIIGGQEARPHSRPYMAYMHFQSAQ-----GQK-TCGGFLVRKDFVMTAAH CFG------------RQTVVILGAHNIRRFERTQQRISVLRAIPHPRYNP-YN-HLNDIM LLQLANRTRQ-NRFVRPVALPRTQARLSPGARCTVAGWGLVSLSRR----TDTLQEVQLT VQRDGECHRR--F-DHYN--GRIQMCVGDPRERKSA--FLGDSGGPLVCGR-----VAQG IVSYGN--RQGT--PPAVFTRVSSFLPWIRRTMSRFQQRGQ------------------A EIPL---------------------------------------- >XP_002696688.2 cathepsin G isoform X1 [Bos taurus] MKLITA------------------------------------------------------ ------------------------------------------------------------ ------------------------AGE----------------------WDCGCLSPHPH PQTPTFTFASSPR-------------------------GSKSG---------------RR KQGQQLLGSLAGKMWPLLLLVAFL------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -LSPRARAGQIIGGREARPHSRPYMAYIQIRSPV-----GIK-VCGGFLVREDFVMTAAH CLG------------SQINVILGAHNIRTLESTQQRIPVLRSIPHPGYSQ-QN-KRNDIM LLQLANRAQR-NRFVRPVPLPQTQNRLRPGTQCTVAGWGLIGLNMR----TDTLQCVQLR VQRDRVCRRR--F-MLYY--GRTQICVGDPRQRKSA--FLGDSGGPLVCSN-----VAQG VVSYGD--RMGT--PPAVFTRISSFLPWIRRTMRRFQEWR-------------------- --PE---------------------------------------- >KAB0338566.1 hypothetical protein FD754_024485 [Muntiacus muntjak] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------MVLLLLLAALL------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -LYPTGEAGKIIGGHEAKPHSRPYMAYLQIQTPE-----NIQ-FCGGFLVREDFVLTAAH CLG------------SSISVTLGAHNIKKQERTQQITAVRRAIPHPRYND-KT-VTNDIM LLQLTRKAKV-TTAVSPISLPRDWDAVNPGMLCSVAGWGRLDVDMY---CPNKLQEIQLK VQRAEKCTSC--Y-KYYR--TTTQICAGDARKRKSS--FKGDSGGPLVCNG-----VAQG IVSYGK--EDGT--PPQVFTRISSFLPWIQKTMKQYELQG-------------------- --PD---------------------------------------- >KAF4008330.1 hypothetical protein G4228_020050 [Cervus hanglu yarkandensis] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------MRPLLLLVVFL------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -LFPRARAGQIIGGREARPHSRPYMAFILIRAPG-----GLK-VCGGFLVREDFVMTAAH CLG------------SQMNVILGAHNVRTLEGTQQRVPVLRPIPHPGYSP-QS-HSNDIM LLQLANRVQR-NRFVRPVPLPQTRNRLRPGTRCTVAGWGLTGLNTR----TDTLQYVQLR VQRDRLCSRR--F-RSYN--GRTQICVGDPRQRKSA--FLGDSGGPLVCNN-----VAQG IVSYGD--RMGT--PPAVFTRISSFLPWIRRTMRRFKEWR-------------------- --PE---------------------------------------- >KAB0369106.1 hypothetical protein FD755_019111 [Muntiacus reevesi] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------MALLLLLAALL------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -LSPTGEAGKIIGGHEAKPHSRPYMAYLQIHTAE-----NIL-ICGGFLVREDFVLTAAH CLG------------SSINVTLGAHNIKKQERTQQVIAVRRAIPHPRYND-KT-VTNDIM LLQLTRRAKV-TTAVSPISLPRDWDAVNPGMLCSVAGWGRLDVDMY---CPNKLQEVQLE VQRAKKCTSR--Y-KYYR--TTTQICAGDTRKRKSS--FKGDSGGPLVCNG-----VAQG IVSYGT--KDGT--PPQVFTKISSFLPWIQKTMKQYKLQG-------------------- --PD---------------------------------------- >XP_043290367.1 mast cell protease 1A-like [Cervus canadensis] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------MVLLLLLAALL------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -LSPTGEAGKIIGGHEAKPHSRPYMAYLQIHTAE-----NIL-FCGGFLVREDFVLTAAH CLG------------SSISITLGAHNIKKQERTQQIIAVKRAIPHPRYNN-KT-VTNDIM LLQLTRKAKV-TTAVSPISLPRDWDTVNPGMLCSVAGWGRLDVDMY---CPNKLQEVQLE VQRAKKCTSR--Y-KYYR--TTTQICAGDPGERKGS--FQGDSGGPLVCNG-----VAQG IVSYGT--KDGT--PPQVFTRISSFLPWIQKTMKQYELQG-------------------- --QD---------------------------------------- >XP_020728783.1 cathepsin G-like isoform X3 [Odocoileus virginianus