PB0012

DATABASE

Click here to access PB0012 phyletic profile

PBID	Uniprot	Name	Gene	Alternative	Organism	Uniprot Description
PB0012	P06702	S100 calcium binding protein A9	S100A9	MIF, NIF, P14, CAGB, CFAG, CGLB, L1AG, LIAG, MRP14, 60B8AG, MAC387, S100-A9	Homo_sapiens	The iNOS-S100A8/A9 transnitrosylase complex is proposed to also direct selective inflammatory stimulus-dependent S-nitrosylation of multiple targets such as ANXA5, EZR, MSN and VIM by recognizing a [IL]-x-C-x-x-[DE] motif (PubMed:25417112).

Domains

Gene Ontology

PF01023 (S_100)

GO:0005509 (enables) calcium ion binding GO:0005515 (enables) protein binding GO:0008017 (enables) microtubule binding GO:0008270 (enables) zinc ion binding GO:0016209 (enables) antioxidant activity GO:0035662 (enables) Toll-like receptor 4 binding GO:0046872 (enables) metal ion binding GO:0048306 (enables) calcium-dependent protein binding GO:0050544 (enables) arachidonic acid binding GO:0050786 (enables) RAGE receptor binding GO:0002376 (involved in) immune system process GO:0002523 (involved in) leukocyte migration involved in inflammatory response GO:0002544 (involved in) chronic inflammatory response GO:0006914 (involved in) autophagy GO:0006915 (involved in) apoptotic process GO:0006919 (involved in) activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006935 (involved in) chemotaxis GO:0006954 (involved in) inflammatory response GO:0007267 (involved in) cell-cell signaling GO:0010976 (involved in) positive regulation of neuron projection development GO:0014002 (involved in) astrocyte development GO:0018119 (involved in) peptidyl-cysteine S-nitrosylation GO:0030307 (involved in) positive regulation of cell growth GO:0030593 (involved in) neutrophil chemotaxis GO:0032119 (involved in) sequestering of zinc ion GO:0032496 (involved in) response to lipopolysaccharide GO:0035425 (involved in) autocrine signaling GO:0035606 (involved in) peptidyl-cysteine S-trans-nitrosylation GO:0035821 (involved in) modulation of process of other organism GO:0042742 (involved in) defense response to bacterium GO:0045087 (involved in) innate immune response GO:0045113 (involved in) regulation of integrin biosynthetic process GO:0050729 (involved in) positive regulation of inflammatory response GO:0050832 (involved in) defense response to fungus GO:0051092 (involved in) positive regulation of NF-kappaB transcription factor activity GO:0051493 (involved in) regulation of cytoskeleton organization GO:0061844 (involved in) antimicrobial humoral immune response mediated by antimicrobial peptide GO:0070488 (involved in) neutrophil aggregation GO:0098869 (involved in) cellular oxidant detoxification GO:2001244 (involved in) positive regulation of intrinsic apoptotic signaling pathway GO:0005615 (is active in) extracellular space GO:0005634 (is active in) nucleus GO:0005737 (is active in) cytoplasm GO:0005576 (located in) extracellular region GO:0005654 (located in) nucleoplasm GO:0005829 (located in) cytosol GO:0005856 (located in) cytoskeleton GO:0005886 (located in) plasma membrane GO:0016020 (located in) membrane GO:0030054 (located in) cell junction GO:0034774 (located in) secretory granule lumen GO:0070062 (located in) extracellular exosome GO:0062023 (part of) collagen-containing extracellular matrix

