PB0009

DATABASE

Click here to access PB0009 phyletic profile

PBID	Uniprot	Name	Gene	Alternative	Organism	Uniprot Description
PB0009	P36955	Pigment epithelium-derived factor	SERPINF1	OI6, OI12, PEDF, EPC-1, PIG35	Homo_sapiens	Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.

Domains

Gene Ontology

PF00079 (Serpin)

GO:0004867 (enables) serine-type endopeptidase inhibitor activity GO:0005515 (enables) protein binding GO:0001822 (involved in) kidney development GO:0007568 (involved in) aging GO:0007614 (involved in) short-term memory GO:0010447 (involved in) response to acidic pH GO:0010596 (involved in) negative regulation of endothelial cell migration GO:0010629 (involved in) negative regulation of gene expression GO:0010951 (involved in) negative regulation of endopeptidase activity GO:0010976 (involved in) positive regulation of neuron projection development GO:0014070 (involved in) response to organic cyclic compound GO:0016525 (involved in) negative regulation of angiogenesis GO:0042698 (involved in) ovulation cycle GO:0046685 (involved in) response to arsenic-containing substance GO:0050728 (involved in) negative regulation of inflammatory response GO:0050769 (involved in) positive regulation of neurogenesis GO:0060041 (involved in) retina development in camera-type eye GO:0060770 (involved in) negative regulation of epithelial cell proliferation involved in prostate gland development GO:0071279 (involved in) cellular response to cobalt ion GO:0071300 (involved in) cellular response to retinoic acid GO:0071333 (involved in) cellular response to glucose stimulus GO:0071549 (involved in) cellular response to dexamethasone stimulus GO:1901215 (involved in) negative regulation of neuron death GO:1901652 (involved in) response to peptide GO:0005615 (is active in) extracellular space GO:0005576 (located in) extracellular region GO:0005604 (located in) basement membrane GO:0030424 (located in) axon GO:0042470 (located in) melanosome GO:0043025 (located in) neuronal cell body GO:0043203 (located in) axon hillock GO:0048471 (located in) perinuclear region of cytoplasm GO:0070062 (located in) extracellular exosome GO:0062023 (part of) collagen-containing extracellular matrix

External Links	Description
Intact	Open source database system and analysis tools for molecular interaction data.
Protein Atlas	An open access resource for human proteins
InterPro (new pfam)	InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish) >sp|P36955|PEDF_HUMAN Pigment epithelium-derived factor OS=Homo sapiens OX=9606 GN=SERPINF1 PE=1 SV=4 MQALVLLLCIGALLGHSSCQNPASPPEEGSPDPDSTGALVEEEDPFFKVPVNKLAAAVSN FGYDLYRVRSSTSPTTNVLLSPLSVATALSALSLGAEQRTESIIHRALYYDLISSPDIHG TYKELLDTVTAPQKNLKSASRIVFEKKLRIKSSFVAPLEKSYGTRPRVLTGNPRLDLQEI NNWVQAQMKGKLARSTKEIPDEISILLLGVAHFKGQWVTKFDSRKTSLEDFYLDEERTVR VPMMSDPKAVLRYGLDSDLSCKIAQLPLTGSMSIIFFLPLKVTQNLTLIEESLTSEFIHD IDRELKTVQAVLTVPKLKLSYEGEVTKSLQEMKLQSLFDSPDFSKITGKPIKLTQVEHRA GFEWNEDGAGTTPSPGLQPAHLTFPLDYHLNQPFIFVLRDTDTGALLFIGKILDPRGP >tr|Q66I20|Q66I20_DANRE Serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium-derived factor), member 1 OS=Danio rerio OX=7955 GN=serpinf1 PE=1 SV=1 MKKIVLLVGLWSLLSLSHAQLADTTDAEGEEEAVDLFTTPRTKLAAATSDFGYNLFRQLA SRDTKASVFLSPMSISAAFTQLSMGASERAEKQIYRALRYHTLQDSQLHDTLRDLLSSLR ASAKGFKSAERILLARKLRLRLEYLNSVEKQYGERPQILAGGARDLKTVNDWFKQQTGGK VDQVVPSPLPRNTALLPVGSAYFKGKWITRFGKPNKMETFRRDGQAPAVIPMMEQENYPV KMGIDSDLGCTIAQVPMEDGVSMYFFLPDEVTQNLTLIEEALTAEFVQDLSNSLHTVKVL LTLPVIKLSYKTNLLPSLSDLGLSEWLAETDLTKITSQPVKLNAVHHKVVLETAPEGAEY ASTTPSATGQSLGLSYRVDRPFLFLVRDEPSGALLFIGKVLNPSDL
Selected proteins from model organisms >NP_002606.3 pigment epithelium-derived factor isoform 1 precursor [Homo sapiens] MQALVLLLCIGALLGHSSCQNPASPPEEGSPDPDSTGALVEEEDPFFKVPVNKLAAAVSNFGYDLYRVRS STSPTTNVLLSPLSVATALSALSLGAEQRTESIIHRALYYDLISSPDIHGTYKELLDTVTAPQKNLKSAS RIVFEKKLRIKSSFVAPLEKSYGTRPRVLTGNPRLDLQEINNWVQAQMKGKLARSTKEIPDEISILLLGV AHFKGQWVTKFDSRKTSLEDFYLDEERTVRVPMMSDPKAVLRYGLDSDLSCKIAQLPLTGSMSIIFFLPL KVTQNLTLIEESLTSEFIHDIDRELKTVQAVLTVPKLKLSYEGEVTKSLQEMKLQSLFDSPDFSKITGKP IKLTQVEHRAGFEWNEDGAGTTPSPGLQPAHLTFPLDYHLNQPFIFVLRDTDTGALLFIGKILDPRGP >NP_035470.3 pigment epithelium-derived factor precursor [Mus musculus] MQALVLLLWTGALLGHGSSQNVPSSSEGSPVPDSTGEPVEEEDPFFKVPVNKLAAAVSNFGYDLYRLRSS ASPTGNVLLSPLSVATALSALSLGAEHRTESVIHRALYYDLITNPDIHSTYKELLASVTAPEKNLKSASR IVFERKLRVKSSFVAPLEKSYGTRPRILTGNPRVDLQEINNWVQAQMKGKIARSTREMPSALSILLLGVA YFKGQWVTKFDSRKTTLQDFHLDEDRTVRVPMMSDPKAILRYGLDSDLNCKIAQLPLTGSMSIIFFLPLT VTQNLTMIEESLTSEFIHDIDRELKTIQAVLTVPKLKLSFEGELTKSLQDMKLQSLFESPDFSKITGKPV KLTQVEHRAAFEWNEEGAGSSPSPGLQPVRLTFPLDYHLNQPFLFVLRDTDTGALLFIGRILDPSST >NP_776565.1 pigment epithelium-derived factor precursor [Bos taurus] MQALVLLLWTGALLGFGRCQNAGQEAGSLTPESTGAPVEEEDPFFKVPVNKLAAAVSNFGYDLYRVRSGE SPTANVLLSPLSVATALSALSLGAEQRTESNIHRALYYDLISNPDIHGTYKDLLASVTAPQKNLKSASRI IFERKLRIKASFIPPLEKSYGTRPRILTGNSRVDLQEINNWVQAQMKGKVARSTREMPSEISIFLLGVAY FKGQWVTKFDSRKTSLEDFYLDEERTVKVPMMSDPQAVLRYGLDSDLNCKIAQLPLTGSTSIIFFLPQKV TQNLTLIEESLTSEFIHDIDRELKTVQAVLTIPKLKLSYEGELTKSVQELKLQSLFDAPDFSKITGKPIK LTQVEHRVGFEWNEDGAGTNSSPGVQPARLTFPLDYHLNQPFIFVLRDTDTGALLFIGKILDPRGT >NP_808788.1 pigment epithelium-derived factor precursor [Rattus norvegicus] MQTLVLLLWTGALLGHGSSQNVPDSSQDSPAPDSTGEPVVEEDDPFFKAPVNKLAAAVSNFGYDLYRLRS GAVSTGNILLSPLSVATALSALSLGAEQRTESVIHRALYYDLINNPDIHSTYKELLASVTAPEKNFKSAS RIVFERKLRVKSSFVAPLEKSYGTRPRILTGNPRIDLQEINNWVQAQMKGKIARSTREMPSALSILLLGV AYFKGQWATKFDSRKTTLQDFHLDEDRTVRVPMMSDPKAILRYGLDSDLNCKIAQLPLTGSMSIIFFLPL TVTQNLTMIEESLTSEFVHDIDRELKTIQAVLTVPKLKLSYEGDVTNSLQDMKLQSLFESPDFSKITGKP VKLTQVEHRAAFEWNEEGAGTSSNPDLQPVRLTFPLDYHLNRPFIFVLRDTDTGALLFIGRILDPSST >NP_001244218.1 pigment epithelium-derived factor precursor [Gallus gallus] MQIPAVLLLLGLLTIPSKSQNSPAGQNSPTTDGTVGEVEEEDPFYKTPINKLAAAVSNFGYDLYRQQSSR TATANVLLSPFSLATALSGLSLGAGERTEDVISRALFYDLLNKAEVHNTYKDLLASVTGPEKSLKSASRI IVEKRLRVKSTFHSQLEKSYRMRLRALSGNTQLDLQEINNWVRQQTRGRILRFMKDMPTDVSILLAGAAY FKGTWKTKFDTKRTVLKDFHLDEDRTVQVSMMSDPKAILRYGFDSELNCKIAQLPLTEGVSAMFFLPTKV TQNMTLIEESLTSEFVHDVDRELKTVHAVLSLPKLKLNYEEALGNTVKETRLQSLFTSPDFTKISAKPIK LSHVQHKAVLELNEDGEKSTPNPGVNAARLTFPIEYHVDRPFLLVLRDDTTGTLLFIGKILDPRSV >NP_001004539.1 pigment epithelium-derived factor precursor [Danio rerio] MKKIVLLVGLWSLLSLSHAQLADTTDAEGEEEAVDLFTTPRTKLAAATSDFGYNLFRQLASRDTKASVFL SPMSISAAFTQLSMGASERAEKQIYRALRYHTLQDSQLHDTLRDLLSSLRASAKGFKSAERILLARKLRL RLEYLNSVEKQYGERPQILAGGARDLKTVNDWFKQQTGGKVDQVVPSPLPRNTALLPVGSAYFKGKWITR FGKPNKMETFRRDGQAPAVIPMMEQENYPVKMGIDSDLGCTIAQVPMEDGVSMYFFLPDEVTQNLTLIEE ALTAEFVQDLSNSLHTVKVLLTLPVIKLSYKTNLLPSLSDLGLSEWLAETDLTKITSQPVKLNAVHHKVV LETAPEGAEYASTTPSATGQSLGLSYRVDRPFLFLVRDEPSGALLFIGKVLNPSDL >XP_001155004.3 pigment epithelium-derived factor isoform X1 [Pan troglodytes] MQALVLLLCIGALLGHSSCQNPASPPEEGSPDPDSTGALVEEEDPFFKVPVNKLAAAVSNFGYDLYRVRS SMSPTTNVLLSPLSVATALSALSLGAEQRTESIIHRALYYDLISSPDIHGTYKELLDTVTAPQKNLKSAS RIVFEKKLRIKSSFVAPLEKSYGTRPRVLTGNPRLDLQEINNWVQAQMKGKLARSTKEIPDEISILLLGV AHFKGQWVTKFDSRKTSLEDFHLDEERTVRVPMMSDPKAVLRYGLDSDLSCKIAQLPLTGSTSIIFFLPL KVTQNLTLIEESLTSEFIHDIDRELKTVQAVLTVPKLKLSYEGEVTKSLQEMKLQSLFDSPDFSKITGKP IKLTQVEHRAGFEWNEDGAGTTPSPGLQPAHLTFPLDYHLNQPFIFVLRDTDTGALLFIGKILDPRGT >XP_038531033.1 pigment epithelium-derived factor isoform X1 [Canis lupus familiaris] MQALVLLLWTGALLGHSSCQNDAGGPQEDSPAPDATGVPVEEEDPFFRVPVNKLAAAISNFGYDLYRVRS SFSPAANVLLSPLSVATALSALSLGAEQRTESTIHRALYYDLISNPDIHSTYKELLASVTAPEKNFKSAS RIVFERKLRIKSSFVAPLEKSYSTRPRILTGNPRLDLQEVNNWVQAQMKGKIARSTREIPSGISILLLGV AYFKGQWVTKFDSRKTSLEDFHLDEERTVKVPMMSDPKAILRYGLDSDLSCKIAQLPLTGSMSIIFFLPL KVTQNLTMIEESLTSEFIHDIDRELKTIQAVLTIPKLKLSYEGEVTKSLQEMKLQSLVDSPDFSKITGKP IKLTQVEHRAGFEWNEDGAGTTPSPGLQPTRLTFPLDYHLNRPFIFVLRDTDTGALLFIGKILDPRGI >NP_001072130.1 pigment epithelium-derived factor precursor [Sus scrofa] MQALVLLLWTGALLGSGSCQNAGPEEGSPAPDTVGAPVEEEDPFFKVPVNKLAAAVSNFGYDLYRVRSSE SPTANVLLSPLSVATALSALSLGAEQRTESSLHRALYYDLISNPDLHGTYKELLAAVTAPQKNLKSASRI IFEKKLRIKASFVAPLEKSYGTRPRILTGNSRLDLQEVNNWVQAQTKGKVARSTRELPGEISILLLGVAY FKGQWVTKFDSRKTSLEDFHLDEERTVKVPMMSDPKAVLRYGLDSDLNCKIAQLPLTGSMSIIFFLPLKV TQNLTMIEESLTSEFIHDIDRELKTVQAVLTVPKLKLSYEGELTKSVQELKLQSLFDSPDFSKITGKPIK LTQVEHRIGFEWNEDGGSATSSPGPRLTFPLDYHLNQPFIFVLRDTDTGALLFIGKILDPRST >NP_001132919.1 pigment epithelium-derived factor precursor [Ovis aries] MQALVLLLWTGALLGFGHCQNAGPEAGSLAPESTGAPVEEEDPFFKVPVNKLAAAVSNFGYDLYRVRSGE SPTTNVLLSPLSVATALSALSLGAEQRTESSIHRALYYDLISNPDIHGTYKDLLASVTAPQKNLKSASRI IFERKLRIKASFVPPLEKSYGTRPRILTGNSRIDLQEINNWVQAQMKGKIARSTREIPSGISILLLGVAY FKGQWVTKFDSRKTSLEDFHLDEGRTVKVPMMSDPKAVLRYGLDSDLNCKIAQLPLTGSTSIIFFLPQKV TQNLTLIEESLTSEFIHDIDRELKTVQAVLTIPKLKLSYEGELTKSVQELKLQSLFDAPDFSKITGKPIK LTQVEHRIGFEWNEDGAGTNSSPGVQPARLTFPLDYHLNQPFIFVLRDTDTGALLFIGKILDPRGT >XP_008269150.1 PREDICTED: pigment epithelium-derived