PB0002

DATABASE

Click here to access PB0002 phyletic profile

PBID	Uniprot	Name	Gene	Alternative	Organism	Uniprot Description
PB0002	P61769	Beta-2-microglobulin	B2M	IMD43	Homo_sapiens	Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation.

Domains

Gene Ontology

PF07654 (C1-set)

GO:0003254 (involved in) regulation of membrane depolarization GO:0019731 (involved in) antibacterial humoral response GO:0045087 (involved in) innate immune response GO:0050829 (involved in) defense response to Gram-negative bacterium GO:0050830 (involved in) defense response to Gram-positive bacterium GO:0061844 (involved in) antimicrobial humoral immune response mediated by antimicrobial peptide GO:0071222 (involved in) cellular response to lipopolysaccharide

External Links	Description
Intact	Open source database system and analysis tools for molecular interaction data.
Protein Atlas	An open access resource for human proteins
InterPro (new pfam)	InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish) >sp|P61769|B2MG_HUMAN Beta-2-microglobulin OS=Homo sapiens OX=9606 GN=B2M PE=1 SV=1 MSRSVALAVLALLSLSGLEAIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLL KNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM >tr|B0UYS1|B0UYS1_DANRE Beta-2-microglobulin OS=Danio rerio OX=7955 GN=b2m PE=2 SV=1 MRALITFALLCLLYITVQGKVSTPKVHVYSHFPGEYGKPNTLICYVSSFHPPDISIELLK NGQVMSDTKQTDLAFEKGWQFHLTKSVAFTPEKGDEYTCSVRHMKETKKFSWEPNM
Selected proteins from model organisms >NP_004039.1 beta-2-microglobulin precursor [Homo sapiens] MSRSVALAVLALLSLSGLEAIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVE HSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM >NP_001001750.2 beta-2-microglobulin precursor [Gallus gallus] MGKAAAVVLVTLVALLGLAQADLTPKVQVYSRFPASAGTKNVLNCFAAGFHPPKISITLMKDGVPMEGAQ YSDMSFNDDWTFQRLVHADFTPSSGSTYACKVEHETLKEPQVYKWDPEF >XP_030295460.1 beta-2-microglobulin-like [Sparus aurata] MTTSVFAVVFGLLCLQCSMAKESPPKVQVYSRVPGEFGKANTLICHVSGFHPPEITIELLKDEKEMPGAKQTDLAFEENW HYHLSRHVRFTPSEDEKYACRVTHMGTSKTFIWEADM >XP_004083039.1 beta-2-microglobulin [Oryzias latipes] MKGIVVTVVLLVCVDLGVSIKERNEQAPKVQVYSRLPGTLGKENTLICHTSGFHPPEISIKLLKNGNELPGGGQTDLAFE ESWHYHLTKHAPFTPEKGESYTCVVTHTTGTKTYTWEPDV >AAA88837.1 beta-2-microglobulin [Pongo pygmaeus] MSRSVALAVLALLSLSGLEAIQRTPKIQVYTRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGVKIEKVEHSDLSFSKDW SFYLLYYTEFTPTEKDEYACRVNHVTLSQPKTVKWDRDM >XP_015810442.1 PREDICTED: beta-2-microglobulin-like [Nothobranchius furzeri] MKELVYVVALLFLTELISAKLAEPQVQVYSRNPGQYDKSNVLICHVSGFHPPEIRVDLLKNGQEITAAKQTDLAFEEDWH YHMTKHVPFTPRTGDKFECRVSHMGKTKHYFWEPDM >NP_001088585.1 uncharacterized protein LOC495464 precursor [Xenopus laevis] MSGVSVRVVSVLLTLSVCLSSSPPEDYVVQAKSQCYYRNGTDNVRYLQRYIYNQEECVYFDSDVGLFIAKTELGKVHFAD