External Links	Description
Intact	Open source database system and analysis tools for molecular interaction data.
Protein Atlas	An open access resource for human proteins
InterPro (new pfam)	InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish) >sp|P06702|S10A9_HUMAN Protein S100-A9 OS=Homo sapiens OX=9606 GN=S100A9 PE=1 SV=1 MTCKMSQLERNIETIINTFHQYSVKLGHPDTLNQGEFKELVRKDLQNFLKKENKNEKVIE HIMEDLDTNADKQLSFEEFIMLMARLTWASHEKMHEGDEGPGHHHKPGLGEGTP
Selected proteins from model organisms >NP_002956.1 protein S100-A9 [Homo sapiens] MTCKMSQLERNIETIINTFHQYSVKLGHPDTLNQGEFKELVRKDLQNFLKKENKNEKVIEHIMEDLDTNA DKQLSFEEFIMLMARLTWASHEKMHEGDEGPGHHHKPGLGEGTP >NP_001268781.1 protein S100-A9 [Mus musculus] MANKAPSQMERSITTIIDTFHQYSRKEGHPDTLSKKEFRQMVEAQLATFMKKEKRNEALINDIMEDLDTN QDNQLSFEECMMLMAKLIFACHEKLHENNPRGHGHSHGKGCGK >KAB0385539.1 hypothetical protein FD755_000495 [Muntiacus reevesi] MADQMSQMECSIETIINIFHQYSVRLGHPDTLMQKEFKQLVKKELPNFLKKQKKNDKLINEIMEDLDTNQDKQLSFEEFI MLVAKLTVASHEEMHKTAPPGDGHRHGPGFGQGGSGPCPSQGGPSQGGPGHGHSHDHGHGHGHDHGHGHGHSH >XP_043312449.1 protein S100-A9 [Cervus canadensis] MADQMSQMECSIETIINIFHHYSVRLGHPDTLMQKEFKQLVKKELPNFLKKQKKNDKAINEIMEDLDTNQDKQLSFEEFI MLVAKLTVASHEEMHKTAPPGDGHRHGPGFGQGGSGPCPSQGGSDHSHDHGHGHGHDHGHGHGHSH >NP_001292080.1 protein MRP-126 [Gallus gallus] MSKGCQTQGPLSELEKAIDVIIDVFHQYSRREGDKDTLTRKELKLLIEKQLANYLKHVKNQVSIDQIFKDLDNNKDQQLS FGEVMLLIIRVTVATHEHLHFCEDHQQQHQHQHQHQHNH >XP_005512844.2 protein MRP-126 [Columba livia] MPRLDQPRSSLSGSRCLATMSKSSQTQEPLSELEKSMDVIIDVFHQYSRREGDRDTLTKKELKLLIEKQLANYLKHVKSK ATIDEIMKDLDINRDAQISFCEVMLLITRVTIATHEHLHDVEGQQQQQQQQLKQQHHH >XP_010725281.1 protein MRP-126 [Meleagris gallopavo] MLLSRPAAVQPETVICCFSNMSKGCQTQGPLSELEKAIDVIIDVFHQFSRREGDKDTLTKKELKLLIEKQLANYLKHVKN QASIDQIFKDLDGNKDQQLSFGEVMLLIMRVTAATHEHLHFCEDQQHQHQHQHQHQHNH >XP_006031036.1 protein MRP-126-like [Alligator sinensis] MSKKCPDAQTELEKAIEKIIDIFHQYSVRVGHFDTLTKMEMKLLIDKQLPNYMKNKIKPGEIDALFKDLDKNKDQQLSFG EFMGLISKVTIATHEHLHHCGEEEGHHHHQDEHHHH >OWK04948.1 S100A12 [Cervus elaphus hippelaphus] MTKLEDYLEGIINIFHQYSVRLGDYDTLIKRELKQLITKELPNTLKLDANKDGQVSFEEFIVLVSRVLKTAHEDIHKE >XP_030267160.1 protein S100-A1-like [Sparus aurata] MPSELETAMESLIKVFHRYASREGKTGTLNRRELRELMENELSNFLKSQKDPAAVDKIMKDLDTNGDGQVDFEEFVSLVV GLSIACEQCYQMHMKKTCKK >NP_998168.1 protein S100-A10b [Danio rerio] MPSDLERAMETLITVFHRYSGAEGNSSTLSRRELKQLMEKELASFLKSQKDPAAVDKIMKDLDANGDGEVNFEEFVSLVV GLSIACEQLYQKQMKAAAKK >XP_018098399.1 protein S100-Z [Xenopus laevis] MPTKLESAMDTLIRIFHHYSGKEGDKYKLNKGELKQLLQSELTDFLACQKDPQLVDKIMNDLDSNKDNEVDFGEFVVLVA ALTVACNEFFEEQQRKKSK >XP_015805913.1 PREDICTED: protein S100-A1-like [Nothobranchius furzeri] MTDLEKAMESLITVFHRYAKEGGNKNTLSKKELKKLIEGELPTFLKSQKNPDTLDTILKDLDENKDDELDFEEFVPFVAG LTIACEKHYSLANEGKKGKK >XP_004074549.1 protein S100-Z [Oryzias latipes] MPSQLEGAMGALITVFYNYSGNDGDKHKLNKGELKELLHSELTDFLTSQKDPLLVEKIMNDLDSNKDNEVDFNEFVVLVA ALTVACNDFFQEQNKHAK >XP_040189548.1 protein S100-A1-like [Rana