factor isoform X1 [Oryctolagus cuniculus] MSPTMQALVLLLWTGALLGHGSCQSIASSPEEGSPAPDGTGPPLEEDDPFFKVPVNKLAAAVSNFGYDLY RQRSAESPTANVLLSPLSVATALSALSLGAEQRTESLIQRALYYDLISNPDIHGTYKELLAAVTAPQKNL KSASRIIFERKLRIKSSFVAPLEKAYGTRPRVLSGNPRLDLQELNGWVQAQMKGKVARSAREVPSDISIF LLGVAYFKGQWVTKFDSRKTSLQDFHLDEERTVRVPMMSDPKATLRYGLDSDLNCKIAQLPLTGSMSIIF FLPLRPTQNLTLIEESLTSEFIHDIDRELKTIQAALSIPRLKLSFEGEVTKALQEIKLQPLFESPDFSKI TGKPIKLTHVEHRAGFEWNEDGAATSPGPEVQPARLAFSLDYHLNQPFIFVLRDSDTGALLFVGKILDPR GT >XP_009249388.1 pigment epithelium-derived factor isoform X1 [Pongo abelii] MQALVLLLCIGALLGHSSCQNPASPPEEGSPDPDSTGALVEEEDPFFKVPVNKLAAAVSNFGYDLYRVRS SMSPTTNVLLSPLSVATALSALSLGAEQRTESTIHRALYYDLISSPDIHGTYKELLDTVTAPQKNFKSAS RIVFEKKLRIKSSFVAPLEKSYGTRPRVLTGNPHLDQQEINNWVQAQMKGKLARSTKEIPHEISILLLGV AHFKGQWVTKFDSRKTSLEDFHLDEDRTVRIPMMSDPKAVLRYGLDSDLSCKIAQLPLTGSMSIIFFLPL KVTQNLTLIEESLTSEFIYDIDRELKTVQAVLTVPKLKLSYEGEVTKSLQEMKLQSLFDSPDFSKITGKP IKLTQVEHRAGFEWNEDGAGTTPSPGLQPAHLTFPLDYHLNQPFIFVLRDTDTGALLFIGKILDPRGT >XP_003211790.1 pigment epithelium-derived factor [Meleagris gallopavo] MQIPAILLLLGLLTIPSKSQNSPTGQNSPTTDGTVGEVEEEDPFYKTPVNKLAAAVSNFGYDLYRQQSSR TATANVLLSPFSLATALSGLSLGAGERTEDVISRALFYDLLNKAEVHNTYKDLLASVTGPEKSLKSASRI IVEKRLRVKSTFHSQLEKSYKMRLRALSGNTQLDLQEINNWVRQQTRGRILRFMKDMPTDVSILLAGAAY FKGTWKTKFDTKRTVLNDFHLDEDRTVKVSMMSDPKAILRYGFDSELNCKIAQLPLTEGVSAMFFLPTKV TQNMTLIEESLTSEFIHDVDRELKTVHAVLSLPKLKLNYEEALGNTLKETRLQSLFTSPDFTKISAKPIK LSHVQHKAVLELNEDGEKSTPNPGVNAARLTFPIEYHVDRPFLLVLRDDTTGTLLFIGKILDPRSV >XP_008968201.2 pigment epithelium-derived factor isoform X1 [Pan paniscus] MYPFCACQATRRGPRMQALVLLLCIGALLGHSSCQNPASPPEEGSPDPDSTGALVEEEDPFFKVPVNKLA AAVSNFGYDLYRVRSSMSPTTNVLLSPLSVATALSALSLGAEQRTESIIHRALYYDLISSPDIHGTYKEL LDTVTAPQKNLKSASRIVFEKKLRIKSSFVAPLEKSYGTRPRVLTGNPRLDLQEINNWVQAQMKGKLARS TKEIPDEISILLLGVAHFKGQWVTKFDSRKTSLEDFHLDEERTVRVPMMSDPKAVLRYGLDSDLSCKIAQ LPLTGSTSIIFFLPLKVTQNLTLIEESLTSEFIHDIDQELKTVQAVLTVPKLKLSYEGEVTKSLQEMKLQ SLFDSPDFSKITGKPIKLTQVEHRAGFEWNEDGAGTTPSPGLQPAHLTFPLDYHLNQPFIFVLRDTDTGA LLFIGKILDPRGT >XP_003996465.1 pigment epithelium-derived factor [Felis catus] MQALMLLLWAGALLGPGSCQDNAGSLEDSPAPDATGVPVEEEDPFFKVPVNKLAAAISNFGYDLYRVRSS LSPTANVLLSPLSVATALSALSLGAEQRTESTIHRALYYDLISNPDIHGTYKELLAAVTAPQKNFKSASR IIFERKLRIKSSFVAPLEKSYGTRPRILTGNSRLDLQEVNNWVQAQMKGKIARSTREIPSEISILLLGVA YFKGQWVTKFDPRKTSLEDFHLDEERTVRVPMMSDPKAILRYGLDSDLSCKIAQLPLTGSMSIIFFLPLK VTQNLTMIEESLTSEFIHDIDRELKTIQAVLTIPKLKLSYEGEVTKSLQEMKLQSLFDSPDFSKITGKPI KLTQVEHRGGFEWNEDGASTAPSAGLQPARLTFPLDYHLNQPFIFVLRDTDTGALLFIGKILDPRGI >XP_004058286.3 pigment epithelium-derived factor isoform X1 [Gorilla gorilla gorilla] MQALVLLLCIGALLGHSGCQNPASPPEEGSPDPDSTGALVEEEDPFFKVPVNKLAAAVSNFGYDLYRVRS SMSPTTNVLLSPLSVATALSALSLGAEQRTESIIHRALYYDLISSPDIHGTYKELLDMVTAPQKNLKSAS RIVFEKKLRIKSSFVAPLEKSYGTRPRVLTGNPRLDLQEINNWVQAQMKGKLARSTKEIPDEISILLLGV AHFKGQWVTKFDSRKTSLEDFHLDEERTVRVPMMSDPRAVLRYGLDSDLSCKIAQLPLTGSMSIIFFLPL KVTQNLTLIEESLTSEFVHDIDRELKTVQAVLTVPKLKLSYEGEVTKPLQEMKLQSLFDSPDFSKITGKP IKLTQVEHRAGFEWNEDGAGTTPSPGLQPAHLTFPLDYHLNQPFIFVLRDTDTGALLFIGKILDPRGT >XP_020564755.2 pigment epithelium-derived factor [Oryzias latipes] MKRFSLLLMLAAVLSFCQAQSESGGEGEGLEEEPVELFTTPTTKLGAAVSDFGYNLFRALASRETSSNIF LSPISVSAALSQLSLGASEGSQRQLFRALRYHTLQDPQLHSTLKTMLASVTATGKGLSTAARLYLARRLR PKQDFFKAVEQQYGVRPKALMGGAKDVKEVNDWVSQQTGRKVLQFLAKPFPRAAGVNAVSASYFKGKWVT RFGQSGALDNFQVEGDVPVRVPMMQQDNYPVKMGSDSDLSCVIAQIQMQDGVSMFIFLPDGVTANMTLLE ESLTAEFVQDLAMTLLPAKVSLTLPVLRLSFSTDLLPLLGDLGLSEWMENPELDNISTQRSKLSSLDHKV VMETAPEGSQYPDVASTHGHLTYRVDRPFLYLIRDEASGALLFIGRVVNPKGLTI >XP_005502067.1 pigment epithelium-derived factor [Columba livia] MRIPVVLLFLGLLTVPSRSQNLASEQNSATADGANAGEVEEEDPFYKSPINKLAAAVSNFGYDLYRQQSS RTATANVLLSPFSLATALSGLSLGAGERTEDVISRALFYDLLDKAEVHNTYKDLLTSVAGPEKSMKSASR IILEKRLRVKPGFHSQLEKSYKMRLRALSGNTQLDLQEVNNWVRQQTKGRIMRLMKDMPTDVSILLAGAA YFKGTWKTKFDTKKTALNDFHLDEDRTVKVSMMSDPKAILRYGFDSELNCKIAQLPLTEGISAMFFLPTK VTQNMTLIEESLTSEFVHDVDKELKTVHAVLSLPKLKLNYEEALGSTLKETRLQSLFASPDFTKISVKPI KLSHVQHKAVLELSEDGERTTPNPGVNAARLTFPIEYHVDRPFLLVLRDDTTGTLLFIGKILDPRSV >XP_005693374.1 PREDICTED: pigment epithelium-derived factor [Capra hircus] MQALMLLLWTGALLGFGRCQNAGPEAGSLAPESTGAPVEEEDPFFKVPVNKLAAAVSNFGYDLYRVRSGE SPTANVLLSPLSVATALSALSLGAEQRTESSIHRALYYDLISNPDIHGTYKDLLASVTAPQKNLKSASRI IFERKLRIKASFVPPLEKSYGSRPRILTGNSRIDLQEINNWVQAQMKGKVARSTRELPSEISIFLLGVAY FKGQWVTKFDSRKTSLEDFHLDEGRTVKVPMMSDPKAVLRYGLDSDLNCKIAQLPLTGSTSIIFFLPQKV TQNLTLIEESLTSEFIHDIDRELKTVQAVLTIPKLKLSYEGELTKSVQELKLQSLFDAPDFSKITGKPIK LTQVEHRIGFEWNEDGAGTNSSPGVQPARLTFPLDYHLNQPFIFVLRDTDTGALLFIGKILDPRGT >XP_006032909.1 pigment epithelium-derived factor [Alligator sinensis] MQTPLVFLLLGLLASPGSSQNSANEQDSATPDGGNAGEAEEEDPFYKTPVNKLAAAVSNFGYDLYRQQSG RTATANVLLSPFSVATALSGLSLGAGQRTEDLISRTLYYDLLNKAEVHNTYKELLTSISAPEKGFRSVFR IILERKLRMKVGFPSQLEKAYRIRLKILTGNSQADLQELNNWVRQQTKGKILRFLKDMPTDVSIFLAGAA YFKGHWATKFDPRKTTLQDFYLEEDRIVTVPMMSDPKAILRYGFDSELNCKIAQLPLTGGVSAMFFLPLK VTQNLTLIEESLSSEFVHDIDKELKTVHAVLSVPKLKLSFEESLGSTLQEMRLQQLFISPDFSKMSAKPI KLSHVHHKTVLELSEDGANSTPNPGANAARLTFPLDYHLNRPFLLVLRDDATGTLFFIGKILDPRNI >XP_006260666.2 PREDICTED: pigment epithelium-derived factor [Alligator mississippiensis] MQTPLVFLLLLLLLGLLASPGSSQNSANEQDSATPDGGNAGEAEEEDPFYKTPVNKLAAAVSNFGYDLYR QQSGRTATANVLLSPFSVATALSGLSLGAGQRTEDLISRTLYYDLLNKAEVHNTYKELLTSISAPEKGFR SVFRIILERKLRMKVGFPSQLEKAYRIRLKILTGNSQTDLQELNNWVRQQTKGKILRFLKDMPTDVSIFL AGAAYFKGHWATKFDPRKTTLQDFYLEEDRIVTVPMMSDPNAILRYGFDSELNCKIAQLPLTGGVSAMFF LPLKVTQNLTLIEESLSSEFVHDIDKELKTVHAVLSVPKLKLSFEESLGSTLQEMRLQQLFISPDFSKMS AKPIKLSHVHHKTVLELSEDGANSTPNPGVNAARLTFPLDYHLNRPFLLVLRDDATGTLFFIGKILDPRN I >KAB0367960.1 hypothetical protein FD755_021284 [Muntiacus reevesi] MQALVLLLWTGALLGLGCCQNAGPEAGSMAPESTGAPVEEEDPFFKVPVNKLAAAVSNFGYDLYRVRSGESPTTNVLLSP LSVATALSALSLGAEQRTESIIHRALYYDLISNPDIHGTYKDLLASVTAPQKNLKSASRIIFERKLRIKASFIPPLEKSY GTRPRILTGNSRIDLQEINNWVQAQMKGKVARSTREMPSEISIFLLGVAYFKGQWVTKFDSRKTSLEDFHLDEERTVKVP MMSDPKAVLRYGLDSDLNCKIAQLPLTGSTSIIFFLPQRVTQNLTLIEESLTSEFIHDIDRELKTVQAVLTVPKLKLSYE GELTKSVQELKLQSLFDAPDFSKITGKPIKLTQVEHRIGFEWNEDGAGTNPSPGVQPARLTFPLDYHLNQPFIFVLRDTD TGALLFIGKILDPRGT >XP_043334263.1 pigment epithelium-derived factor [Cervus canadensis] MQALALLLWTGALLGLGRCQNAGPEAGSLAPESTGAPVEEEDPFFKVPVNKLAAAISNFGYDLYRVRSGESPTANVLLSP LSVATALSALSLGAEQRTESIIHRALYYDLISNPDIHGTYKDLLASVTAPQKNLKSASRIIFEKKLRIKASFIPPLEKSY GTRPRILTGNSRIDLQEINNWVQAQMKGKVSRSTREMPSEISIFLLGVAYFKGQWVTKFDSRKTSLEDFHLDEERTVKVP MMSDPKAVLRYGLDSDLNCKIAQLPLTGSTSIIFFLPQRVTQNLTLIEESLTSEFIHDIDRELKTVQAVLAIPKLKLSYE GELTKSVQELKLQSLFDAPDFSKITGKPIKLTQVEHRIGFEWNEDGAGTNPSPGVQPARLTFPLDYHLNQPFIFVLRDTD TGALLFIGKILDPRGT >KAB0366159.1 hypothetical protein FD754_010315 [Muntiacus muntjak] MQALVLLLWTGALLGLGCCQNAGLEAGSLAPESTGAPVEEEDPFFKVPVNKLAAAVSNFGYDLYRVRSGESPTANVLLSP LSVATALSALSLGAEQRTESIIHRALYYDLISNPDIHGTYKDLLASVTAPQKNLKSASRIIFERKLRIKASFIPPLEKSY GTRPRILTGNSRIDLQEINNWVQAQMKGKVARSTREMPSEISIFLLGVAYFKGQWVTKFDSRKTSLEDFHLDEERTVKVP TMSDPKAVLRYGLDSDLNCKIAQLPLTGSTSIIFFLPQRVTQNLTLIEESLTSEFIHDIDRELKTVQAVLTVPKLKLSYE GEFTKSVQELKLQSLFDAPDFSKITGKPIKLTQVEHRIGFEWNEDGAGTNPSPGVQPARLTFPLDYHLNQPFIFVLRDTD TGALLFIGKILDPRGT >KAF4012198.1 hypothetical protein G4228_003074 [Cervus hanglu yarkandensis] MQGSLAPESTGAPVEEEDPFFKVPVNKLAAAISNFGYDLYRVRSGESPTANVLLSPLSVATALSALSLGAEQRTESIIHR ALYYDLISNPDIHGTYKDLLASVTAPQKNLKSASRIIFEKKLRIKASFIPPLEKSYGTRPRILTGNSRIDLQEINNWVQA QMKGKVSRSTREMPSEISIFLLGVAYFKGQWVTKFDSRKTSLEDFHLDEERTVKVPMMSDPKAVLRYGLDSDLNCKIAQL PLTGSTSIIFFLPQRVTQNLTLIEESLTSEFIHDIDRELKTVQAVLAIPKLKLSYEGELTKSVQELKLQSLFDAPDFSKI TGKPIKLTQVEHRIGFEWNEDGAAFMLATQLNPLVEEERLSSNCICQINRFIVNTLKDGRRVVILMELEVLKSAEAVGSK IGNPMPYNEGHGQQPVVPPPVSAASPPTSRPQQQNGSPGVASTASKAFGASKTFGKVGSTSQMNSSGGTQAKVVPIASLT PYQSKWTICARVTNKSQIRTWSNSRGEGKLFSIELVDESGEIRATAFNEQADKFFPLIDVNKVYYFSKGTLKIANKQFTA VKNDYEMTFNSETSVMPCEDGHHLPTVQFDFTGIGDLESKSKDSLVDIIGICKNYEDVTKIIVKSNNREVSKRNIYLMDM SGKVVNATLWGDDADKFDGSRQPVMAIKGARVSDFGGRSLSVLSSSTIIVNPDIPEAYKLRGWFDSEGQALDGISISDLK SGGAGGSNTNWKTLYEVKSENLGQGDKPDYFSSVATVVYLRKENCMYQACPTQDCNKKVIDQQNGLYRCEKCDSEFPNFK YRMILAVNIADFQENQWVTCFQESAEAILGQSTAYLGELKEKNEQAFEEVFQNANFRSFTFRIRVKLETYNDESRIKATV VDVKPVDYREYGRRLVMNIRRNAAM >NP_001085983.1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 L homeolog precursor [Xenopus laevis] MKIYLALLFTGTFLSSTSAQNAAEEVLPEVEEEDPFYKSPLNRLTSSASNFGYDLYRMQANKNPNSNIFISPLSIATSLS SLSLGSGQRTESLIHRSLYYDLLNDPELHATYKELLASLTSHGSGLKSTWRIMLERKLRLRLDFVTQVEKFYGNKPRILT GNTRLDLQEANDFVQKQTQAKVVKFFKEIPAGVSILLLGTSYLKGQWAYKFNPRETVQSEFHLDEQTSVTVPMMSSKNLP VRYGLDSDFNCKIVQLPLTGGVSIMFFLPNTVTQNLTMIEEGLTSEFIHDIDQALQTVNMDLRIPKLKLNYEVELKEALQ ESKLQSLFSTPDFSKISSKPLKLSHVVHKATLELNEDGAETAPKAEASSRKYFPLEYHLDHPFLFVLRANDNGALLFIGK VMDPKGFSF >XP_038050239.1 leukocyte elastase inhibitor-like [Patiria miniata] MYKLTLLVTSSRPDSIMAVIQIISILTVIALLYMSVFATSTGPDPQLELADANNRFAFHLYQTLADDPHRDNIFFSPMSI