PB0006

DATABASE

Click here to access PB0006 phyletic profile

PBID	Uniprot	Name	Gene	Alternative	Organism	Uniprot Description
PB0006	P09486	secreted protein acidic and cysteine rich	SPARC	ON, ONT, OI17, BM-40	Homo_sapiens	Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca2+ with a low affinity and an EF-hand loop that binds a Ca2+ ion with a high affinity.

Domains

Gene Ontology

PF00050 (Kazal_1) PF09289 (FOLN) PF10591 (SPARC_Ca_bdg)

GO:0005201 (enables) extracellular matrix structural constituent GO:0005509 (enables) calcium ion binding GO:0005515 (enables) protein binding GO:0005518 (enables) collagen binding GO:0046872 (enables) metal ion binding GO:0050840 (enables) extracellular matrix binding GO:0001937 (involved in) negative regulation of endothelial cell proliferation GO:0010595 (involved in) positive regulation of endothelial cell migration GO:0016525 (involved in) negative regulation of angiogenesis GO:0022604 (involved in) regulation of cell morphogenesis GO:0048856 (involved in) anatomical structure development GO:0005576 (located in) extracellular region GO:0005604 (located in) basement membrane GO:0005615 (located in) extracellular space GO:0005737 (located in) cytoplasm GO:0005886 (located in) plasma membrane GO:0009986 (located in) cell surface GO:0016363 (located in) nuclear matrix GO:0031091 (located in) platelet alpha granule GO:0031092 (located in) platelet alpha granule membrane GO:0031093 (located in) platelet alpha granule lumen GO:0043231 (located in) intracellular membrane-bounded organelle GO:0062023 (located in) collagen-containing extracellular matrix GO:0071682 (located in) endocytic vesicle lumen

External Links	Description
Intact	Open source database system and analysis tools for molecular interaction data.
Protein Atlas	An open access resource for human proteins
InterPro (new pfam)	InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish) >sp|P09486|SPRC_HUMAN SPARC OS=Homo sapiens OX=9606 GN=SPARC PE=1 SV=1 MRAWIFFLLCLAGRALAAPQQEALPDETEVVEETVAEVTEVSVGANPVQVEVGEFDDGAE ETEEEVVAENPCQNHHCKHGKVCELDENNTPMCVCQDPTSCPAPIGEFEKVCSNDNKTFD SSCHFFATKCTLEGTKKGHKLHLDYIGPCKYIPPCLDSELTEFPLRMRDWLKNVLVTLYE RDEDNNLLTEKQKLRVKKIHENEKRLEAGDHPVELLARDFEKNYNMYIFPVHWQFGQLDQ HPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLDNDKYIALDEWAGCFGIKQKDIDKD LVI >tr|Q6PVV8|Q6PVV8_DANRE SPARC OS=Danio rerio OX=7955 GN=sparc PE=1 SV=1 MRVWIFFLFCLAGKTLAAPTEEEPAVEEELEVGINPVQVETGEFDEAIEVVEDVIAENPC LNHHCKKGKVCEVDDSNQPMCVCQDPLTCPAPIGDFEHVCGTNNKTYESSCHFFATKCSL EGTKKGHKLHMDYIGPCKYIAPCLENELNEFPLRMRDWLKNVLVTLYERDEDNNLLTEKQ KLRVKKIYENEKRLQAGDHSLDLLALDFEKNYNMYIFPVHWQFGQLDQHPIDGFLSHTEL APLRAPLIPMEHCTTSFFEQCDADQDKYIALEEWANCFGIKEQDVDKDLVI
Selected proteins from model organisms >NP_003109.1 SPARC isoform 1 precursor [Homo sapiens] MRAWIFFLLCLAGRALAAPQQEALPDETEVVEETVAEVTEVSVGANPVQVEVGEFDDGAEETEEEVVAEN PCQNHHCKHGKVCELDENNTPMCVCQDPTSCPAPIGEFEKVCSNDNKTFDSSCHFFATKCTLEGTKKGHK LHLDYIGPCKYIPPCLDSELTEFPLRMRDWLKNVLVTLYERDEDNNLLTEKQKLRVKKIHENEKRLEAGD HPVELLARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLDNDKY IALDEWAGCFGIKQKDIDKDLVI >XP_039273208.1 SPARC-like [Styela clava] MEMRRWIFLLIVIFCFAIVSAKRNSGDHKSDRERHVRAHLEEKNNRSSKIKEADDRRENRVNRDGTPLLKNPCAKVRCKK GKECSLDKNNSPKCVCIQECSTMVTIDDKVCGTDNKTYESECVLRRLKCLGSNDRNIKKTLRKLKVNYLGECKMLTSCKK SEMKEYPTRMRSWLKNVFLEMYDTPEEEGGLSAKQRYHGRKVFYEKDRLQDFEETEPHDIVEREFKKFYPLYKYPIHWKF AELDKKPKDMKLSKRELEPLRAPLIPMEHCTKSFFKRADKNKDKKISLQEWGHALGLEEGDIDSKLIV >XP_006562631.2 SPARC [Apis mellifera] MRAKVELLLFALLLVALLVDVSAQQQRRRKHRRRTTTTEASIQDEVMNMLEADEIAEEDAEVTVEDGRNEVGSKRQSLLR LDPCMDKHCDAGRVCKAVDDETAECVCIEICDKEIDPRRKVCTNHNETFGSDCEVYQARCFCDTNDPRCRGTKYQHVHVV YYGECRQMPECKPEDMADFPRRMRDWLFNIMRDLADRQELPSHYLKMQREAETNHTLRWTNAAIWKWCDLDGHPHDRAVS RHELFPIKAPLMALEHCIAPFLDSCDIDGDHKITLIEWGKCLELNEEDLDDKCDELAETKNSEQ >XP_038060164.1 SPARC-like [Patiria miniata] MSFSRVVILLCVVAVVLASKHKSKHQQMKASRHEMRGAKKALESLSYTKEEQIYSIDGYKEEPEESINDVTDKCNTLPCP PGETCYIDRDGAPYCDCVEFCIEEDGDPFIQVCSTGNVTYRSQCELYRLRCVNPREMDAEHLDYFGPCKIMEQCNPADLA TFPQRMRTWFLEVMKELSGLTEEQGGLDEEEREFEKLAEAETKPWRRPLHWKFFNMDIAPNDFHLSESELMPMRAQLLPM EPCTDAFIASCDTNDDDLISIVEWGTCMGLNEEEILY >NP_001091924.1 secreted protein, acidic, cysteine-rich precursor [Strongylocentrotus purpuratus] MMKIFIVLCLASLAIANKHEMLADQELARAKIALDELTFTKEEHIYNVDGYVEGEKEIGYENEIDDPCANMECRIGRECV LDNQREPFCDCATSCPQGETSEDAIHRTKVCTTTNATFTNLCEFHRQKCMEVDLMEVHVDYYGECAEMGSCSAEDLREYP ERMTNWFIKSLALIRNRPEEHGGLSQKEKETLQQEWSQSTHAIFWKFDRLDKNPSDHYLDFAELEGLRAPIVLFEPCTKP FLQACDVDNDTLISAVEFGRCLNLSDEQVPY >XP_031562150.1 SPARC-like [Actinia tenebrosa] MKFFLEEILGLVVIGLFAVSVSSQQISTCENTFCPYGRMCVEQTGGGTICQCPEECPVTVEPVCSVYGKEFDNMCELHKF ACALGVSIAVKHRGLCTEDDLNPRTRCNDYQLLQFPYRFLDWLMIARGMSLNPKFRLGRRAEALREEEVRDXTLWEFENR DKDKNRELDDNEIKTIENRLLPLESCIHGFLKSCDLDGVGGISAREWSTCFPRGRRSEATGSRKL >NP_033268.1 SPARC precursor [Mus musculus] MRAWIFFLLCLAGRALAAPQQTEVAEEIVEEETVVEETGVPVGANPVQVEMGEFEDGAEETVEEVVADNP CQNHHCKHGKVCELDESNTPMCVCQDPTSCPAPIGEFEKVCSNDNKTFDSSCHFFATKCTLEGTKKGHKL HLDYIGPCKYIAPCLDSELTEFPLRMRDWLKNVLVTLYERDEGNNLLTEKQKLRVKKIHENEKRLEAGDH PVELLARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLDNDKYI ALEEWAGCFGIKEQDINKDLVI >KAB0357987.1 hypothetical protein FD754_002143 [Muntiacus muntjak] MLGRLVKITSQTLQTLGPGYSPWEPWVGDPLPPPGLSSPLNKERAVLGDSCWPLQSQRSARSVCLGKSSRTHVAGGVGRW VRAALREERRKALEDGDSFGCGEKGRGGEGKEETQEEEGPRGGGGDRPSPEVPSIMRAWIFFLLCLAGRALAAPQQEALP DETEVVEETVAEVAEVPVGANPVQVEVGEFDEGAEETEEEVVAENPCQNHHCKHGKVCEVDENNTPMCVCQDPTSCPAPI GEFEKVCSNDNKTFDSSCHFFATKCTLEGTKKGHKLHLDYIGPCKYIPPCLDSELTEFPLRMRDWLKNVLVTLYERDEDN NLLTEKQKLRVKKIHENEKRLEAGDHPVELLARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHC TTRFFETCDLDNDKYIALDEWAGCFGIKEKDIDKDLVI >XP_043320843.1 SPARC [Cervus canadensis] MRAWIFFLLCLAGRALAAPQQEALPDETEVVEETVAEVAEVPVGANPVQVEVGEFDEGAEETEEEVVAENPCQNHHCKHG KVCELDENNTPMCVCQDPTSCPAPIGEFEKVCSNDNKTFDSSCHFFATKCTLEGTKKGHKLHLDYIGPCKYIPPCLDSEL TEFPLRMRDWLKNVLVTLYERDEDNNLLTEKQKLRVKKIHENEKRLEAGDHPVELLARDFEKNYNMYIFPVHWQFGQLDQ HPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLDNDKYIALDEWAGCFGIKEKDIDKDLVI >KAB0386973.1 hypothetical protein FD755_001929 [Muntiacus reevesi] MLGSLVKITSQTLQTLGPGYSPWEPWVGDPLPPPGLSSPLNKERAVLGDSCWPLQSQRSARSVCLGKSSRTHVAGGVGRR EGLGRRRQLWLWGEGEGREREGGDIGGGGTAGWRGRQTQPRALSGFLLPGSKPLTFLQTFRLPGARLLPARPPLRVPSIM RAWILFLLCLAGTALAAPQQEALPDETEVVEETVAEVAEVPVGANPVQVEVGEFDEGAEETEEEVVAENPCQNHHCKHGK VCEVDENNTPMCVCQDPTSCPAPIGEFEKVCSNDNKTFDSSCHFFATKCTLEGTKKGHKLHLDYIGPCKYIPPCLDSELT EFPLRMRDWLKNVLVTLYERDEDNNLLTEKQKLRVKKIHENEKRLEAGDHPMELLARDFEKNYNMYIFPVHWQFGQLDQH PIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLDNDKYIALDEWAGCFGIKEKDIDKDLVI >KAF4015265.1 hypothetical protein G4228_006558 [Cervus hanglu yarkandensis] MMWEMEKTPSSDQRDSQPSHAMVPVCETIRNFNAPVPSIMRAWIFFLLCLAGRALAAPQQEALPDETEVVEETVAEVAEV PVGANPVQVEVGEFDEGAEETEEEVVAENPCQNHHCKHGKVCELDENNTPMCVCQDPTSCPAPIGEFEKVCSNDNKTFDS SCHFFATKCTLEGTKKGHKLHLDYIGPCKYIPPCLDSELTEFPLRMRDWLKNVLVTLYERDEDNNLLTEKQKLRVKKIHE NEKRLEAGDHPVELLARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLDNDKYI ALDEWAGCFGIKESECLSKGSAILSLPPRCSLYVCPSCPSLLCAWLTPVCSPCLGGPHSFR >OWK12266.1 SPARC [Cervus elaphus hippelaphus] MGVAERVSVPLGKHGWVPSIMRAWIFFLLCLAGRALAAPQQEALPDETEVVEETVAEVAEVPVGANPVQVEVGEFDEGAE