temporaria] MSKLEKAMDTLIEVFHTYSAREGDKHKLCKRELKDLLQNELGEYLEEQKDATSVDKILKELDENGDGEVDFQEFVILVAS LTVACNTFFCESS >KAB0366408.1 hypothetical protein FD754_010564 [Muntiacus muntjak] MADQMSQMECSIETIINIFHQYSVRLGHPDTLMQKEFKQLVKKELPNFLKKQKKDDKLINEIMEDLDTNQDKQLSFEEFI MLVAKLTVASHEEMHKTAPPGDGHRHGPGFGQGGSGPCPSQGGPGHGHSHDHGHGHGHDHGHGHGHSH >XP_006278580.2 PREDICTED: protein MRP-126 [Alligator mississippiensis] MSKKCPDAQTELEKAIETIINIFHQYSVRVGHFDTLTKMEMKLLIEKQLPNYMKNQTKPGEIDALFKDLDKNKDKQLSFG EFMVLITRVTIATHEHLHHCGEEEGQHHHQDEHHHH >NP_446039.2 protein S100-A9 [Rattus norvegicus] MAAKTGSQLERSISTIINVFHQYSRKYGHPDTLNKAEFKEMVNKDLPNFLKREKRNENLLRDIMEDLDTN QDNQLSFEECMMLMGKLIFACHEKLHENNPRGHDHSHGKGCGK >XP_514430.1 protein S100-A9 [Pan troglodytes] MTCKMSQLERNIETIINTFHQYSVKLGHPDTLNQGEFKELVQKDLQNFLKKENKNEKVIEHIMEDLDTNA DKQLSFEEFIMLMARLTWASHEKMHEGDEGPGHHHKPGLGEGTP >XP_005622884.1 protein S100-A9 [Canis lupus familiaris] MADQMSQLECSIETIINIFHQYSVRLEHPDKLNQKEMKQLVKKELPNFLKKQKKNDNAINKIMEDLDTNG DKELNFEEFSILVARLTVASHEEMHKNAPEGEGHSHGPGFGEGSQGHCHSHGGHGHGHSH >XP_005203785.2 protein S100-A9 isoform X1 [Bos taurus] MEDKMSQMESSIETIINIFHQYSVRLGHYDTLIQKEFKQLVQKELPNFLKKQKKNEAAINEIMEDLDTNV DKQLSFEEFIMLVARLTVASHEEMHNTAPPGQGHRHGPGYGKGGSGSCSGQGSPDQGSHDQGSHGHGHGH SHGGHGHSHGGHGHSH >NP_001243402.1 protein S100-A9 [Oryctolagus cuniculus] MSCGMSQLERSIDTIINVFHQYSXRVGPRDSLSQKEFKQLVQKELHNFLKKEARDEKAINDIMEDLDTNQ DKQLSFEEFVILMARLVHASHEEMHKNAPHDHEGHSHGPGLGGGGPGHGHGHSHGHGHGHSH >XP_013852489.2 S100 calcium binding protein A9 isoform X1 [Sus scrofa] MLGPLLAVQPLCVAPGLGDRRCRGSSPSERANPCFSIAQTECRKMADQMSQMECSIETIINIFHQYSVRL GNRDTLNQKEFKQLVKKELPNFLKKQKRDEKAINHILEDLDTNVDKQLSFEEFSMLVAKLTVASHEEMHK TAPPGDGHHHGPGFGSSSSGPCAGQESQTPGGHGHGHSHGGHGHGHSH >XP_002810212.1 protein S100-A9 [Pongo abelii] MTCKMSQLERNIETIINTFHQYSVKLGHPDTLNQGEFKELVQKDLQNFLKKENKKEKVIEHIMEDLDTNA DKQLSFEEFIMLMARLTWASHEKMHEGDEGPGHHHKPGLGEDTP >XP_003817233.1 protein S100-A9 [Pan paniscus] MTCKMSQLERNIETIINTFHQYSVKLGHPDTLNQGEFKELVQKDLQNFLKKENKNEKVIEHIMEDLDTNA DKQLSFEEFIMLMARLTWASHEKMHEGDEGPGHHHKPGLGEGTP >XP_023103613.1 protein S100-A9 isoform X1 [Felis catus] MLAHRVLSNPVVWLLGRQECRKMADQLSQMECSIETIINIFHQYCVRLGHPDKLNPEELKQLVKKELPNF LKPQKQKKNDTVINKIMEDLDTNGDKELNFEEFSILVGRLTVASHEEMHKNAPEGEGHSHGPGFGEGGQS HCHSHGGHGHSHGGHGHSH >XP_012037113.2 protein S100-A9 [Ovis aries] MADQLSQMESSIETIINIFHQYSIRLRDPETLIRKELKQLVQKELPNFLKKQHKDEEAINEIMEDLDTNQ DKQLSFEEFIMLVARLTVASHEEMHKTAPPGRGHRHGPGFDKGGAGPCPGQGGPDHSHGGHGHSHGGHGH SHGGHGHSH >XP_004026771.1 protein S100-A9 [Gorilla gorilla gorilla] MTCKMSQLERNIETIINTFHQYSVKLGHPDTLNQGEFKELVRKDLQNFLKKENKNEKVIEHIMEDLDTNA DKQLSFEEFIMLMARLTWASHEKMHEGDEGPGHHHKPGLGEGTP >XP_013832703.2 PREDICTED: protein S100-A9 [Capra hircus] MADQLSQMECSIETIINIFHQYSIRLRDPETLIQRELKQLVQKELPNFLKKQNKDEEAINEIMEDLDTNQ DKQLSFEEFIMLVARLTVASHEEMHKTAPPGKGHRHGPGFDKGGAGPCPGQGGPDHSHGGHGHSHGGHGH SHGGHGHGHSH >XP_020763218.1 protein S100-A9 [Odocoileus virginianus texanus] MADQMSQMECSIEAIINIFHQYSVRLGHPDTLMQKEFKQLVQKELPNFIKKQKKDEKVINEIMEDLDTNQ DKQLSFEEFIMLVAKLTVASHEEMHKTAPPGDGHRHGPGFGQGGSGPCPSQGGHGHSHGGHGHGHSHGGH GHSH