SIALAMTSLGARGNTARQIKDVLKFSTLEESRLHSSFAELNSAIFGANADKYVLRKANRLFGHKGFDLRQEFLADAERYY SSHMASLDFVEDTEVAREFINSWVGRETEDKIRDLLPHGSITGMTQLVLVNAIYFKADWVRQFDKSKTFDQDFHVSKDQV LEVPMMHRKSKFNFAEDITLRCKLIELPYVGQDFSMIVVLPDEIDGIDRLQKHLTNEKLQHLLNNLSNVTVGVAIPKFKL EETLHMNDVLYSMGMRDLFVRDKADLSGITGTRDLFVSSVIHRAFLEVNEEGSEAAAATAVTINKRSISLAPEFIADHPF LFFIADSKTKAIVFMGHCRKPEGVSLNHEEL >NP_524953.1 serpin 55B [Drosophila melanogaster] MFDFNLEFARGGARFTSELFQLLSAGGLKENVVFSPFSIQTCIALAFAGSQGETADEIAKALHFVSNFPPEVAQTFQFVL EKYRNSNLLRVANKLYVQEGKQLKPAYQSAIKEQYHSEAESINFALNDAAAQAINAWVNAKTQGKITELVSADSFSDNTR LVLLNALHFKGSWAHKFSEERTEEDIFWVGEEEQVKINYMNQKAKFNYGFFEDLGCTALEMPYQDSDLSMFVLLPQERTG IYALAEKLKTVNLVDLADKLTVEEVHVKFPKFKVDYSLELAEKLKQLGITKMFTDQAEFSNLLESPEGVFVSKVLHKATI EVNEEGTEAAAATGMIMMTRMMTFPLQFQADRPFLYVIWNKKNILFAGAFVKAA >XP_011666177.1 leukocyte elastase inhibitor [Strongylocentrotus purpuratus] MSEYIRNMAFYKQQDISEQLVQLSSANTRFALDLYQTFQDERRGTNLFFSPLSISTALAMTQLGACGDTATQIADVFRFN QVDQDQLHGTFKELNNLLYQTNSGYKLHAANRLYGKSGYNFVQSFLEGTASYYGAAIEAVDNFAAPTATHSINDWVSKQT EDKITNLIPPGILNDLTRLVLVNAIYFKGNWESKFRAENTTQETFKVLDERKKVPVSLMIQKGKFALAVDKTNDCLVLEM PYQGRNLSLLIALPVKDDGLGNLQTKLSADILRSWDAGLKSRQVNVLLPKFKLEAEFQLKEVLKRMGMPDAFNDGKANFE GISGDRELYISAVIHKAFVDINEEGSEAAAATAVAVKLGCARPREPEKPTLFRADHPFIFMIRHRPTKSVLFMGRMMDPS >XP_031557330.1 leukocyte elastase inhibitor-like [Actinia tenebrosa] MGNNIITCNTFRLHSVLILAVSLVFCSVLLSTMAQADLIKASTNKFSLHLHQVLRGQATFDAEQNLFYSPSSILVALAMT HLGARGNTAKQMSSSFHLDEIPEKQLNAEFQKFLQKLNQSNAKGNEIAMANRLFVQMGFEVSKQFQEDSEKFFNAEAALV DYQKNSEGARQEVNQWVEQKTKNKIKDLIPEGMFGPDTRLTLVNAIYFKGSWMSKFDSNNTQTGPFQLTPSKTVQVPMMY KSDKFKYFENEGLKCKMLELPYSDEKISMIILLPDEVDGLSKLEDSLNYSKLDEAIGHLKMAPKEEVEVTLPKFKLSEKF SLKEVLSKMGASDLFNAAKADLTGINKDGQLYVSEVVHKAFVDVNEEGTEAAAATAVRVALMCMPMNPIFFANHPFLFLI RHNESGAILFIGRLANPK >XP_039254966.1 leukocyte elastase inhibitor-like [Styela clava] MNYSLLILLIGLVFHCGEASKKKSIVSGTPWPGFPFNRPPMGYFSKSPVEPDEYYEDYDLVEENDLDENEKSTTKPDYKK SNAFHAGIASAIHDFTFDLYKGMVRNKSVEDNLVFSPLSVYTALCMLTLGLGGKSHSQAMEVLHGDAFPDVHNAMSELSD AIFDNSRSGSVTLTKANRIFIDRSVRLLKEFKSSMRKDYHVSAKKVNFMNAPDLNRRRINQFVQRHTERKIKDLAPRGSI SSDTRLFIANAMYMKASWETRFTFTDKGRFTVNPSEKIIVDMMQSSSGSCYTTLSNELNAEVIRILMKGDVSFIAIVPST PGDFSLLEDGRGKGRTRRALEALYEPGFSVWPQLCRITMPKFKIDFKADDLIDVLKDMGMTDIFDPTEADLSKMTPSREP LYVSDVRHKATIDVNENGLEAAAATGIGVAARMMPQPVTIDRPFLFMVRDEKTGATIFTGKVVRPKYE >XP_016773435.2 serine protease inhibitor 27A isoform X2 [Apis mellifera] MCYLIVTYIIILTLKQCKSEIMNNKSQSIFDTNVTRNINHEIINHNKTNNDFVPYQGERFDIFDWTFFKSISKKYSKNVI ISPISLKIALVLLYEGAQGETAYELANILQLPATRNATRKKFSNILQSLQTNFTAYTLNIGTRIYIDSNILVRQQYEANV KFFYNTDVIIANLSNAQPLVKAINNWVNNITNANIDRIIEDDNSVKNSLMLIVNTLFFKGLWRGKYFSPENTRNGKFYLI DNRTVDTSIMHAYGRFYYVESSDLDAKILRIPYDGQFAIYLLLPRIINGIDELIDKINPFVLTRYMWLMQDLSVDVLIPK FKFDFSSHLESILRELGICDIFDDTATLTGIAQTKRTSKRLKVSNILQKAGIEINENGTTAYVATEIEIGNKNQDETFHA NHPFLFYIEDESIGTIIYIGKIMNPLDTMDNVKIK >AAS13528.1 serine or cysteine protease inhibitor [Caenorhabditis elegans] MSDNATSQTDFALKLLATLPHSGSVVLSPLSISLGLALIHAGACGSTQKELEDVLGGSRIFEEFSGLMEAVGDTDNGVET KIVNRVFVNQAYTIHQDYLETVEKLYKASGESLDFSQTEQAAKTMNTFVENHTNGKIKDLIPADSANNAFAFLVNAMYFK ADWQSKFAKESTTGREFFTSEAESRQIPFLTDVDEHRDYTEDVLFQVLSLKYADPKFTLAIFLPKQRFGLVDALEKINGE YIQNLLNDLKSSYVSVQIPKFKIEKELDLKETLEAIGIKEIFAEGADLSGIADKVFISSGIHKAIIEVDEDGTTAAAASA FKVQLEMMIMAEPTQFVADHPFLFAVLFENHTLFLGVHA >XP_015817461.1 PREDICTED: pigment epithelium-derived factor [Nothobranchius furzeri] MKQTTFLLVFVVLLNICWAQLESGGEEVVVEEEEHVELFTTPKTKMGAAISDFGYNLFRALASHEASANI FLSPISVSAVLTQLSMGGSEQAQRQLYRALRYHTLQDAQLHNTLKDLLTSVKTSGKGLSMAARLYMARRL RPKQDFFKVVEQQYGVRPKALLGGAKDLKEVNDWVSQQTGRKVQQFLSKPLPRTSGVNAVSSTYFKGRWV TRFSQSGTLENFQVDGGTPVQVPMMQQDNYPVKMGVDSDLRCTIAQVQMQDDISMFVFLPEDVTTNTTLL EESLTAEFVQDLSMALQPAQLSLLLPILRLSFSTDLLPLLGDLGLSEWLENPELDDISIQPAKLSSVHHK VVMEMAPEGNQYPVATLEPSHLTYRVDRPFIYLIRDEPSGALLFIGKVVNPKDLTI >XP_020765464.1 pigment epithelium-derived factor [Odocoileus virginianus texanus] MQALVLLFCGALLGLGCCQNAGPEAGSLSPESTGAPVEEEDPFFKVPVNKLAAAVSNFGYDLYRVRSGES PTANVLLSPLSVATALSALSLGAEQRTESVIHRALYYDLISNPDIHGTYKDLLASVTAPQKNLKSASRII FERKLRIKASFIPPLEKSYGTRPRILTGNSRIDLQEINNWVQAQMKGKVARSTREMPSEISIFLLGVAYF KGQWVTKFDSRKTSLEDFHLDEERTVKVPMMSDPKAVLRYGLDSDLNCKIAQLPLTGSTSIIFFLPQRVT QNLTLIEESLTSEFIHDIDRELKTVQAVLTIPKLKLSYEGELTKSVQELKLQSLFDAPDFSKITGKPIKL TQVEHRIGFEWNEDGAGTNPSPGVQPARLTFPLDYHLNQPFIFVLRDTETGALLFIGKILDPRGT >XP_030292862.1 pigment epithelium-derived factor [Sparus aurata] MKRTAFLLVFGVVLSFCEAQTDTGGEEGGEEEHVELFTTPQTKMGAATSDFGYNLFRTLASRDSATNVFL APISVSAALTQLSMGGSERAQRQLFRALRYHTLQDPQLHNTLKDLLTAVKAPGKGLSTAARIYLDRRLRL KQEFFALVEQQYGVRPKGLQGVARDMNEVNSWMSQQTGGKVQSLLTSSFPRNFGVSTVSAAYFKGKWVTR FGQSGAMENFQVDGGASVRVPMMQQDNYPVKMGADSDLSCVIAQIQMQNDVSMFVFLPDDVTSNMTLLEE SLTAEFVQDLSMTLLPAQVTLTLPALKLSYSTDLQPLLSDLGLSEWLADTDLEKISALPAKLSSVHHKVV METAPEGNQYPGAASTPSHLTYRVDRPFLYLIRDEVSGALLFIGRVVNPKTLTM >XP_040194308.1 pigment epithelium-derived factor [Rana temporaria] MKNYLVFLLAATIFSFTSSQDAAEENPTVVVEEEEDPFYKTPVNRLASSASNFGYDLYRMHASKNPSINI FMSPLTLATALSSVSLGAGERTESLIHRTLYYDLLNDPEIHATYKELLASLSSKDKVKSTHRVILERRLR LKVDFVNQMEKFYGQKPRVLSGNSRLDLSEANNFVQQRTDGKVLKCFKEIPSGVSVLLLGAAYFKGQWVH KFNPRETVLREFYTDEQTSISVPMMTANNVPVRYGLDSDFSCRIMQLPLIGGISIMFFLPLTVTQNLTLI EEGLTSEFVHDIDRALQSVTIKLSLPKLKLDYEAELGSALQDMKLQPLFSAPDFSKISSKSVKLTQAVHK VAMELSEDGKEEVPKVDPKQINHFPLEFHLDHPFIFVLRADDNGALLFIGKVMNPKGLSR
Mafft alignment of selected proteins >NP_002606.3 pigment epithelium-derived factor isoform 1 precursor [Homo sapiens] ---------------MQALV-------------------LL----LCIGALLGHSSCQNP ASPP-----------------------------EEGSPDPDS-TGAL-V-EEEDPFFKV- --PVNKLAAAVSNFGYDLYRVR-SSTSP---TTNVLLSPLSVATALSALSLGAEQRTESI IHRALYYDLISSPDIHGTYKELLDTVTA----PQKNLKSASRIVFEKKLRIKSSFVAPLE KSYGTRPRVLTGNPR--LDLQEINNWVQAQMKGKLARST--KEIPDEISILLLGVAHFKG QWVTK-FDSRKTSLEDFYL-DEERTVRVPMMSDPKAVLRYGLDSDLSCKIAQLPLTG-SM SIIFFLPLKVTQNLTLIEESLTSEFIHDIDRELK-------TVQAVLTVPKLKLSYEG-E VTKSLQEMKLQSLFDS--PDFSKITG-----KPIKLTQVEHRAGFEWNEDGA----GTTP SPGLQPAHLTF-------PLDYHLNQPFIFVLRDTDTGALLFIGKILDPRGP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >NP_035470.3 pigment epithelium-derived factor precursor [Mus musculus] ---------------MQALV-------------------LL----LWTGALLGHGSSQNV PSS------------------------------SEGSPVPDS-TGEP-V-EEEDPFFKV- --PVNKLAAAVSNFGYDLYRLR-SSASP---TGNVLLSPLSVATALSALSLGAEHRTESV IHRALYYDLITNPDIHSTYKELLASVTA----PEKNLKSASRIVFERKLRVKSSFVAPLE KSYGTRPRILTGNPR--VDLQEINNWVQAQMKGKIARST--REMPSALSILLLGVAYFKG QWVTK-FDSRKTTLQDFHL-DEDRTVRVPMMSDPKAILRYGLDSDLNCKIAQLPLTG-SM SIIFFLPLTVTQNLTMIEESLTSEFIHDIDRELK-------TIQAVLTVPKLKLSFEG-E LTKSLQDMKLQSLFES--PDFSKITG-----KPVKLTQVEHRAAFEWNEEGA----GSSP SPGLQPVRLTF-------PLDYHLNQPFLFVLRDTDTGALLFIGRILDPSST-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >NP_776565.1 pigment epithelium-derived factor precursor [Bos taurus] ---------------MQALV-------------------LL----LWTGALLGFGRCQN- -AGQ-----------------------------EAGSLTPES-TGAP-V-EEEDPFFKV- --PVNKLAAAVSNFGYDLYRVR-SGESP---TANVLLSPLSVATALSALSLGAEQRTESN IHRALYYDLISNPDIHGTYKDLLASVTA----PQKNLKSASRIIFERKLRIKASFIPPLE KSYGTRPRILTGNSR--VDLQEINNWVQAQMKGKVARST--REMPSEISIFLLGVAYFKG QWVTK-FDSRKTSLEDFYL-DEERTVKVPMMSDPQAVLRYGLDSDLNCKIAQLPLTG-ST SIIFFLPQKVTQNLTLIEESLTSEFIHDIDRELK-------TVQAVLTIPKLKLSYEG-E LTKSVQELKLQSLFDA--PDFSKITG-----KPIKLTQVEHRVGFEWNEDGA----GTNS SPGVQPARLTF-------PLDYHLNQPFIFVLRDTDTGALLFIGKILDPRGT-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >NP_808788.1 pigment epithelium-derived factor precursor [Rattus norvegicus] ---------------MQTLV-------------------LL----LWTGALLGHGSSQNV PDS------------------------------SQDSPAPDS-TGEPVV-EEDDPFFKA- --PVNKLAAAVSNFGYDLYRLR-SGAVS---TGNILLSPLSVATALSALSLGAEQRTESV IHRALYYDLINNPDIHSTYKELLASVTA----PEKNFKSASRIVFERKLRVKSSFVAPLE KSYGTRPRILTGNPR--IDLQEINNWVQAQMKGKIARST--REMPSALSILLLGVAYFKG QWATK-FDSRKTTLQDFHL-DEDRTVRVPMMSDPKAILRYGLDSDLNCKIAQLPLTG-SM SIIFFLPLTVTQNLTMIEESLTSEFVHDIDRELK-------TIQAVLTVPKLKLSYEG-D VTNSLQDMKLQSLFES--PDFSKITG-----KPVKLTQVEHRAAFEWNEEGA----GTSS NPDLQPVRLTF-------PLDYHLNRPFIFVLRDTDTGALLFIGRILDPSST-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >NP_001244218.1 pigment epithelium-derived factor precursor [Gallus gallus] ---------------MQIPA-------------------VL----LLLGLLTIPSKSQNS PAG-------------------------------QNSPTTDG-TVGE-V-EEEDPFYKT- --PINKLAAAVSNFGYDLYRQQ-SSRTA---TANVLLSPFSLATALSGLSLGAGERTEDV ISRALFYDLLNKAEVHNTYKDLLASVTG----PEKSLKSASRIIVEKRLRVKSTFHSQLE KSYRMRLRALSGNTQ--LDLQEINNWVRQQTRGRILRFM--KDMPTDVSILLAGAAYFKG TWKTK-FDTKRTVLKDFHL-DEDRTVQVSMMSDPKAILRYGFDSELNCKIAQLPLTE-GV SAMFFLPTKVTQNMTLIEESLTSEFVHDVDRELK-------TVHAVLSLPKLKLNYEE-A LGNTVKETRLQSLFTS--PDFTKISA-----KPIKLSHVQHKAVLELNEDGE----KSTP NPGVNAARLTF-------PIEYHVDRPFLLVLRDDTTGTLLFIGKILDPRSV-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >NP_001004539.1 pigment epithelium-derived factor precursor [Danio