ETEEEVVAENPCQNHHCKHGKVCELDENNTPMCVCQDPTSCPAPIGEFEKTFDSSCHFFATKCTLEGTKKGHKLHLDYIG PCKYIPPCLDSELTEFPLRMRDWLKNVLVTLYERDEDNNLLTEKQKLRVKKIHENEKRLEAGDHPVELLARDFEKNYNMY IFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLDNDKYIALDEWAGCFGIKEKDIDKDLVI >NP_989347.1 SPARC precursor [Xenopus tropicalis] MRVWVFFVLCLVGKALAAPQQDALPEEEEVIEDVPTEETVGANPVQVEVGEFDDAVNEEEEEEPSENPCLNHHCKHGKVC EVDESNTPMCVCQDPSTCPSSLAEFEKVCGTDNKTYESSCHFFATKCTLEGTKKGHKLHLDYIGPCKYIAPCLDNELSEF PLRMRDWLKNVLVSLYERDENNNLLNEKQKLRVKKIHENEKRLEAGDHSMELLARDFEKNYNMYIFPVHWQFGQLDQHPI DGYLSHTELSPLRAPLIPMEHCTTRFFDECDTDNDKYIALEEWAKCFGIKEQDVDKDMIV >NP_500039.1 SPARC [Caenorhabditis elegans] MRYALAACLLLLAASSFVDAKKKKIADDELGELLDNIDADEEKKSVEPAKNPCEDHQCGWGKECVVGKKGEPTCECISKC PELDGDPMDKVCANNNQTFTSLCDLYRERCLCKRKSKECSKAFNAKVHLEYLGECKKLDECTEEHMAQFPERMADWLFQV MKELKKRRELHKLEWEELLSEAENDDEKKHVYPVIWKFCELDTKPHDKSVSHHELIPITAPVIPMESCIKPFLEGCDANN DGNISIKEWGKCLGLKEGEIQERC >NP_001262998.1 secreted protein, acidic, cysteine-rich, isoform B [Drosophila melanogaster] MRSLWLLLGLGLLAVSHVQASTEFSEDLLDEDLDLSDIDENEEEFLRLLEEKNKIKDIERENEIATKLAEVQHNLLNPVV EVDLCETMSCGAGRICQMHDEKPKCVCIPECPEEVDTRRLVCTNTNETWPSDCSVYQQRCWCDSGEPGCTNPDNAHMHID YYGACHEPRSCEGEDLKDFPRRMRDWLFNVMRDLAERDELTEHYMQMELEAETNNSRRWSNAAVWKWCDLDGDTDRSVSR HELFPIRAPLVSLEHCIAPFLESCDSNKDHRITLVEWGACLELDPEDLKERCDDVQRAQPHLLG >XP_011478747.1 SPARC isoform X1 [Oryzias latipes] MKPRPPEQKGEEHLRAGLGRPTGNVFCVKLQSASDRPGAPHTPDFSALPKLKTLKMRVWIVFLLCLAGHA MAAPAEEEPALEELVTEEPAEEVEVGANPVQVEVGEFDEAIEVVEDAAENPCLNHRCKKGKVCEVDDTNT PMCVCQDPSSCPAAEGEFEHICGNDNKTYDSSCHFFATKCALEGTKKGHKLHLDYIGSCKLIEPCLDNEL TEFPLRMRDWLKNVLVTLYARDEDNNLLTEKQKLRVKKIYENEKRLEAGDHSLDLLARDFQKNYNMYIFP VHWQFGQLDQHPADGYLTHSELAPLRAPLIPMEHCTTRFFEECDADKDKYIALEEWAACFGIKEQDVDKD LVI >XP_030252915.1 SPARC [Sparus aurata] MRVWIVFVLCLAGHAMAAPTEEEVIVEEPVTEEPVVEEIEVGANPVQVEVGEFDEAIEIVEDAVEDVAAE NPCLNHHCKKGKVCEVDESNTPMCVCQDPTTCPAAEGVFEHVCGTDNKTYDTSCHFFATKCTLEGTKKGH KLHLDYIGACKMIEPCMDSELKEFPLRMRDWLKNVLVTLYERDEDNNLLTEKQKLRVKKIYENEKRLQAG EHSLDLLAHDFEKNYNMYIFPVHWQFGQLDQHPVDGYLTHTELSPLRAPLIPMEHCTTRFFEECDADSDK YIALEEWAACFGIKEQDVDNDLII >NP_036788.1 SPARC precursor [Rattus norvegicus] MRAWIFFLLCLAGRALAAPQTEAAEEMVAEETVVEETGLPVGANPVQVEMGEFEEGAEETVEEVVAENPC QNHHCKHGKVCELDESNTPMCVCQDPTSCPAPIGEFEKVCSNDNKTFDSSCHFFATKCTLEGTKKGHKLH LDYIGPCKYIAPCLDSELTEFPLRMRDWLKNVLVTLYERDEGNNLLTEKQKLRVKKIHENEKRLEAGDHP VELLARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLDNDKYIA LEEWAGCFGIKEQDINKDLVI >NP_776889.1 SPARC precursor [Bos taurus] MRAWIFFLLCLAGRALAAPQQEALPDETEVVEETVAEVAEVPVGANPVQVEVGEFDDGAEETEEEVVAEN PCQNHHCKHGKVCELDENNTPMCVCQDPTSCPAPIGEFEKVCSNDNKTFDSSCHFFATKCTLEGTKKGHK LHLDYIGPCKYIPPCLDSELTEFPLRMRDWLKNVLVTLYERDEDNNLLTEKQKLRVKKIHENEKRLEAGC DHPVELLARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLDNDK YIALDEWAGCFGIKEKDIDKDLVI >NP_001001942.1 SPARC precursor [Danio rerio] MRVWIFFLFCLAGKTLAAPTEEEPAVEEELEVGINPVQVETGEFDEAIEVVEDVIAENPCLNHHCKKGKV CEVDDSNQPMCVCQDPLTCPAPIGDFEHVCGTNNKTYESSCHFFATKCSLEGTKKGHKLHIDYIGPCKYI APCLENELNEFPLRMRDWLKNVLVTLYERDEDNNLLTEKQKLRVKKIYENEKRLQAGDHSLDLLALDFEK NYNMYIFPVHWQFGQLDQHPIDGFLSHTELAPLRAPLIPMEHCTTSFFEQCDADQDKYIALEEWANCFGI KEQDVDKDLVI >NP_989741.1 SPARC precursor [Gallus gallus] MRTWIFFFLCLAGKALAAPQEALADETEVIEDLTTEGPVGANPVQVEVGEFEEPTEDVEEIVAENPCQNH HCKHGKVCEVDDNNSPMCVCQDPSSCPAHSGVFEKVCGTDNKTYDSSCHFFATKCTLEGTKKGHKLHLDY IGPCKFIPACLDTELTEFPLRMRDWLKNVLITLYERDEDNNLLTEKQKLKVKNIHENEKRLEAGDHTVEL LARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFEACDLDFDKYIALEE WASCFGIKEQDIDKDLVI >XP_001168719.1 SPARC [Pan troglodytes] MRAWIFFLLCLAGRALAAPQQEALPDETEVVEETVAEVTEVSVGANPVQVEVGEFDDGAEETEEEVVAEN PCQNHHCKHGKVCELDENNTPMCVCQDPTSCPAPIGEFEKVCSNDNKTFDSSCHFFATKCTLEGTKKGHK LHLDYIGPCKYIPPCLDSELTEFPLRMRDWLKNVLVTLYERDEDNNLLTEKQKLRVKKIHENEKRLEAGD HPVELLARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLDNDKY IALDEWAGCFGIKQKDIDKDLVI >NP_001026964.1 SPARC precursor [Sus scrofa] MRAWIFFLLCLAGKALAAPQQEALPDETEVVEETVAEVPVGANPVQVEVGEFDDGAEEAEEEVVAENPCQ NHHCKHGKVCELDENNSPMCVCQDPTSCPAPIGEFEKVCSNDNKTFDSSCHFFATKCTLEGTKKGHKLHL DYIGPCKYIPPCLDSELTEFPLRMRDWLKNVLVTLYERDENNNLLTEKQKLRVKKIHENEKRLEAGDHPV ELLARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFQTCDLDNDKYIAL DEWAGCFGIKEQDIDKDLVI >XP_008253505.1 PREDICTED: SPARC isoform X1 [Oryctolagus cuniculus] MKAWIFFLVCLAGRALAAPQQEALPDETEVVEETVAEVAEVAEVPVGANPVQVEVGEFEEVEETEEEVVA ENPCQNHHCKHGKVCELDENNTPMCVCQDPTSCPAPVGEFEKVCSNDNKTFDSSCHFFATKCTLEGTKKG HKLHLDYIGPCKYIPPCLDSELSEFPLRMRDWLKNVLVTLYERDEGNNLLTEKQKLRVKKIHENEKRLEA GDHPVELLARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFENCDLDND KYIALEEWAGCFGIKEKDIDKDLVI >NP_001127042.1 SPARC precursor [Pongo abelii] MRAWIFFLLCLAGRALAAPQQEALPDETEVVEETVAEVTEVSVGANPVQVEVGEFDDGAEETEEEVVAEN PCQNHHCKHGKVCELDENNTPMCMCQDPTSCPAPIGEFEKVCSNDNKTFDSSCHFFATKCTLEGTKKGHK LHLDYIGPCKYIPPCLDSELTEFPLRMRDWLKNVLVTLYERDEDNNLLTEKQKLRVKKIHENEKRLEAGD HPVELLARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLDNDKY IALDEWAGCFGIKQKDIDKDLVI >NP_001159674.1 SPARC precursor [Ovis aries] MRAWIFFLLCLAGRALAAPQQEALPDETEVVEETVAEVAEVPVGANPVQVEVGEFDEGAEEVEEEVVAEN PCQNHHCKHGKVCELDESNTPMCVCQDPTSCPAPIGEFEKVCSNDNKTFDSSCHFFATKCTLEGTKKGHK LHLDYIGPCKYIPPCLDSELTEFPLRMRDWLKNVLVTLYERDEDNNLLTEKQKLRVKKIHENEKRLEAGD HPVELLARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLDNDKY IALDEWAGCFGIKEKDIDKDLVI >XP_010717456.1 SPARC [Meleagris gallopavo] MRAWIFFLLCLAGKALAAPQEALPDETEVIEDLTTEEPVGANPVQVEVGEFEEPTEDVEEIVAENPCQNH HCKHGKVCEVDDNNSPMCVCQDPSSCPATSGVFEKVCGTDNKTYDSSCHFFATKCTLEGTKKGHKLHLDY IGPCKFIPACLDTELTEFPLRMRDWLKNVLITLYERDEDNNLLTEKQKLKVKKIHENEKRLEAGDHTVEL LARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFEACDLDNDKYIALEE WASCFGIKEQDIDKDLVI >XP_005619329.1 SPARC [Canis lupus familiaris] MRAWIFFLLCLAGRALAAPQQEALPDETEVVEETVAEVAEGPVGANPVQVEVGEFDEGAEETEEEVVAEN PCQNHHCKHGKVCELDENNTPMCVCQDPTSCPGPIGDFEKVCSNDNKTFDSSCHFFATKCTLEGTKKGHK LHLDYIGPCKYIPPCLDSELTEFPLRMRDWLKNVLVTLYERDEDNNLLTEKQKLRVKKIHENEKRLEAGD HPVELLARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLDNDKY IALDEWAGCFGIKEQDIDKDLVI >NP_001272591.1 SPARC precursor [Capra hircus] MRAWIFFLLCLAGRALAAPQQEALPDETEVVEETVAEVAEVPVGANPVQVEVGEFDEGAEEVEEEVVAEN PCQNHHCKHGKVCELDESNTPMCVCQDPTSCPAPIGEFEKVCSNDNKTFDSSCHFFATKCTLEGTKKGHK LHLDYIGPCKYIPPCLDSELTEFPLRMRDWLKNVLVTLYERDEDNNLLTEKQKLRVKKIHENEKRLEAGD HPVELLARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLDNDKY IALDEWAGCFGIKEKDIDKDLVI >XP_008952671.1 SPARC [Pan paniscus] MRAWIFFLLCLAGRALAAPQQEALPDETEVVEETVAEVTEVSVGANPVQVEVGEFDDGAEETEEEVVAEN PCQNHHCKHGKVCELDENNTPMCVCQDPTSCPAPIGEFEKVCSNDNKTFDSSCHFFATKCTLEGTKKGHK LHLDYIGPCKYIPPCLDSELTEFPLRMRDWLKNVLVTLYERDEDNNLLTEKQKLRVKKIHENEKRLEAGD HPVELLARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLDNDKY IALDEWAGCFGIKQKDIDKDLVI >XP_003981423.1 SPARC [Felis catus] MRAWIFFLLCLAGRALAAPQQEALPDETEVVEETVAEVAEGPVGANPVQVEVGEFDEGAEEAEQEVVAEN PCQNHHCKHGKVCELDENNTPMCVCQDPTSCPAPIGEFEKVCSNDNKTFDSSCHFFATKCTLEGTKKGHK LHLDYIGPCKYIPPCLDSELTEFPLRMRDWLKNVLVTLYERDEDNNLLTEKQKLRVKKIHENEKRLEAGD HPVELLARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLDNDKY IALDEWAGCFGIKEQDIDKDLVI >XP_004042902.1 SPARC [Gorilla gorilla gorilla] MRAWIFFLLCLAGRALAAPQQEALPDETEVVEETVAEVTEVSVGANPVQVDVGEFDDGAEETEEEVVAEN PCQNHHCKHGKVCELDENNTPMCVCQDPTSCPAPIGEFEKVCSNDNKTFDSSCHFFATKCTLEGTKKGHK