Mafft alignment of selected proteins >NP_002956.1 protein S100-A9 [Homo sapiens] ---------------------------------------------MTCKMSQLERNIETI INTFHQYSVKLGHPDTLNQGEFKELVRKDLQNFLK--KENKNEKVIEHIMEDLDTNADKQ LSFEEFIMLMARLTWASHEKMHEGD-EG-PGHHHKPGLGEGTP----------------- --------------------------------- >NP_001268781.1 protein S100-A9 [Mus musculus] M--------------------------------------------ANKAPSQMERSITTI IDTFHQYSRKEGHPDTLSKKEFRQMVEAQLATFMK--KEKRNEALINDIMEDLDTNQDNQ LSFEECMMLMAKLIFACHEKLHENNPRG-HGHSHGKGCGK-------------------- --------------------------------- >KAB0385539.1 hypothetical protein FD755_000495 [Muntiacus reevesi] ---------------------------------------------MADQMSQMECSIETI INIFHQYSVRLGHPDTLMQKEFKQLVKKELPNFLK--KQKKNDKLINEIMEDLDTNQDKQ LSFEEFIMLVAKLTVASHEEMHKTAPPG-DGHRHGPGFGQGGSGPCPSQGGPSQGGPGHG H----SHDHGH-----GHGHDHG-HGHGHSH-- >XP_043312449.1 protein S100-A9 [Cervus canadensis] ---------------------------------------------MADQMSQMECSIETI INIFHHYSVRLGHPDTLMQKEFKQLVKKELPNFLK--KQKKNDKAINEIMEDLDTNQDKQ LSFEEFIMLVAKLTVASHEEMHKTAPPG-DGHRHGPGFGQGGSGPC-----PSQGGSDH- -----SHDHGH-----GHGHDHG-HGHGHSH-- >NP_001292080.1 protein MRP-126 [Gallus gallus] ---------------------------------------MSKGCQTQGPLSELEKAIDVI IDVFHQYSRREGDKDTLTRKELKLLIEKQLANYLK--HV-KNQVSIDQIFKDLDNNKDQQ LSFGEVMLLIIRVTVATHEHLHFCEDHQ-QQHQHQ------------------------- ------------------------HQHQHNH-- >XP_005512844.2 protein MRP-126 [Columba livia] M--------PRLDQP-----------RSSLSGSRCLA-TMSKSSQTQEPLSELEKSMDVI IDVFHQYSRREGDRDTLTKKELKLLIEKQLANYLK--HV-KSKATIDEIMKDLDINRDAQ ISFCEVMLLITRVTIATHEHLHDVEGQQ-QQQQQQ------------------------- ------------------------LKQQHHH-- >XP_010725281.1 protein MRP-126 [Meleagris gallopavo] ML----LSRPAAVQP-----------ETVIC---CFS-NMSKGCQTQGPLSELEKAIDVI IDVFHQFSRREGDKDTLTKKELKLLIEKQLANYLK--HV-KNQASIDQIFKDLDGNKDQQ LSFGEVMLLIMRVTAATHEHLHFCEDQQ-HQHQHQ------------------------- ------------------------HQHQHNH-- >XP_006031036.1 protein MRP-126-like [Alligator sinensis] M-----------------------------------------SKKCPDAQTELEKAIEKI IDIFHQYSVRVGHFDTLTKMEMKLLIDKQLPNYMK--NK-IKPGEIDALFKDLDKNKDQQ LSFGEFMGLISKVTIATHEHLHHCGEEE-GHHHHQ------------------------- ------------------------DEHHH-H-- >OWK04948.1 S100A12 [Cervus elaphus hippelaphus] -------------------------------------------------MTKLEDYLEGI INIFHQYSVRLGDYDTLIKRELKQLITKELPNTLK-----------------LDANKDGQ VSFEEFIVLVSRVLKTAHEDIHKE------------------------------------ --------------------------------- >XP_030267160.1 protein S100-A1-like [Sparus aurata] ------------------------------------------------MPSELETAMESL IKVFHRYASREGKTGTLNRRELRELMENELSNFLK--SQ-KDPAAVDKIMKDLDTNGDGQ VDFEEFVSLVVGLSIACEQCYQMHMKKT-CKK---------------------------- --------------------------------- >NP_998168.1 protein S100-A10b [Danio rerio] ------------------------------------------------MPSDLERAMETL ITVFHRYSGAEGNSSTLSRRELKQLMEKELASFLK--SQ-KDPAAVDKIMKDLDANGDGE VNFEEFVSLVVGLSIACEQLYQKQMKAA-AKK---------------------------- --------------------------------- >XP_018098399.1 protein S100-Z [Xenopus laevis] ------------------------------------------------MPTKLESAMDTL IRIFHHYSGKEGDKYKLNKGELKQLLQSELTDFLA--CQ-KDPQLVDKIMNDLDSNKDNE