texanus] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------MRPLLLLVAFL------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -LFPRVWAGQIIGGREARPHSYPYMAFIQIRTPV-----RRK-VCGGFLVREDFVMTAAH CLG------------SQMNVILGAHNIRTLEGTQQRIPVVRPIPHPGYSPLQS-HSNDIM LLQLANRVQR-NRFVRPVPLPQTQNRLRPGTRCTVAGWGLTGPNTR----TDTLQCVQLR VQRDGVCRRR--F-VSYN--GRTQICVGDPRQRKSA--FVGDSGGPLVCNN-----VAQG IVSYGD--RMGT--PPAVFTRISSFLPWIRRTMRRFKEWR-------------------- --PE---------------------------------------- >XP_006932885.1 granzyme B(G,H) [Felis catus] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------MQPLLLLLAFF------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -LPSRAKAGEIIGGHEAKPHSRPYMAHLWIQNRE-----VCS-KCGGFLIQEKFVLTAAH CWG------------SSINVTLGAHNIKKQEKTQQIIPVRRAIPHPDYNP-KN-YSNDIM LLQLVKKAKL-TAAVRPLGLPKGKDRVRPGQVCSVAGWGRVATGRY----PDTLQEVELI VQEDQECKSR--FPNYYN--HKTQLCMGDPKEKKSS--FQGDSGGPLLCNN-----VAQG IVSYGL--KDRA--SPRAYTKVTSFLPWIKKTMRGLFLQE-------------------- --PDYLL------------------------------------- >XP_002718156.1 PREDICTED: granzyme H [Oryctolagus cuniculus] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------MQPLLLLLAFF------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -LPPWAEAGEIIGGHEAKPHSRPYMAYLQYWKDN-----RKR-TCGGFLVREDFVLTAAH CHG------------SSINVTLGAHNIKQQERTQQVIPVRRAIPHKDYKQ-KG-YINDIM LLQLERKAKK-TKAVQPISLPRGKAQVKPGQVCQVAGWGQDASGTL----ATTLQEVELT VQQDQECESL--FRGYYS--RATEICVGDPETKKSS--FKGDSGGPLVCNN-----VAQG IVSYGP--KERNP-PPVVYTKISSFLPWIKKTMKTR------------------------ -------------------------------------------- >OWK08743.1 GZMB [Cervus elaphus hippelaphus] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------MQPLLLLVAFL------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -LTPRAKAGEIIGGHEAKPHSRPYMAYLQFWVKD-----DEM-KCGGFLVRQDFVLTAAH CNG------------SSISVTLGAHNIKQRERTQQVIRVRRAIPHPDYNP-ED-ISNDIM LLKLERKAKQ-TSAVKPVSLPRAMPQVKPGQTCSVAGWGKDSMTTY----PETLQEVKLI VQEDWKCESH--LGKYYN--HTTQLCVGDPKTKNTS--FQGDSGGPLMCGN-----VAQG IVSYGR--KDGS--TPRACTKLSSFLPWIKKTMKSL------------------------ -------------------------------------------- >XP_006270497.2 PREDICTED: mast cell protease 1A [Alligator mississippiensis] M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------LLLLLFPVTFL------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -LPAGTGAGKIIGGREARPHSRPYMAFLNGQRGE-----KKY-MCGGSLVHEHFVLTAAH CSG------------DQITVLLGAHNIHKKEESWQEIKVHRQIPHPRYKK-KT-REKDIM LLQLERKANL-SEQVGIIRLPQPGEAVKPGSVCGVAGWGQTNVTFGE--SSNVLLEIDLE VLGDTICEDH--YNCYYD--PRTMLCVGDFKGNKSS--FQGDSGGPLVCDR-----VVQG IISWGP--NNAA--PPEVYTKVSRFIAWIKNELAKLKKPLD------------------- -IPGFFS------------------------------------- >XP_005505199.2 cathepsin G [Columba livia] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------MLFLLLTSAFL------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -LVSWAEAGRIIGGQEARPHSRRYMAYVSIGSRS-----GTS-NCGGFLIHPYAVLSAAH CVAG--------KTGVNITVTLGAHNIKKEELSQQKFHIGRWVIHPNYSG-DT-LANDIM LLKLKPNAKL-TKQVNRVPLPRHNEHIKQGTRCKVAGWGWTSTTRD---KTSVLMEVDLK VQSEDICEKS--FKKNYL--RESMICCGDEDGKKST--SRGDSGGPLVCNG-----KAHG IVSYGH--KNRI--FPKVFTRVSYFEPWIRKELRKFALQDL------------------P DSPSSY-------------------------------------- >XP_014382706.2 mast cell protease 1A-like [Alligator sinensis] MV---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------SASLSRLKAKLSH---------------------------------- ------------------------------------------------------------ ---------------------------------GDGIV---------------------- ------------------------------------------------------------ TTSHDRSSDEIIGGREAKKYSRPYMAYTIIKTSE-----NEELACGGFLIQEDVVVTAAH CNTEP-------RHLSKMSVILGAHNIRKPEPNSQQIKVRHWIPHPKYNR-TT-LRYDIM LLQLKHKARL-NHRVQTIPLPAWKKNVKPGTMCSVAGWGRIHLWSNK--TSDVLLEVDLM VQKDRICKKT--F-SGYS--RKVQMCVGDSSGKKST--FKGDSGGPLVCNG-----AAYG IVSYGP--HGTT--FPDVFAKVSSFIPWIKKELKKMHS---------------------- -------------------------------------------- >XP_040548520.1 mast cell protease 1A [Gallus gallus] MRRPH------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------CPLL----- ------------------------------------------------------------ -------------LALLLLLSCLR------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -ADGSALRGQIIGGHEAKPHSHPYMAYLKLR---------MS-ACGGFLVAPDWVMTAAH CLE------------GNITVILGAHDIHEPEQSQQVRGVLKYYPHPAYNP-NT-VANDIM LLKLTAKVKL-NKYVRTIALPKTSSDLPTGTSCTIAGWGLIDEDER----TSKLFETEVS IYSRRKCILF--Y-PHL---DNSMVCAGSFHEMKDS--SQGDSGGPLVCNK-----VAQG VVSFGY--DS----PPGVYARIANYLPWIKKVMKK------------------------- -------------------------------------------- >XP_010723125.1 mast cell protease 1A-like isoform X1 [Meleagris gallopavo] MRRPH------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------CPLL----- ------------------------------------------------------------ -------------LALLLLLSCPR------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -ADGSALRGQIIGGHEAEPHSHPYMAYLKLE---------RS-ACGGFLVASDWVMTAAH CLS------------GNITVVLGAHEIFQPEQSQQVRGVLRYHPHPAYNP-KT-FANDIM LLKLTAKAKL-NKYVRTIALPKTSSYLLTGTSCTIAGWGLIDEDEI----ADRLFETKVS IYSRRKCILF--Y-PHL---DDGMVCAGSFHELKDS--SQGDSGGPLVCNK-----VAQG IVSFGY--NN----PPGVYARIANYLHWIKKIMRT------------------------- -------------------------------------------- >XP_030284343.1 mast cell protease 4-like [Sparus aurata] MIH--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AYCIILLLQLL------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -SPTGGSESGIVNGKVSKPHSRPYMASLQYD--------GQH-SCGGILIREDFVLTAAH CKQS-----------DTMTVVLGAHNISKKEKSQQRINVTKYIKHPKYNG-K--YDYDIM LLKLKKNATL-NKFVKTIGLPKKKGKIPANIKCTVAGWGRTGQDKP---ASDVLKENTEK LQFNSECKYI--WQQYFD--DDSMICTKFTRKAGGI--CQGDSGGPLICNS-----MPQG ITAFTAGDDCNNPKYPHVFTKVNAFIPWIKEVLKGNRNVA-------------------- -------------------------------------------- >XP_018099449.2 mast cell protease 1A [Xenopus laevis] MRMD-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------SVSFVFLAFFI------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---QYTIADGIIKGKEVCPHSKPYMAFLNITSYD-----KQEVRCGGILISENFVLTAAH CKG------------SKIVVTLGAHNIDEREESQQKIDVCEQIQHPLYKN-DD--SKDIM LLKLRRKAVP-NQHVLPIRLSQSGPKLKTGDLCNVAGWGRINKFNYR--MASKLQELDMK VVAPDECTKA--F-PNYN--TKELICAQNFTEPKSS--CWGDSGGPLFCDQ-----YLHG LVYGGK--GDCG--GPRLFTSVFSYIKWINSSLKKPKCKIESY----------------- -------------------------------------------- >NP_001108167.1 granzyme 3, tandem duplicate 4 [Danio rerio] MYYN-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------NICIILISYSV------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -IKTGGMESGIVGGREVKLHSRPYMASLQVQ--------RKH-NCGGILIKEDYVLTSAH CWKDT----------TNLEVVLGAHNISQRENSQQIIQVQKYIKHPNYQK-KN-HSFDIM LLKLKTKAVL-NHFVNITNLPKHEPSILAPVECSIAGWGMQRPGEG---ASNVLREVNLQ LESNSYCKSK--WQVYFN--SKNMVCTAS-DGKKAF--CQGDSGSPLFCNS-----ELYG MAAYTYPNNCTFKEYPEVYMKVSAFLPWIKKNMK-------------------------- -------------------------------------------- >XP_040191811.1 mast cell protease 1A-like [Rana temporaria] M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ TLLYYPKPDKIIGGDEVSPHSMPYMAFLKFDVTG----NTYK-RCGGILISEDVVLTAAH CND------------TNMQVILGAHNIMSKENSWQVIKVCKMVPHHEHEK----PGNDIM LLKLREKAVL-NRYVLPLPINHTERKVKPGNVCSVAGWGRYKVYNND--EAPTLRKVDVK VVSAEICSKT--F-PKID--VKKFICAGDPQEEKYA--YNGDSGGPLFCGK-----DLQG IVQGGD--KP----PTGLYTKVSSHVKWIKQTIRTMKCKKE------------V------ -------------------------------------------- >XP_004086989.3 granzyme E [Oryzias latipes] MKG--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------ACSFLCVLLMV------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -STAGASEGGIFGGRVAKPHSRPYMASLQFQ--------GQH-SCGGILIRDDYVLTSAH CKNDV----------QPMTVVLGAHDISKKEKTQQHFKVQKYNQHPDYKC-E--QANDIM LIKLETKAKL-NKYVKPIELSKKNGDIRANIKCAVAGWGKTAVDKP---ASNVLKEATEE TQFKAECNNI--WKEHFN--STQMICTKFSRKTGGI--CQGDSGGPLICNT-----KPLG LAAFTKQDNCNDPKFPHVFIKINFYLPWIKKIMTE------------------------- -------------------------------------------- >XP_015797764.1 PREDICTED: trypsin-3-like [Nothobranchius furzeri] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------MKLFLLLISLG------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -GAAALDDDRIVGGYECPKNSVPYQVSLFA---------GYN-YCGGILLSDEWVLSAAH CKSK-----------SDVEVRLGEHDIWEPENTEQHIMSAEFIHHPDYNP-RT-QDSDIM LIRLSRTATL-NSFVRPVALPS--KCASAGSRCLVSGWGNIRPSDDASRYPDKLQCLDIP VLSDDTCFNS--Y-PFQI--TDNMICAGFLEGGKDS--CQGDSGGPLVCDG-----ELQG VVSWGK--GCALKNKPGVYTKVCNYVSWIKTTMASG------------------------ -------------------------------------------- >NP_031826.1 cathepsin G preproprotein [Mus musculus] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------MQPLLLLLTFI------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -LLQGDEAGKIIGGREARPHSYPYMAFLLIQSPE-----GLS-ACGGFLVREDFVLTAAH CLG------------SSINVTLGAHNIQMRERTQQLITVLRAIRHPDYNP-QN-IRNDIM LLQLRRRARR-SGSVKPVALPQASKKLQPGDLCTVAGWGRVSQSRG----TNVLQEVQLR VQMDQMCANR--F-QFYN--SQTQICVGNPRERKSA--FRGDSGGPLVCSN-----VAQG IVSYGS--NNGN--PPAVFTKIQSFMPWIKRTMRRFAPRYQ------------------- -RPANSLS----QAQT---------------------------- >XP_522810.1 cathepsin G [Pan troglodytes] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------MQPLLLLLAFL------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -LPTGAEAGEIIGGQESRPHSRPYMAYLQIQSPA-----GQS-RCGGFLVREDFVLTAAH CWG------------SNINVTLGAHNVQRRENTQQHITARRAIRHPQYNQ-RT-IQNDIM LLQLSRRVRR-NRNVNPVALPRAQEGLRPGTRCTVAGWGRVSLRRG----TDTLREVQLR VQRDSQCLRI--F-DSYD--PRRQICVGDRRERKSA--FKGDSGGPLLCNN-----VAHG IVSYGK--SSGV--PPEVFTRVSSFLPWIRRTMRSFKLLDQ------------------M ETPL---------------------------------------- >XP_024087523.1 cathepsin G [Pongo abelii] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------MQPLLLLLAFL------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -LPTGAEAGEIIGGRESRPHSRPYMAYLQIQSPA-----GQS-RCGGFLVREDFVLTAGH CWG------------SDINVTLGAHNVRRRESTQQHITVRRAIRHPQYNQ-QL-IQNDIM LLQLSRRVRR-NRNVNPVALPRAQEGLRPGTRCTVAGWGLVSMRRG----TDTLREVQLR VQRDSQCRRI--F-PFYD--PRTQICVGDRRERKGA--FKGDSGGPLLCNN-----VAHG VVSYGK--SSGV--PPEVFTRVSSFLPWIRRTMRSFKLLDQ------------------M ETPL---------------------------------------- >XP_003809162.1 cathepsin G [Pan paniscus] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------MQPLLLLLAFL------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -LPTGAEAGEIIGGQESRPHSRPYMAYLQIQSPA-----GQS-RCGGFLVREDFVLTAAH CWG------------SNINVTLGAHNVQRRENTQQHITARRAIRHPQYNQ-RT-IQNDIM LLQLSRRVRR-NRNVNPVALPRAQEGLRPGTRCTVAGWGRVSLRRG----TDTLREVQLR