LHLDYIGPCKYIPPCLDSELTEFPLRMRDWLKNVLVTLYERDEDNNLLTEKQKLRVKKIHENEKRLEAGD HPVELLARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLDNDKY IALDEWAGCFGIKQKDIDKDLVI >XP_005503434.1 SPARC [Columba livia] MRAWIFFLLCLAGKALAAPQEALPDETEVIEDPTTEEPVGANPVQVEVGEFEEPAEDVEEIVAENPCQNH HCKHGKVCEVDDNNSPMCVCQDPSSCPATAGVFEKVCGTDNKTYDSSCHFFATKCTLEGTKKGHKLHLDY IGPCKFIPACLDTELTEFPLRMRDWLKNVLITLYERDEDNNLLTEKQKLKVKKIHENEKRLEAGDHTVEL LARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFDACDLDNDKYIALEE WASCFGIKEQDIDKNLVI >XP_014374238.1 SPARC [Alligator sinensis] MQAWVFFLLCLAGKALAAPQDALPDEIEVVEDPTTEEPVGVNPVQVEVGEFEEPTVDVEEIVAENPCQNH HCKHGKVCEVDDNNSPMCVCQDPSSCPSSTGVFEKVCGTDNKTYDTSCHFFATKCTLEGTKKGHKLHLDY IGPCKYIPACLDTELTEFPLRMRDWLKNVLITLYERDEDNNLLTEKQKLKVKKIHENEKRLEAGDHTMEL LARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFEACDVDNDKYIALEE WAGCFGIKEQDIDKDLII >XP_006270448.1 PREDICTED: SPARC [Alligator mississippiensis] MQAWVFFLLCLAGKALAAPQDALPDEIEVVEDPTTEEPVGVNPVQVEVGEFEEPTVDVEEIVAENPCQNH HCKHGKVCEVDDNNSPMCVCQDPSSCPSSTGVFEKVCGTDNKTYDTSCHFFATKCTLEGTKKGHKLHLDY IGPCKYIPACLDTELTEFPLRMRDWLKNVLITLYERDEDNNLLTEKQKLKVKKIHENEKRLEAGDHTMEL LARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFEACDVDNDKYIALEE WAGCFGIKEQDIDKDLII >XP_015807480.1 PREDICTED: SPARC [Nothobranchius furzeri] MRVWVVFLLCLAGHAFAAPTEEEPNVEELVAEEPAAEEVDVGTNPVQVEVGEFDEGIEVDEDVAENPCLN YQCKKGKVCEVDESNTPMCVCQDPSTCPPAEGEFEHVCGTDNKTYDSSCHFFATKCTLEGTKKGHKLHLD YIGPCKLIEPCLDSELNEFPLRMRDWLKNVLVTLYERDEDNNLLTEKQKLRVKKIFENEKRLQAGDHSLD LLARDFAKNYNMYIFPVHWQFGQLDQHPIDGYLTHSELAPLRAPLIPMEHCTTRFFEECDADDDKYIALE EWASCFGIKEQDVDKDLII >XP_020736578.1 SPARC [Odocoileus virginianus texanus] MRAWIFFLLCLAGRALAAPQQEALPDETEVVEETVAEVAEVPVGANPVQVEVGEFDEGAEETEEEVVAEN PCQNHHCKHGKVCELDENNTPMCVCQDPTSCPAPIGEFEKVCSNDNKTFDSSCHFFATKCTLEGTKKGHK LHLDYIGPCKSSLLPQVKKIHENEKRLEAGDHPVELLARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSH TELAPLRAPLIPMEHCTTRFFKTCDLDNDKYIALDEWAGCFGIKEKDIDKDLGIGCQGVIPKWPEDGQRE VTGXVTLYERDEDNNLLTEKQKLRVKKIHENEKRLEAGDHPVELLARDFEKNYNMYIFPVHWQFGQLDQH PIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLDNDKYIALDEWAGCFGIKEKDIDKDLVI >XP_040201059.1 SPARC [Rana temporaria] MRVWIFFVLCLAGRALAAPQQDALPEEEEVIEDVVTEEAVVGANPVQVEVGEFDEAIAEDEEEETTSENP CLNHHCKHGKVCEVDESNKPMCVCQDPSSCPESVGEFEKVCGNDNKTYDSSCHFFATKCTLEGTKKGHKL HLDYIGPCKYIPACMDSELTEFPLRMRDWLKNVLVSLYERDDNNNLLNEKQKLRVKKIHENEKRLEAGSH PVELLARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELSPLRAPLIPMEHCTTRFFEECDLDSDKYI ALDEWAKCFGIKDDDVDQDMIV
Mafft alignment of selected proteins >NP_003109.1 SPARC isoform 1 precursor [Homo sapiens] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------MRAWIFFLLCLA GRALA-----APQQEALPDETEVVEET---VAEVTEVSVGANPVQVEVGEFDDGA-EETE E------------------------EVVAENPCQNHHCKHGKVCELDENNTPMCVCQDPT SCPA-----PIGEFEKVCSNDNKTFDSSCHFFATKCTLEG------TKKGHKLHLDYIGP CK-------------------------------------YIPP----------------- ----------------------------------CLDSELTEFPLRMRDWLKNV------ ---------------LVTLYERDEDNNLLTEKQKLRVKKIHENEKRLEAG-DH--PVELL ARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLD NDKYIALDEWAGCF--GIKQKD-IDKDLVI------------------------------ -------- >XP_039273208.1 SPARC-like [Styela clava] ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MEMRRWIFLLIVIF CFAIV-----SAKRNSGDHKSDRERHV-------RAHLEEKNNRSSKIKEADDRR-ENRV NR---------------------DGTPLLKNPCAKVRCKKGKECSLDKNNSPKCVC--IQ ECST-----MVTIDDKVCGTDNKTYESECVLRRLKCLGSNDRN--IKKTLRKLKVNYLGE CK-------------------------------------MLTS----------------- ----------------------------------CKKSEMKEYPTRMRSWLKNV------ ---------------FLEMYDTPEEEGGLSAKQRYHGRKVFYEKDRLQDF-EETEPHDIV EREFKKFYPLYKYPIHWKFAELDKKPKDMKLSKRELEPLRAPLIPMEHCTKSFFKRADKN KDKKISLQEWGHAL--GLEEGD-IDSKLIV------------------------------ -------- >XP_006562631.2 SPARC [Apis mellifera] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------MRA-KVELLLFA LLLVALLVDVSAQQQRRRKHRRRTTTT----EASIQDEVMNMLEADEIAEEDAEV-TVED GR-------NEVGSK--------RQSLLRLDPCMDKHCDAGRVCKAVDDETAECVC--IE ICDK-----EIDPRRKVCTNHNETFGSDCEVYQARCFCDTNDPRCRGTKYQHVHVVYYGE CR-------------------------------------QMPE----------------- ----------------------------------CKPEDMADFPRRMRDWLFNI------ ---------------MRDLADRQELPSHYLKMQR-------------------------- -EAETNHTLRWTNAAIWKWCDLDGHPHDRAVSRHELFPIKAPLMALEHCIAPFLDSCDID GDHKITLIEWGKCL--ELNEED-LDDKCDELAETK------------------------- ----NSEQ >XP_038060164.1 SPARC-like [Patiria miniata] ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MSFSR-VVILLCVV AVVLA-----SKHKSKHQQMKASRHEM---RGAKKALESLSYTKEEQIYSIDGYK-EEPE ES-----------------------INDVTDKCNTLPCPPGETCYIDRDGAPYCDC--VE FCIE----EDGDPFIQVCSTGNVTYRSQCELYRLRCVN--------PREMDAEHLDYFGP CK-------------------------------------IMEQ----------------- ----------------------------------CNPADLATFPQRMRTWFLEV------ ---------------MKELSGLTEEQGGLDEEER---------------------EFEKL AEAETKP---WRRPLHWKFFNMDIAPNDFHLSESELMPMRAQLLPMEPCTDAFIASCDTN DDDLISIVEWGTCM--GLNEEE-ILY---------------------------------- -------- >NP_001091924.1 secreted protein, acidic, cysteine-rich precursor [Strongylocentrotus purpuratus] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------MMK-IFIVLCLA SLAIA-----NKHEMLADQELARA---------KIALDELTFTKEEHIYNVDGYV-EGEK EI---------------------GYENEIDDPCANMECRIGRECVLDNQREPFCDC--AT SCPQGETSEDAIHRTKVCTTTNATFTNLCEFHRQKCM---------EVDLMEVHVDYYGE CA-------------------------------------EMGS----------------- ----------------------------------CSAEDLREYPERMTNWFIKS------ ---------------LALIRNRPEEHGGLSQKEK-------------------------- -ETLQQEWSQSTHAIFWKFDRLDKNPSDHYLDFAELEGLRAPIVLFEPCTKPFLQACDVD NDTLISAVEFGRCL--NLSDEQ-VPY---------------------------------- -------- >XP_031562150.1 SPARC-like [Actinia tenebrosa] MK---------------------------------------------------------- ------------------------------------------------------------ ----------------------------------------------FFLEE-ILGLVVIG LFAVSV------------------------------------------------------ -------------------------SSQQISTCENTFCPYGRMCVEQTGGGTICQC--PE ECPV--------TVEPVCSVYGKEFDNMCELHKFACAL-----------GVSIAVKHRGL CTED-----------------------------------DLNP----------------- ------------------RTR-------------CNDYQLLQFPYRFLDWLM-I------ ---------------ARGMSLNPKFRLGRRA--------------------------EAL REEE------VRDXTLWEFENRDKDK-NRELDDNEIKTIENRLLPLESCIHGFLKSCDLD GVGGISAREWSTCFPRGRRSEATGSRKL-------------------------------- -------- >NP_033268.1 SPARC precursor [Mus musculus] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------MRAWIFFLLCLA GRALA-----APQQTEVA-EEIVEEET---VVEETGVPVGANPVQVEMGEFEDGA-EETV E------------------------EVVADNPCQNHHCKHGKVCELDESNTPMCVCQDPT SCPA-----PIGEFEKVCSNDNKTFDSSCHFFATKCTLEG------TKKGHKLHLDYIGP CK-------------------------------------YIAP----------------- ----------------------------------CLDSELTEFPLRMRDWLKNV------ ---------------LVTLYERDEGNNLLTEKQKLRVKKIHENEKRLEAG-DH--PVELL ARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLD NDKYIALEEWAGCF--GIKEQD-INKDLVI------------------------------ -------- >KAB0357987.1 hypothetical protein FD754_002143 [Muntiacus muntjak] MLGRLVKITSQTLQTLGPGYSPWEPWVGDPLPPPGLSSPLNKERAVLGDSCWPLQSQRSA RSVCLGKSSRTHVAGGVGRWVRAALREERR---------KALEDGDSFGCGEKGRGGEGK