VDFGEFVVLVAALTVACNEFFEEQQRKK-SK----------------------------- --------------------------------- >XP_015805913.1 PREDICTED: protein S100-A1-like [Nothobranchius furzeri] -------------------------------------------------MTDLEKAMESL ITVFHRYAKEGGNKNTLSKKELKKLIEGELPTFLK--SQ-KNPDTLDTILKDLDENKDDE LDFEEFVPFVAGLTIACEKHYSLANEGK-KGKK--------------------------- --------------------------------- >XP_004074549.1 protein S100-Z [Oryzias latipes] ------------------------------------------------MPSQLEGAMGAL ITVFYNYSGNDGDKHKLNKGELKELLHSELTDFLT--SQ-KDPLLVEKIMNDLDSNKDNE VDFNEFVVLVAALTVACNDFFQEQNKHA-K------------------------------ --------------------------------- >XP_040189548.1 protein S100-A1-like [Rana temporaria] -------------------------------------------------MSKLEKAMDTL IEVFHTYSAREGDKHKLCKRELKDLLQNELGEYLE--EQ-KDATSVDKILKELDENGDGE VDFQEFVILVASLTVACNTFFCESS----------------------------------- --------------------------------- >KAB0366408.1 hypothetical protein FD754_010564 [Muntiacus muntjak] ---------------------------------------------MADQMSQMECSIETI INIFHQYSVRLGHPDTLMQKEFKQLVKKELPNFLK--KQKKDDKLINEIMEDLDTNQDKQ LSFEEFIMLVAKLTVASHEEMHKTAPPG-DGHRHGPGFGQGGSGPC-----PSQGGPGHG H----SHDHGH-----GHGHDHG-HGHGHSH-- >XP_006278580.2 PREDICTED: protein MRP-126 [Alligator mississippiensis] M-----------------------------------------SKKCPDAQTELEKAIETI INIFHQYSVRVGHFDTLTKMEMKLLIEKQLPNYMK--NQ-TKPGEIDALFKDLDKNKDKQ LSFGEFMVLITRVTIATHEHLHHCGEEE-GQHHHQ------------------------- ------------------------DEHHH-H-- >NP_446039.2 protein S100-A9 [Rattus norvegicus] M--------------------------------------------AAKTGSQLERSISTI INVFHQYSRKYGHPDTLNKAEFKEMVNKDLPNFLK--REKRNENLLRDIMEDLDTNQDNQ LSFEECMMLMGKLIFACHEKLHENNPRG-HDHSHGKGCGK-------------------- --------------------------------- >XP_514430.1 protein S100-A9 [Pan troglodytes] ---------------------------------------------MTCKMSQLERNIETI INTFHQYSVKLGHPDTLNQGEFKELVQKDLQNFLK--KENKNEKVIEHIMEDLDTNADKQ LSFEEFIMLMARLTWASHEKMHEGD-EG-PGHHHKPGLGEGTP----------------- --------------------------------- >XP_005622884.1 protein S100-A9 [Canis lupus familiaris] ---------------------------------------------MADQMSQLECSIETI INIFHQYSVRLEHPDKLNQKEMKQLVKKELPNFLK--KQKKNDNAINKIMEDLDTNGDKE LNFEEFSILVARLTVASHEEMHKNAPEG-EGHSHGPGFGEGSQGHC------------H- -----SHG--------GH-------GHGHSH-- >XP_005203785.2 protein S100-A9 isoform X1 [Bos taurus] ---------------------------------------------MEDKMSQMESSIETI INIFHQYSVRLGHYDTLIQKEFKQLVQKELPNFLK--KQKKNEAAINEIMEDLDTNVDKQ LSFEEFIMLVARLTVASHEEMHNTAPPG-QGHRHGPGYGKGGSGSC-----SGQGSPDQG SHDQGSHGHGHGHSHGGHGHSHG--GHGHSH-- >NP_001243402.1 protein S100-A9 [Oryctolagus cuniculus] ---------------------------------------------MSCGMSQLERSIDTI INVFHQYSXRVGPRDSLSQKEFKQLVQKELHNFLK--KEARDEKAINDIMEDLDTNQDKQ LSFEEFVILMARLVHASHEEMHKNAPHDHEGHSHGPGLGGGGP----------------- ---------GH-----GHGHSHG-HGHGHSH-- >XP_013852489.2 S100 calcium binding protein A9 isoform X1 [Sus scrofa] MLGPLLAVQPLCVAPGLGDRRCRGSSPSERANP-CFSIAQTECRKMADQMSQMECSIETI INIFHQYSVRLGNRDTLNQKEFKQLVKKELPNFLK--KQKRDEKAINHILEDLDTNVDKQ LSFEEFSMLVAKLTVASHEEMHKTAPPG-DGHHHGPGFGSSSSGPC-----AGQESQTPG ---------GH-----GHGHSHGGHGHGHSH-- >XP_002810212.1 protein S100-A9 [Pongo abelii] ---------------------------------------------MTCKMSQLERNIETI INTFHQYSVKLGHPDTLNQGEFKELVQKDLQNFLK--KENKKEKVIEHIMEDLDTNADKQ LSFEEFIMLMARLTWASHEKMHEGD-EG-PGHHHKPGLGEDTP----------------- --------------------------------- >XP_003817233.1 protein S100-A9 [Pan paniscus] ---------------------------------------------MTCKMSQLERNIETI INTFHQYSVKLGHPDTLNQGEFKELVQKDLQNFLK--KENKNEKVIEHIMEDLDTNADKQ LSFEEFIMLMARLTWASHEKMHEGD-EG-PGHHHKPGLGEGTP----------------- --------------------------------- >XP_023103613.1 protein S100-A9 isoform X1 [Felis catus] ML-----------------------AHRVLSNPVVWLLGRQECRKMADQLSQMECSIETI INIFHQYCVRLGHPDKLNPEELKQLVKKELPNFLKPQKQKKNDTVINKIMEDLDTNGDKE LNFEEFSILVGRLTVASHEEMHKNAPEG-EGHSHGPGFGEGGQSHC------------H- -----SHG--------GHGHSHG--GHGHSH-- >XP_012037113.2 protein S100-A9 [Ovis aries] ---------------------------------------------MADQLSQMESSIETI INIFHQYSIRLRDPETLIRKELKQLVQKELPNFLK--KQHKDEEAINEIMEDLDTNQDKQ LSFEEFIMLVARLTVASHEEMHKTAPPG-RGHRHGPGFDKGGAGPC-----PGQGGPDH- -----SHG-GHGHSHGGHGHSHG--GHGHSH-- >XP_004026771.1 protein S100-A9 [Gorilla gorilla gorilla] ---------------------------------------------MTCKMSQLERNIETI INTFHQYSVKLGHPDTLNQGEFKELVRKDLQNFLK--KENKNEKVIEHIMEDLDTNADKQ LSFEEFIMLMARLTWASHEKMHEGD-EG-PGHHHKPGLGEGTP----------------- --------------------------------- >XP_013832703.2 PREDICTED: protein S100-A9 [Capra hircus] ---------------------------------------------MADQLSQMECSIETI INIFHQYSIRLRDPETLIQRELKQLVQKELPNFLK--KQNKDEEAINEIMEDLDTNQDKQ LSFEEFIMLVARLTVASHEEMHKTAPPG-KGHRHGPGFDKGGAGPC-----PGQGGPDH- -----SHG-GHGHSHGGHGHSHG--GHGHGHSH >XP_020763218.1 protein S100-A9 [Odocoileus virginianus texanus] ---------------------------------------------MADQMSQMECSIEAI INIFHQYSVRLGHPDTLMQKEFKQLVQKELPNFIK--KQKKDEKVINEIMEDLDTNQDKQ LSFEEFIMLVAKLTVASHEEMHKTAPPG-DGHRHGPGFGQGGSGPC-----PSQGGHGH- -----SHG-GH-----GHGHSHG--GHGHSH--
BMGE Cleaned alignment of selected proteins >NP_002956.1 protein S100-A9 [Homo sapiens] MTCKMSQLERNIETIINTFHQYSVKLGHPDTLNQGEFKELVRKDLQNFLKKENKNEVIEHIMEDLDTNADKQLSFEEFIMLMARLTWASHEKMHEPGHHHKPGLGEGTP >NP_001268781.1 protein S100-A9 [Mus musculus] ANKAPSQMERSITTIIDTFHQYSRKEGHPDTLSKKEFRQMVEAQLATFMKKEKRNELINDIMEDLDTNQDNQLSFEECMMLMAKLIFACHEKLHEHGHSHGKGCGK--- >KAB0385539.1 hypothetical protein FD755_000495 [Muntiacus reevesi] MADQMSQMECSIETIINIFHQYSVRLGHPDTLMQKEFKQLVKKELPNFLKKQKKNDLINEIMEDLDTNQDKQLSFEEFIMLVAKLTVASHEEMHKDGHRHGPGFGQGGS >XP_043312449.1 protein S100-A9 [Cervus canadensis] MADQMSQMECSIETIINIFHHYSVRLGHPDTLMQKEFKQLVKKELPNFLKKQKKNDAINEIMEDLDTNQDKQLSFEEFIMLVAKLTVASHEEMHKDGHRHGPGFGQGGS >NP_001292080.1 protein MRP-126 [Gallus gallus] TQGPLSELEKAIDVIIDVFHQYSRREGDKDTLTRKELKLLIEKQLANYLKHV-KNQSIDQIFKDLDNNKDQQLSFGEVMLLIIRVTVATHEHLHFQQHQHQ-------- >XP_005512844.2 protein MRP-126 [Columba livia] TQEPLSELEKSMDVIIDVFHQYSRREGDRDTLTKKELKLLIEKQLANYLKHV-KSKTIDEIMKDLDINRDAQISFCEVMLLITRVTIATHEHLHDQQQQQQ-------- >XP_010725281.1 protein MRP-126 [Meleagris gallopavo] TQGPLSELEKAIDVIIDVFHQFSRREGDKDTLTKKELKLLIEKQLANYLKHV-KNQSIDQIFKDLDGNKDQQLSFGEVMLLIMRVTAATHEHLHFHQHQHQ-------- >XP_006031036.1 