PB0004

DATABASE

Click here to access PB0004 phyletic profile

PBID	Uniprot	Name	Gene	Alternative	Organism	Uniprot Description
PB0004	P08493	Matrix Gla protein	MGP	NTI, GIG36, MGLAP	Homo_sapiens	Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.

Domains

Gene Ontology

PF00594 (GLA domain)

GO:0005201 (enables) extracellular matrix structural constituent GO:0005509 (enables) calcium ion binding GO:0005515 (enables) protein binding GO:0008147 (enables) structural constituent of bone GO:0001502 (involved in) cartilage condensation GO:0001503 (involved in) ossification GO:0030154 (involved in) cell differentiation GO:0030500 (involved in) regulation of bone mineralization GO:0051216 (involved in) cartilage development GO:0005576 (located in) extracellular region GO:0031012 (located in) extracellular matrix GO:0062023 (located in) collagen-containing extracellular matrix GO:0070062 (located in) extracellular exosome

External Links	Description
Intact	Open source database system and analysis tools for molecular interaction data.
Protein Atlas	An open access resource for human proteins
InterPro (new pfam)	InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish) >sp|P08493|MGP_HUMAN Matrix Gla protein OS=Homo sapiens OX=9606 GN=MGP PE=1 SV=2 MKSLILLAILAALAVVTLCYESHESMESYELNPFINRRNANTFISPQQRWRAKVQERIRE RSKPVHELNREACDDYRLCERYAMVYGYNAAYNRYFRKRRGTK >tr|Q6YND0|Q6YND0_DANRE Matrix Gla protein OS=Danio rerio OX=7955 GN=mgp PE=2 SV=1 MCVSPQCVFLCVVLALGAAAAYDSQESRESLEVFVNPYQANAFMRNTQHNPYIYRRMKTP AERRAEVCEDFSPCRVFALRYGSQVAYQTFFSPQQLRANQQLRRY
Selected proteins from model organisms >NP_000891.2 matrix Gla protein isoform 2 preproprotein [Homo sapiens] MKSLILLAILAALAVVTLCYESHESMESYELNPFINRRNANTFISPQQRWRAKVQERIRERSKPVHELNR EACDDYRLCERYAMVYGYNAAYNRYFRKRRGTK >NP_032623.1 matrix Gla protein precursor [Mus musculus] MKSLLPLAILAALAVATLCYESHESMESYEISPFINRRNANTFMSPQQRWRAKAQKRVQERNKPAYEINR EACDDYKLCERYAMVYGYNAAYNRYFRQRRGAKY >OWK03864.1 MGP [Cervus elaphus hippelaphus] MPTSLHLLRPPPTGSTPFSCSDSYKNPTAFHQQPVVVPPHCCCRRRCERPGDTMKSLLLLSILAALAMAALCYESHESLE SYEINPFINRRNANTFISPQLRWRAKAQERIRELNKPQYELNREACDDFKLCERYAMMYGYNAAYDRYFRQRRGAK >XP_040214619.1 matrix Gla protein-like [Rana temporaria] MKTLGVLLVLALAAVVALAYDSHESHESNERYDPFVNSRTANTFMRTQQRPSRMNERIRERNKSPQERQREVCEDYKPCD RYALRHGYTAAYRKYFGQRAGGK >XP_043296428.1 matrix Gla protein [Cervus canadensis] MKSLLLLSILAALAMAALCYESHESLESYEINPFINRRNANTFISPQLRWRVKAQERIRELNKPQYELNREACDDFKLCE RYAMMYGYNAAYDRYFRQRRGAK >KAB0347300.1 hypothetical protein FD754_012157 [Muntiacus muntjak] MKSLLLLCILAALAMAALCYGEWEKGEIFSFSVVSVLSLTWHRAQCEMSAEAKSHESLESYEISPFINRRNANTFISPQL RWRAKAQERIRELNKPQYELNREACDDFKLCERYAMVYGYNAAYDRYFRQRRGAK >KAB0387143.1 hypothetical protein FD755_002099 [Muntiacus reevesi] MKSQLLLCILAALAMAALCYGEWEKEEIFSFSVVSVLSLTWHRAQCEMSAEAKSHESLESYEISPFINRRNANTFISPQL RWRAKAQERIRELNKPQYELNREACDDFKLCERYAMVYGYNAAYDRYFRQRRGAK >KAF4022749.1 hypothetical protein