EETQEEEGPRGGGG------------------------DRPSPEVPSIMRAWIFFLLCLA GRALA-----APQQEALPDETEVVEET---VAEVAEVPVGANPVQVEVGEFDEGA-EETE E------------------------EVVAENPCQNHHCKHGKVCEVDENNTPMCVCQDPT SCPA-----PIGEFEKVCSNDNKTFDSSCHFFATKCTLEG------TKKGHKLHLDYIGP CK-------------------------------------YIPP----------------- ----------------------------------CLDSELTEFPLRMRDWLKNV------ ---------------LVTLYERDEDNNLLTEKQKLRVKKIHENEKRLEAG-DH--PVELL ARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLD NDKYIALDEWAGCF--GIKEKD-IDKDLVI------------------------------ -------- >XP_043320843.1 SPARC [Cervus canadensis] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------MRAWIFFLLCLA GRALA-----APQQEALPDETEVVEET---VAEVAEVPVGANPVQVEVGEFDEGA-EETE E------------------------EVVAENPCQNHHCKHGKVCELDENNTPMCVCQDPT SCPA-----PIGEFEKVCSNDNKTFDSSCHFFATKCTLEG------TKKGHKLHLDYIGP CK-------------------------------------YIPP----------------- ----------------------------------CLDSELTEFPLRMRDWLKNV------ ---------------LVTLYERDEDNNLLTEKQKLRVKKIHENEKRLEAG-DH--PVELL ARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLD NDKYIALDEWAGCF--GIKEKD-IDKDLVI------------------------------ -------- >KAB0386973.1 hypothetical protein FD755_001929 [Muntiacus reevesi] MLGSLVKITSQTLQTLGPGYSPWEPWVGDPLPPPGLSSPLNKERAVLGDSCWPLQSQRSA RSVCLGKSSRTHVAGGVGR--REGLGRRRQLWLWGEGEGREREGGDIGGGGTAGWRGR-- -QTQ----PRALSGFLLPGSKPLTFLQTFRLPGARLLPARPPLRVPSIMRAWILFLLCLA GTALA-----APQQEALPDETEVVEET---VAEVAEVPVGANPVQVEVGEFDEGA-EETE E------------------------EVVAENPCQNHHCKHGKVCEVDENNTPMCVCQDPT SCPA-----PIGEFEKVCSNDNKTFDSSCHFFATKCTLEG------TKKGHKLHLDYIGP CK-------------------------------------YIPP----------------- ----------------------------------CLDSELTEFPLRMRDWLKNV------ ---------------LVTLYERDEDNNLLTEKQKLRVKKIHENEKRLEAG-DH--PMELL ARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLD NDKYIALDEWAGCF--GIKEKD-IDKDLVI------------------------------ -------- >KAF4015265.1 hypothetical protein G4228_006558 [Cervus hanglu yarkandensis] MM--------------------WE---------------MEKT---------PSSDQR-- ----DSQPSHAMVP--VCE-------------------------------TIRNFNA--- --------P-----------------------------------VPSIMRAWIFFLLCLA GRALA-----APQQEALPDETEVVEET---VAEVAEVPVGANPVQVEVGEFDEGA-EETE E------------------------EVVAENPCQNHHCKHGKVCELDENNTPMCVCQDPT SCPA-----PIGEFEKVCSNDNKTFDSSCHFFATKCTLEG------TKKGHKLHLDYIGP CK-------------------------------------YIPP----------------- ----------------------------------CLDSELTEFPLRMRDWLKNV------ ---------------LVTLYERDEDNNLLTEKQKLRVKKIHENEKRLEAG-DH--PVELL ARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLD NDKYIALDEWAGCF--GIKESECLSKGSAILSLPPRCSLYVCPSCPSLLCAWLTPVCSPC LGGPHSFR >OWK12266.1 SPARC [Cervus elaphus hippelaphus] ------------------------------------------------------------ ----MGVAERVSVP--LGK---------------------------------HGW----- --------------------------------------------VPSIMRAWIFFLLCLA GRALA-----APQQEALPDETEVVEET---VAEVAEVPVGANPVQVEVGEFDEGA-EETE E------------------------EVVAENPCQNHHCKHGKVCELDENNTPMCVCQDPT SCPA-----PIGEFE-------KTFDSSCHFFATKCTLEG------TKKGHKLHLDYIGP CK-------------------------------------YIPP----------------- ----------------------------------CLDSELTEFPLRMRDWLKNV------ ---------------LVTLYERDEDNNLLTEKQKLRVKKIHENEKRLEAG-DH--PVELL ARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLD NDKYIALDEWAGCF--GIKEKD-IDKDLVI------------------------------ -------- >NP_989347.1 SPARC precursor [Xenopus tropicalis] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------MRVWVFFVLCLV GKALA-----APQQDALPEEEEVIEDV---PT---EETVGANPVQVEVGEFDDAV-NEEE E------------------------EEPSENPCLNHHCKHGKVCEVDESNTPMCVCQDPS TCPS-----SLAEFEKVCGTDNKTYESSCHFFATKCTLEG------TKKGHKLHLDYIGP CK-------------------------------------YIAP----------------- ----------------------------------CLDNELSEFPLRMRDWLKNV------ ---------------LVSLYERDENNNLLNEKQKLRVKKIHENEKRLEAG-DH--SMELL ARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELSPLRAPLIPMEHCTTRFFDECDTD NDKYIALEEWAKCF--GIKEQD-VDKDMIV------------------------------ -------- >NP_500039.1 SPARC [Caenorhabditis elegans] MR---------------------------------------------------------- ------------------------------------------------------------ ----------------------------------------------YALAA-CLLLLAAS SFVDA-----KKKKIADD----------------------------ELGELLDNI-DADE EK---------------------KSVEPAKNPCEDHQCGWGKECVVGKKGEPTCEC--IS KCPE----LDGDPMDKVCANNNQTFTSLCDLYRERCLCKRKSKECSKAFNAKVHLEYLGE CK-------------------------------------KLDE----------------- ----------------------------------CTEEHMAQFPERMADWLFQV------ ---------------MKELKKRRELHKLEWE--------------------------ELL SEAENDDEKKHVYPVIWKFCELDTKPHDKSVSHHELIPITAPVIPMESCIKPFLEGCDAN NDGNISIKEWGKCL--GLKEGE-IQERC-------------------------------- -------- >NP_001262998.1 secreted protein, acidic, cysteine-rich, isoform B [Drosophila melanogaster] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------MRS-LWLLLGLG LLAVS--------------HVQASTEF----SEDLLDEDLDLSDIDENEEEFLRL-LEEK NKIKDIERENEIATKLAEVQHNLLNPVVEVDLCETMSCGAGRICQM-HDEKPKCVC--IP ECPE-----EVDTRRLVCTNTNETWPSDCSVYQQRCWCDSGEPGCTNPDNAHMHIDYYGA CH-------------------------------------EPRS----------------- ----------------------------------CEGEDLKDFPRRMRDWLFNV------ ---------------MRDLAERDELTEHYMQMEL-------------------------- -EAETNNSRRWSNAAVWKWCDLDGDT-DRSVSRHELFPIRAPLVSLEHCIAPFLESCDSN KDHRITLVEWGACL--ELDPED-LKERCDDVQRAQ------------------------- ---PHLLG >XP_011478747.1 SPARC isoform X1 [Oryzias latipes] MK---------------------------PRPPE--QKGEEHLRAGLGR---PTGNVFCV K--LQSASDRPGAP------------------------------------HTPDFSAL-- --------PKL---------------------------------KTLKMRVWIVFLLCLA GHAMA-----APAEEEPALEELVTEEP----AE--EVEVGANPVQVEVGEFDEAI-EVVE D--------------------------AAENPCLNHRCKKGKVCEVDDTNTPMCVCQDPS SCPA-----AEGEFEHICGNDNKTYDSSCHFFATKCALEG------TKKGHKLHLDYIGS CK-------------------------------------LIEP----------------- ----------------------------------CLDNELTEFPLRMRDWLKNV------ ---------------LVTLYARDEDNNLLTEKQKLRVKKIYENEKRLEAG-DH--SLDLL ARDFQKNYNMYIFPVHWQFGQLDQHPADGYLTHSELAPLRAPLIPMEHCTTRFFEECDAD KDKYIALEEWAACF--GIKEQD-VDKDLVI------------------------------ -------- >XP_030252915.1 SPARC [Sparus aurata] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------MRVWIVFVLCLA GHAMA-----APTEEEVIVEEPVTEEP---VVE--EIEVGANPVQVEVGEFDEAI-EIVE DA---------------------VEDVAAENPCLNHHCKKGKVCEVDESNTPMCVCQDPT TCPA-----AEGVFEHVCGTDNKTYDTSCHFFATKCTLEG------TKKGHKLHLDYIGA CK-------------------------------------MIEP----------------- ----------------------------------CMDSELKEFPLRMRDWLKNV------ ---------------LVTLYERDEDNNLLTEKQKLRVKKIYENEKRLQAG-EH--SLDLL AHDFEKNYNMYIFPVHWQFGQLDQHPVDGYLTHTELSPLRAPLIPMEHCTTRFFEECDAD SDKYIALEEWAACF--GIKEQD-VDNDLII------------------------------ -------- >NP_036788.1 SPARC precursor [Rattus norvegicus] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------MRAWIFFLLCLA GRALA-----APQTEAA--EEMVAEET---VVEETGLPVGANPVQVEMGEFEEGA-EETV E------------------------EVVAENPCQNHHCKHGKVCELDESNTPMCVCQDPT SCPA-----PIGEFEKVCSNDNKTFDSSCHFFATKCTLEG------TKKGHKLHLDYIGP CK-------------------------------------YIAP----------------- ----------------------------------CLDSELTEFPLRMRDWLKNV------ ---------------LVTLYERDEGNNLLTEKQKLRVKKIHENEKRLEAG-DH--PVELL ARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLD NDKYIALEEWAGCF--GIKEQD-INKDLVI------------------------------ -------- >NP_776889.1 SPARC precursor [Bos taurus] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------MRAWIFFLLCLA GRALA-----APQQEALPDETEVVEET---VAEVAEVPVGANPVQVEVGEFDDGA-EETE E------------------------EVVAENPCQNHHCKHGKVCELDENNTPMCVCQDPT SCPA-----PIGEFEKVCSNDNKTFDSSCHFFATKCTLEG------TKKGHKLHLDYIGP CK-------------------------------------YIPP----------------- ----------------------------------CLDSELTEFPLRMRDWLKNV------ ---------------LVTLYERDEDNNLLTEKQKLRVKKIHENEKRLEAGCDH--PVELL ARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLD NDKYIALDEWAGCF--GIKEKD-IDKDLVI------------------------------ -------- >NP_001001942.1 SPARC precursor [Danio rerio] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------MRVWIFFLFCLA GKTLA-----APTEEEPAVE------------E--ELEVGINPVQVETGEFDEAI-EVVE D-------------------------VIAENPCLNHHCKKGKVCEVDDSNQPMCVCQDPL TCPA-----PIGDFEHVCGTNNKTYESSCHFFATKCSLEG------TKKGHKLHIDYIGP CK-------------------------------------YIAP----------------- ----------------------------------CLENELNEFPLRMRDWLKNV------ ---------------LVTLYERDEDNNLLTEKQKLRVKKIYENEKRLQAG-DH--SLDLL ALDFEKNYNMYIFPVHWQFGQLDQHPIDGFLSHTELAPLRAPLIPMEHCTTSFFEQCDAD QDKYIALEEWANCF--GIKEQD-VDKDLVI------------------------------ -------- >NP_989741.1 SPARC precursor [Gallus gallus] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------MRTWIFFFLCLA GKALA-----AP-QEALADETEVIEDL------TTEGPVGANPVQVEVGEFEEPT-EDV- E------------------------EIVAENPCQNHHCKHGKVCEVDDNNSPMCVCQDPS SCPA-----HSGVFEKVCGTDNKTYDSSCHFFATKCTLEG------TKKGHKLHLDYIGP CK-------------------------------------FIPA----------------- ----------------------------------CLDTELTEFPLRMRDWLKNV------ ---------------LITLYERDEDNNLLTEKQKLKVKNIHENEKRLEAG-DH--TVELL ARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFEACDLD FDKYIALEEWASCF--GIKEQD-IDKDLVI------------------------------ -------- >XP_001168719.1 SPARC [Pan troglodytes] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------MRAWIFFLLCLA GRALA-----APQQEALPDETEVVEET---VAEVTEVSVGANPVQVEVGEFDDGA-EETE E------------------------EVVAENPCQNHHCKHGKVCELDENNTPMCVCQDPT SCPA-----PIGEFEKVCSNDNKTFDSSCHFFATKCTLEG------TKKGHKLHLDYIGP CK-------------------------------------YIPP----------------- ----------------------------------CLDSELTEFPLRMRDWLKNV------ ---------------LVTLYERDEDNNLLTEKQKLRVKKIHENEKRLEAG-DH--PVELL ARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLD NDKYIALDEWAGCF--GIKQKD-IDKDLVI------------------------------ -------- >NP_001026964.1 SPARC precursor [Sus scrofa] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------MRAWIFFLLCLA GKALA-----APQQEALPDETEVVEET------VAEVPVGANPVQVEVGEFDDGA-EEAE E------------------------EVVAENPCQNHHCKHGKVCELDENNSPMCVCQDPT SCPA-----PIGEFEKVCSNDNKTFDSSCHFFATKCTLEG------TKKGHKLHLDYIGP CK-------------------------------------YIPP----------------- ----------------------------------CLDSELTEFPLRMRDWLKNV------ ---------------LVTLYERDENNNLLTEKQKLRVKKIHENEKRLEAG-DH--PVELL ARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFQTCDLD NDKYIALDEWAGCF--GIKEQD-IDKDLVI------------------------------ -------- >XP_008253505.1 PREDICTED: SPARC isoform X1 [Oryctolagus cuniculus] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------MKAWIFFLVCLA GRALA-----APQQEALPDETEVVEETVAEVAEVAEVPVGANPVQVEVGEFEE-V-EETE E------------------------EVVAENPCQNHHCKHGKVCELDENNTPMCVCQDPT SCPA-----PVGEFEKVCSNDNKTFDSSCHFFATKCTLEG------TKKGHKLHLDYIGP CK-------------------------------------YIPP----------------- ----------------------------------CLDSELSEFPLRMRDWLKNV------ ---------------LVTLYERDEGNNLLTEKQKLRVKKIHENEKRLEAG-DH--PVELL ARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFENCDLD NDKYIALEEWAGCF--GIKEKD-IDKDLVI------------------------------ -------- >NP_001127042.1 SPARC precursor [Pongo abelii] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------MRAWIFFLLCLA GRALA-----APQQEALPDETEVVEET---VAEVTEVSVGANPVQVEVGEFDDGA-EETE E------------------------EVVAENPCQNHHCKHGKVCELDENNTPMCMCQDPT SCPA-----PIGEFEKVCSNDNKTFDSSCHFFATKCTLEG------TKKGHKLHLDYIGP CK-------------------------------------YIPP----------------- ----------------------------------CLDSELTEFPLRMRDWLKNV------ ---------------LVTLYERDEDNNLLTEKQKLRVKKIHENEKRLEAG-DH--PVELL ARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLD NDKYIALDEWAGCF--GIKQKD-IDKDLVI------------------------------ -------- >NP_001159674.1 SPARC precursor [Ovis aries] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------MRAWIFFLLCLA GRALA-----APQQEALPDETEVVEET---VAEVAEVPVGANPVQVEVGEFDEGA-EEVE E------------------------EVVAENPCQNHHCKHGKVCELDESNTPMCVCQDPT SCPA-----PIGEFEKVCSNDNKTFDSSCHFFATKCTLEG------TKKGHKLHLDYIGP CK-------------------------------------YIPP----------------- ----------------------------------CLDSELTEFPLRMRDWLKNV------ ---------------LVTLYERDEDNNLLTEKQKLRVKKIHENEKRLEAG-DH--PVELL ARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLD NDKYIALDEWAGCF--GIKEKD-IDKDLVI------------------------------ -------- >XP_010717456.1 SPARC [Meleagris gallopavo] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------MRAWIFFLLCLA GKALA-----AP-QEALPDETEVIEDL------TTEEPVGANPVQVEVGEFEEPT-EDV- E------------------------EIVAENPCQNHHCKHGKVCEVDDNNSPMCVCQDPS SCPA-----TSGVFEKVCGTDNKTYDSSCHFFATKCTLEG------TKKGHKLHLDYIGP CK-------------------------------------FIPA----------------- ----------------------------------CLDTELTEFPLRMRDWLKNV------ ---------------LITLYERDEDNNLLTEKQKLKVKKIHENEKRLEAG-DH--TVELL ARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFEACDLD NDKYIALEEWASCF--GIKEQD-IDKDLVI------------------------------ -------- >XP_005619329.1 SPARC [Canis lupus familiaris] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------MRAWIFFLLCLA GRALA-----APQQEALPDETEVVEET---VAEVAEGPVGANPVQVEVGEFDEGA-EETE E------------------------EVVAENPCQNHHCKHGKVCELDENNTPMCVCQDPT SCPG-----PIGDFEKVCSNDNKTFDSSCHFFATKCTLEG------TKKGHKLHLDYIGP CK-------------------------------------YIPP----------------- ----------------------------------CLDSELTEFPLRMRDWLKNV------ ---------------LVTLYERDEDNNLLTEKQKLRVKKIHENEKRLEAG-DH--PVELL ARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLD NDKYIALDEWAGCF--GIKEQD-IDKDLVI------------------------------ -------- >NP_001272591.1 SPARC precursor [Capra hircus] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------MRAWIFFLLCLA GRALA-----APQQEALPDETEVVEET---VAEVAEVPVGANPVQVEVGEFDEGA-EEVE E------------------------EVVAENPCQNHHCKHGKVCELDESNTPMCVCQDPT SCPA-----PIGEFEKVCSNDNKTFDSSCHFFATKCTLEG------TKKGHKLHLDYIGP CK-------------------------------------YIPP----------------- ----------------------------------CLDSELTEFPLRMRDWLKNV------ ---------------LVTLYERDEDNNLLTEKQKLRVKKIHENEKRLEAG-DH--PVELL ARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLD NDKYIALDEWAGCF--GIKEKD-IDKDLVI------------------------------ -------- >XP_008952671.1 SPARC [Pan paniscus] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------MRAWIFFLLCLA GRALA-----APQQEALPDETEVVEET---VAEVTEVSVGANPVQVEVGEFDDGA-EETE E------------------------EVVAENPCQNHHCKHGKVCELDENNTPMCVCQDPT