rerio] ---------------MKKIV-------------------LL----VGLWSLLSLSHAQLA DTT----------------------------------------DAEG-E-EEAVDLFTT- --PRTKLAAATSDFGYNLFRQL-ASRDT---KASVFLSPMSISAAFTQLSMGASERAEKQ IYRALRYHTLQDSQLHDTLRDLLSSLRA----SAKGFKSAERILLARKLRLRLEYLNSVE KQYGERPQILAGGAR---DLKTVNDWFKQQTGGKVDQVVP-SPLPRNTALLPVGSAYFKG KWITR-FG-KPNKMETFRR-DGQAPAVIPMMEQENYPVKMGIDSDLGCTIAQVPMED-GV SMYFFLPDEVTQNLTLIEEALTAEFVQDLSNSLH-------TVKVLLTLPVIKLSYKT-N LLPSLSDLGLSEWLAE--TDLTKITS-----QPVKLNAVHHKVVLETAPEGA----EYAS TT-PSATGQSL-------GLSYRVDRPFLFLVRDEPSGALLFIGKVLNPSDL-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >XP_001155004.3 pigment epithelium-derived factor isoform X1 [Pan troglodytes] ---------------MQALV-------------------LL----LCIGALLGHSSCQNP ASPP-----------------------------EEGSPDPDS-TGAL-V-EEEDPFFKV- --PVNKLAAAVSNFGYDLYRVR-SSMSP---TTNVLLSPLSVATALSALSLGAEQRTESI IHRALYYDLISSPDIHGTYKELLDTVTA----PQKNLKSASRIVFEKKLRIKSSFVAPLE KSYGTRPRVLTGNPR--LDLQEINNWVQAQMKGKLARST--KEIPDEISILLLGVAHFKG QWVTK-FDSRKTSLEDFHL-DEERTVRVPMMSDPKAVLRYGLDSDLSCKIAQLPLTG-ST SIIFFLPLKVTQNLTLIEESLTSEFIHDIDRELK-------TVQAVLTVPKLKLSYEG-E VTKSLQEMKLQSLFDS--PDFSKITG-----KPIKLTQVEHRAGFEWNEDGA----GTTP SPGLQPAHLTF-------PLDYHLNQPFIFVLRDTDTGALLFIGKILDPRGT-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >XP_038531033.1 pigment epithelium-derived factor isoform X1 [Canis lupus familiaris] ---------------MQALV-------------------LL----LWTGALLGHSSCQND AGGP-----------------------------QEDSPAPDA-TGVP-V-EEEDPFFRV- --PVNKLAAAISNFGYDLYRVR-SSFSP---AANVLLSPLSVATALSALSLGAEQRTEST IHRALYYDLISNPDIHSTYKELLASVTA----PEKNFKSASRIVFERKLRIKSSFVAPLE KSYSTRPRILTGNPR--LDLQEVNNWVQAQMKGKIARST--REIPSGISILLLGVAYFKG QWVTK-FDSRKTSLEDFHL-DEERTVKVPMMSDPKAILRYGLDSDLSCKIAQLPLTG-SM SIIFFLPLKVTQNLTMIEESLTSEFIHDIDRELK-------TIQAVLTIPKLKLSYEG-E VTKSLQEMKLQSLVDS--PDFSKITG-----KPIKLTQVEHRAGFEWNEDGA----GTTP SPGLQPTRLTF-------PLDYHLNRPFIFVLRDTDTGALLFIGKILDPRGI-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >NP_001072130.1 pigment epithelium-derived factor precursor [Sus scrofa] ---------------MQALV-------------------LL----LWTGALLGSGSCQN- -AGP-----------------------------EEGSPAPDT-VGAP-V-EEEDPFFKV- --PVNKLAAAVSNFGYDLYRVR-SSESP---TANVLLSPLSVATALSALSLGAEQRTESS LHRALYYDLISNPDLHGTYKELLAAVTA----PQKNLKSASRIIFEKKLRIKASFVAPLE KSYGTRPRILTGNSR--LDLQEVNNWVQAQTKGKVARST--RELPGEISILLLGVAYFKG QWVTK-FDSRKTSLEDFHL-DEERTVKVPMMSDPKAVLRYGLDSDLNCKIAQLPLTG-SM SIIFFLPLKVTQNLTMIEESLTSEFIHDIDRELK-------TVQAVLTVPKLKLSYEG-E LTKSVQELKLQSLFDS--PDFSKITG-----KPIKLTQVEHRIGFEWNEDGG----SATS SPG---PRLTF-------PLDYHLNQPFIFVLRDTDTGALLFIGKILDPRST-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >NP_001132919.1 pigment epithelium-derived factor precursor [Ovis aries] ---------------MQALV-------------------LL----LWTGALLGFGHCQN- -AGP-----------------------------EAGSLAPES-TGAP-V-EEEDPFFKV- --PVNKLAAAVSNFGYDLYRVR-SGESP---TTNVLLSPLSVATALSALSLGAEQRTESS IHRALYYDLISNPDIHGTYKDLLASVTA----PQKNLKSASRIIFERKLRIKASFVPPLE KSYGTRPRILTGNSR--IDLQEINNWVQAQMKGKIARST--REIPSGISILLLGVAYFKG QWVTK-FDSRKTSLEDFHL-DEGRTVKVPMMSDPKAVLRYGLDSDLNCKIAQLPLTG-ST SIIFFLPQKVTQNLTLIEESLTSEFIHDIDRELK-------TVQAVLTIPKLKLSYEG-E LTKSVQELKLQSLFDA--PDFSKITG-----KPIKLTQVEHRIGFEWNEDGA----GTNS SPGVQPARLTF-------PLDYHLNQPFIFVLRDTDTGALLFIGKILDPRGT-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >XP_008269150.1 PREDICTED: pigment epithelium-derived factor isoform X1 [Oryctolagus cuniculus] M-----------SPTMQALV-------------------LL----LWTGALLGHGSCQSI ASSP-----------------------------EEGSPAPDG-TGPP-L-EEDDPFFKV- --PVNKLAAAVSNFGYDLYRQR-SAESP---TANVLLSPLSVATALSALSLGAEQRTESL IQRALYYDLISNPDIHGTYKELLAAVTA----PQKNLKSASRIIFERKLRIKSSFVAPLE KAYGTRPRVLSGNPR--LDLQELNGWVQAQMKGKVARSA--REVPSDISIFLLGVAYFKG QWVTK-FDSRKTSLQDFHL-DEERTVRVPMMSDPKATLRYGLDSDLNCKIAQLPLTG-SM SIIFFLPLRPTQNLTLIEESLTSEFIHDIDRELK-------TIQAALSIPRLKLSFEG-E VTKALQEIKLQPLFES--PDFSKITG-----KPIKLTHVEHRAGFEWNEDGA----ATSP GPEVQPARLAF-------SLDYHLNQPFIFVLRDSDTGALLFVGKILDPRGT-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >XP_009249388.1 pigment epithelium-derived factor isoform X1 [Pongo abelii] ---------------MQALV-------------------LL----LCIGALLGHSSCQNP ASPP-----------------------------EEGSPDPDS-TGAL-V-EEEDPFFKV- --PVNKLAAAVSNFGYDLYRVR-SSMSP---TTNVLLSPLSVATALSALSLGAEQRTEST IHRALYYDLISSPDIHGTYKELLDTVTA----PQKNFKSASRIVFEKKLRIKSSFVAPLE KSYGTRPRVLTGNPH--LDQQEINNWVQAQMKGKLARST--KEIPHEISILLLGVAHFKG QWVTK-FDSRKTSLEDFHL-DEDRTVRIPMMSDPKAVLRYGLDSDLSCKIAQLPLTG-SM SIIFFLPLKVTQNLTLIEESLTSEFIYDIDRELK-------TVQAVLTVPKLKLSYEG-E VTKSLQEMKLQSLFDS--PDFSKITG-----KPIKLTQVEHRAGFEWNEDGA----GTTP SPGLQPAHLTF-------PLDYHLNQPFIFVLRDTDTGALLFIGKILDPRGT-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >XP_003211790.1 pigment epithelium-derived factor [Meleagris gallopavo] ---------------MQIPA-------------------IL----LLLGLLTIPSKSQNS PTG-------------------------------QNSPTTDG-TVGE-V-EEEDPFYKT- --PVNKLAAAVSNFGYDLYRQQ-SSRTA---TANVLLSPFSLATALSGLSLGAGERTEDV ISRALFYDLLNKAEVHNTYKDLLASVTG----PEKSLKSASRIIVEKRLRVKSTFHSQLE KSYKMRLRALSGNTQ--LDLQEINNWVRQQTRGRILRFM--KDMPTDVSILLAGAAYFKG TWKTK-FDTKRTVLNDFHL-DEDRTVKVSMMSDPKAILRYGFDSELNCKIAQLPLTE-GV SAMFFLPTKVTQNMTLIEESLTSEFIHDVDRELK-------TVHAVLSLPKLKLNYEE-A LGNTLKETRLQSLFTS--PDFTKISA-----KPIKLSHVQHKAVLELNEDGE----KSTP NPGVNAARLTF-------PIEYHVDRPFLLVLRDDTTGTLLFIGKILDPRSV-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >XP_008968201.2 pigment epithelium-derived factor isoform X1 [Pan paniscus] MYPFCACQATRRGPRMQALV-------------------LL----LCIGALLGHSSCQNP ASPP-----------------------------EEGSPDPDS-TGAL-V-EEEDPFFKV- --PVNKLAAAVSNFGYDLYRVR-SSMSP---TTNVLLSPLSVATALSALSLGAEQRTESI IHRALYYDLISSPDIHGTYKELLDTVTA----PQKNLKSASRIVFEKKLRIKSSFVAPLE KSYGTRPRVLTGNPR--LDLQEINNWVQAQMKGKLARST--KEIPDEISILLLGVAHFKG QWVTK-FDSRKTSLEDFHL-DEERTVRVPMMSDPKAVLRYGLDSDLSCKIAQLPLTG-ST SIIFFLPLKVTQNLTLIEESLTSEFIHDIDQELK-------TVQAVLTVPKLKLSYEG-E VTKSLQEMKLQSLFDS--PDFSKITG-----KPIKLTQVEHRAGFEWNEDGA----GTTP SPGLQPAHLTF-------PLDYHLNQPFIFVLRDTDTGALLFIGKILDPRGT-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >XP_003996465.1 pigment epithelium-derived factor [Felis catus] ---------------MQALM-------------------LL----LWAGALLGPGSCQDN AGS------------------------------LEDSPAPDA-TGVP-V-EEEDPFFKV- --PVNKLAAAISNFGYDLYRVR-SSLSP---TANVLLSPLSVATALSALSLGAEQRTEST IHRALYYDLISNPDIHGTYKELLAAVTA----PQKNFKSASRIIFERKLRIKSSFVAPLE KSYGTRPRILTGNSR--LDLQEVNNWVQAQMKGKIARST--REIPSEISILLLGVAYFKG QWVTK-FDPRKTSLEDFHL-DEERTVRVPMMSDPKAILRYGLDSDLSCKIAQLPLTG-SM SIIFFLPLKVTQNLTMIEESLTSEFIHDIDRELK-------TIQAVLTIPKLKLSYEG-E VTKSLQEMKLQSLFDS--PDFSKITG-----KPIKLTQVEHRGGFEWNEDGA----STAP SAGLQPARLTF-------PLDYHLNQPFIFVLRDTDTGALLFIGKILDPRGI-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >XP_004058286.3 pigment epithelium-derived factor isoform X1 [Gorilla gorilla gorilla] ---------------MQALV-------------------LL----LCIGALLGHSGCQNP ASPP-----------------------------EEGSPDPDS-TGAL-V-EEEDPFFKV- --PVNKLAAAVSNFGYDLYRVR-SSMSP---TTNVLLSPLSVATALSALSLGAEQRTESI IHRALYYDLISSPDIHGTYKELLDMVTA----PQKNLKSASRIVFEKKLRIKSSFVAPLE KSYGTRPRVLTGNPR--LDLQEINNWVQAQMKGKLARST--KEIPDEISILLLGVAHFKG QWVTK-FDSRKTSLEDFHL-DEERTVRVPMMSDPRAVLRYGLDSDLSCKIAQLPLTG-SM SIIFFLPLKVTQNLTLIEESLTSEFVHDIDRELK-------TVQAVLTVPKLKLSYEG-E VTKPLQEMKLQSLFDS--PDFSKITG-----KPIKLTQVEHRAGFEWNEDGA----GTTP SPGLQPAHLTF-------PLDYHLNQPFIFVLRDTDTGALLFIGKILDPRGT-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >XP_020564755.2 pigment epithelium-derived factor [Oryzias latipes] ---------------MKRFS-------------------LL----LMLAAVLSFCQAQSE SGG-------------------------------------EG-EGL--E-EEPVELFTT- --PTTKLGAAVSDFGYNLFRAL-ASRET---SSNIFLSPISVSAALSQLSLGASEGSQRQ LFRALRYHTLQDPQLHSTLKTMLASVTA----TGKGLSTAARLYLARRLRPKQDFFKAVE QQYGVRPKALMGGAK---DVKEVNDWVSQQTGRKVLQFLA-KPFPRAAGVNAVSASYFKG KWVTR-FG-QSGALDNFQV-EGDVPVRVPMMQQDNYPVKMGSDSDLSCVIAQIQMQD-GV SMFIFLPDGVTANMTLLEESLTAEFVQDLAMTLL-------PAKVSLTLPVLRLSFST-D LLPLLGDLGLSEWMEN--PELDNIST-----QRSKLSSLDHKVVMETAPEGS----QY-- ---PDVASTHG-------HLTYRVDRPFLYLIRDEASGALLFIGRVVNPKGL-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------TI------------------------- --------------------- >XP_005502067.1 pigment epithelium-derived factor [Columba livia] ---------------MRIPV-------------------VL----LFLGLLTVPSRSQNL ASE-------------------------------QNSATADGANAGE-V-EEEDPFYKS- --PINKLAAAVSNFGYDLYRQQ-SSRTA---TANVLLSPFSLATALSGLSLGAGERTEDV ISRALFYDLLDKAEVHNTYKDLLTSVAG----PEKSMKSASRIILEKRLRVKPGFHSQLE KSYKMRLRALSGNTQ--LDLQEVNNWVRQQTKGRIMRLM--KDMPTDVSILLAGAAYFKG TWKTK-FDTKKTALNDFHL-DEDRTVKVSMMSDPKAILRYGFDSELNCKIAQLPLTE-GI SAMFFLPTKVTQNMTLIEESLTSEFVHDVDKELK-------TVHAVLSLPKLKLNYEE-A LGSTLKETRLQSLFAS--PDFTKISV-----KPIKLSHVQHKAVLELSEDGE----RTTP