G4228_014984 [Cervus hanglu yarkandensis] MKSLLLLSILAALAMAALCYDPFINRRNANTFISPQLRWRAKAQERIRELNKPQYELNREACDDFKLCERYAMMYGYNAA YDRYFRQRRGAK >NP_001079088.1 matrix Gla protein L homeolog precursor [Xenopus laevis] MKTLPVILLLALAAAVAFAYDSYESHESLEVYDPFLNSRKANSFMNSQAKNQRMNERIRERNKSPRERQREACEDYDPCE RYALRYGFTAAYKRYFGQRRGEKK >XP_004071859.1 matrix Gla protein [Oryzias latipes] MRSLLQCLALCAAVSFCACYDSHESTESFEDLFVPRNRANSFITPQRRNVFVPPRSIGNNQFNVWRPRKS PAEMQAETCEDFSPCRLYAYRFGYQQAYRRYFGLGGRNRLPQSYRPAGSRGF >XP_030262438.1 matrix Gla protein isoform X1 [Sparus aurata] MRSLLQFLALFAAVSVCLCYESHESTESIEDLFVPPNQANSFITPQRGNVYSPPRGNGLNNYNLMRKVKS PAERRAETCEDYSPCRFYAYRHGFQQAYQRYFGARNTPQRPAATRRY >NP_036994.2 matrix Gla protein precursor [Rattus norvegicus] MKSLLPLAILAALAVAALCYESHESMESYEVSPFTNRRNANTFISPQQRWHAKAQERVRELNKPAQEINR EACDDYKLCERYALIYGYNAAYNRYFRQRRGAK >NP_777132.1 matrix Gla protein precursor [Bos taurus] MKSLLLLSILAALAVAALCYESHESLESYEINPFINRRNANSFISPQQRWRAKAQERIRELNKPQYELNR EACDDFKLCERYAMVYGYNAAYDRYFRQRRGAK >NP_990375.1 matrix Gla protein precursor [Gallus gallus] MRALIVLVLLAVLVMAATCYESHESMESHEYLNPFLNRQRANGFIRDDTGLRAVLQERIRERNKAPQERQ REICEDFHLCEQYALNHGYPAAYRHYFGRRRNK >NP_999281.1 matrix Gla protein precursor [Sus scrofa] MKSLLLLSVLAALAVAALCYESHESLESYEINPFLNRRNANTFISPQQRWRAKAQERIRELNKPPYELNR EACDDYKLCERYAMVYGYNAAYNRYFRQRPGAK >NP_991203.1 matrix Gla protein precursor [Danio rerio] MCVSPQCVFLCVVLALGAAAAYDSQESRESLEVFVNPYQANAFMRNTQHNPYIYRRMKTPAERRAEVCED FSPCRVFALRYGSQVAYQTFFSPQQLRANQQLRRY >XP_520764.3 matrix Gla protein [Pan troglodytes] MKSLILLAILAALVVVTLCYESHESMESYELNPFINRRHANTFISPQQRWRAKVQERIRERSKPVHELNR EACDDYRLCERYAMVYGYNAAYNRYFRKRRGAK >NP_001075669.1 matrix Gla protein precursor [Oryctolagus cuniculus] MRSLLLLTVLAALVVAILCYESHESMESYEINPFINRRNANTFMSPQQRWMAKAQERVREQRKPAYELNR EACDDYKLCERYAMVYGYNAAYNRYFRQRRRAE >NP_001125014.1 matrix Gla protein precursor [Pongo abelii] MKSLVLLAILAALAVVTLCYESHESMESYELNPFINRRNANIFISPQQRWRAKVQERIRERSKPVHELNR EACDDYRLCERYAMVYGYNAAYNRYFRERRGAK >XP_003202250.1 matrix Gla protein [Meleagris gallopavo] MRSLVVLVLLAVSVMAATCYESHESMESHEYLNPFLNRQRANGFIRDDTGLRAVLQERIRERNKAPQERQ REICEDFYLCEQYALNHGYPAAYRHYFGRRRNK >XP_003640024.1 matrix Gla protein [Canis lupus familiaris] MKSLLLLSILAALAVAALCYESHESMESYEINPFINRRNANTFISPQQRWRAKAQERIRETTKPAYELNR EACDDFKLCERYAMVYGYNAAYNRYFRHRRGGK >XP_003816565.1 matrix Gla protein [Pan paniscus] MKSLILLAILAALAVVTLCYESHESMESYELNPFINRRHANTFISPQQRWRAKVQERIRERSKPVHELNR EACDDYRLCERYAMVYGYNAAYNRYFRKRRGAK >XP_003988494.1 matrix Gla protein [Felis catus] MKSLLLLSILAALAVAVLCYESHESMESYEIYPFTNRRNANTFISPQQRWRAKAHERIRERTKPTYEINR EACDDFKLCERYAMVYGYNAAYNRYFQQRRGGK >XP_004006882.1 matrix Gla protein [Ovis aries] MKSLLLLSILAALAVAALCYESHESLESYEINPFINRRNANTFISPQQRWRAKAQERIRELNKPQYELNR EACDDFKLCERYAMVYGYNAAYDRYFRQRRGAK >XP_004052839.1 matrix Gla protein isoform X1 [Gorilla gorilla gorilla] MKSLILLAILAALAVVTLCYGEWQKEENFCFDIVSVLSLNWHRAQESHESMESYELNPFINRRHANTFIS