VQRDSQCLRI--F-DSYD--PRRQICVGDRRERKSA--FKGDSGGPLLCNN-----VAHG IVSYGK--SSGV--PPEVFTRVSSFLPWIRRTMRSFKLLDQ------------------M ETPL---------------------------------------- >XP_004055078.3 cathepsin G [Gorilla gorilla gorilla] MQPFLLLLAFLLTPGAGTEEIIGGHEAKPHSRPYMAFVQFLQVKSRKRCCGILVRKDFVL TAAHCQGSSINVTLGAHNITEQERTQQLIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKW TTAVRPLRLPSSKAQVKPGQVCSVAGWGYVSMGTLATTLQEVSLTVQKDWECERLFPENY SRATEICVGDPKKTQTSSKGDSGGPLVCKDVAQGILSYGNKKGTPPGVYIKVSHFLPWIK RTMKRLLGSLSGKMQPLLLLLAFL------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -LSTGAEAGEIIGGRESRPHSRPYMAYLRIQSPA-----GQS-RCGGFLVREDFVLTAAH CWG------------SNISVTLGAHNVQRRENTQQHITARRAIRHPQYNQ-RT-IQNDIM LLQLSRRVRR-NRNVNPVALPRAQEGLRPGTRCTVAGWGRVSLRRG----TDTLREVQLR VQRDSQCLRI--F-GSYD--PRRQICVGDRRERKSA--FKGDSGGPLLCNN-----VAHG IVSYGK--SSGV--PPEVFTRVSSFLPWIRRTMRSFKLLDQ------------------M ETPL---------------------------------------- >XP_013971285.1 cathepsin G [Canis lupus familiaris] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------MPLFLFLVAFL------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -LPPGAGAGDIIGGREARPHSRPYMAYLQIRSPN----GGSS-ACGGFLVREDFVLTAAH CWG------------SRIAVTLGAHDVGRRERVQQRTTARRAIRHPRYNP-QT-TANDIM LLQLADRMRR-TRQVRPVPLPRAQAGVRPGATCTVAGWGRLGLNRR----TNKLHEVQLT VQNNSRCSRR--F-NFFN--GQTQICVGNPRAGKSA--FLGDSGGPLVCNG-----VAQG IVSYGD--RRGT--PPAVFTRISAFMPWVRRTMRRFQQQCQ------------------- --P-----------------------------------------
BMGE Cleaned alignment of selected proteins >NP_001902.1 cathepsin G preproprotein [Homo sapiens] PLLLLLAFLAGEIIGGRESRPHSRPYMAYLQRCGGFLVREDFVLTAAHCWGNVTLGAHNIRENTQQHAIRHPQYNNDIMLLQLSNVNPVALPRRPGTLCTVAGWGRDTLREVQLRVQQICVGDRFKGDSGGPLLCNNVAHGIVSYGKPPEVFTRVSSFLPWIRTTM >XP_039266389.1 trypsin-3-like [Styela clava] ICWTVLCFLCDKIVGGYEARPHSAPYIAHLDFCCGTLIHESWVLSAAHCHYKVIIGDHDRVEGTEQTALNHELYNNDVMMVKLEYVQLALLPTGSGIECLACGWGYDRLQCVEVFTVMLCAE--CNGDSGGPLMCGNLLHGVTSTGFFPGIYARVTEFTSWIQMVM >XP_031571314.1 chymotrypsinogen A-like [Actinia tenebrosa] LLLVLPALIGTRVINGQDAAPHSWPWQISLRICGGTLIRPDWVLTAAHCVNIVAVGAHRRITSVERFVIMHSGYTHDIALLQLRKVNLACLPTAVGAKCYITGWGRDTLQQAMLPVAHICAGDACHGDSGGPLVCEEVQHGIVSFGKFYTVFARVSSYLDWVNSKI >XP_030844513.1 trypsin-2 [Strongylocentrotus purpuratus] KAIVLLSCVNTFIVGGDAAMPGSWPWQVGIRMCGATLIDNQWIVSAAHCFYTITLGSHDRVDSTQVNIFVHEDYNNDIAMLKLEAISEACVATPADTMCVVTGWGDAELQQVYVPIIMFCAGYSCQGDSGGPFVCKNELTGVVSWGYNPGVYTRVTQYNDWISGIK >XP_016768428.1 trypsin-7 [Apis mellifera] VLLLLSTVLQPRIIGGHNASIIEYPYQVSIHHCGGSIISENWLLTAAHCIYPVNFKIRAGYNNNGIEIIMHEKYNYDVALIMLSTTKPIALAQEIGKNAVVTGWGYDILQVLTLPIVMICAGSLCKGDSGGPLVYNNVQIGIVSWGLYPGVYTRVSAIRDWIKKKT >XP_038051917.1 trypsin-like [Patiria miniata] KFLVLCALALSKIVGGDEAVPGSWPWQVMLRFCGGTLINDQWVVTAAHCFYSAVVGAHDRVDATQSSVFLHEDYNNDITLLKLSYVTPACLPQATGTDCVVTGWGDPALQQVVVPIIMICAGYSCQGDSGGPFVCAAELVGVVSWGYNPGVYAKVLNYVDWINNIV >CAE1324442.1 Plasminogen,Apolipoprotein(a),Chymotrypsinogen B2,Chymotrypsinogen A,Chymotrypsinogen 2,Chymotrypsinogen B [Sepia pharaonis] RSLFLSRFLNYRIVGGYEVRRHSWPWQVAILYCGGTLISPQWVLTAAHCVRIVRMGEHDLRSGNEITDFPHPKFDNDIALLKLKNVGFACLPTHAGTICNIIGWGKKILREAEVPVVQICAGFKCGGDSGGPLICANHPNRTTQWAN--SVLDADFSFSPSLFMH- >NP_727055.1 uncharacterized protein Dmel_CG32755 [Drosophila melanogaster] MCLLIVATHLPKIVGGYTVTIDQVPFQVSVRVCGGAVISQRVVCSAAHCYAVVVAGSSAITDRFTQEIVGHKDYNNDIALLFLNGVRAIPLAIEEGTTCLIHGWGKASLQQAPVPILQMCAGFLCQGDSGGPLICDGRLAGIISWGVYPGVYTNVSHFLKWIRRAN >NP_494910.2 Peptidase S1 domain-containing protein [Caenorhabditis