SCPA-----PIGEFEKVCSNDNKTFDSSCHFFATKCTLEG------TKKGHKLHLDYIGP CK-------------------------------------YIPP----------------- ----------------------------------CLDSELTEFPLRMRDWLKNV------ ---------------LVTLYERDEDNNLLTEKQKLRVKKIHENEKRLEAG-DH--PVELL ARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLD NDKYIALDEWAGCF--GIKQKD-IDKDLVI------------------------------ -------- >XP_003981423.1 SPARC [Felis catus] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------MRAWIFFLLCLA GRALA-----APQQEALPDETEVVEET---VAEVAEGPVGANPVQVEVGEFDEGA-EEAE Q------------------------EVVAENPCQNHHCKHGKVCELDENNTPMCVCQDPT SCPA-----PIGEFEKVCSNDNKTFDSSCHFFATKCTLEG------TKKGHKLHLDYIGP CK-------------------------------------YIPP----------------- ----------------------------------CLDSELTEFPLRMRDWLKNV------ ---------------LVTLYERDEDNNLLTEKQKLRVKKIHENEKRLEAG-DH--PVELL ARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLD NDKYIALDEWAGCF--GIKEQD-IDKDLVI------------------------------ -------- >XP_004042902.1 SPARC [Gorilla gorilla gorilla] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------MRAWIFFLLCLA GRALA-----APQQEALPDETEVVEET---VAEVTEVSVGANPVQVDVGEFDDGA-EETE E------------------------EVVAENPCQNHHCKHGKVCELDENNTPMCVCQDPT SCPA-----PIGEFEKVCSNDNKTFDSSCHFFATKCTLEG------TKKGHKLHLDYIGP CK-------------------------------------YIPP----------------- ----------------------------------CLDSELTEFPLRMRDWLKNV------ ---------------LVTLYERDEDNNLLTEKQKLRVKKIHENEKRLEAG-DH--PVELL ARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLD NDKYIALDEWAGCF--GIKQKD-IDKDLVI------------------------------ -------- >XP_005503434.1 SPARC [Columba livia] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------MRAWIFFLLCLA GKALA-----AP-QEALPDETEVIEDP------TTEEPVGANPVQVEVGEFEEPA-EDV- E------------------------EIVAENPCQNHHCKHGKVCEVDDNNSPMCVCQDPS SCPA-----TAGVFEKVCGTDNKTYDSSCHFFATKCTLEG------TKKGHKLHLDYIGP CK-------------------------------------FIPA----------------- ----------------------------------CLDTELTEFPLRMRDWLKNV------ ---------------LITLYERDEDNNLLTEKQKLKVKKIHENEKRLEAG-DH--TVELL ARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFDACDLD NDKYIALEEWASCF--GIKEQD-IDKNLVI------------------------------ -------- >XP_014374238.1 SPARC [Alligator sinensis] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------MQAWVFFLLCLA GKALA-----AP-QDALPDEIEVVEDP------TTEEPVGVNPVQVEVGEFEEPT-VDV- E------------------------EIVAENPCQNHHCKHGKVCEVDDNNSPMCVCQDPS SCPS-----STGVFEKVCGTDNKTYDTSCHFFATKCTLEG------TKKGHKLHLDYIGP CK-------------------------------------YIPA----------------- ----------------------------------CLDTELTEFPLRMRDWLKNV------ ---------------LITLYERDEDNNLLTEKQKLKVKKIHENEKRLEAG-DH--TMELL ARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFEACDVD NDKYIALEEWAGCF--GIKEQD-IDKDLII------------------------------ -------- >XP_006270448.1 PREDICTED: SPARC [Alligator mississippiensis] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------MQAWVFFLLCLA GKALA-----AP-QDALPDEIEVVEDP------TTEEPVGVNPVQVEVGEFEEPT-VDV- E------------------------EIVAENPCQNHHCKHGKVCEVDDNNSPMCVCQDPS SCPS-----STGVFEKVCGTDNKTYDTSCHFFATKCTLEG------TKKGHKLHLDYIGP CK-------------------------------------YIPA----------------- ----------------------------------CLDTELTEFPLRMRDWLKNV------ ---------------LITLYERDEDNNLLTEKQKLKVKKIHENEKRLEAG-DH--TMELL ARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFEACDVD NDKYIALEEWAGCF--GIKEQD-IDKDLII------------------------------ -------- >XP_015807480.1 PREDICTED: SPARC [Nothobranchius furzeri] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------MRVWVVFLLCLA GHAFA-----APTEEEPNVEELVAEEP---AAE--EVDVGTNPVQVEVGEFDEGI-EVDE D--------------------------VAENPCLNYQCKKGKVCEVDESNTPMCVCQDPS TCPP-----AEGEFEHVCGTDNKTYDSSCHFFATKCTLEG------TKKGHKLHLDYIGP CK-------------------------------------LIEP----------------- ----------------------------------CLDSELNEFPLRMRDWLKNV------ ---------------LVTLYERDEDNNLLTEKQKLRVKKIFENEKRLQAG-DH--SLDLL ARDFAKNYNMYIFPVHWQFGQLDQHPIDGYLTHSELAPLRAPLIPMEHCTTRFFEECDAD DDKYIALEEWASCF--GIKEQD-VDKDLII------------------------------ -------- >XP_020736578.1 SPARC [Odocoileus virginianus texanus] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------MRAWIFFLLCLA GRALA-----APQQEALPDETEVVEET---VAEVAEVPVGANPVQVEVGEFDEGA-EETE E------------------------EVVAENPCQNHHCKHGKVCELDENNTPMCVCQDPT SCPA-----PIGEFEKVCSNDNKTFDSSCHFFATKCTLEG------TKKGHKLHLDYIGP CKSSLLPQVKKIHENEKRLEAGDHPVELLARDFEKNYNMYIFPVHWQFGQLDQHPIDGYL SHTELAPLRAPLIPMEHCTTRFFKTCDLDNDKYIALDEWAGCFGIKEKDIDKDLGIGCQG VIPKWPEDGQREVTGXVTLYERDEDNNLLTEKQKLRVKKIHENEKRLEAG-DH--PVELL ARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLD NDKYIALDEWAGCF--GIKEKD-IDKDLVI------------------------------ -------- >XP_040201059.1 SPARC [Rana temporaria] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------MRVWIFFVLCLA GRALA-----APQQDALPEEEEVIEDV---VTE--EAVVGANPVQVEVGEFDEAIAEDEE E------------------------ETTSENPCLNHHCKHGKVCEVDESNKPMCVCQDPS SCPE-----SVGEFEKVCGNDNKTYDSSCHFFATKCTLEG------TKKGHKLHLDYIGP CK-------------------------------------YIPA----------------- ----------------------------------CMDSELTEFPLRMRDWLKNV------ ---------------LVSLYERDDNNNLLNEKQKLRVKKIHENEKRLEAG-SH--PVELL ARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELSPLRAPLIPMEHCTTRFFEECDLD SDKYIALDEWAKCF--GIKDDD-VDQDMIV------------------------------ --------
BMGE Cleaned alignment of selected proteins >NP_003109.1 SPARC isoform 1 precursor [Homo sapiens] MRAWIFFLLCLAGRALAAPQQEALPDETEVVEETVAEVTEVSVGANPVQVEVGEFDDGAEETEEEVVAENPCQNHHCKHGKVCELDENNTPMCVCQDPTSCPAPIGEFEKVCSNDNKTFDSSCHFFATKCTLEGTKKGHKLHLDYIGPCKCLDSELTEFPLRMRDWLKNVLVTLYERDEDNNLLTEKQKLRVKKIHENEKRLEAGPVELLARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLDNDKYIALDEWAGCFGIKQKDIDKDLVI >XP_039273208.1 SPARC-like [Styela clava] MRRWIFLLIVIFCFAIVSAKRNSGDHKSDRERHV----RAHLEEKNNRSSKIKEADDRRENRVNTPLLKNPCAKVRCKKGKECSLDKNNSPKCVC--IQECSTMVTIDDKVCGTDNKTYESECVLRRLKCLGSNKKTLRKLKVNYLGECKCKKSEMKEYPTRMRSWLKNVFLEMYDTPEEEGGLSAKQRYHGRKVFYEKDRLQDFPHDIVEREFKKFYPLYKYPIHWKFAELDKKPKDMKLSKRELEPLRAPLIPMEHCTKSFFKRADKNKDKKISLQEWGHALGLEEGDIDSKLIV >XP_006562631.2 SPARC [Apis mellifera] MRA-KVELLLFALLLVASAQQQRRRKHRRRTTTT-EASIQDEVMNMLEADEIAEEDAEVTVEDGSLLRLDPCMDKHCDAGRVCKAVDDETAECVC--IEICDKEIDPRRKVCTNHNETFGSDCEVYQARCFCDTGTKYQHVHVVYYGECRCKPEDMADFPRRMRDWLFNIMRDLADRQELPSHYLKMQR----------------------EAETNHTLRWTNAAIWKWCDLDGHPHDRAVSRHELFPIKAPLMALEHCIAPFLDSCDIDGDHKITLIEWGKCLELNEEDLDDKCDE >XP_038060164.1 SPARC-like [Patiria miniata] FSR-VVILLCVVAVVLASKHKSKHQQMKASRHEMRGAKKALESLSYTKEEQIYSIDGYKEEPEEINDVTDKCNTLPCPPGETCYIDRDGAPYCDC--VEFCIEDGDPFIQVCSTGNVTYRSQCELYRLRCVN--PREMDAEHLDYFGPCKCNPADLATFPQRMRTWFLEVMKELSGLTEEQGGLDEEER----------------EFEKLAEAETKP---WRRPLHWKFFNMDIAPNDFHLSESELMPMRAQLLPMEPCTDAFIASCDTNDDDLISIVEWGTCMGLNEEEILY---- >NP_001091924.1 secreted protein, acidic, cysteine-rich precursor [Strongylocentrotus purpuratus] MMK-IFIVLCLASLAIANKHEMLADQELARA------KIALDELTFTKEEHIYNVDGYVEGEKEENEIDDPCANMECRIGRECVLDNQREPFCDC--ATSCPQDAIHRTKVCTTTNATFTNLCEFHRQKCM---EVDLMEVHVDYYGECACSAEDLREYPERMTNWFIKSLALIRNRPEEHGGLSQKEK----------------------ETLQQEWSQSTHAIFWKFDRLDKNPSDHYLDFAELEGLRAPIVLFEPCTKPFLQACDVDNDTLISAVEFGRCLNLSDEQVPY---- >XP_031562150.1 SPARC-like [Actinia tenebrosa] LEE-ILGLVVIGLFAVS-----------------------------------------------SSQQISTCENTFCPYGRMCVEQTGGGTICQC--PEECPV---TVEPVCSVYGKEFDNMCELHKFACAL-----GVSIAVKHRGLCTCNDYQLLQFPYRFLDWLM-IARGMSLNPKFRLGRRA---------------------EALREEE------VRDXTLWEFENRDKDK-NRELDDNEIKTIENRLLPLESCIHGFLKSCDLDGVGGISAREWSTCFGRRSEAGSRKL-- >NP_033268.1 SPARC precursor [Mus musculus] MRAWIFFLLCLAGRALAAPQQTEVA-EEIVEEETVVEETGVPVGANPVQVEMGEFEDGAEETVEEVVADNPCQNHHCKHGKVCELDESNTPMCVCQDPTSCPAPIGEFEKVCSNDNKTFDSSCHFFATKCTLEGTKKGHKLHLDYIGPCKCLDSELTEFPLRMRDWLKNVLVTLYERDEGNNLLTEKQKLRVKKIHENEKRLEAGPVELLARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLDNDKYIALEEWAGCFGIKEQDINKDLVI >KAB0357987.1 hypothetical protein FD754_002143 [Muntiacus muntjak] MRAWIFFLLCLAGRALAAPQQEALPDETEVVEETVAEVAEVPVGANPVQVEVGEFDEGAEETEEEVVAENPCQNHHCKHGKVCEVDENNTPMCVCQDPTSCPAPIGEFEKVCSNDNKTFDSSCHFFATKCTLEGTKKGHKLHLDYIGPCKCLDSELTEFPLRMRDWLKNVLVTLYERDEDNNLLTEKQKLRVKKIHENEKRLEAGPVELLARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLDNDKYIALDEWAGCFGIKEKDIDKDLVI >XP_043320843.1 SPARC [Cervus canadensis] MRAWIFFLLCLAGRALAAPQQEALPDETEVVEETVAEVAEVPVGANPVQVEVGEFDEGAEETEEEVVAENPCQNHHCKHGKVCELDENNTPMCVCQDPTSCPAPIGEFEKVCSNDNKTFDSSCHFFATKCTLEGTKKGHKLHLDYIGPCKCLDSELTEFPLRMRDWLKNVLVTLYERDEDNNLLTEKQKLRVKKIHENEKRLEAGPVELLARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLDNDKYIALDEWAGCFGIKEKDIDKDLVI >KAB0386973.1 hypothetical protein FD755_001929 [Muntiacus reevesi] MRAWILFLLCLAGTALAAPQQEALPDETEVVEETVAEVAEVPVGANPVQVEVGEFDEGAEETEEEVVAENPCQNHHCKHGKVCEVDENNTPMCVCQDPTSCPAPIGEFEKVCSNDNKTFDSSCHFFATKCTLEGTKKGHKLHLDYIGPCKCLDSELTEFPLRMRDWLKNVLVTLYERDEDNNLLTEKQKLRVKKIHENEKRLEAGPMELLARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLDNDKYIALDEWAGCFGIKEKDIDKDLVI >KAF4015265.1 hypothetical protein G4228_006558 [Cervus hanglu yarkandensis] MRAWIFFLLCLAGRALAAPQQEALPDETEVVEETVAEVAEVPVGANPVQVEVGEFDEGAEETEEEVVAENPCQNHHCKHGKVCELDENNTPMCVCQDPTSCPAPIGEFEKVCSNDNKTFDSSCHFFATKCTLEGTKKGHKLHLDYIGPCKCLDSELTEFPLRMRDWLKNVLVTLYERDEDNNLLTEKQKLRVKKIHENEKRLEAGPVELLARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLDNDKYIALDEWAGCFGIKESELSKGSAI >OWK12266.1 SPARC [Cervus elaphus hippelaphus] MRAWIFFLLCLAGRALAAPQQEALPDETEVVEETVAEVAEVPVGANPVQVEVGEFDEGAEETEEEVVAENPCQNHHCKHGKVCELDENNTPMCVCQDPTSCPAPIGEFE-------KTFDSSCHFFATKCTLEGTKKGHKLHLDYIGPCKCLDSELTEFPLRMRDWLKNVLVTLYERDEDNNLLTEKQKLRVKKIHENEKRLEAGPVELLARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLDNDKYIALDEWAGCFGIKEKDIDKDLVI >NP_989347.1 SPARC precursor [Xenopus tropicalis] MRVWVFFVLCLVGKALAAPQQDALPEEEEVIEDVPT---EETVGANPVQVEVGEFDDAVNEEEEEEPSENPCLNHHCKHGKVCEVDESNTPMCVCQDPSTCPSSLAEFEKVCGTDNKTYESSCHFFATKCTLEGTKKGHKLHLDYIGPCKCLDNELSEFPLRMRDWLKNVLVSLYERDENNNLLNEKQKLRVKKIHENEKRLEAGSMELLARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELSPLRAPLIPMEHCTTRFFDECDTDNDKYIALEEWAKCFGIKEQDVDKDMIV >NP_500039.1 SPARC [Caenorhabditis elegans] LAA-CLLLLAASSFVDAKKKKIADD-------------------------ELGELLDNIDADEEVEPAKNPCEDHQCGWGKECVVGKKGEPTCEC--ISKCPEDGDPMDKVCANNNQTFTSLCDLYRERCLCKRKAFNAKVHLEYLGECKCTEEHMAQFPERMADWLFQVMKELKKRRELHKLEWE---------------------ELLSEAENDDEKKHVYPVIWKFCELDTKPHDKSVSHHELIPITAPVIPMESCIKPFLEGCDANNDGNISIKEWGKCLGLKEGEIQERC-- >NP_001262998.1 secreted protein, acidic, cysteine-rich, isoform B [Drosophila melanogaster] MRS-LWLLLGLGLLAVS---------HVQASTEF-SEDLLDEDLDLSDIDENEEEFLRLLEEKNPVVEVDLCETMSCGAGRICQM-HDEKPKCVC--IPECPEEVDTRRLVCTNTNETWPSDCSVYQQRCWCDSNPDNAHMHIDYYGACHCEGEDLKDFPRRMRDWLFNVMRDLAERDELTEHYMQMEL----------------------EAETNNSRRWSNAAVWKWCDLDGDT-DRSVSRHELFPIRAPLVSLEHCIAPFLESCDSNKDHRITLVEWGACLELDPEDLKERCDD >XP_011478747.1 SPARC isoform X1 [Oryzias latipes] MRVWIVFLLCLAGHAMAAPAEEEPALEELVTEEP-AE--EVEVGANPVQVEVGEFDEAIEVVED--AAENPCLNHRCKKGKVCEVDDTNTPMCVCQDPSSCPAAEGEFEHICGNDNKTYDSSCHFFATKCALEGTKKGHKLHLDYIGSCKCLDNELTEFPLRMRDWLKNVLVTLYARDEDNNLLTEKQKLRVKKIYENEKRLEAGSLDLLARDFQKNYNMYIFPVHWQFGQLDQHPADGYLTHSELAPLRAPLIPMEHCTTRFFEECDADKDKYIALEEWAACFGIKEQDVDKDLVI >XP_030252915.1 SPARC [Sparus aurata] MRVWIVFVLCLAGHAMAAPTEEEVIVEEPVTEEPVVE--EIEVGANPVQVEVGEFDEAIEIVEDDVAAENPCLNHHCKKGKVCEVDESNTPMCVCQDPTTCPAAEGVFEHVCGTDNKTYDTSCHFFATKCTLEGTKKGHKLHLDYIGACKCMDSELKEFPLRMRDWLKNVLVTLYERDEDNNLLTEKQKLRVKKIYENEKRLQAGSLDLLAHDFEKNYNMYIFPVHWQFGQLDQHPVDGYLTHTELSPLRAPLIPMEHCTTRFFEECDADSDKYIALEEWAACFGIKEQDVDNDLII >NP_036788.1 SPARC precursor [Rattus norvegicus] MRAWIFFLLCLAGRALAAPQTEAA--EEMVAEETVVEETGLPVGANPVQVEMGEFEEGAEETVEEVVAENPCQNHHCKHGKVCELDESNTPMCVCQDPTSCPAPIGEFEKVCSNDNKTFDSSCHFFATKCTLEGTKKGHKLHLDYIGPCKCLDSELTEFPLRMRDWLKNVLVTLYERDEGNNLLTEKQKLRVKKIHENEKRLEAGPVELLARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLDNDKYIALEEWAGCFGIKEQDINKDLVI >NP_776889.1 SPARC precursor [Bos taurus] MRAWIFFLLCLAGRALAAPQQEALPDETEVVEETVAEVAEVPVGANPVQVEVGEFDDGAEETEEEVVAENPCQNHHCKHGKVCELDENNTPMCVCQDPTSCPAPIGEFEKVCSNDNKTFDSSCHFFATKCTLEGTKKGHKLHLDYIGPCKCLDSELTEFPLRMRDWLKNVLVTLYERDEDNNLLTEKQKLRVKKIHENEKRLEAGPVELLARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLDNDKYIALDEWAGCFGIKEKDIDKDLVI >NP_001001942.1 SPARC precursor [Danio rerio] MRVWIFFLFCLAGKTLAAPTEEEPAVE---------E--ELEVGINPVQVETGEFDEAIEVVED-VIAENPCLNHHCKKGKVCEVDDSNQPMCVCQDPLTCPAPIGDFEHVCGTNNKTYESSCHFFATKCSLEGTKKGHKLHIDYIGPCKCLENELNEFPLRMRDWLKNVLVTLYERDEDNNLLTEKQKLRVKKIYENEKRLQAGSLDLLALDFEKNYNMYIFPVHWQFGQLDQHPIDGFLSHTELAPLRAPLIPMEHCTTSFFEQCDADQDKYIALEEWANCFGIKEQDVDKDLVI >NP_989741.1 SPARC precursor [Gallus gallus] MRTWIFFFLCLAGKALAAP-QEALADETEVIEDL---TTEGPVGANPVQVEVGEFEEPTEDV-EEIVAENPCQNHHCKHGKVCEVDDNNSPMCVCQDPSSCPAHSGVFEKVCGTDNKTYDSSCHFFATKCTLEGTKKGHKLHLDYIGPCKCLDTELTEFPLRMRDWLKNVLITLYERDEDNNLLTEKQKLKVKNIHENEKRLEAGTVELLARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFEACDLDFDKYIALEEWASCFGIKEQDIDKDLVI >XP_001168719.1 SPARC [Pan troglodytes] MRAWIFFLLCLAGRALAAPQQEALPDETEVVEETVAEVTEVSVGANPVQVEVGEFDDGAEETEEEVVAENPCQNHHCKHGKVCELDENNTPMCVCQDPTSCPAPIGEFEKVCSNDNKTFDSSCHFFATKCTLEGTKKGHKLHLDYIGPCKCLDSELTEFPLRMRDWLKNVLVTLYERDEDNNLLTEKQKLRVKKIHENEKRLEAGPVELLARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLDNDKYIALDEWAGCFGIKQKDIDKDLVI >NP_001026964.1 SPARC precursor [Sus scrofa] MRAWIFFLLCLAGKALAAPQQEALPDETEVVEET---VAEVPVGANPVQVEVGEFDDGAEEAEEEVVAENPCQNHHCKHGKVCELDENNSPMCVCQDPTSCPAPIGEFEKVCSNDNKTFDSSCHFFATKCTLEGTKKGHKLHLDYIGPCKCLDSELTEFPLRMRDWLKNVLVTLYERDENNNLLTEKQKLRVKKIHENEKRLEAGPVELLARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFQTCDLDNDKYIALDEWAGCFGIKEQDIDKDLVI >XP_008253505.1 PREDICTED: SPARC isoform X1 [Oryctolagus cuniculus] MKAWIFFLVCLAGRALAAPQQEALPDETEVVEETVAEVAEVPVGANPVQVEVGEFEE-VEETEEEVVAENPCQNHHCKHGKVCELDENNTPMCVCQDPTSCPAPVGEFEKVCSNDNKTFDSSCHFFATKCTLEGTKKGHKLHLDYIGPCKCLDSELSEFPLRMRDWLKNVLVTLYERDEGNNLLTEKQKLRVKKIHENEKRLEAGPVELLARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFENCDLDNDKYIALEEWAGCFGIKEKDIDKDLVI >NP_001127042.1 SPARC precursor [Pongo abelii] MRAWIFFLLCLAGRALAAPQQEALPDETEVVEETVAEVTEVSVGANPVQVEVGEFDDGAEETEEEVVAENPCQNHHCKHGKVCELDENNTPMCMCQDPTSCPAPIGEFEKVCSNDNKTFDSSCHFFATKCTLEGTKKGHKLHLDYIGPCKCLDSELTEFPLRMRDWLKNVLVTLYERDEDNNLLTEKQKLRVKKIHENEKRLEAGPVELLARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLDNDKYIALDEWAGCFGIKQKDIDKDLVI >NP_001159674.1 SPARC precursor [Ovis