PQQRWRAKVQERIRERSKPVHELNREACDDYRLCERYAMVYGYNAAYNRYFRKRRGAK >XP_005515132.1 matrix Gla protein [Columba livia] MRTLIIFTLLAVLAAIATCYESHESMESHEYLNPFINRRRANGFMQADTRLEGISQERLRERIKSPQERQ REICEDYYPCELYAFRHGYAAAYKHYFGRRRTK >XP_006024255.1 matrix Gla protein [Alligator sinensis] MRTIIILALLAVLVMAAFCYESQESMESHEFTSPFVTRQSAHDFMRPDPRQKAIMRERIRERHKSPQERH REICEDYYPCERYAYHHGYAAAYKRFFVKRTTK >XP_006268116.1 PREDICTED: matrix Gla protein [Alligator mississippiensis] MRTIIILALLAVLVMAAFCYESQESMESHEFTSPFVTRQSAHDFMRPDPRQKAIMRERIRERHKSPQERH REICEDYYPCERYAYHHGYAAAYKRFFVKRTTK >XP_015800807.1 PREDICTED: matrix Gla protein isoform X1 [Nothobranchius furzeri] MRSLLQLVALCATLSLCVCYDSHESTESREVPDLFVRPNQANSFISSNRFNQLGRNRFNYFMRSRKPQSE IRAETCEDYSPCRLYAYRYGYQQAYQRYFRARLPTQQAYRPAGIRGF >XP_017903930.1 PREDICTED: matrix Gla protein [Capra hircus] MKSLLLLSILAALAVAALCYESHESLESYEINPFINRRNANTFISPQQRWRAKAQERIRELNKPQYELNR EACDDFKLCERYAMVYGYNAAYDRYFRQRRGAK >XP_020743123.1 matrix Gla protein [Odocoileus virginianus texanus] MKSLLLLSILAALAMAALCYESHESLESYEINPFINRRNANTFISPQLRWRAKAQERIRELNKPQYELNR EACDDFKLCERYAMVYGYNAAYDRYFRQRRGAK
Mafft alignment of selected proteins >NP_000891.2 matrix Gla protein isoform 2 preproprotein [Homo sapiens] -----------------------------------------------------MKSLILL AILAALAVVTLCY--------------------------------ESHESMESYE-LNPF INRRNANTFISPQQR-------WRAKVQER-IRERSKPVHELNREACDDYRLCERYAMVY GYNAAYNRYFR--KRRGTK----------- >NP_032623.1 matrix Gla protein precursor [Mus musculus] -----------------------------------------------------MKSLLPL AILAALAVATLCY--------------------------------ESHESMESYE-ISPF INRRNANTFMSPQQR-------WRAKAQKR-VQERNKPAYEINREACDDYKLCERYAMVY GYNAAYNRYFR--QRRGAK----------Y >OWK03864.1 MGP [Cervus elaphus hippelaphus] MPTSLHLLRPPPTGSTPFSCSDSYKNPTAFHQQPVVVPPHCCCRRRCERPGDTMKSLLLL SILAALAMAALCY--------------------------------ESHESLESYE-INPF INRRNANTFISPQLR-------WRAKAQER-IRELNKPQYELNREACDDFKLCERYAMMY GYNAAYDRYFR--QRRGAK----------- >XP_040214619.1 matrix Gla protein-like [Rana temporaria] -----------------------------------------------------MKTLGVL LVLALAAVVALAY--------------------------------DSHESHESNERYDPF VNSRTANTFMRTQQR--------PSRMNER-IRERNKSPQERQREVCEDYKPCDRYALRH GYTAAYRKYFG--QRAGGK----------- >XP_043296428.1 matrix Gla protein [Cervus canadensis] -----------------------------------------------------MKSLLLL SILAALAMAALCY--------------------------------ESHESLESYE-INPF INRRNANTFISPQLR-------WRVKAQER-IRELNKPQYELNREACDDFKLCERYAMMY GYNAAYDRYFR--QRRGAK----------- >KAB0347300.1 hypothetical protein FD754_012157 [Muntiacus muntjak] -----------------------------------------------------MKSLLLL CILAALAMAALCYGEWEKGEIFSFSVVSVLSLTWHRAQCEMSAEAKSHESLESYE-ISPF INRRNANTFISPQLR-------WRAKAQER-IRELNKPQYELNREACDDFKLCERYAMVY GYNAAYDRYFR--QRRGAK----------- >KAB0387143.1 hypothetical protein FD755_002099 [Muntiacus reevesi] -----------------------------------------------------MKSQLLL