PBID | Uniprot | Name | Gene | Alternative | Organism | Uniprot Description |
PB0011 | P04406 | Glyceraldehyde-3-phosphate dehydrogenase | GAPDH | G3PD, GAPD, HEL-S-162eP | Homo_sapiens | Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity). |
Domains | Gene Ontology |
PF00044 (Gp_dh_N) PF02800 (Gp_dh_C) |
GO:0004365 (enables) glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GO:0005515 (enables) protein binding GO:0008017 (enables) microtubule binding GO:0016491 (enables) oxidoreductase activity GO:0016620 (enables) oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor GO:0016740 (enables) transferase activity GO:0019828 (enables) aspartic-type endopeptidase inhibitor activity GO:0035605 (enables) peptidyl-cysteine S-nitrosylase activity GO:0042802 (enables) identical protein binding GO:0050661 (enables) NADP binding GO:0051287 (enables) NAD binding GO:0097718 (enables) disordered domain specific binding GO:0000226 (involved in) microtubule cytoskeleton organization GO:0001819 (involved in) positive regulation of cytokine production GO:0002376 (involved in) immune system process GO:0006006 (involved in) glucose metabolic process GO:0006096 (involved in) glycolytic process GO:0006417 (involved in) regulation of translation GO:0006915 (involved in) apoptotic process GO:0010951 (involved in) negative regulation of endopeptidase activity GO:0016241 (involved in) regulation of macroautophagy GO:0017148 (involved in) negative regulation of translation GO:0031640 (involved in) killing of cells of other organism GO:0032481 (involved in) positive regulation of type I interferon production GO:0035606 (involved in) peptidyl-cysteine S-trans-nitrosylation GO:0043123 (involved in) positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0045087 (involved in) innate immune response GO:0050821 (involved in) protein stabilization GO:0050832 (involved in) defense response to fungus GO:0051402 (involved in) neuron apoptotic process GO:0051873 (involved in) killing by host of symbiont cells GO:0061844 (involved in) antimicrobial humoral immune response mediated by antimicrobial peptide GO:0071346 (involved in) cellular response to interferon-gamma GO:0005634 (located in) nucleus GO:0005737 (located in) cytoplasm GO:0005811 (located in) lipid droplet GO:0005829 (located in) cytosol GO:0005856 (located in) cytoskeleton GO:0005886 (located in) plasma membrane GO:0015630 (located in) microtubule cytoskeleton GO:0016020 (located in) membrane GO:0031965 (located in) nuclear membrane GO:0031982 (located in) vesicle GO:0043231 (located in) intracellular membrane-bounded organelle GO:0048471 (located in) perinuclear region of cytoplasm GO:0070062 (located in) extracellular exosome GO:0097452 (part of) GAIT complex GO:1990904 (part of) ribonucleoprotein complex |
External Links | Description |
Intact | Open source database system and analysis tools for molecular interaction data. |
Protein Atlas | An open access resource for human proteins |
InterPro (new pfam) | InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. |