aries] MRAWIFFLLCLAGRALAAPQQEALPDETEVVEETVAEVAEVPVGANPVQVEVGEFDEGAEEVEEEVVAENPCQNHHCKHGKVCELDESNTPMCVCQDPTSCPAPIGEFEKVCSNDNKTFDSSCHFFATKCTLEGTKKGHKLHLDYIGPCKCLDSELTEFPLRMRDWLKNVLVTLYERDEDNNLLTEKQKLRVKKIHENEKRLEAGPVELLARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLDNDKYIALDEWAGCFGIKEKDIDKDLVI >XP_010717456.1 SPARC [Meleagris gallopavo] MRAWIFFLLCLAGKALAAP-QEALPDETEVIEDL---TTEEPVGANPVQVEVGEFEEPTEDV-EEIVAENPCQNHHCKHGKVCEVDDNNSPMCVCQDPSSCPATSGVFEKVCGTDNKTYDSSCHFFATKCTLEGTKKGHKLHLDYIGPCKCLDTELTEFPLRMRDWLKNVLITLYERDEDNNLLTEKQKLKVKKIHENEKRLEAGTVELLARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFEACDLDNDKYIALEEWASCFGIKEQDIDKDLVI >XP_005619329.1 SPARC [Canis lupus familiaris] MRAWIFFLLCLAGRALAAPQQEALPDETEVVEETVAEVAEGPVGANPVQVEVGEFDEGAEETEEEVVAENPCQNHHCKHGKVCELDENNTPMCVCQDPTSCPGPIGDFEKVCSNDNKTFDSSCHFFATKCTLEGTKKGHKLHLDYIGPCKCLDSELTEFPLRMRDWLKNVLVTLYERDEDNNLLTEKQKLRVKKIHENEKRLEAGPVELLARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLDNDKYIALDEWAGCFGIKEQDIDKDLVI >NP_001272591.1 SPARC precursor [Capra hircus] MRAWIFFLLCLAGRALAAPQQEALPDETEVVEETVAEVAEVPVGANPVQVEVGEFDEGAEEVEEEVVAENPCQNHHCKHGKVCELDESNTPMCVCQDPTSCPAPIGEFEKVCSNDNKTFDSSCHFFATKCTLEGTKKGHKLHLDYIGPCKCLDSELTEFPLRMRDWLKNVLVTLYERDEDNNLLTEKQKLRVKKIHENEKRLEAGPVELLARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLDNDKYIALDEWAGCFGIKEKDIDKDLVI >XP_008952671.1 SPARC [Pan paniscus] MRAWIFFLLCLAGRALAAPQQEALPDETEVVEETVAEVTEVSVGANPVQVEVGEFDDGAEETEEEVVAENPCQNHHCKHGKVCELDENNTPMCVCQDPTSCPAPIGEFEKVCSNDNKTFDSSCHFFATKCTLEGTKKGHKLHLDYIGPCKCLDSELTEFPLRMRDWLKNVLVTLYERDEDNNLLTEKQKLRVKKIHENEKRLEAGPVELLARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLDNDKYIALDEWAGCFGIKQKDIDKDLVI >XP_003981423.1 SPARC [Felis catus] MRAWIFFLLCLAGRALAAPQQEALPDETEVVEETVAEVAEGPVGANPVQVEVGEFDEGAEEAEQEVVAENPCQNHHCKHGKVCELDENNTPMCVCQDPTSCPAPIGEFEKVCSNDNKTFDSSCHFFATKCTLEGTKKGHKLHLDYIGPCKCLDSELTEFPLRMRDWLKNVLVTLYERDEDNNLLTEKQKLRVKKIHENEKRLEAGPVELLARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLDNDKYIALDEWAGCFGIKEQDIDKDLVI >XP_004042902.1 SPARC [Gorilla gorilla gorilla] MRAWIFFLLCLAGRALAAPQQEALPDETEVVEETVAEVTEVSVGANPVQVDVGEFDDGAEETEEEVVAENPCQNHHCKHGKVCELDENNTPMCVCQDPTSCPAPIGEFEKVCSNDNKTFDSSCHFFATKCTLEGTKKGHKLHLDYIGPCKCLDSELTEFPLRMRDWLKNVLVTLYERDEDNNLLTEKQKLRVKKIHENEKRLEAGPVELLARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLDNDKYIALDEWAGCFGIKQKDIDKDLVI >XP_005503434.1 SPARC [Columba livia] MRAWIFFLLCLAGKALAAP-QEALPDETEVIEDP---TTEEPVGANPVQVEVGEFEEPAEDV-EEIVAENPCQNHHCKHGKVCEVDDNNSPMCVCQDPSSCPATAGVFEKVCGTDNKTYDSSCHFFATKCTLEGTKKGHKLHLDYIGPCKCLDTELTEFPLRMRDWLKNVLITLYERDEDNNLLTEKQKLKVKKIHENEKRLEAGTVELLARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFDACDLDNDKYIALEEWASCFGIKEQDIDKNLVI >XP_014374238.1 SPARC [Alligator sinensis] MQAWVFFLLCLAGKALAAP-QDALPDEIEVVEDP---TTEEPVGVNPVQVEVGEFEEPTVDV-EEIVAENPCQNHHCKHGKVCEVDDNNSPMCVCQDPSSCPSSTGVFEKVCGTDNKTYDTSCHFFATKCTLEGTKKGHKLHLDYIGPCKCLDTELTEFPLRMRDWLKNVLITLYERDEDNNLLTEKQKLKVKKIHENEKRLEAGTMELLARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFEACDVDNDKYIALEEWAGCFGIKEQDIDKDLII >XP_006270448.1 PREDICTED: SPARC [Alligator mississippiensis] MQAWVFFLLCLAGKALAAP-QDALPDEIEVVEDP---TTEEPVGVNPVQVEVGEFEEPTVDV-EEIVAENPCQNHHCKHGKVCEVDDNNSPMCVCQDPSSCPSSTGVFEKVCGTDNKTYDTSCHFFATKCTLEGTKKGHKLHLDYIGPCKCLDTELTEFPLRMRDWLKNVLITLYERDEDNNLLTEKQKLKVKKIHENEKRLEAGTMELLARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFEACDVDNDKYIALEEWAGCFGIKEQDIDKDLII >XP_015807480.1 PREDICTED: SPARC [Nothobranchius furzeri] MRVWVVFLLCLAGHAFAAPTEEEPNVEELVAEEPAAE--EVDVGTNPVQVEVGEFDEGIEVDED--VAENPCLNYQCKKGKVCEVDESNTPMCVCQDPSTCPPAEGEFEHVCGTDNKTYDSSCHFFATKCTLEGTKKGHKLHLDYIGPCKCLDSELNEFPLRMRDWLKNVLVTLYERDEDNNLLTEKQKLRVKKIFENEKRLQAGSLDLLARDFAKNYNMYIFPVHWQFGQLDQHPIDGYLTHSELAPLRAPLIPMEHCTTRFFEECDADDDKYIALEEWASCFGIKEQDVDKDLII >XP_020736578.1 SPARC [Odocoileus virginianus texanus] MRAWIFFLLCLAGRALAAPQQEALPDETEVVEETVAEVAEVPVGANPVQVEVGEFDEGAEETEEEVVAENPCQNHHCKHGKVCELDENNTPMCVCQDPTSCPAPIGEFEKVCSNDNKTFDSSCHFFATKCTLEGTKKGHKLHLDYIGPCKALDEWAGCFGIKEKDIDKDLXVTLYERDEDNNLLTEKQKLRVKKIHENEKRLEAGPVELLARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLDNDKYIALDEWAGCFGIKEKDIDKDLVI >XP_040201059.1 SPARC [Rana temporaria] MRVWIFFVLCLAGRALAAPQQDALPEEEEVIEDVVTE--EAVVGANPVQVEVGEFDEAIEDEEEETTSENPCLNHHCKHGKVCEVDESNKPMCVCQDPSSCPESVGEFEKVCGNDNKTYDSSCHFFATKCTLEGTKKGHKLHLDYIGPCKCMDSELTEFPLRMRDWLKNVLVSLYERDDNNNLLNEKQKLRVKKIHENEKRLEAGPVELLARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELSPLRAPLIPMEHCTTRFFEECDLDSDKYIALDEWAKCFGIKDDDVDQDMIV
PhyML tree of selected proteins (XP_040201059_1_SPARC__Rana_temporaria_:0.05612702,NP_989347_1_SPARC_precursor__Xenopus_tropicalis_:0.07599838,((((OWK12266_1_SPARC__Cervus_elaphus_hippelaphus_:0.00000001,((((NP_001159674_1_SPARC_precursor__Ovis_aries_:0.00000001,NP_001272591_1_SPARC_precursor__Capra_hircus_:0.00000001):0.0072356,((KAF4015265_1_hypothetical_protein_G4228_006558__Cervus_hanglu_yarkandensis_:0.02578172,(NP_001026964_1_SPARC_precursor__Sus_scrofa_:0.02226487,(XP_005619329_1_SPARC__Canis_lupus_familiaris_:0.00727566,XP_003981423_1_SPARC__Felis_catus_:0.0072949):0.00374589):0.00000001):0.00359702,(XP_008253505_1_PREDICTED__SPARC_isoform_X1__Oryctolagus_cuniculus_:0.02232563,(NP_036788_1_SPARC_precursor__Rattus_norvegicus_:0.0106174,NP_033268_1_SPARC_precursor__Mus_musculus_:0.02409815):0.05406403):0.01070132):0.00000001):0.00000001,(NP_776889_1_SPARC_precursor__Bos_taurus_:0.00000001,((XP_001168719_1_SPARC__Pan_troglodytes_:0.00000001,(NP_003109_1_SPARC_isoform_1_precursor__Homo_sapiens_:0.00000001,XP_008952671_1_SPARC__Pan_paniscus_:0.00000001):0.00000001):0.00000001,(NP_001127042_1_SPARC_precursor__Pongo_abelii_:0.00357746,XP_004042902_1_SPARC__Gorilla_gorilla_gorilla_:0.00356619):0.00000001):0.01086273):0.00360422):0.00000001,(XP_043320843_1_SPARC__Cervus_canadensis_:0.00000001,XP_020736578_1_SPARC__Odocoileus_virginianus_texanus_:0.06142833):0.00000001):0.00000001):0.00361367,(KAB0386973_1_hypothetical_protein_FD755_001929__Muntiacus_reevesi_:0.01098618,KAB0357987_1_hypothetical_protein_FD754_002143__Muntiacus_muntjak_:0.00000001):0.00000001):0.06214085,(XP_005503434_1_SPARC__Columba_livia_:0.00880835,((XP_014374238_1_SPARC__Alligator_sinensis_:0.00000001,XP_006270448_1_PREDICTED__SPARC__Alligator_mississippiensis_:0.00000001):0.05703116,((XP_039273208_1_SPARC_like__Styela_clava_:0.99804603,((XP_038060164_1_SPARC_like__Patiria_miniata_:0.96797613,NP_001091924_1_secreted_protein__acidic__cysteine_rich_precursor__Strongylocentrotus_purpuratus_:1.08254963):0.34357568,(XP_031562150_1_SPARC_like__Actinia_tenebrosa_:3.55342181,(NP_500039_1_SPARC__Caenorhabditis_elegans_:0.7185574,(NP_001262998_1_secreted_protein__acidic__cysteine_rich__isoform_B__Drosophila_melanogaster_:0.54426095,XP_006562631_2_SPARC__Apis_mellifera_:0.44694063):1.02083852):0.28272783):0.28164536):0.65003618):1.02068324,(NP_989741_1_SPARC_precursor__Gallus_gallus_:0.02655978,XP_010717456_1_SPARC__Meleagris_gallopavo_:0.00000001):0.00000001):0.00468208):0.00526791):0.06348262):0.03718451,(NP_001001942_1_SPARC_precursor__Danio_rerio_:0.10368714,(XP_015807480_1_PREDICTED__SPARC__Nothobranchius_furzeri_:0.0672756,(XP_011478747_1_SPARC_isoform_X1__Oryzias_latipes_:0.07011973,XP_030252915_1_SPARC__Sparus_aurata_:0.07070721):0.01407621):0.0253352):0.09668925):0.07561675);
BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)