elegans] IFLLLVGVIDHRLIGGSESSPHSWPWTVQLLRCGGSLIDPNFVLTAAHCFASVRVGGH--RSGSGSPVSIHPWYNYDFAIMRIHTARPICLPSVENRLCVVTGWGSPTLREIHVPLLMLCAGYSCQGDSGGPLMCARELTGVVSWGIMPGVYGNVHSASTWINLEM >XP_006252103.1 cathepsin G isoform X1 [Rattus norvegicus] PLLFLLIFVAGKIIGGREARPNSHPYMAFLLACGGFLVREDFVLTAGHCFGNVTLGAHNIQEGTQQHAIRHPDYNNDIMLLQLRAVKPVALPQQPGALCTVAGWGLNVLQEVKLRVQQICVGNPFKGDSGGPLVCNNVAQGIVSYGSPPAVFTRIQSFMPWIKRTM >XP_017921433.1 PREDICTED: cathepsin G-like isoform X1 [Capra hircus] PLLLLMAFLAGQIIGGREARPHSRPYMAFLQACGGFLVREDFVMTAAHCLGNVILGAHNILESTQQHSIPHPGHTNDIMLLQLAFVRPVPLPQRPGTQCTVAGWGLDTLQCVQLRVQQICVGDPFQGDSGGPLVCSNVAQGIVSYGDPPAVFTRISSFLPWIRRTM >XP_014957329.3 cathepsin G-like [Ovis aries] PLLLLMAFLAGQIIGGREARPHSRPYMAFLQACGGFLVREDFVMTAAHCLGNVILGAHNILESTQQHSIPHPGHTNDIMLLQLAFVRPVPLPQRPGTQCTAAGWGLDTLQYVQLRVQQICVGDPFQGDSGGPLVCSNVAQGIVSYGDPPAVFTRISSFLPWIRRTM >XP_001926799.2 cathepsin G [Sus scrofa] PLLLLVALLAGEIIGGQEARPHSRPYMAYMHTCGGFLVRKDFVMTAAHCFGVVILGAHNIFERTQQRAIPHPRYNNDIMLLQLAFVRPVALPRSPGARCTVAGWGLDTLQEVQLTVQQMCVGDPFLGDSGGPLVCGRVAQGIVSYGNPPAVFTRVSSFLPWIRRTM >XP_002696688.2 cathepsin G isoform X1 [Bos taurus] PLLLLVAFLAGQIIGGREARPHSRPYMAYIQVCGGFLVREDFVMTAAHCLGNVILGAHNILESTQQRSIPHPGYSNDIMLLQLAFVRPVPLPQRPGTQCTVAGWGLDTLQCVQLRVQQICVGDPFLGDSGGPLVCSNVAQGVVSYGDPPAVFTRISSFLPWIRRTM >KAB0338566.1 hypothetical protein FD754_024485 [Muntiacus muntjak] LLLLLAALLAGKIIGGHEAKPHSRPYMAYLQFCGGFLVREDFVLTAAHCLGSVTLGAHNIQERTQQIAIPHPRYNNDIMLLQLTAVSPISLPRNPGMLCSVAGWGRNKLQEIQLKVQQICAGDAFKGDSGGPLVCNGVAQGIVSYGKPPQVFTRISSFLPWIQKTM >KAF4008330.1 hypothetical protein G4228_020050 [Cervus hanglu yarkandensis] PLLLLVVFLAGQIIGGREARPHSRPYMAFILVCGGFLVREDFVMTAAHCLGNVILGAHNVLEGTQQRPIPHPGYSNDIMLLQLAFVRPVPLPQRPGTRCTVAGWGLDTLQYVQLRVQQICVGDPFLGDSGGPLVCNNVAQGIVSYGDPPAVFTRISSFLPWIRRTM >KAB0369106.1 hypothetical protein FD755_019111 [Muntiacus reevesi] LLLLLAALLAGKIIGGHEAKPHSRPYMAYLQICGGFLVREDFVLTAAHCLGNVTLGAHNIQERTQQVAIPHPRYNNDIMLLQLTAVSPISLPRNPGMLCSVAGWGRNKLQEVQLEVQQICAGDTFKGDSGGPLVCNGVAQGIVSYGTPPQVFTKISSFLPWIQKTM >XP_043290367.1 mast cell protease 1A-like [Cervus canadensis] LLLLLAALLAGKIIGGHEAKPHSRPYMAYLQFCGGFLVREDFVLTAAHCLGSITLGAHNIQERTQQIAIPHPRYNNDIMLLQLTAVSPISLPRNPGMLCSVAGWGRNKLQEVQLEVQQICAGDPFQGDSGGPLVCNGVAQGIVSYGTPPQVFTRISSFLPWIQKTM >XP_020728783.1 cathepsin G-like isoform X3 [Odocoileus virginianus texanus] PLLLLVAFLAGQIIGGREARPHSYPYMAFIQVCGGFLVREDFVMTAAHCLGNVILGAHNILEGTQQRPIPHPGYSNDIMLLQLAFVRPVPLPQRPGTRCTVAGWGLDTLQCVQLRVQQICVGDPFVGDSGGPLVCNNVAQGIVSYGDPPAVFTRISSFLPWIRRTM >XP_006932885.1 granzyme B(G,H) [Felis catus] PLLLLLAFFAGEIIGGHEAKPHSRPYMAHLWKCGGFLIQEKFVLTAAHCWGNVTLGAHNIQEKTQQIAIPHPDYNNDIMLLQLVAVRPLGLPKRPGQVCSVAGWGRDTLQEVELIVQQLCMGDPFQGDSGGPLLCNNVAQGIVSYGLSPRAYTKVTSFLPWIKKTM >XP_002718156.1 PREDICTED: granzyme H [Oryctolagus cuniculus] PLLLLLAFFAGEIIGGHEAKPHSRPYMAYLQTCGGFLVREDFVLTAAHCHGNVTLGAHNIQERTQQVAIPHKDYKNDIMLLQLEAVQPISLPRKPGQVCQVAGWGQTTLQEVELTVQEICVGDPFKGDSGGPLVCNNVAQGIVSYGPPPVVYTKISSFLPWIKKTM >OWK08743.1 GZMB [Cervus elaphus hippelaphus] PLLLLVAFLAGEIIGGHEAKPHSRPYMAYLQKCGGFLVRQDFVLTAAHCNGSVTLGAHNIRERTQQVAIPHPDYNNDIMLLKLEAVKPVSLPRKPGQTCSVAGWGKETLQEVKLIVQQLCVGDPFQGDSGGPLMCGNVAQGIVSYGRTPRACTKLSSFLPWIKKTM >XP_006270497.2 PREDICTED: mast cell protease 1A [Alligator mississippiensis] LLLFPVTFLAGKIIGGREARPHSRPYMAFLNMCGGSLVHEHFVLTAAHCSGTVLLGAHNIKEESWQEQIPHPRYKKDIMLLQLEQVGIIRLPQKPGSVCGVAGWGQNVLLEIDLEVLMLCVGDFFQGDSGGPLVCDRVVQGIISWGPPPEVYTKVSRFIAWIKNEL >XP_005505199.2 cathepsin