NPGVNAARLTF-------PIEYHVDRPFLLVLRDDTTGTLLFIGKILDPRSV-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >XP_005693374.1 PREDICTED: pigment epithelium-derived factor [Capra hircus] ---------------MQALM-------------------LL----LWTGALLGFGRCQN- -AGP-----------------------------EAGSLAPES-TGAP-V-EEEDPFFKV- --PVNKLAAAVSNFGYDLYRVR-SGESP---TANVLLSPLSVATALSALSLGAEQRTESS IHRALYYDLISNPDIHGTYKDLLASVTA----PQKNLKSASRIIFERKLRIKASFVPPLE KSYGSRPRILTGNSR--IDLQEINNWVQAQMKGKVARST--RELPSEISIFLLGVAYFKG QWVTK-FDSRKTSLEDFHL-DEGRTVKVPMMSDPKAVLRYGLDSDLNCKIAQLPLTG-ST SIIFFLPQKVTQNLTLIEESLTSEFIHDIDRELK-------TVQAVLTIPKLKLSYEG-E LTKSVQELKLQSLFDA--PDFSKITG-----KPIKLTQVEHRIGFEWNEDGA----GTNS SPGVQPARLTF-------PLDYHLNQPFIFVLRDTDTGALLFIGKILDPRGT-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >XP_006032909.1 pigment epithelium-derived factor [Alligator sinensis] ---------------MQTPL-------------------VF----LLLGLLASPGSSQNS ANE-------------------------------QDSATPDGGNAGE-A-EEEDPFYKT- --PVNKLAAAVSNFGYDLYRQQ-SGRTA---TANVLLSPFSVATALSGLSLGAGQRTEDL ISRTLYYDLLNKAEVHNTYKELLTSISA----PEKGFRSVFRIILERKLRMKVGFPSQLE KAYRIRLKILTGNSQ--ADLQELNNWVRQQTKGKILRFL--KDMPTDVSIFLAGAAYFKG HWATK-FDPRKTTLQDFYL-EEDRIVTVPMMSDPKAILRYGFDSELNCKIAQLPLTG-GV SAMFFLPLKVTQNLTLIEESLSSEFVHDIDKELK-------TVHAVLSVPKLKLSFEE-S LGSTLQEMRLQQLFIS--PDFSKMSA-----KPIKLSHVHHKTVLELSEDGA----NSTP NPGANAARLTF-------PLDYHLNRPFLLVLRDDATGTLFFIGKILDPRNI-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >XP_006260666.2 PREDICTED: pigment epithelium-derived factor [Alligator mississippiensis] ---------------MQTPL-------------------VFLLLLLLLGLLASPGSSQNS ANE-------------------------------QDSATPDGGNAGE-A-EEEDPFYKT- --PVNKLAAAVSNFGYDLYRQQ-SGRTA---TANVLLSPFSVATALSGLSLGAGQRTEDL ISRTLYYDLLNKAEVHNTYKELLTSISA----PEKGFRSVFRIILERKLRMKVGFPSQLE KAYRIRLKILTGNSQ--TDLQELNNWVRQQTKGKILRFL--KDMPTDVSIFLAGAAYFKG HWATK-FDPRKTTLQDFYL-EEDRIVTVPMMSDPNAILRYGFDSELNCKIAQLPLTG-GV SAMFFLPLKVTQNLTLIEESLSSEFVHDIDKELK-------TVHAVLSVPKLKLSFEE-S LGSTLQEMRLQQLFIS--PDFSKMSA-----KPIKLSHVHHKTVLELSEDGA----NSTP NPGVNAARLTF-------PLDYHLNRPFLLVLRDDATGTLFFIGKILDPRNI-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >KAB0367960.1 hypothetical protein FD755_021284 [Muntiacus reevesi] ---------------MQALV-------------------LL----LWTGALLGLGCCQN- -AGP-----------------------------EAGSMAPES-TGAP-V-EEEDPFFKV- --PVNKLAAAVSNFGYDLYRVR-SGESP---TTNVLLSPLSVATALSALSLGAEQRTESI IHRALYYDLISNPDIHGTYKDLLASVTA----PQKNLKSASRIIFERKLRIKASFIPPLE KSYGTRPRILTGNSR--IDLQEINNWVQAQMKGKVARST--REMPSEISIFLLGVAYFKG QWVTK-FDSRKTSLEDFHL-DEERTVKVPMMSDPKAVLRYGLDSDLNCKIAQLPLTG-ST SIIFFLPQRVTQNLTLIEESLTSEFIHDIDRELK-------TVQAVLTVPKLKLSYEG-E LTKSVQELKLQSLFDA--PDFSKITG-----KPIKLTQVEHRIGFEWNEDGA----GTNP SPGVQPARLTF-------PLDYHLNQPFIFVLRDTDTGALLFIGKILDPRGT-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >XP_043334263.1 pigment epithelium-derived factor [Cervus canadensis] ---------------MQALA-------------------LL----LWTGALLGLGRCQN- -AGP-----------------------------EAGSLAPES-TGAP-V-EEEDPFFKV- --PVNKLAAAISNFGYDLYRVR-SGESP---TANVLLSPLSVATALSALSLGAEQRTESI IHRALYYDLISNPDIHGTYKDLLASVTA----PQKNLKSASRIIFEKKLRIKASFIPPLE KSYGTRPRILTGNSR--IDLQEINNWVQAQMKGKVSRST--REMPSEISIFLLGVAYFKG QWVTK-FDSRKTSLEDFHL-DEERTVKVPMMSDPKAVLRYGLDSDLNCKIAQLPLTG-ST SIIFFLPQRVTQNLTLIEESLTSEFIHDIDRELK-------TVQAVLAIPKLKLSYEG-E LTKSVQELKLQSLFDA--PDFSKITG-----KPIKLTQVEHRIGFEWNEDGA----GTNP SPGVQPARLTF-------PLDYHLNQPFIFVLRDTDTGALLFIGKILDPRGT-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >KAB0366159.1 hypothetical protein FD754_010315 [Muntiacus muntjak] ---------------MQALV-------------------LL----LWTGALLGLGCCQN- -AGL-----------------------------EAGSLAPES-TGAP-V-EEEDPFFKV- --PVNKLAAAVSNFGYDLYRVR-SGESP---TANVLLSPLSVATALSALSLGAEQRTESI IHRALYYDLISNPDIHGTYKDLLASVTA----PQKNLKSASRIIFERKLRIKASFIPPLE KSYGTRPRILTGNSR--IDLQEINNWVQAQMKGKVARST--REMPSEISIFLLGVAYFKG QWVTK-FDSRKTSLEDFHL-DEERTVKVPTMSDPKAVLRYGLDSDLNCKIAQLPLTG-ST SIIFFLPQRVTQNLTLIEESLTSEFIHDIDRELK-------TVQAVLTVPKLKLSYEG-E FTKSVQELKLQSLFDA--PDFSKITG-----KPIKLTQVEHRIGFEWNEDGA----GTNP SPGVQPARLTF-------PLDYHLNQPFIFVLRDTDTGALLFIGKILDPRGT-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >KAF4012198.1 hypothetical protein G4228_003074 [Cervus hanglu yarkandensis] ------------------------------------------------------------ ---------------------------------MQGSLAPES-TGAP-V-EEEDPFFKV- --PVNKLAAAISNFGYDLYRVR-SGESP---TANVLLSPLSVATALSALSLGAEQRTESI IHRALYYDLISNPDIHGTYKDLLASVTA----PQKNLKSASRIIFEKKLRIKASFIPPLE KSYGTRPRILTGNSR--IDLQEINNWVQAQMKGKVSRST--REMPSEISIFLLGVAYFKG QWVTK-FDSRKTSLEDFHL-DEERTVKVPMMSDPKAVLRYGLDSDLNCKIAQLPLTG-ST SIIFFLPQRVTQNLTLIEESLTSEFIHDIDRELK-------TVQAVLAIPKLKLSYEG-E LTKSVQELKLQSLFDA--PDFSKITG-----KPIKLTQVEHRIGFEWNEDGAAFMLATQL NPLVEEERLSS-------NCICQINRFIVNTLKDGRRVVILMELEVLKSAEAVGSKIGNP MPYNEGHGQQPVVPPPVSAASPPTSRPQQQNGSPGVASTASKAFGASKTFGKVGSTSQMN SSGGTQAKVVPIASLTPYQSKWTICARVTNKSQIRTWSNSRGEGKLFSIELVDESGEIRA TAFNEQADKFFPLIDVNKVYYFSKGTLKIANKQFTAVKNDYEMTFNSETSVMPCEDGHHL PTVQFDFTGIGDLESKSKDSLVDIIGICKNYEDVTKIIVKSNNREVSKRNIYLMDMSGKV VNATLWGDDADKFDGSRQPVMAIKGARVSDFGGRSLSVLSSSTIIVNPDIPEAYKLRGWF DSEGQALDGISISDLKSGGAGGSNTNWKTLYEVKSENLGQGDKPDYFSSVATVVYLRKEN CMYQACPTQDCNKKVIDQQNGLYRCEKCDSEFPNFKYRMILAVNIADFQENQWVTCFQES AEAILGQSTAYLGELKEKNEQAFEEVFQNANFRSFTFRIRVKLETYNDESRIKATVVDVK PVDYREYGRRLVMNIRRNAAM >NP_001085983.1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 L homeolog precursor [Xenopus laevis] ---------------MKIYL-------------------AL----LFTGTFLSSTSAQNA AEE----------------------------------------VLPE-V-EEEDPFYKS- --PLNRLTSSASNFGYDLYRMQ-ANKNP---NSNIFISPLSIATSLSSLSLGSGQRTESL IHRSLYYDLLNDPELHATYKELLASLTS----HGSGLKSTWRIMLERKLRLRLDFVTQVE KFYGNKPRILTGNTR--LDLQEANDFVQKQTQAKVVKFF--KEIPAGVSILLLGTSYLKG QWAYK-FNPRETVQSEFHL-DEQTSVTVPMMSSKNLPVRYGLDSDFNCKIVQLPLTG-GV SIMFFLPNTVTQNLTMIEEGLTSEFIHDIDQALQ-------TVNMDLRIPKLKLNYEV-E LKEALQESKLQSLFST--PDFSKISS-----KPLKLSHVVHKATLELNEDGA----ETAP KAEAS-SRKYF-------PLEYHLDHPFLFVLRANDNGALLFIGKVMDPKGF-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SF------------------------- --------------------- >XP_038050239.1 leukocyte elastase inhibitor-like [Patiria miniata] ---------------MYKLTLLVTSSRPDSIMAVIQIISIL----TVIALLYMSVFATST GPD--------------------------------------------------------- --PQLELADANNRFAFHLYQTL-ADDPH---RDNIFFSPMSISIALAMTSLGARGNTARQ IKDVLKFSTLEESRLHSSFAELNSAIFGAN-ADKYVLRKANRLFGHKGFDLRQEFLADAE RYYSSHMASLDFVEDTEVAREFINSWVGRETEDKIRDLLPHGSITGMTQLVLVNAIYFKA DWVRQ-FDKSKTFDQDFHV-SKDQVLEVPMMHRKS-KFNFAEDITLRCKLIELPYVGQDF SMIVVLPDEI-DGIDRLQKHLTNEKLQHLLNNLS-------NVTVGVAIPKFKLEETL-H MNDVLYSMGMRDLFVRDKADLSGITGT---RD-LFVSSVIHRAFLEVNEEGS----EAAA ATAVTINKRSIS-----LAPEFIADHPFLFFIADSKTKAIVFMGHCRKPEGV-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SLNHEE--------------------- --------------------L >NP_524953.1 serpin 55B [Drosophila melanogaster] ---------------------------------------MF------------------- ------------------------------------------------------------ -DFNLEFARGGARFTSELFQLL-SAGGL---KENVVFSPFSIQTCIALAFAGSQGETADE IAKALHFVSNFPPEVAQTFQFVLEKYR-----NSNLLRVANKLYVQEGKQLKPAYQSAIK EQYHSEAESINFALN-DAAAQAINAWVNAKTQGKITELVSADSFSDNTRLVLLNALHFKG SWAHK-FSEERTEEDIFWV-GEEEQVKINYMNQKA-KFNYGFFEDLGCTALEMPYQDSDL SMFVLLPQER-TGIYALAEKLKTVNLVDLADKLT-------VEEVHVKFPKFKVDYSL-E LAEKLKQLGITKMFTDQ-AEFSNLLES---PEGVFVSKVLHKATIEVNEEGT----EAAA ATGMIMMTRMMT-----FPLQFQADRPFLYVIWNKKN--ILFAGAFVKAA---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >XP_011666177.1 leukocyte elastase inhibitor [Strongylocentrotus purpuratus] ---------------MSEYI----------------------RN--------MAFYKQQD ISE--------------------------------------------------------- --QLVQLSSANTRFALDLYQTF-QDERR---GTNLFFSPLSISTALAMTQLGACGDTATQ IADVFRFNQVDQDQLHGTFKELNNLLYQTN--SGYKLHAANRLYGKSGYNFVQSFLEGTA SYYGAAIEAVDNFAA-PTATHSINDWVSKQTEDKITNLIPPGILNDLTRLVLVNAIYFKG NWESK-FRAENTTQETFKVLDERKKVPVSLMIQKG-KFALAVDKTNDCLVLEMPYQGRNL SLLIALPVKD-DGLGNLQTKLSADILRSWDAGLK-------SRQVNVLLPKFKLEAEF-Q LKEVLKRMGMPDAFNDGKANFEGISGD---RE-LYISAVIHKAFVDINEEGS----EAAA ATAVAVKLGCARPREPEKPTLFRADHPFIFMIRHRPTKSVLFMGRMMDPS---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >XP_031557330.1 leukocyte elastase inhibitor-like [Actinia tenebrosa] ---------------MGNNIITCNTFRLHSV--------LI----LAVSLVFCSVLLSTM A----------------------------------------------------------- --QADLIKASTNKFSLHLHQVL-RGQATFDAEQNLFYSPSSILVALAMTHLGARGNTAKQ MSSSFHLDEIPEKQLNAEFQKFLQKLNQSN-AKGNEIAMANRLFVQMGFEVSKQFQEDSE KFFNAEAALVDYQKNSEGARQEVNQWVEQKTKNKIKDLIPEGMFGPDTRLTLVNAIYFKG SWMSK-FDSNNTQTGPFQL-TPSKTVQVPMMYKSD-KFKYFENEGLKCKMLELPYSDEKI SMIILLPDEV-DGLSKLEDSLNYSKLDEAIGHLKM----APKEEVEVTLPKFKLSEKF-S LKEVLSKMGASDLFNAAKADLTGINKD---GQ-LYVSEVVHKAFVDVNEEGT----EAAA ATAVRVALMCMP-----MNPIFFANHPFLFLIRHNESGAILFIGRLANPK---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >XP_039254966.1 leukocyte elastase inhibitor-like [Styela clava] ---------------MNYSL-------------------LI----LLIGLVFHCGEASKK KSIVSGTPWPGFPFNRPPMGYFSKSPVEPDEYYEDYDLVEEN-DLDENEKSTTKPDYKKS NAFHAGIASAIHDFTFDLYKGMVRNKSV---EDNLVFSPLSVYTALCMLTLGLGGKSHSQ AMEVLHGDAF--PDVHNAMSELSDAIFDNSRSGSVTLTKANRIFIDRSVRLLKEFKSSMR KDYHVSAKKVNFMNAPDLNRRRINQFVQRHTERKIKDLAPRGSISSDTRLFIANAMYMKA SWETR-FT--FTDKGRFTV-NPSEKIIVDMMQSSSGSCYTTLSNELNAEVIRILMKG-DV SFIAIVPSTP-GDFSLLEDGRGKGRTRRALEALYEPGFSVWPQLCRITMPKFKIDFKADD LIDVLKDMGMTDIFDPTEADLSKMTPS---REPLYVSDVRHKATIDVNENGL----EAAA ATGIGVAARMM-------PQPVTIDRPFLFMVRDEKTGATIFTGKVVRPKYE-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >XP_016773435.2 serine protease inhibitor 27A isoform X2 [Apis mellifera] ---------------MCYLIVT-----------------YI----IILTLKQCKSEIMNN KSQ----------------------------------SIFDT-NVTRNINHEIINHNKTN NDFVPYQGERFDIFDWTFFKSI--SKKY---SKNVIISPISLKIALVLLYEGAQGETAYE LANILQLPAT-RNATRKKFSNILQSLQTNF--TAYTLNIGTRIYIDSNILVRQQYEANVK FFYNTDVIIANLSNA-QPLVKAINNWVNNITNANIDRIIEDDNSVKNSLMLIVNTLFFKG LWRGKYFSPENTRNGKFYL-IDNRTVDTSIMHAYG-RFYYVESSDLDAKILRIPYDG-QF AIYLLLPRII-NGIDELIDKINPFVLTRYMWLMQ-------DLSVDVLIPKFKFDFSS-H LESILRELGICDIFDDT-ATLTGIAQTKRTSKRLKVSNILQKAGIEINENGT----TAYV ATEIEIGNKNQ-------DETFHANHPFLFYIEDESIGTIIYIGKIMNPLDT-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MD----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------NVKIK---------------------- --------------------- >AAS13528.1 serine or cysteine protease inhibitor [Caenorhabditis elegans] ---------------MS------------------------------------------- ----------------------------------------DN------------------ -------ATSQTDFALKLLATL----PH---SGSVVLSPLSISLGLALIHAGACGSTQKE LEDVLG-----GSRIFEEFSGLMEAVGDTD--NGVETKIVNRVFVNQAYTIHQDYLETVE KLYKASGESLDFSQT-EQAAKTMNTFVENHTNGKIKDLIPADS-ANNAFAFLVNAMYFKA DWQSK-FAKESTTGREFFT-SEAESRQIPFLTDVDEHRDY--TEDVLFQVLSLKYADPKF TLAIFLPKQR-FGLVDALEKINGEYIQNLLNDLK-------SSYVSVQIPKFKIEKEL-D LKETLEAIGIKEIFAEG-ADLSGIAD-----K-VFISSGIHKAIIEVDEDGT----TAAA ASAFKVQLEMMIM---AEPTQFVADHPFLFAVLFENH--TLFLGVHA------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >XP_015817461.1 PREDICTED: pigment epithelium-derived factor [Nothobranchius furzeri] ---------------MKQTT-------------------FL----LVFVVLLNICWAQLE SGG-------------------------------------EE-VVVE-E-EEHVELFTT- --PKTKMGAAISDFGYNLFRAL-ASHEA---SANIFLSPISVSAVLTQLSMGGSEQAQRQ LYRALRYHTLQDAQLHNTLKDLLTSVKT----SGKGLSMAARLYMARRLRPKQDFFKVVE QQYGVRPKALLGGAK---DLKEVNDWVSQQTGRKVQQFLS-KPLPRTSGVNAVSSTYFKG RWVTR-FS-QSGTLENFQV-DGGTPVQVPMMQQDNYPVKMGVDSDLRCTIAQVQMQD-DI SMFVFLPEDVTTNTTLLEESLTAEFVQDLSMALQ-------PAQLSLLLPILRLSFST-D LLPLLGDLGLSEWLEN--PELDDISI-----QPAKLSSVHHKVVMEMAPEGN----QY-- ---PVATLEPS-------HLTYRVDRPFIYLIRDEPSGALLFIGKVVNPKDL-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------TI------------------------- --------------------- >XP_020765464.1 pigment epithelium-derived factor [Odocoileus virginianus texanus] ---------------MQALV--------------------L----LFCGALLGLGCCQN- -AGP-----------------------------EAGSLSPES-TGAP-V-EEEDPFFKV- --PVNKLAAAVSNFGYDLYRVR-SGESP---TANVLLSPLSVATALSALSLGAEQRTESV IHRALYYDLISNPDIHGTYKDLLASVTA----PQKNLKSASRIIFERKLRIKASFIPPLE KSYGTRPRILTGNSR--IDLQEINNWVQAQMKGKVARST--REMPSEISIFLLGVAYFKG QWVTK-FDSRKTSLEDFHL-DEERTVKVPMMSDPKAVLRYGLDSDLNCKIAQLPLTG-ST SIIFFLPQRVTQNLTLIEESLTSEFIHDIDRELK-------TVQAVLTIPKLKLSYEG-E LTKSVQELKLQSLFDA--PDFSKITG-----KPIKLTQVEHRIGFEWNEDGA----GTNP SPGVQPARLTF-------PLDYHLNQPFIFVLRDTETGALLFIGKILDPRGT-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >XP_030292862.1 pigment epithelium-derived factor [Sparus aurata] ---------------MKRTA-------------------FL----LVFGVVLSFCEAQTD TGG----------------------------------------EEGG-E-EEHVELFTT- --PQTKMGAATSDFGYNLFRTL-ASRDS---ATNVFLAPISVSAALTQLSMGGSERAQRQ LFRALRYHTLQDPQLHNTLKDLLTAVKA----PGKGLSTAARIYLDRRLRLKQEFFALVE QQYGVRPKGLQGVAR---DMNEVNSWMSQQTGGKVQSLLT-SSFPRNFGVSTVSAAYFKG KWVTR-FG-QSGAMENFQV-DGGASVRVPMMQQDNYPVKMGADSDLSCVIAQIQMQN-DV SMFVFLPDDVTSNMTLLEESLTAEFVQDLSMTLL-------PAQVTLTLPALKLSYST-D LQPLLSDLGLSEWLAD--TDLEKISA-----LPAKLSSVHHKVVMETAPEGN----QY-- ---PGAASTPS-------HLTYRVDRPFLYLIRDEVSGALLFIGRVVNPKTL-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------TM------------------------- --------------------- >XP_040194308.1 pigment epithelium-derived factor [Rana temporaria] ---------------MKNYL-------------------VF----LLAATIFSFTSSQDA AEE-------------------------------------NP-TVVV-E-EEEDPFYKT- --PVNRLASSASNFGYDLYRMH-ASKNP---SINIFMSPLTLATALSSVSLGAGERTESL IHRTLYYDLLNDPEIHATYKELLASLSS----KDK-VKSTHRVILERRLRLKVDFVNQME KFYGQKPRVLSGNSR--LDLSEANNFVQQRTDGKVLKCF--KEIPSGVSVLLLGAAYFKG QWVHK-FNPRETVLREFYT-DEQTSISVPMMTANNVPVRYGLDSDFSCRIMQLPLIG-GI SIMFFLPLTVTQNLTLIEEGLTSEFVHDIDRALQ-------SVTIKLSLPKLKLDYEA-E LGSALQDMKLQPLFSA--PDFSKISS-----KSVKLTQAVHKVAMELSEDGK----EEVP KVDPK-QINHF-------PLEFHLDHPFIFVLRADDNGALLFIGKVMNPKGL-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SR------------------------- ---------------------
BMGE Cleaned alignment of selected proteins >NP_002606.3 pigment epithelium-derived factor isoform 1 precursor [Homo sapiens] MQALVLCIGALLGHEEGSPDPDSEEEDPFFKVPVNKLAAAVSNFGYDLYRVRTTNVLLSPLSVATALSALSLGAEQRTESIIHRALYYDLISSPDIHGTYKELLDTVTAPQKNLKSASRIVFEKKLRIKSSFVPLEKSYGTRPRVLTGNPRLDLQEINNWVQAQMKGKLARSTKEIPDISILLLGVAHFKGQWVTKFDSRKTSLEDFYLDEERTVRVPMMSDPKAVLRYGLDSDLSCKIAQLPLTGSMSIIFFLPLKVTQNLTLIEESLTSEFIHDIDRELKTVQAVLTVPKLKLSYEGSLQEMKLQSLFDSPDFSKITGKPIKLTQVEHRAGFEWNEDGAGTTPSPGLAHLTFPLDYHLNQPFIFVLRDTDTGALLFIGKILDPRGP >NP_035470.3 pigment epithelium-derived factor precursor [Mus musculus] MQALVLWTGALLGHSEGSPVPDSEEEDPFFKVPVNKLAAAVSNFGYDLYRLRTGNVLLSPLSVATALSALSLGAEHRTESVIHRALYYDLITNPDIHSTYKELLASVTAPEKNLKSASRIVFERKLRVKSSFVPLEKSYGTRPRILTGNPRVDLQEINNWVQAQMKGKIARSTREMPSLSILLLGVAYFKGQWVTKFDSRKTTLQDFHLDEDRTVRVPMMSDPKAILRYGLDSDLNCKIAQLPLTGSMSIIFFLPLTVTQNLTMIEESLTSEFIHDIDRELKTIQAVLTVPKLKLSFEGSLQDMKLQSLFESPDFSKITGKPVKLTQVEHRAAFEWNEEGAGSSPSPGLVRLTFPLDYHLNQPFLFVLRDTDTGALLFIGRILDPSST >NP_776565.1 pigment epithelium-derived factor precursor [Bos taurus] MQALVLWTGALLGFEAGSLTPESEEEDPFFKVPVNKLAAAVSNFGYDLYRVRTANVLLSPLSVATALSALSLGAEQRTESNIHRALYYDLISNPDIHGTYKDLLASVTAPQKNLKSASRIIFERKLRIKASFIPLEKSYGTRPRILTGNSRVDLQEINNWVQAQMKGKVARSTREMPSISIFLLGVAYFKGQWVTKFDSRKTSLEDFYLDEERTVKVPMMSDPQAVLRYGLDSDLNCKIAQLPLTGSTSIIFFLPQKVTQNLTLIEESLTSEFIHDIDRELKTVQAVLTIPKLKLSYEGSVQELKLQSLFDAPDFSKITGKPIKLTQVEHRVGFEWNEDGAGTNSSPGVARLTFPLDYHLNQPFIFVLRDTDTGALLFIGKILDPRGT >NP_808788.1 pigment epithelium-derived factor precursor [Rattus norvegicus] MQTLVLWTGALLGHSQDSPAPDSEEDDPFFKAPVNKLAAAVSNFGYDLYRLRTGNILLSPLSVATALSALSLGAEQRTESVIHRALYYDLINNPDIHSTYKELLASVTAPEKNFKSASRIVFERKLRVKSSFVPLEKSYGTRPRILTGNPRIDLQEINNWVQAQMKGKIARSTREMPSLSILLLGVAYFKGQWATKFDSRKTTLQDFHLDEDRTVRVPMMSDPKAILRYGLDSDLNCKIAQLPLTGSMSIIFFLPLTVTQNLTMIEESLTSEFVHDIDRELKTIQAVLTVPKLKLSYEGSLQDMKLQSLFESPDFSKITGKPVKLTQVEHRAAFEWNEEGAGTSSNPDLVRLTFPLDYHLNRPFIFVLRDTDTGALLFIGRILDPSST >NP_001244218.1 pigment epithelium-derived factor precursor [Gallus gallus] MQIPALLLGLLTIP-QNSPTTDGEEEDPFYKTPINKLAAAVSNFGYDLYRQQTANVLLSPFSLATALSGLSLGAGERTEDVISRALFYDLLNKAEVHNTYKDLLASVTGPEKSLKSASRIIVEKRLRVKSTFHQLEKSYRMRLRALSGNTQLDLQEINNWVRQQTRGRILRFMKDMPTVSILLAGAAYFKGTWKTKFDTKRTVLKDFHLDEDRTVQVSMMSDPKAILRYGFDSELNCKIAQLPLTEGVSAMFFLPTKVTQNMTLIEESLTSEFVHDVDRELKTVHAVLSLPKLKLNYEETVKETRLQSLFTSPDFTKISAKPIKLSHVQHKAVLELNEDGEKSTPNPGVARLTFPIEYHVDRPFLLVLRDDTTGTLLFIGKILDPRSV >NP_001004539.1 pigment epithelium-derived factor precursor [Danio rerio] MKKIVVGLWSLLSL---------EEAVDLFTTPRTKLAAATSDFGYNLFRQLKASVFLSPMSISAAFTQLSMGASERAEKQIYRALRYHTLQDSQLHDTLRDLLSSLRASAKGFKSAERILLARKLRLRLEYLSVEKQYGERPQILAGGAR-DLKTVNDWFKQQTGGKVDQVVSPLPRTALLPVGSAYFKGKWITRFG-KPNKMETFRRDGQAPAVIPMMEQENYPVKMGIDSDLGCTIAQVPMEDGVSMYFFLPDEVTQNLTLIEEALTAEFVQDLSNSLHTVKVLLTLPVIKLSYKTSLSDLGLSEWLAETDLTKITSQPVKLNAVHHKVVLETAPEGAEYASTT-PTGQSLGLSYRVDRPFLFLVRDEPSGALLFIGKVLNPSDL >XP_001155004.3 pigment epithelium-derived factor isoform X1 [Pan troglodytes] MQALVLCIGALLGHEEGSPDPDSEEEDPFFKVPVNKLAAAVSNFGYDLYRVRTTNVLLSPLSVATALSALSLGAEQRTESIIHRALYYDLISSPDIHGTYKELLDTVTAPQKNLKSASRIVFEKKLRIKSSFVPLEKSYGTRPRVLTGNPRLDLQEINNWVQAQMKGKLARSTKEIPDISILLLGVAHFKGQWVTKFDSRKTSLEDFHLDEERTVRVPMMSDPKAVLRYGLDSDLSCKIAQLPLTGSTSIIFFLPLKVTQNLTLIEESLTSEFIHDIDRELKTVQAVLTVPKLKLSYEGSLQEMKLQSLFDSPDFSKITGKPIKLTQVEHRAGFEWNEDGAGTTPSPGLAHLTFPLDYHLNQPFIFVLRDTDTGALLFIGKILDPRGT >XP_038531033.1 pigment epithelium-derived factor isoform X1 [Canis lupus familiaris] MQALVLWTGALLGHQEDSPAPDAEEEDPFFRVPVNKLAAAISNFGYDLYRVRAANVLLSPLSVATALSALSLGAEQRTESTIHRALYYDLISNPDIHSTYKELLASVTAPEKNFKSASRIVFERKLRIKSSFVPLEKSYSTRPRILTGNPRLDLQEVNNWVQAQMKGKIARSTREIPSISILLLGVAYFKGQWVTKFDSRKTSLEDFHLDEERTVKVPMMSDPKAILRYGLDSDLSCKIAQLPLTGSMSIIFFLPLKVTQNLTMIEESLTSEFIHDIDRELKTIQAVLTIPKLKLSYEGSLQEMKLQSLVDSPDFSKITGKPIKLTQVEHRAGFEWNEDGAGTTPSPGLTRLTFPLDYHLNRPFIFVLRDTDTGALLFIGKILDPRGI >NP_001072130.1 pigment epithelium-derived factor precursor [Sus scrofa] MQALVLWTGALLGSEEGSPAPDTEEEDPFFKVPVNKLAAAVSNFGYDLYRVRTANVLLSPLSVATALSALSLGAEQRTESSLHRALYYDLISNPDLHGTYKELLAAVTAPQKNLKSASRIIFEKKLRIKASFVPLEKSYGTRPRILTGNSRLDLQEVNNWVQAQTKGKVARSTRELPGISILLLGVAYFKGQWVTKFDSRKTSLEDFHLDEERTVKVPMMSDPKAVLRYGLDSDLNCKIAQLPLTGSMSIIFFLPLKVTQNLTMIEESLTSEFIHDIDRELKTVQAVLTVPKLKLSYEGSVQELKLQSLFDSPDFSKITGKPIKLTQVEHRIGFEWNEDGGSATSSPG-PRLTFPLDYHLNQPFIFVLRDTDTGALLFIGKILDPRST >NP_001132919.1 pigment epithelium-derived factor precursor [Ovis aries] MQALVLWTGALLGFEAGSLAPESEEEDPFFKVPVNKLAAAVSNFGYDLYRVRTTNVLLSPLSVATALSALSLGAEQRTESSIHRALYYDLISNPDIHGTYKDLLASVTAPQKNLKSASRIIFERKLRIKASFVPLEKSYGTRPRILTGNSRIDLQEINNWVQAQMKGKIARSTREIPSISILLLGVAYFKGQWVTKFDSRKTSLEDFHLDEGRTVKVPMMSDPKAVLRYGLDSDLNCKIAQLPLTGSTSIIFFLPQKVTQNLTLIEESLTSEFIHDIDRELKTVQAVLTIPKLKLSYEGSVQELKLQSLFDAPDFSKITGKPIKLTQVEHRIGFEWNEDGAGTNSSPGVARLTFPLDYHLNQPFIFVLRDTDTGALLFIGKILDPRGT >XP_008269150.1 PREDICTED: pigment epithelium-derived factor isoform X1 [Oryctolagus cuniculus] MQALVLWTGALLGHEEGSPAPDGEEDDPFFKVPVNKLAAAVSNFGYDLYRQRTANVLLSPLSVATALSALSLGAEQRTESLIQRALYYDLISNPDIHGTYKELLAAVTAPQKNLKSASRIIFERKLRIKSSFVPLEKAYGTRPRVLSGNPRLDLQELNGWVQAQMKGKVARSAREVPSISIFLLGVAYFKGQWVTKFDSRKTSLQDFHLDEERTVRVPMMSDPKATLRYGLDSDLNCKIAQLPLTGSMSIIFFLPLRPTQNLTLIEESLTSEFIHDIDRELKTIQAALSIPRLKLSFEGALQEIKLQPLFESPDFSKITGKPIKLTHVEHRAGFEWNEDGAATSPGPEVARLAFSLDYHLNQPFIFVLRDSDTGALLFVGKILDPRGT >XP_009249388.1 pigment epithelium-derived factor isoform X1 [Pongo abelii] MQALVLCIGALLGHEEGSPDPDSEEEDPFFKVPVNKLAAAVSNFGYDLYRVRTTNVLLSPLSVATALSALSLGAEQRTESTIHRALYYDLISSPDIHGTYKELLDTVTAPQKNFKSASRIVFEKKLRIKSSFVPLEKSYGTRPRVLTGNPHLDQQEINNWVQAQMKGKLARSTKEIPHISILLLGVAHFKGQWVTKFDSRKTSLEDFHLDEDRTVRIPMMSDPKAVLRYGLDSDLSCKIAQLPLTGSMSIIFFLPLKVTQNLTLIEESLTSEFIYDIDRELKTVQAVLTVPKLKLSYEGSLQEMKLQSLFDSPDFSKITGKPIKLTQVEHRAGFEWNEDGAGTTPSPGLAHLTFPLDYHLNQPFIFVLRDTDTGALLFIGKILDPRGT >XP_003211790.1 pigment epithelium-derived factor [Meleagris gallopavo] MQIPALLLGLLTIP-QNSPTTDGEEEDPFYKTPVNKLAAAVSNFGYDLYRQQTANVLLSPFSLATALSGLSLGAGERTEDVISRALFYDLLNKAEVHNTYKDLLASVTGPEKSLKSASRIIVEKRLRVKSTFHQLEKSYKMRLRALSGNTQLDLQEINNWVRQQTRGRILRFMKDMPTVSILLAGAAYFKGTWKTKFDTKRTVLNDFHLDEDRTVKVSMMSDPKAILRYGFDSELNCKIAQLPLTEGVSAMFFLPTKVTQNMTLIEESLTSEFIHDVDRELKTVHAVLSLPKLKLNYEETLKETRLQSLFTSPDFTKISAKPIKLSHVQHKAVLELNEDGEKSTPNPGVARLTFPIEYHVDRPFLLVLRDDTTGTLLFIGKILDPRSV >XP_008968201.2 pigment epithelium-derived factor isoform X1 [Pan paniscus] MQALVLCIGALLGHEEGSPDPDSEEEDPFFKVPVNKLAAAVSNFGYDLYRVRTTNVLLSPLSVATALSALSLGAEQRTESIIHRALYYDLISSPDIHGTYKELLDTVTAPQKNLKSASRIVFEKKLRIKSSFVPLEKSYGTRPRVLTGNPRLDLQEINNWVQAQMKGKLARSTKEIPDISILLLGVAHFKGQWVTKFDSRKTSLEDFHLDEERTVRVPMMSDPKAVLRYGLDSDLSCKIAQLPLTGSTSIIFFLPLKVTQNLTLIEESLTSEFIHDIDQELKTVQAVLTVPKLKLSYEGSLQEMKLQSLFDSPDFSKITGKPIKLTQVEHRAGFEWNEDGAGTTPSPGLAHLTFPLDYHLNQPFIFVLRDTDTGALLFIGKILDPRGT >XP_003996465.1 pigment epithelium-derived factor [Felis catus] MQALMLWAGALLGPLEDSPAPDAEEEDPFFKVPVNKLAAAISNFGYDLYRVRTANVLLSPLSVATALSALSLGAEQRTESTIHRALYYDLISNPDIHGTYKELLAAVTAPQKNFKSASRIIFERKLRIKSSFVPLEKSYGTRPRILTGNSRLDLQEVNNWVQAQMKGKIARSTREIPSISILLLGVAYFKGQWVTKFDPRKTSLEDFHLDEERTVRVPMMSDPKAILRYGLDSDLSCKIAQLPLTGSMSIIFFLPLKVTQNLTMIEESLTSEFIHDIDRELKTIQAVLTIPKLKLSYEGSLQEMKLQSLFDSPDFSKITGKPIKLTQVEHRGGFEWNEDGASTAPSAGLARLTFPLDYHLNQPFIFVLRDTDTGALLFIGKILDPRGI >XP_004058286.3 pigment epithelium-derived factor isoform X1 [Gorilla gorilla gorilla] MQALVLCIGALLGHEEGSPDPDSEEEDPFFKVPVNKLAAAVSNFGYDLYRVRTTNVLLSPLSVATALSALSLGAEQRTESIIHRALYYDLISSPDIHGTYKELLDMVTAPQKNLKSASRIVFEKKLRIKSSFVPLEKSYGTRPRVLTGNPRLDLQEINNWVQAQMKGKLARSTKEIPDISILLLGVAHFKGQWVTKFDSRKTSLEDFHLDEERTVRVPMMSDPRAVLRYGLDSDLSCKIAQLPLTGSMSIIFFLPLKVTQNLTLIEESLTSEFVHDIDRELKTVQAVLTVPKLKLSYEGPLQEMKLQSLFDSPDFSKITGKPIKLTQVEHRAGFEWNEDGAGTTPSPGLAHLTFPLDYHLNQPFIFVLRDTDTGALLFIGKILDPRGT >XP_020564755.2 pigment epithelium-derived factor [Oryzias latipes] MKRFSLMLAAVLSF-------EGEEPVELFTTPTTKLGAAVSDFGYNLFRALSSNIFLSPISVSAALSQLSLGASEGSQRQLFRALRYHTLQDPQLHSTLKTMLASVTATGKGLSTAARLYLARRLRPKQDFFAVEQQYGVRPKALMGGAK-DVKEVNDWVSQQTGRKVLQFLKPFPRAGVNAVSASYFKGKWVTRFG-QSGALDNFQVEGDVPVRVPMMQQDNYPVKMGSDSDLSCVIAQIQMQDGVSMFIFLPDGVTANMTLLEESLTAEFVQDLAMTLLPAKVSLTLPVLRLSFSTLLGDLGLSEWMENPELDNISTQRSKLSSLDHKVVMETAPEGSQY-----PASTHGHLTYRVDRPFLYLIRDEASGALLFIGRVVNPKGL >XP_005502067.1 pigment epithelium-derived factor [Columba livia] MRIPVLFLGLLTVP-QNSATADGEEEDPFYKSPINKLAAAVSNFGYDLYRQQTANVLLSPFSLATALSGLSLGAGERTEDVISRALFYDLLDKAEVHNTYKDLLTSVAGPEKSMKSASRIILEKRLRVKPGFHQLEKSYKMRLRALSGNTQLDLQEVNNWVRQQTKGRIMRLMKDMPTVSILLAGAAYFKGTWKTKFDTKKTALNDFHLDEDRTVKVSMMSDPKAILRYGFDSELNCKIAQLPLTEGISAMFFLPTKVTQNMTLIEESLTSEFVHDVDKELKTVHAVLSLPKLKLNYEETLKETRLQSLFASPDFTKISVKPIKLSHVQHKAVLELSEDGERTTPNPGVARLTFPIEYHVDRPFLLVLRDDTTGTLLFIGKILDPRSV >XP_005693374.1 PREDICTED: pigment epithelium-derived factor [Capra hircus] MQALMLWTGALLGFEAGSLAPESEEEDPFFKVPVNKLAAAVSNFGYDLYRVRTANVLLSPLSVATALSALSLGAEQRTESSIHRALYYDLISNPDIHGTYKDLLASVTAPQKNLKSASRIIFERKLRIKASFVPLEKSYGSRPRILTGNSRIDLQEINNWVQAQMKGKVARSTRELPSISIFLLGVAYFKGQWVTKFDSRKTSLEDFHLDEGRTVKVPMMSDPKAVLRYGLDSDLNCKIAQLPLTGSTSIIFFLPQKVTQNLTLIEESLTSEFIHDIDRELKTVQAVLTIPKLKLSYEGSVQELKLQSLFDAPDFSKITGKPIKLTQVEHRIGFEWNEDGAGTNSSPGVARLTFPLDYHLNQPFIFVLRDTDTGALLFIGKILDPRGT >XP_006032909.1 pigment epithelium-derived factor [Alligator sinensis] MQTPLLLLGLLASP-QDSATPDGEEEDPFYKTPVNKLAAAVSNFGYDLYRQQTANVLLSPFSVATALSGLSLGAGQRTEDLISRTLYYDLLNKAEVHNTYKELLTSISAPEKGFRSVFRIILERKLRMKVGFPQLEKAYRIRLKILTGNSQADLQELNNWVRQQTKGKILRFLKDMPTVSIFLAGAAYFKGHWATKFDPRKTTLQDFYLEEDRIVTVPMMSDPKAILRYGFDSELNCKIAQLPLTGGVSAMFFLPLKVTQNLTLIEESLSSEFVHDIDKELKTVHAVLSVPKLKLSFEETLQEMRLQQLFISPDFSKMSAKPIKLSHVHHKTVLELSEDGANSTPNPGAARLTFPLDYHLNRPFLLVLRDDATGTLFFIGKILDPRNI >XP_006260666.2 PREDICTED: pigment epithelium-derived factor [Alligator mississippiensis] MQTPLLLLGLLASP-QDSATPDGEEEDPFYKTPVNKLAAAVSNFGYDLYRQQTANVLLSPFSVATALSGLSLGAGQRTEDLISRTLYYDLLNKAEVHNTYKELLTSISAPEKGFRSVFRIILERKLRMKVGFPQLEKAYRIRLKILTGNSQTDLQELNNWVRQQTKGKILRFLKDMPTVSIFLAGAAYFKGHWATKFDPRKTTLQDFYLEEDRIVTVPMMSDPNAILRYGFDSELNCKIAQLPLTGGVSAMFFLPLKVTQNLTLIEESLSSEFVHDIDKELKTVHAVLSVPKLKLSFEETLQEMRLQQLFISPDFSKMSAKPIKLSHVHHKTVLELSEDGANSTPNPGVARLTFPLDYHLNRPFLLVLRDDATGTLFFIGKILDPRNI >KAB0367960.1 hypothetical protein FD755_021284 [Muntiacus reevesi] MQALVLWTGALLGLEAGSMAPESEEEDPFFKVPVNKLAAAVSNFGYDLYRVRTTNVLLSPLSVATALSALSLGAEQRTESIIHRALYYDLISNPDIHGTYKDLLASVTAPQKNLKSASRIIFERKLRIKASFIPLEKSYGTRPRILTGNSRIDLQEINNWVQAQMKGKVARSTREMPSISIFLLGVAYFKGQWVTKFDSRKTSLEDFHLDEERTVKVPMMSDPKAVLRYGLDSDLNCKIAQLPLTGSTSIIFFLPQRVTQNLTLIEESLTSEFIHDIDRELKTVQAVLTVPKLKLSYEGSVQELKLQSLFDAPDFSKITGKPIKLTQVEHRIGFEWNEDGAGTNPSPGVARLTFPLDYHLNQPFIFVLRDTDTGALLFIGKILDPRGT >XP_043334263.1 pigment epithelium-derived factor [Cervus canadensis] MQALALWTGALLGLEAGSLAPESEEEDPFFKVPVNKLAAAISNFGYDLYRVRTANVLLSPLSVATALSALSLGAEQRTESIIHRALYYDLISNPDIHGTYKDLLASVTAPQKNLKSASRIIFEKKLRIKASFIPLEKSYGTRPRILTGNSRIDLQEINNWVQAQMKGKVSRSTREMPSISIFLLGVAYFKGQWVTKFDSRKTSLEDFHLDEERTVKVPMMSDPKAVLRYGLDSDLNCKIAQLPLTGSTSIIFFLPQRVTQNLTLIEESLTSEFIHDIDRELKTVQAVLAIPKLKLSYEGSVQELKLQSLFDAPDFSKITGKPIKLTQVEHRIGFEWNEDGAGTNPSPGVARLTFPLDYHLNQPFIFVLRDTDTGALLFIGKILDPRGT >KAB0366159.1 hypothetical protein FD754_010315 [Muntiacus muntjak] MQALVLWTGALLGLEAGSLAPESEEEDPFFKVPVNKLAAAVSNFGYDLYRVRTANVLLSPLSVATALSALSLGAEQRTESIIHRALYYDLISNPDIHGTYKDLLASVTAPQKNLKSASRIIFERKLRIKASFIPLEKSYGTRPRILTGNSRIDLQEINNWVQAQMKGKVARSTREMPSISIFLLGVAYFKGQWVTKFDSRKTSLEDFHLDEERTVKVPTMSDPKAVLRYGLDSDLNCKIAQLPLTGSTSIIFFLPQRVTQNLTLIEESLTSEFIHDIDRELKTVQAVLTVPKLKLSYEGSVQELKLQSLFDAPDFSKITGKPIKLTQVEHRIGFEWNEDGAGTNPSPGVARLTFPLDYHLNQPFIFVLRDTDTGALLFIGKILDPRGT >KAF4012198.1 hypothetical protein G4228_003074 [Cervus hanglu yarkandensis] --------------MQGSLAPESEEEDPFFKVPVNKLAAAISNFGYDLYRVRTANVLLSPLSVATALSALSLGAEQRTESIIHRALYYDLISNPDIHGTYKDLLASVTAPQKNLKSASRIIFEKKLRIKASFIPLEKSYGTRPRILTGNSRIDLQEINNWVQAQMKGKVSRSTREMPSISIFLLGVAYFKGQWVTKFDSRKTSLEDFHLDEERTVKVPMMSDPKAVLRYGLDSDLNCKIAQLPLTGSTSIIFFLPQRVTQNLTLIEESLTSEFIHDIDRELKTVQAVLAIPKLKLSYEGSVQELKLQSLFDAPDFSKITGKPIKLTQVEHRIGFEWNEDGAATQLNPLVERLSSNCICQINRFIVNTLKDGRRVVILMELEVLKSAEA >NP_001085983.1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 L homeolog precursor [Xenopus laevis] MKIYLLFTGTFLSS---------EEEDPFYKSPLNRLTSSASNFGYDLYRMQNSNIFISPLSIATSLSSLSLGSGQRTESLIHRSLYYDLLNDPELHATYKELLASLTSHGSGLKSTWRIMLERKLRLRLDFVQVEKFYGNKPRILTGNTRLDLQEANDFVQKQTQAKVVKFFKEIPAVSILLLGTSYLKGQWAYKFNPRETVQSEFHLDEQTSVTVPMMSSKNLPVRYGLDSDFNCKIVQLPLTGGVSIMFFLPNTVTQNLTMIEEGLTSEFIHDIDQALQTVNMDLRIPKLKLNYEVALQESKLQSLFSTPDFSKISSKPLKLSHVVHKATLELNEDGAETAPKAEASRKYFPLEYHLDHPFLFVLRANDNGALLFIGKVMDPKGF >XP_038050239.1 leukocyte elastase inhibitor-like [Patiria