CILAALAMAALCYGEWEKEEIFSFSVVSVLSLTWHRAQCEMSAEAKSHESLESYE-ISPF INRRNANTFISPQLR-------WRAKAQER-IRELNKPQYELNREACDDFKLCERYAMVY GYNAAYDRYFR--QRRGAK----------- >KAF4022749.1 hypothetical protein G4228_014984 [Cervus hanglu yarkandensis] -----------------------------------------------------MKSLLLL SILAALAMAALCY--------------------------------D------------PF INRRNANTFISPQLR-------WRAKAQER-IRELNKPQYELNREACDDFKLCERYAMMY GYNAAYDRYFR--QRRGAK----------- >NP_001079088.1 matrix Gla protein L homeolog precursor [Xenopus laevis] -----------------------------------------------------MKTLPVI LLLALAAAVAFAY--------------------------------DSYESHESLEVYDPF LNSRKANSFMNSQAK--------NQRMNER-IRERNKSPRERQREACEDYDPCERYALRY GFTAAYKRYFG--QRRGEK----------K >XP_004071859.1 matrix Gla protein [Oryzias latipes] -----------------------------------------------------MRSLLQC LALCAAVSFCACY--------------------------------DSHESTESFE--DLF VPRNRANSFITPQRRNVFVPPRSIGNNQFN-VWRPRKSPAEMQAETCEDFSPCRLYAYRF GYQQAYRRYFGLGGRNRLPQSYRPAGSRGF >XP_030262438.1 matrix Gla protein isoform X1 [Sparus aurata] -----------------------------------------------------MRSLLQF LALFAAVSVCLCY--------------------------------ESHESTESIE--DLF VPPNQANSFITPQRGNVYSPPRGNGLNNYN-LMRKVKSPAERRAETCEDYSPCRFYAYRH GFQQAYQRYFG--ARNTPQ---RPAATRRY >NP_036994.2 matrix Gla protein precursor [Rattus norvegicus] -----------------------------------------------------MKSLLPL AILAALAVAALCY--------------------------------ESHESMESYE-VSPF TNRRNANTFISPQQR-------WHAKAQER-VRELNKPAQEINREACDDYKLCERYALIY GYNAAYNRYFR--QRRGAK----------- >NP_777132.1 matrix Gla protein precursor [Bos taurus] -----------------------------------------------------MKSLLLL SILAALAVAALCY--------------------------------ESHESLESYE-INPF INRRNANSFISPQQR-------WRAKAQER-IRELNKPQYELNREACDDFKLCERYAMVY GYNAAYDRYFR--QRRGAK----------- >NP_990375.1 matrix Gla protein precursor [Gallus gallus] -----------------------------------------------------MRALIVL VLLAVLVMAATCY--------------------------------ESHESMESHEYLNPF LNRQRANGFIRDDTG-------LRAVLQER-IRERNKAPQERQREICEDFHLCEQYALNH GYPAAYRHYFG--RRRNK------------ >NP_999281.1 matrix Gla protein precursor [Sus scrofa] -----------------------------------------------------MKSLLLL SVLAALAVAALCY--------------------------------ESHESLESYE-INPF LNRRNANTFISPQQR-------WRAKAQER-IRELNKPPYELNREACDDYKLCERYAMVY GYNAAYNRYFR--QRPGAK----------- >NP_991203.1 matrix Gla protein precursor [Danio rerio] M------------------C---------------------------------VSPQCVF LCVVLALGAAAAY--------------------------------DSQESRESLE---VF VNPYQANAFMRNTQHNPY-------------IYRRMKTPAERRAEVCEDFSPCRVFALRY GSQVAYQTFFS--PQQLRA----NQQLRRY >XP_520764.3 matrix Gla protein [Pan troglodytes] -----------------------------------------------------MKSLILL AILAALVVVTLCY--------------------------------ESHESMESYE-LNPF INRRHANTFISPQQR-------WRAKVQER-IRERSKPVHELNREACDDYRLCERYAMVY GYNAAYNRYFR--KRRGAK----------- >NP_001075669.1 