protein MRP-126-like [Alligator sinensis] CPDAQTELEKAIEKIIDIFHQYSVRVGHFDTLTKMEMKLLIDKQLPNYMKNK-IKPEIDALFKDLDKNKDQQLSFGEFMGLISKVTIATHEHLHHGHHHHQ-------- >OWK04948.1 S100A12 [Cervus elaphus hippelaphus] ----MTKLEDYLEGIINIFHQYSVRLGDYDTLIKRELKQLITKELPNTLK--------------LDANKDGQVSFEEFIVLVSRVLKTAHEDIHK-------------- >XP_030267160.1 protein S100-A1-like [Sparus aurata] ---MPSELETAMESLIKVFHRYASREGKTGTLNRRELRELMENELSNFLKSQ-KDPAVDKIMKDLDTNGDGQVDFEEFVSLVVGLSIACEQCYQMCKK----------- >NP_998168.1 protein S100-A10b [Danio rerio] ---MPSDLERAMETLITVFHRYSGAEGNSSTLSRRELKQLMEKELASFLKSQ-KDPAVDKIMKDLDANGDGEVNFEEFVSLVVGLSIACEQLYQKAKK----------- >XP_018098399.1 protein S100-Z [Xenopus laevis] ---MPTKLESAMDTLIRIFHHYSGKEGDKYKLNKGELKQLLQSELTDFLACQ-KDPLVDKIMNDLDSNKDNEVDFGEFVVLVAALTVACNEFFEESK------------ >XP_015805913.1 PREDICTED: protein S100-A1-like [Nothobranchius furzeri] ----MTDLEKAMESLITVFHRYAKEGGNKNTLSKKELKKLIEGELPTFLKSQ-KNPTLDTILKDLDENKDDELDFEEFVPFVAGLTIACEKHYSLKGKK---------- >XP_004074549.1 protein S100-Z [Oryzias latipes] ---MPSQLEGAMGALITVFYNYSGNDGDKHKLNKGELKELLHSELTDFLTSQ-KDPLVEKIMNDLDSNKDNEVDFNEFVVLVAALTVACNDFFQEK------------- >XP_040189548.1 protein S100-A1-like [Rana temporaria] ----MSKLEKAMDTLIEVFHTYSAREGDKHKLCKRELKDLLQNELGEYLEEQ-KDASVDKILKELDENGDGEVDFQEFVILVASLTVACNTFFCE-------------- >KAB0366408.1 hypothetical protein FD754_010564 [Muntiacus muntjak] MADQMSQMECSIETIINIFHQYSVRLGHPDTLMQKEFKQLVKKELPNFLKKQKKDDLINEIMEDLDTNQDKQLSFEEFIMLVAKLTVASHEEMHKDGHRHGPGFGQGGS >XP_006278580.2 PREDICTED: protein MRP-126 [Alligator mississippiensis] CPDAQTELEKAIETIINIFHQYSVRVGHFDTLTKMEMKLLIEKQLPNYMKNQ-TKPEIDALFKDLDKNKDKQLSFGEFMVLITRVTIATHEHLHHGQHHHQ-------- >NP_446039.2 protein S100-A9 [Rattus norvegicus] AAKTGSQLERSISTIINVFHQYSRKYGHPDTLNKAEFKEMVNKDLPNFLKREKRNELLRDIMEDLDTNQDNQLSFEECMMLMGKLIFACHEKLHEHDHSHGKGCGK--- >XP_514430.1 protein S100-A9 [Pan troglodytes] MTCKMSQLERNIETIINTFHQYSVKLGHPDTLNQGEFKELVQKDLQNFLKKENKNEVIEHIMEDLDTNADKQLSFEEFIMLMARLTWASHEKMHEPGHHHKPGLGEGTP >XP_005622884.1 protein S100-A9 [Canis lupus familiaris] MADQMSQLECSIETIINIFHQYSVRLEHPDKLNQKEMKQLVKKELPNFLKKQKKNDAINKIMEDLDTNGDKELNFEEFSILVARLTVASHEEMHKEGHSHGPGFGEGSQ >XP_005203785.2 protein S100-A9 isoform X1 [Bos taurus] MEDKMSQMESSIETIINIFHQYSVRLGHYDTLIQKEFKQLVQKELPNFLKKQKKNEAINEIMEDLDTNVDKQLSFEEFIMLVARLTVASHEEMHNQGHRHGPGYGKGGS >NP_001243402.1 protein S100-A9 [Oryctolagus cuniculus] MSCGMSQLERSIDTIINVFHQYSXRVGPRDSLSQKEFKQLVQKELHNFLKKEARDEAINDIMEDLDTNQDKQLSFEEFVILMARLVHASHEEMHKEGHSHGPGLGGGGP >XP_013852489.2 S100 calcium binding protein A9 isoform X1 [Sus scrofa] MADQMSQMECSIETIINIFHQYSVRLGNRDTLNQKEFKQLVKKELPNFLKKQKRDEAINHILEDLDTNVDKQLSFEEFSMLVAKLTVASHEEMHKDGHHHGPGFGSSSS >XP_002810212.1 protein S100-A9 [Pongo abelii] MTCKMSQLERNIETIINTFHQYSVKLGHPDTLNQGEFKELVQKDLQNFLKKENKKEVIEHIMEDLDTNADKQLSFEEFIMLMARLTWASHEKMHEPGHHHKPGLGEDTP >XP_003817233.1 protein S100-A9 [Pan paniscus] MTCKMSQLERNIETIINTFHQYSVKLGHPDTLNQGEFKELVQKDLQNFLKKENKNEVIEHIMEDLDTNADKQLSFEEFIMLMARLTWASHEKMHEPGHHHKPGLGEGTP >XP_023103613.1 protein S100-A9 isoform X1 [Felis catus] MADQLSQMECSIETIINIFHQYCVRLGHPDKLNPEELKQLVKKELPNFLKKQKKNDVINKIMEDLDTNGDKELNFEEFSILVGRLTVASHEEMHKEGHSHGPGFGEGGQ >XP_012037113.2 protein S100-A9 [Ovis aries] MADQLSQMESSIETIINIFHQYSIRLRDPETLIRKELKQLVQKELPNFLKKQHKDEAINEIMEDLDTNQDKQLSFEEFIMLVARLTVASHEEMHKRGHRHGPGFDKGGA >XP_004026771.1 protein S100-A9 [Gorilla gorilla gorilla] MTCKMSQLERNIETIINTFHQYSVKLGHPDTLNQGEFKELVRKDLQNFLKKENKNEVIEHIMEDLDTNADKQLSFEEFIMLMARLTWASHEKMHEPGHHHKPGLGEGTP >XP_013832703.2 PREDICTED: protein S100-A9 [Capra hircus] MADQLSQMECSIETIINIFHQYSIRLRDPETLIQRELKQLVQKELPNFLKKQNKDEAINEIMEDLDTNQDKQLSFEEFIMLVARLTVASHEEMHKKGHRHGPGFDKGGA >XP_020763218.1 protein S100-A9 [Odocoileus virginianus texanus] MADQMSQMECSIEAIINIFHQYSVRLGHPDTLMQKEFKQLVQKELPNFIKKQKKDEVINEIMEDLDTNQDKQLSFEEFIMLVAKLTVASHEEMHKDGHRHGPGFGQGGS
PhyML tree of selected proteins (((NP_001243402_1_protein_S100_A9__Oryctolagus_cuniculus_:0.1955867,(((NP_002956_1_protein_S100_A9__Homo_sapiens_:0.00000001,XP_004026771_1_protein_S100_A9__Gorilla_gorilla_gorilla_:0.00000001):0.00925925,(XP_002810212_1_protein_S100_A9__Pongo_abelii_:0.01856669,(XP_514430_1_protein_S100_A9__Pan_troglodytes_:0.00000001,XP_003817233_1_protein_S100_A9__Pan_paniscus_:0.00000001):0.00000001):0.00000001):0.20784527,(NP_001268781_1_protein_S100_A9__Mus_musculus_:0.15482245,NP_446039_2_protein_S100_A9__Rattus_norvegicus_:0.12664254):0.31060368):0.05048217):0.15235281,((XP_020763218_1_protein_S100_A9__Odocoileus_virginianus_texanus_:0.03596837,((KAB0385539_1_hypothetical_protein_FD755_000495__Muntiacus_reevesi_:0.00000001,KAB0366408_1_hypothetical_protein_FD754_010564__Muntiacus_muntjak_:0.00900467):0.00911127,(XP_043312449_1_protein_S100_A9__Cervus_canadensis_:0.00896002,(XP_013852489_2_S100_calcium_binding_protein_A9_isoform_X1__Sus_scrofa_:0.11120864,(XP_023103613_1_protein_S100_A9_isoform_X1__Felis_catus_:0.06726494,XP_005622884_1_protein_S100_A9__Canis_lupus_familiaris_:0.02912929):0.11337541):0.03716837):0.00000001):0.01860637):0.03672152,(XP_013832703_2_PREDICTED__protein_S100_A9__Capra_hircus_:0.01079612,XP_012037113_2_protein_S100_A9__Ovis_aries_:0.03589471):0.10889657):0.00124939):0.0424388,XP_005203785_2_protein_S100_A9_isoform_X1__Bos_taurus_:0.02988546,(OWK04948_1_S100A12__Cervus_elaphus_hippelaphus_:0.42102885,(((XP_006278580_2_PREDICTED__protein_MRP_126__Alligator_mississippiensis_:0.00000001,XP_006031036_1_protein_MRP_126_like__Alligator_sinensis_:0.11300087):0.22014974,(XP_005512844_2_protein_MRP_126__Columba_livia_:0.18676685,(XP_010725281_1_protein_MRP_126__Meleagris_gallopavo_:0.04975358,NP_001292080_1_protein_MRP_126__Gallus_gallus_:0.01361835):0.05261876):0.28644956):0.23326288,(XP_015805913_1_PREDICTED__protein_S100_A1_like__Nothobranchius_furzeri_:0.34536493,((XP_030267160_1_protein_S100_A1_like__Sparus_aurata_:0.20932032,NP_998168_1_protein_S100_A10b__Danio_rerio_:0.10324038):0.1055547,(XP_040189548_1_protein_S100_A1_like__Rana_temporaria_:0.36317271,(XP_018098399_1_protein_S100_Z__Xenopus_laevis_:0.11635107,XP_004074549_1_protein_S100_Z__Oryzias_latipes_:0.17159923):0.19477039):0.28423418):0.26151348):0.57382645):0.13802911):0.21848687);
BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)