miniata] MYKLTTVIALLYMS------------------PQLELADANNRFAFHLYQTLRDNIFFSPMSISIALAMTSLGARGNTARQIKDVLKFSTLEESRLHSSFAELNSAIFGDKYVLRKANRLFGHKGFDLRQEFLDAERYYSSHMASLDFVEDVAREFINSWVGRETEDKIRDLLGSITGTQLVLVNAIYFKADWVRQFDKSKTFDQDFHVSKDQVLEVPMMHRKS-KFNFAEDITLRCKLIELPYVGDFSMIVVLPDEI-DGIDRLQKHLTNEKLQHLLNNLSNVTVGVAIPKFKLEETLVLYSMGMRDLFVRADLSGITGD-LFVSSVIHRAFLEVNEEGSEAAAATAVNKRSIAPEFIADHPFLFFIADSKTKAIVFMGHCRKPEGV >NP_524953.1 serpin 55B [Drosophila melanogaster] --------------------------------FNLEFARGGARFTSELFQLLKENVVFSPFSIQTCIALAFAGSQGETADEIAKALHFVSNFPPEVAQTFQFVLEKYR-NSNLLRVANKLYVQEGKQLKPAYQAIKEQYHSEAESINFALNAAAQAINAWVNAKTQGKITELVDSFSDTRLVLLNALHFKGSWAHKFSEERTEEDIFWVGEEEQVKINYMNQKA-KFNYGFFEDLGCTALEMPYQDDLSMFVLLPQER-TGIYALAEKLKTVNLVDLADKLTVEEVHVKFPKFKVDYSLKLKQLGITKMFTDAEFSNLLEEGVFVSKVLHKATIEVNEEGTEAAAATGMMTRMMPLQFQADRPFLYVIWNKKN--ILFAGAFVKAA-- >XP_011666177.1 leukocyte elastase inhibitor [Strongylocentrotus purpuratus] MSEYI-------MA------------------QLVQLSSANTRFALDLYQTFGTNLFFSPLSISTALAMTQLGACGDTATQIADVFRFNQVDQDQLHGTFKELNNLLYQSGYKLHAANRLYGKSGYNFVQSFLGTASYYGAAIEAVDNFAATATHSINDWVSKQTEDKITNLIGILNDTRLVLVNAIYFKGNWESKFRAENTTQETFKVDERKKVPVSLMIQKG-KFALAVDKTNDCLVLEMPYQGNLSLLIALPVKD-DGLGNLQTKLSADILRSWDAGLKSRQVNVLLPKFKLEAEFVLKRMGMPDAFNDANFEGISGE-LYISAVIHKAFVDINEEGSEAAAATAVKLGCAPTLFRADHPFIFMIRHRPTKSVLFMGRMMDPS-- >XP_031557330.1 leukocyte elastase inhibitor-like [Actinia tenebrosa] MGNNILAVSLVFCS------------------QADLIKASTNKFSLHLHQVLEQNLFYSPSSILVALAMTHLGARGNTAKQMSSSFHLDEIPEKQLNAEFQKFLQKLNQKGNEIAMANRLFVQMGFEVSKQFQDSEKFFNAEAALVDYQKNGARQEVNQWVEQKTKNKIKDLIGMFGPTRLTLVNAIYFKGSWMSKFDSNNTQTGPFQLTPSKTVQVPMMYKSD-KFKYFENEGLKCKMLELPYSDKISMIILLPDEV-DGLSKLEDSLNYSKLDEAIGHLKKEEVEVTLPKFKLSEKFVLSKMGASDLFNAADLTGINKQ-LYVSEVVHKAFVDVNEEGTEAAAATAVALMCMNPIFFANHPFLFLIRHNESGAILFIGRLANPK-- >XP_039254966.1 leukocyte elastase inhibitor-like [Styela clava] MNYSLLLIGLVFHCEDYDLVEENSTTKPDYKKFHAGIASAIHDFTFDLYKGMEDNLVFSPLSVYTALCMLTLGLGGKSHSQAMEVLHGDAF--PDVHNAMSELSDAIFDGSVTLTKANRIFIDRSVRLLKEFKSMRKDYHVSAKKVNFMNALNRRRINQFVQRHTERKIKDLAGSISSTRLFIANAMYMKASWETRFT--FTDKGRFTVNPSEKIIVDMMQSSSGSCYTTLSNELNAEVIRILMKGDVSFIAIVPSTP-GDFSLLEDGRGKGRTRRALEALYPQLCRITMPKFKIDFKAVLKDMGMTDIFDPADLSKMTPEPLYVSDVRHKATIDVNENGLEAAAATGIAARMMPQPVTIDRPFLFMVRDEKTGATIFTGKVVRPKYE >XP_016773435.2 serine protease inhibitor 27A isoform X2 [Apis mellifera] MCYLIIILTLKQCK----SIFDTHEIINHNKTFVPYQGERFDIFDWTFFKSISKNVIISPISLKIALVLLYEGAQGETAYELANILQLPAT-RNATRKKFSNILQSLQTTAYTLNIGTRIYIDSNILVRQQYENVKFFYNTDVIIANLSNAPLVKAINNWVNNITNANIDRIIDNSVKSLMLIVNTLFFKGLWRGKFSPENTRNGKFYLIDNRTVDTSIMHAYG-RFYYVESSDLDAKILRIPYDGQFAIYLLLPRII-NGIDELIDKINPFVLTRYMWLMQDLSVDVLIPKFKFDFSSILRELGICDIFDDATLTGIAQKRLKVSNILQKAGIEINENGTTAYVATEIGNKNQDETFHANHPFLFYIEDESIGTIIYIGKIMNPLDT >AAS13528.1 serine or cysteine protease inhibitor [Caenorhabditis elegans] MS-------------------DN--------------ATSQTDFALKLLATLSGSVVLSPLSISLGLALIHAGACGSTQKELEDVLG-----GSRIFEEFSGLMEAVGDNGVETKIVNRVFVNQAYTIHQDYLTVEKLYKASGESLDFSQTQAAKTMNTFVENHTNGKIKDLIDS-ANAFAFLVNAMYFKADWQSKFAKESTTGREFFTSEAESRQIPFLTDVDEHRDY--TEDVLFQVLSLKYADKFTLAIFLPKQR-FGLVDALEKINGEYIQNLLNDLKSSYVSVQIPKFKIEKELTLEAIGIKEIFAEADLSGIADK-VFISSGIHKAIIEVDEDGTTAAAASAFQLEMMPTQFVADHPFLFAVLFENH--TLFLGVHA----- >XP_015817461.1 PREDICTED: pigment epithelium-derived factor [Nothobranchius furzeri] MKQTTLVFVVLLNI-------EEEEHVELFTTPKTKMGAAISDFGYNLFRALSANIFLSPISVSAVLTQLSMGGSEQAQRQLYRALRYHTLQDAQLHNTLKDLLTSVKTSGKGLSMAARLYMARRLRPKQDFFVVEQQYGVRPKALLGGAK-DLKEVNDWVSQQTGRKVQQFLKPLPRSGVNAVSSTYFKGRWVTRFS-QSGTLENFQVDGGTPVQVPMMQQDNYPVKMGVDSDLRCTIAQVQMQDDISMFVFLPEDVTTNTTLLEESLTAEFVQDLSMALQPAQLSLLLPILRLSFSTLLGDLGLSEWLENPELDDISIQPAKLSSVHHKVVMEMAPEGNQY-----PTLEPSHLTYRVDRPFIYLIRDEPSGALLFIGKVVNPKDL >XP_020765464.1 pigment epithelium-derived factor [Odocoileus virginianus texanus] MQALVLFCGALLGLEAGSLSPESEEEDPFFKVPVNKLAAAVSNFGYDLYRVRTANVLLSPLSVATALSALSLGAEQRTESVIHRALYYDLISNPDIHGTYKDLLASVTAPQKNLKSASRIIFERKLRIKASFIPLEKSYGTRPRILTGNSRIDLQEINNWVQAQMKGKVARSTREMPSISIFLLGVAYFKGQWVTKFDSRKTSLEDFHLDEERTVKVPMMSDPKAVLRYGLDSDLNCKIAQLPLTGSTSIIFFLPQRVTQNLTLIEESLTSEFIHDIDRELKTVQAVLTIPKLKLSYEGSVQELKLQSLFDAPDFSKITGKPIKLTQVEHRIGFEWNEDGAGTNPSPGVARLTFPLDYHLNQPFIFVLRDTETGALLFIGKILDPRGT >XP_030292862.1 pigment epithelium-derived factor [Sparus aurata] MKRTALVFGVVLSF---------EEHVELFTTPQTKMGAATSDFGYNLFRTLATNVFLAPISVSAALTQLSMGGSERAQRQLFRALRYHTLQDPQLHNTLKDLLTAVKAPGKGLSTAARIYLDRRLRLKQEFFLVEQQYGVRPKGLQGVAR-DMNEVNSWMSQQTGGKVQSLLSSFPRFGVSTVSAAYFKGKWVTRFG-QSGAMENFQVDGGASVRVPMMQQDNYPVKMGADSDLSCVIAQIQMQNDVSMFVFLPDDVTSNMTLLEESLTAEFVQDLSMTLLPAQVTLTLPALKLSYSTLLSDLGLSEWLADTDLEKISALPAKLSSVHHKVVMETAPEGNQY-----PASTPSHLTYRVDRPFLYLIRDEVSGALLFIGRVVNPKTL >XP_040194308.1 pigment epithelium-derived factor [Rana temporaria] MKNYLLLAATIFSF-------NPEEEDPFYKTPVNRLASSASNFGYDLYRMHSINIFMSPLTLATALSSVSLGAGERTESLIHRTLYYDLLNDPEIHATYKELLASLSSKDK-VKSTHRVILERRLRLKVDFVQMEKFYGQKPRVLSGNSRLDLSEANNFVQQRTDGKVLKCFKEIPSVSVLLLGAAYFKGQWVHKFNPRETVLREFYTDEQTSISVPMMTANNVPVRYGLDSDFSCRIMQLPLIGGISIMFFLPLTVTQNLTLIEEGLTSEFVHDIDRALQSVTIKLSLPKLKLDYEAALQDMKLQPLFSAPDFSKISSKSVKLTQAVHKVAMELSEDGKEEVPKVDPQINHFPLEFHLDHPFIFVLRADDNGALLFIGKVMNPKGL
PhyML tree of selected proteins (XP_038050239_1_leukocyte_elastase_inhibitor_like__Patiria_miniata_:0.58793231,XP_011666177_1_leukocyte_elastase_inhibitor__Strongylocentrotus_purpuratus_:0.66800526,(XP_031557330_1_leukocyte_elastase_inhibitor_like__Actinia_tenebrosa_:0.666452,((XP_039254966_1_leukocyte_elastase_inhibitor_like__Styela_clava_:1.05949064,((NP_001004539_1_pigment_epithelium_derived_factor_precursor__Danio_rerio_:0.23092604,(XP_030292862_1_pigment_epithelium_derived_factor__Sparus_aurata_:0.09195329,(XP_015817461_1_PREDICTED__pigment_epithelium_derived_factor__Nothobranchius_furzeri_:0.14175322,XP_020564755_2_pigment_epithelium_derived_factor__Oryzias_latipes_:0.1417774):0.07247879):0.27108496):0.44160805,((((XP_006260666_2_PREDICTED__pigment_epithelium_derived_factor__Alligator_mississippiensis_:0.00400029,XP_006032909_1_pigment_epithelium_derived_factor__Alligator_sinensis_:0.00394865):0.10967447,(XP_005502067_1_pigment_epithelium_derived_factor__Columba_livia_:0.04829647,(XP_003211790_1_pigment_epithelium_derived_factor__Meleagris_gallopavo_:0.00405059,NP_001244218_1_pigment_epithelium_derived_factor_precursor__Gallus_gallus_:0.01149008):0.02688856):0.13796801):0.15440806,(XP_008269150_1_PREDICTED__pigment_epithelium_derived_factor_isoform_X1__Oryctolagus_cuniculus_:0.08014727,(((XP_009249388_1_pigment_epithelium_derived_factor_isoform_X1__Pongo_abelii_:0.01789535,((XP_001155004_3_pigment_epithelium_derived_factor_isoform_X1__Pan_troglodytes_:0.00000001,XP_008968201_2_pigment_epithelium_derived_factor_isoform_X1__Pan_paniscus_:0.00262833):0.00262804,(XP_004058286_3_pigment_epithelium_derived_factor_isoform_X1__Gorilla_gorilla_gorilla_:0.01055709,NP_002606_3_pigment_epithelium_derived_factor_isoform_1_precursor__Homo_sapiens_:0.00528703):0.00000001):0.00354489):0.04485988,((XP_038531033_1_pigment_epithelium_derived_factor_isoform_X1__Canis_lupus_familiaris_:0.02425735,XP_003996465_1_pigment_epithelium_derived_factor__Felis_catus_:0.03292286):0.01780592,(NP_035470_3_pigment_epithelium_derived_factor_precursor__Mus_musculus_:0.01733802,NP_808788_1_pigment_epithelium_derived_factor_precursor__Rattus_norvegicus_:0.03636243):0.07166885):0.01016398):0.00921204,(NP_001072130_1_pigment_epithelium_derived_factor_precursor__Sus_scrofa_:0.04329574,((NP_001132919_1_pigment_epithelium_derived_factor_precursor__Ovis_aries_:0.00903721,XP_005693374_1_PREDICTED__pigment_epithelium_derived_factor__Capra_hircus_:0.00688621):0.00282089,(NP_776565_1_pigment_epithelium_derived_factor_precursor__Bos_taurus_:0.01432684,(XP_020765464_1_pigment_epithelium_derived_factor__Odocoileus_virginianus_texanus_:0.01310907,((XP_043334263_1_pigment_epithelium_derived_factor__Cervus_canadensis_:0.00000001,KAF4012198_1_hypothetical_protein_G4228_003074__Cervus_hanglu_yarkandensis_:0.12338521):0.01309084,(KAB0366159_1_hypothetical_protein_FD754_010315__Muntiacus_muntjak_:0.00262321,KAB0367960_1_hypothetical_protein_FD755_021284__Muntiacus_reevesi_:0.00522436):0.00259073):0.00000001):0.01056162):0.00645184):0.03085798):0.02436195):0.02181046):0.17726916):0.13331058,(NP_001085983_1_serpin_peptidase_inhibitor__clade_F__alpha_2_antiplasmin__pigment_epithelium_derived_factor___member_1_L_homeolog_precursor__Xenopus_laevis_:0.14663844,XP_040194308_1_pigment_epithelium_derived_factor__Rana_temporaria_:0.24062109):0.18608884):0.34612315):0.75282824):0.27077495,(XP_016773435_2_serine_protease_inhibitor_27A_isoform_X2__Apis_mellifera_:1.49604022,(NP_524953_1_serpin_55B__Drosophila_melanogaster_:0.88015291,AAS13528_1_serine_or_cysteine_protease_inhibitor__Caenorhabditis_elegans_:1.04593147):0.07701621):0.18382902):0.11046224):0.13554703);
BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)