matrix Gla protein precursor [Oryctolagus cuniculus] -----------------------------------------------------MRSLLLL TVLAALVVAILCY--------------------------------ESHESMESYE-INPF INRRNANTFMSPQQR-------WMAKAQER-VREQRKPAYELNREACDDYKLCERYAMVY GYNAAYNRYFR--QRRRAE----------- >NP_001125014.1 matrix Gla protein precursor [Pongo abelii] -----------------------------------------------------MKSLVLL AILAALAVVTLCY--------------------------------ESHESMESYE-LNPF INRRNANIFISPQQR-------WRAKVQER-IRERSKPVHELNREACDDYRLCERYAMVY GYNAAYNRYFR--ERRGAK----------- >XP_003202250.1 matrix Gla protein [Meleagris gallopavo] -----------------------------------------------------MRSLVVL VLLAVSVMAATCY--------------------------------ESHESMESHEYLNPF LNRQRANGFIRDDTG-------LRAVLQER-IRERNKAPQERQREICEDFYLCEQYALNH GYPAAYRHYFG--RRRNK------------ >XP_003640024.1 matrix Gla protein [Canis lupus familiaris] -----------------------------------------------------MKSLLLL SILAALAVAALCY--------------------------------ESHESMESYE-INPF INRRNANTFISPQQR-------WRAKAQER-IRETTKPAYELNREACDDFKLCERYAMVY GYNAAYNRYFR--HRRGGK----------- >XP_003816565.1 matrix Gla protein [Pan paniscus] -----------------------------------------------------MKSLILL AILAALAVVTLCY--------------------------------ESHESMESYE-LNPF INRRHANTFISPQQR-------WRAKVQER-IRERSKPVHELNREACDDYRLCERYAMVY GYNAAYNRYFR--KRRGAK----------- >XP_003988494.1 matrix Gla protein [Felis catus] -----------------------------------------------------MKSLLLL SILAALAVAVLCY--------------------------------ESHESMESYE-IYPF TNRRNANTFISPQQR-------WRAKAHER-IRERTKPTYEINREACDDFKLCERYAMVY GYNAAYNRYFQ--QRRGGK----------- >XP_004006882.1 matrix Gla protein [Ovis aries] -----------------------------------------------------MKSLLLL SILAALAVAALCY--------------------------------ESHESLESYE-INPF INRRNANTFISPQQR-------WRAKAQER-IRELNKPQYELNREACDDFKLCERYAMVY GYNAAYDRYFR--QRRGAK----------- >XP_004052839.1 matrix Gla protein isoform X1 [Gorilla gorilla gorilla] -----------------------------------------------------MKSLILL AILAALAVVTLCYGEWQKEENFCFDIVSVLSLNWHRAQ-------ESHESMESYE-LNPF INRRHANTFISPQQR-------WRAKVQER-IRERSKPVHELNREACDDYRLCERYAMVY GYNAAYNRYFR--KRRGAK----------- >XP_005515132.1 matrix Gla protein [Columba livia] -----------------------------------------------------MRTLIIF TLLAVLAAIATCY--------------------------------ESHESMESHEYLNPF INRRRANGFMQADTR-------LEGISQER-LRERIKSPQERQREICEDYYPCELYAFRH GYAAAYKHYFG--RRRTK------------ >XP_006024255.1 matrix Gla protein [Alligator sinensis] -----------------------------------------------------MRTIIIL ALLAVLVMAAFCY--------------------------------ESQESMESHEFTSPF VTRQSAHDFMRPDPR-------QKAIMRER-IRERHKSPQERHREICEDYYPCERYAYHH GYAAAYKRFFV--KRTTK------------ >XP_006268116.1 PREDICTED: matrix Gla protein [Alligator mississippiensis] -----------------------------------------------------MRTIIIL ALLAVLVMAAFCY--------------------------------ESQESMESHEFTSPF