G [Columba livia] FLLLTSAFLAGRIIGGQEARPHSRRYMAYVSNCGGFLIHPYAVLSAAHCVATVTLGAHNIEELSQQKWVIHPNYSNDIMLLKLKQVNRVPLPRKQGTRCKVAGWGWSVLMEVDLKVQMICCGDESRGDSGGPLVCNGKAHGIVSYGHFPKVFTRVSYFEPWIRKEL >XP_014382706.2 mast cell protease 1A-like [Alligator sinensis] SLSRLKAKLSDEIIGGREAKKYSRPYMAYTIACGGFLIQEDVVVTAAHCNTSVILGAHNIPEPNSQQWIPHPKYNYDIMLLQLKRVQTIPLPAKPGTMCSVAGWGRDVLLEVDLMVQQMCVGDSFKGDSGGPLVCNGAAYGIVSYGPFPDVFAKVSSFIPWIKKEL >XP_040548520.1 mast cell protease 1A [Gallus gallus] LLLLLSCLRRGQIIGGHEAKPHSHPYMAYLKACGGFLVAPDWVMTAAHCLETVILGAHDIPEQSQQVYYPHPAYNNDIMLLKLTYVRTIALPKPTGTSCTIAGWGLSKLFETEVSIYMVCAGSFSQGDSGGPLVCNKVAQGVVSFGYPPGVYARIANYLPWIKKVM >XP_010723125.1 mast cell protease 1A-like isoform X1 [Meleagris gallopavo] LLLLLSCPRRGQIIGGHEAEPHSHPYMAYLKACGGFLVASDWVMTAAHCLSTVVLGAHEIPEQSQQVYHPHPAYNNDIMLLKLTYVRTIALPKLTGTSCTIAGWGLDRLFETKVSIYMVCAGSFSQGDSGGPLVCNKVAQGIVSFGYPPGVYARIANYLHWIKKIM >XP_030284343.1 mast cell protease 4-like [Sparus aurata] CIILLLQLLESGIVNGKVSKPHSRPYMASLQSCGGILIREDFVLTAAHCKQTVVLGAHNIKEKSQQRYIKHPKYNYDIMLLKLKFVKTIGLPKPANIKCTVAGWGRDVLKENTEKLQMICTKFTCQGDSGGPLICNSMPQGITAFTAYPHVFTKVNAFIPWIKEVL >XP_018099449.2 mast cell protease 1A [Xenopus laevis] SFVFLAFFIADGIIKGKEVCPHSKPYMAFLNRCGGILISENFVLTAAHCKGVVTLGAHNIREESQQKQIQHPLYKKDIMLLKLRHVLPIRLSQKTGDLCNVAGWGRSKLQELDMKVVLICAQNFCWGDSGGPLFCDQYLHGLVYGGKGPRLFTSVFSYIKWINSSL >NP_001108167.1 granzyme 3, tandem duplicate 4 [Danio rerio] CIILISYSVESGIVGGREVKLHSRPYMASLQNCGGILIKEDYVLTSAHCWKEVVLGAHNIRENSQQIYIKHPNYQFDIMLLKLKFVNITNLPKLAPVECSIAGWGMNVLREVNLQLEMVCTAS-CQGDSGSPLFCNSELYGMAAYTYYPEVYMKVSAFLPWIKKNM >XP_040191811.1 mast cell protease 1A-like [Rana temporaria] ---------PDKIIGGDEVSPHSMPYMAFLKRCGGILISEDVVLTAAHCNDQVILGAHNIKENSWQVMVPHHEHENDIMLLKLRYVLPLPINHKPGNVCSVAGWGRPTLRKVDVKVVFICAGDPYNGDSGGPLFCGKDLQGIVQGGDPTGLYTKVSSHVKWIKQTI >XP_004086989.3 granzyme E [Oryzias latipes] SFLCVLLMVEGGIFGGRVAKPHSRPYMASLQSCGGILIRDDYVLTSAHCKNTVVLGAHDIKEKTQQHYNQHPDYKNDIMLIKLEYVKPIELSKRANIKCAVAGWGKNVLKEATEETQMICTKFSCQGDSGGPLICNTKPLGLAAFTKFPHVFIKINFYLPWIKKIM >XP_015797764.1 PREDICTED: trypsin-3-like [Nothobranchius furzeri] LFLLLISLGDDRIVGGYECPKNSVPYQVSLFYCGGILLSDEWVLSAAHCKSEVRLGEHDIPENTEQHFIHHPDYNSDIMLIRLSFVRPVALPSSAGSRCLVSGWGNDKLQCLDIPVLMICAGFLCQGDSGGPLVCDGELQGVVSWGKKPGVYTKVCNYVSWIKTTM >NP_031826.1 cathepsin G preproprotein [Mus musculus] PLLLLLTFIAGKIIGGREARPHSYPYMAFLLACGGFLVREDFVLTAAHCLGNVTLGAHNIRERTQQLAIRHPDYNNDIMLLQLRSVKPVALPQQPGDLCTVAGWGRNVLQEVQLRVQQICVGNPFRGDSGGPLVCSNVAQGIVSYGSPPAVFTKIQSFMPWIKRTM >XP_522810.1 cathepsin G [Pan troglodytes] PLLLLLAFLAGEIIGGQESRPHSRPYMAYLQRCGGFLVREDFVLTAAHCWGNVTLGAHNVRENTQQHAIRHPQYNNDIMLLQLSNVNPVALPRRPGTRCTVAGWGRDTLREVQLRVQQICVGDRFKGDSGGPLLCNNVAHGIVSYGKPPEVFTRVSSFLPWIRRTM >XP_024087523.1 cathepsin G [Pongo abelii] PLLLLLAFLAGEIIGGRESRPHSRPYMAYLQRCGGFLVREDFVLTAGHCWGNVTLGAHNVRESTQQHAIRHPQYNNDIMLLQLSNVNPVALPRRPGTRCTVAGWGLDTLREVQLRVQQICVGDRFKGDSGGPLLCNNVAHGVVSYGKPPEVFTRVSSFLPWIRRTM >XP_003809162.1 cathepsin G [Pan paniscus] PLLLLLAFLAGEIIGGQESRPHSRPYMAYLQRCGGFLVREDFVLTAAHCWGNVTLGAHNVRENTQQHAIRHPQYNNDIMLLQLSNVNPVALPRRPGTRCTVAGWGRDTLREVQLRVQQICVGDRFKGDSGGPLLCNNVAHGIVSYGKPPEVFTRVSSFLPWIRRTM >XP_004055078.3 cathepsin G [Gorilla gorilla gorilla] PLLLLLAFLAGEIIGGRESRPHSRPYMAYLRRCGGFLVREDFVLTAAHCWGSVTLGAHNVRENTQQHAIRHPQYNNDIMLLQLSNVNPVALPRRPGTRCTVAGWGRDTLREVQLRVQQICVGDRFKGDSGGPLLCNNVAHGIVSYGKPPEVFTRVSSFLPWIRRTM >XP_013971285.1 cathepsin G [Canis lupus familiaris] LFLFLVAFLAGDIIGGREARPHSRPYMAYLQACGGFLVREDFVLTAAHCWGAVTLGAHDVRERVQQRAIRHPRYNNDIMLLQLAQVRPVPLPRRPGATCTVAGWGRNKLHEVQLTVQQICVGNPFLGDSGGPLVCNGVAQGIVSYGDPPAVFTRISAFMPWVRRTM