VTRQSAHDFMRPDPR-------QKAIMRER-IRERHKSPQERHREICEDYYPCERYAYHH GYAAAYKRFFV--KRTTK------------ >XP_015800807.1 PREDICTED: matrix Gla protein isoform X1 [Nothobranchius furzeri] -----------------------------------------------------MRSLLQL VALCATLSLCVCY--------------------------------DSHESTESREVPDLF VRPNQANSFISSNRFN------QLGRNRFNYFMRSRKPQSEIRAETCEDYSPCRLYAYRY GYQQAYQRYFR--ARLPTQQAYRPAGIRGF >XP_017903930.1 PREDICTED: matrix Gla protein [Capra hircus] -----------------------------------------------------MKSLLLL SILAALAVAALCY--------------------------------ESHESLESYE-INPF INRRNANTFISPQQR-------WRAKAQER-IRELNKPQYELNREACDDFKLCERYAMVY GYNAAYDRYFR--QRRGAK----------- >XP_020743123.1 matrix Gla protein [Odocoileus virginianus texanus] -----------------------------------------------------MKSLLLL SILAALAMAALCY--------------------------------ESHESLESYE-INPF INRRNANTFISPQLR-------WRAKAQER-IRELNKPQYELNREACDDFKLCERYAMVY GYNAAYDRYFR--QRRGAK-----------
BMGE Cleaned alignment of selected proteins >NP_000891.2 matrix Gla protein isoform 2 preproprotein [Homo sapiens] MKSLILLAILAALAVVTLCYESHESMESYELNPFINRRNANTFISPQQRWRAKVQERIRERSKPVHELNREACDDYRLCERYAMVYGYNAAYNRYFRKRRGTK >NP_032623.1 matrix Gla protein precursor [Mus musculus] MKSLLPLAILAALAVATLCYESHESMESYEISPFINRRNANTFMSPQQRWRAKAQKRVQERNKPAYEINREACDDYKLCERYAMVYGYNAAYNRYFRQRRGAK >OWK03864.1 MGP [Cervus elaphus hippelaphus] MKSLLLLSILAALAMAALCYESHESLESYEINPFINRRNANTFISPQLRWRAKAQERIRELNKPQYELNREACDDFKLCERYAMMYGYNAAYDRYFRQRRGAK >XP_040214619.1 matrix Gla protein-like [Rana temporaria] MKTLGVLLVLALAAVVALAYDSHESHESNEYDPFVNSRTANTFMRTQQR-PSRMNERIRERNKSPQERQREVCEDYKPCDRYALRHGYTAAYRKYFGQRAGGK >XP_043296428.1 matrix Gla protein [Cervus canadensis] MKSLLLLSILAALAMAALCYESHESLESYEINPFINRRNANTFISPQLRWRVKAQERIRELNKPQYELNREACDDFKLCERYAMMYGYNAAYDRYFRQRRGAK >KAB0347300.1 hypothetical protein FD754_012157 [Muntiacus muntjak] MKSLLLLCILAALAMAALCYKSHESLESYEISPFINRRNANTFISPQLRWRAKAQERIRELNKPQYELNREACDDFKLCERYAMVYGYNAAYDRYFRQRRGAK >KAB0387143.1 hypothetical protein FD755_002099 [Muntiacus reevesi] MKSQLLLCILAALAMAALCYKSHESLESYEISPFINRRNANTFISPQLRWRAKAQERIRELNKPQYELNREACDDFKLCERYAMVYGYNAAYDRYFRQRRGAK >KAF4022749.1 hypothetical protein G4228_014984 [Cervus hanglu yarkandensis] MKSLLLLSILAALAMAALCYD-----------PFINRRNANTFISPQLRWRAKAQERIRELNKPQYELNREACDDFKLCERYAMMYGYNAAYDRYFRQRRGAK >NP_001079088.1 matrix Gla protein L homeolog precursor [Xenopus laevis] MKTLPVILLLALAAAVAFAYDSYESHESLEYDPFLNSRKANSFMNSQAK-NQRMNERIRERNKSPRERQREACEDYDPCERYALRYGFTAAYKRYFGQRRGEK >XP_004071859.1 matrix Gla protein [Oryzias latipes] MRSLLQCLALCAAVSFCACYDSHESTESFE-DLFVPRNRANSFITPQRRSIGNNQFNVWRPRKSPAEMQAETCEDFSPCRLYAYRFGYQQAYRRYFGGRNRLP >XP_030262438.1 matrix Gla protein isoform X1 [Sparus aurata] MRSLLQFLALFAAVSVCLCYESHESTESIE-DLFVPPNQANSFITPQRGGNGLNNYNLMRKVKSPAERRAETCEDYSPCRFYAYRHGFQQAYQRYFGARNTPQ >NP_036994.2 matrix Gla protein precursor [Rattus norvegicus] MKSLLPLAILAALAVAALCYESHESMESYEVSPFTNRRNANTFISPQQRWHAKAQERVRELNKPAQEINREACDDYKLCERYALIYGYNAAYNRYFRQRRGAK >NP_777132.1 matrix Gla protein precursor [Bos taurus] MKSLLLLSILAALAVAALCYESHESLESYEINPFINRRNANSFISPQQRWRAKAQERIRELNKPQYELNREACDDFKLCERYAMVYGYNAAYDRYFRQRRGAK >NP_990375.1 matrix Gla protein precursor [Gallus gallus] MRALIVLVLLAVLVMAATCYESHESMESHELNPFLNRQRANGFIRDDTGLRAVLQERIRERNKAPQERQREICEDFHLCEQYALNHGYPAAYRHYFGRRRNK- >NP_999281.1 matrix Gla protein precursor [Sus scrofa] MKSLLLLSVLAALAVAALCYESHESLESYEINPFLNRRNANTFISPQQRWRAKAQERIRELNKPPYELNREACDDYKLCERYAMVYGYNAAYNRYFRQRPGAK >NP_991203.1 matrix Gla protein precursor [Danio rerio] VSPQCVFLCVVLALGAAAAYDSQESRESLE--VFVNPYQANAFMRNTQH--------IYRRMKTPAERRAEVCEDFSPCRVFALRYGSQVAYQTFFSPQQLRA >XP_520764.3 matrix Gla protein [Pan troglodytes] MKSLILLAILAALVVVTLCYESHESMESYELNPFINRRHANTFISPQQRWRAKVQERIRERSKPVHELNREACDDYRLCERYAMVYGYNAAYNRYFRKRRGAK >NP_001075669.1 matrix Gla protein precursor [Oryctolagus cuniculus] MRSLLLLTVLAALVVAILCYESHESMESYEINPFINRRNANTFMSPQQRWMAKAQERVREQRKPAYELNREACDDYKLCERYAMVYGYNAAYNRYFRQRRRAE >NP_001125014.1 matrix Gla protein precursor [Pongo abelii] MKSLVLLAILAALAVVTLCYESHESMESYELNPFINRRNANIFISPQQRWRAKVQERIRERSKPVHELNREACDDYRLCERYAMVYGYNAAYNRYFRERRGAK >XP_003202250.1 matrix Gla protein [Meleagris gallopavo] MRSLVVLVLLAVSVMAATCYESHESMESHELNPFLNRQRANGFIRDDTGLRAVLQERIRERNKAPQERQREICEDFYLCEQYALNHGYPAAYRHYFGRRRNK- >XP_003640024.1 matrix Gla protein [Canis lupus familiaris] MKSLLLLSILAALAVAALCYESHESMESYEINPFINRRNANTFISPQQRWRAKAQERIRETTKPAYELNREACDDFKLCERYAMVYGYNAAYNRYFRHRRGGK >XP_003816565.1 matrix Gla protein [Pan paniscus] MKSLILLAILAALAVVTLCYESHESMESYELNPFINRRHANTFISPQQRWRAKVQERIRERSKPVHELNREACDDYRLCERYAMVYGYNAAYNRYFRKRRGAK >XP_003988494.1 matrix Gla protein [Felis catus] MKSLLLLSILAALAVAVLCYESHESMESYEIYPFTNRRNANTFISPQQRWRAKAHERIRERTKPTYEINREACDDFKLCERYAMVYGYNAAYNRYFQQRRGGK >XP_004006882.1 matrix Gla protein [Ovis aries] MKSLLLLSILAALAVAALCYESHESLESYEINPFINRRNANTFISPQQRWRAKAQERIRELNKPQYELNREACDDFKLCERYAMVYGYNAAYDRYFRQRRGAK >XP_004052839.1 matrix Gla protein isoform X1 [Gorilla gorilla gorilla] MKSLILLAILAALAVVTLCYESHESMESYELNPFINRRHANTFISPQQRWRAKVQERIRERSKPVHELNREACDDYRLCERYAMVYGYNAAYNRYFRKRRGAK >XP_005515132.1 matrix Gla protein [Columba livia] MRTLIIFTLLAVLAAIATCYESHESMESHELNPFINRRRANGFMQADTRLEGISQERLRERIKSPQERQREICEDYYPCELYAFRHGYAAAYKHYFGRRRTK- >XP_006024255.1 matrix Gla protein [Alligator sinensis] MRTIIILALLAVLVMAAFCYESQESMESHETSPFVTRQSAHDFMRPDPRQKAIMRERIRERHKSPQERHREICEDYYPCERYAYHHGYAAAYKRFFVKRTTK- >XP_006268116.1 PREDICTED: matrix Gla protein [Alligator mississippiensis] MRTIIILALLAVLVMAAFCYESQESMESHETSPFVTRQSAHDFMRPDPRQKAIMRERIRERHKSPQERHREICEDYYPCERYAYHHGYAAAYKRFFVKRTTK- >XP_015800807.1 PREDICTED: matrix Gla protein isoform X1 [Nothobranchius furzeri] MRSLLQLVALCATLSLCVCYDSHESTESREPDLFVRPNQANSFISSNRFQLGRNRFNFMRSRKPQSEIRAETCEDYSPCRLYAYRYGYQQAYQRYFRARLPTQ >XP_017903930.1 PREDICTED: matrix Gla protein [Capra hircus] MKSLLLLSILAALAVAALCYESHESLESYEINPFINRRNANTFISPQQRWRAKAQERIRELNKPQYELNREACDDFKLCERYAMVYGYNAAYDRYFRQRRGAK >XP_020743123.1 matrix Gla protein [Odocoileus virginianus texanus] MKSLLLLSILAALAMAALCYESHESLESYEINPFINRRNANTFISPQLRWRAKAQERIRELNKPQYELNREACDDFKLCERYAMVYGYNAAYDRYFRQRRGAK