PhyML tree of selected proteins (((((((XP_006270497_2_PREDICTED__mast_cell_protease_1A__Alligator_mississippiensis_:0.46816094,(XP_014382706_2_mast_cell_protease_1A_like__Alligator_sinensis_:0.40198277,XP_005505199_2_cathepsin_G__Columba_livia_:0.4805137):0.07332151):0.12041843,(((XP_018099449_2_mast_cell_protease_1A__Xenopus_laevis_:0.60906641,XP_040191811_1_mast_cell_protease_1A_like__Rana_temporaria_:0.42092808):0.34705683,((XP_039266389_1_trypsin_3_like__Styela_clava_:1.12813188,(XP_015797764_1_PREDICTED__trypsin_3_like__Nothobranchius_furzeri_:0.5092156,(((XP_030844513_1_trypsin_2__Strongylocentrotus_purpuratus_:0.52797973,XP_038051917_1_trypsin_like__Patiria_miniata_:0.16572708):0.30626489,(XP_031571314_1_chymotrypsinogen_A_like__Actinia_tenebrosa_:0.9863523,(NP_494910_2_Peptidase_S1_domain_containing_protein__Caenorhabditis_elegans_:0.90349757,CAE1324442_1_Plasminogen_Apolipoprotein_a__Chymotrypsinogen_B2_Chymotrypsinogen_A_Chymotrypsinogen_2_Chymotrypsinogen_B__Sepia_pharaonis_:1.37008204):0.09592838):0.07678004):0.23681468,(NP_727055_1_uncharacterized_protein_Dmel_CG32755__Drosophila_melanogaster_:0.9826071,XP_016768428_1_trypsin_7__Apis_mellifera_:1.05707754):0.30065531):0.16824213):0.14797696):0.32106328,(XP_040548520_1_mast_cell_protease_1A__Gallus_gallus_:0.00095903,XP_010723125_1_mast_cell_protease_1A_like_isoform_X1__Meleagris_gallopavo_:0.10355999):0.47187039):0.16588157):0.09309882,(NP_001108167_1_granzyme_3__tandem_duplicate_4__Danio_rerio_:0.45385612,(XP_004086989_3_granzyme_E__Oryzias_latipes_:0.36690092,XP_030284343_1_mast_cell_protease_4_like__Sparus_aurata_:0.15324823):0.17811212):0.42935608):0.12214968):0.12004044,(KAB0369106_1_hypothetical_protein_FD755_019111__Muntiacus_reevesi_:0.00715758,(XP_043290367_1_mast_cell_protease_1A_like__Cervus_canadensis_:0.01577649,KAB0338566_1_hypothetical_protein_FD754_024485__Muntiacus_muntjak_:0.02680823):0.02772883):0.11439934):0.04357813,(XP_002718156_1_PREDICTED__granzyme_H__Oryctolagus_cuniculus_:0.07747165,(OWK08743_1_GZMB__Cervus_elaphus_hippelaphus_:0.13319898,XP_006932885_1_granzyme_B_G_H___Felis_catus_:0.15486773):0.07225501):0.05363025):0.12690816,(XP_006252103_1_cathepsin_G_isoform_X1__Rattus_norvegicus_:0.0778907,NP_031826_1_cathepsin_G_preproprotein__Mus_musculus_:0.0529142):0.13248674):0.03207769,(XP_013971285_1_cathepsin_G__Canis_lupus_familiaris_:0.17426363,(XP_001926799_2_cathepsin_G__Sus_scrofa_:0.12988034,((XP_002696688_2_cathepsin_G_isoform_X1__Bos_taurus_:0.01065663,(XP_014957329_3_cathepsin_G_like__Ovis_aries_:0.01405464,XP_017921433_1_PREDICTED__cathepsin_G_like_isoform_X1__Capra_hircus_:0.00000001):0.05534499):0.01967519,(XP_020728783_1_cathepsin_G_like_isoform_X3__Odocoileus_virginianus_texanus_:0.01489573,KAF4008330_1_hypothetical_protein_G4228_020050__Cervus_hanglu_yarkandensis_:0.02985061):0.01438477):0.09874536):0.07399145):0.04772572):0.1204565,NP_001902_1_cathepsin_G_preproprotein__Homo_sapiens_:0.00948412,((XP_522810_1_cathepsin_G__Pan_troglodytes_:0.00000001,XP_003809162_1_cathepsin_G__Pan_paniscus_:0.00000001):0.00702897,(XP_004055078_3_cathepsin_G__Gorilla_gorilla_gorilla_:0.01419414,XP_024087523_1_cathepsin_G__Pongo_abelii_:0.02862465):0.00000001):0.01191263);
BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)