PhyML tree of selected proteins (XP_020743123_1_matrix_Gla_protein__Odocoileus_virginianus_texanus_:0.00000001,((XP_004006882_1_matrix_Gla_protein__Ovis_aries_:0.00000001,XP_017903930_1_PREDICTED__matrix_Gla_protein__Capra_hircus_:0.00000001):0.00000001,(NP_777132_1_matrix_Gla_protein_precursor__Bos_taurus_:0.00982594,(NP_999281_1_matrix_Gla_protein_precursor__Sus_scrofa_:0.04417508,((XP_003988494_1_matrix_Gla_protein__Felis_catus_:0.0739254,XP_003640024_1_matrix_Gla_protein__Canis_lupus_familiaris_:0.0202854):0.02563853,(((((XP_040214619_1_matrix_Gla_protein_like__Rana_temporaria_:0.14566976,NP_001079088_1_matrix_Gla_protein_L_homeolog_precursor__Xenopus_laevis_:0.22840831):0.08190848,(NP_991203_1_matrix_Gla_protein_precursor__Danio_rerio_:0.84832393,(XP_030262438_1_matrix_Gla_protein_isoform_X1__Sparus_aurata_:0.14987019,(XP_015800807_1_PREDICTED__matrix_Gla_protein_isoform_X1__Nothobranchius_furzeri_:0.33033473,XP_004071859_1_matrix_Gla_protein__Oryzias_latipes_:0.24600181):0.07936501):0.42754531):0.6813864):0.16520171,((XP_006024255_1_matrix_Gla_protein__Alligator_sinensis_:0.00000001,XP_006268116_1_PREDICTED__matrix_Gla_protein__Alligator_mississippiensis_:0.00000001):0.29743296,(XP_005515132_1_matrix_Gla_protein__Columba_livia_:0.17452727,(NP_990375_1_matrix_Gla_protein_precursor__Gallus_gallus_:0.01907891,XP_003202250_1_matrix_Gla_protein__Meleagris_gallopavo_:0.02183389):0.21706021):0.05157434):0.26058678):0.37830889,(NP_001075669_1_matrix_Gla_protein_precursor__Oryctolagus_cuniculus_:0.11524696,(NP_032623_1_matrix_Gla_protein_precursor__Mus_musculus_:0.02891727,NP_036994_2_matrix_Gla_protein_precursor__Rattus_norvegicus_:0.08752646):0.0353545):0.00246479):0.01491384,(NP_001125014_1_matrix_Gla_protein_precursor__Pongo_abelii_:0.02967542,(NP_000891_2_matrix_Gla_protein_isoform_2_preproprotein__Homo_sapiens_:0.00977678,((XP_003816565_1_matrix_Gla_protein__Pan_paniscus_:0.00000001,XP_004052839_1_matrix_Gla_protein_isoform_X1__Gorilla_gorilla_gorilla_:0.00000001):0.00000001,XP_520764_3_matrix_Gla_protein__Pan_troglodytes_:0.00965702):0.0097057):0.00000001):0.10510839):0.01403722):0.0256383):0.0224685):0.00000001):0.02014708,((XP_043296428_1_matrix_Gla_protein__Cervus_canadensis_:0.00982168,(KAF4022749_1_hypothetical_protein_G4228_014984__Cervus_hanglu_yarkandensis_:0.01057515,OWK03864_1_MGP__Cervus_elaphus_hippelaphus_:0.00000001):0.00000001):0.00998271,(KAB0347300_1_hypothetical_protein_FD754_012157__Muntiacus_muntjak_:0.00000001,KAB0387143_1_hypothetical_protein_FD755_002099__Muntiacus_reevesi_:0.00992318):0.03014449):0.00000001);
BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)