YWNSQKEILEQKRAEVDTICRNNYQIFKPTAIDRKSQPNVKIVNTKTLDLEHENLITCLVDGFFPSMIKVTWLKNGIEEG EQVTSSELLQNGDWTFEIHVMLETTIKHGDTFTCRVEHSSLQQPVSVNWEPDVSDSARNKMLTGIVGFVLGSIFIIVGLV VYLRSKKTMTRFSMVQNENLMS >ABP37878.1 beta-2-microglobulin [Ovis aries] MARFVALVLLGLLSLSGLDAIQRIPEVQVYSRHPPEDGKPNYLNCYVYGFHPPQIEIDLLKNGEKIKSEQSDLSFSKDWS FYLLSHAEFTPNSKDQYSCRVNHVTLTQPKIVKWDRDL >KAB0337810.1 hypothetical protein FD755_025462 [Muntiacus reevesi] MAGLAALVLLGLLSLSGLDAVPRVPKVQVYSRHPPEDGKPNYLNCYVSGFHPPQIEIELLKNGEKMKSEQSDLSFSKDWS FYLLSHAEFTPNSQDTYSCRVSHITYPGPQTFVWDRDL >XP_043328732.1 beta-2-microglobulin [Cervus canadensis] MARFAALVLLGLLSLSGLDAIQRIPKVQVYSRHPPEDGKPNYLNCYVSGFHPPQIEIELLKNGEKMKSEQSDLSFSKDWS FYLLSHAEFTPNSKDQYSCRVKHITFAEPQIYAWDRDL >KAB0342900.1 hypothetical protein FD754_019826 [Muntiacus muntjak] MCLSGLYTYSVPKVQVYSRHPPEDGKPNYLNCYVSGFHPPQIEIELLKNGEKMKSEQSDLSFSKDWSFYLLSHAEFTPNS KDKYSCRVSHVTFPGPQTFVWNRDL >NP_776318.1 beta-2-microglobulin precursor [Bos taurus] MARFVALVLLGLLSLSGLDAIQRPPKIQVYSRHPPEDGKPNYLNCYVYGFHPPQIEIDLLKNGEKIKSEQSDLSFSKDWS FYLLSHAEFTPNSKDQYSCRVKHVTLEQPRIVKWDRDL >P21612.1 RecName: Full=Beta-2-microglobulin [Meleagris gallopavo] DLTPKVQVYSRFPASAGTKNVLNCFAAGFHPPKISITLMKDGVPMEGAQYSDMSFNDDWSFQRLVYADFTPSSDAVYTCK VDHETLKEPQVYKWDPEF >tr|B0UYS1|B0UYS1_DANRE Beta-2-microglobulin OS=Danio rerio OX=7955 GN=b2m PE=2 SV=1 MRALITFALLCLLYITVQGKVSTPKVHVYSHFPGEYGKPNTLICYVSSFHPPDISIELLK NGQVMSDTKQTDLAFEKGWQFHLTKSVAFTPEKGDEYTCSVRHMKETKKFSWEPNM >OWK09923.1 B2M [Cervus elaphus hippelaphus] MARFAALVLLGLLSLSGLDAIQRIPKVQVYSRHPPEDGKPNYLNCYVSGFHPPQIEIELLKNGEKMKSEQSDLSFSKDWS FYLLSHAEFTPNSKDQYSCRVKHITFAEPQIYAWDRDL >KAF4008216.1 hypothetical protein G4228_019883 [Cervus hanglu yarkandensis] MARFAALVLLGLLSLSGLDAIQRIPKVQVYSRHPPEDGKPNYLNCYVSGFHPPQIEIELLKNGEKMKSEQSDLSFSKDWS FYLLSHAEFTPNSKDQYSCRVKHITFAEPQIYAWGKFSSSLVNR >XP_020756417.1 beta-2-microglobulin [Odocoileus virginianus texanus] MPRLAALALLGLLSLSGLDAILRAPKIQVYSRHPPEDGKPNYLNCYVSGFHPPQIEIELLKNGEKMKSEQSDLSFSKDWS FYLLSHAEFTPNSQDRYSCRVTHVTYPQPQEVNWDRNL >NP_033865.2 beta-2-microglobulin precursor [Mus musculus] MARSVTLVFLVLVSLTGLYAIQKTPQIQVYSRHPPENGKPNILNCYVTQFHPPHIEIQMLKNGKKIPKVE MSDMSFSKDWSFYILAHTEFTPTETDTYACRVKHASMAEPKTVYWDRDM >NP_036644.1 beta-2-microglobulin precursor [Rattus norvegicus] MARSVTVIFLVLVSLAVVLAIQKTPQIQVYSRHPPENGKPNFLNCYVSQFHPPQIEIELLKNGKKIPNIE MSDLSFSKDWSFYILAHTEFTPTETDVYACRVKHVTLKEPKTVTWDRDM >XP_024204735.1 beta-2-microglobulin isoform X1 [Pan troglodytes] MSRSVALAVLALLSLSGLEAIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVE HSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWGKSYILL >NP_001009876.1 beta-2-microglobulin precursor [Felis catus] MARFVVLVLLGLLYLSHLDAVQHSPKVQVYSRHPAENGKPNFLNCYVSGFHPPQIDITLMKNGKKMEAEQ TDLSFNRDWTFYLLVHTEFTPTVEDEYSCQVNHTTLSEPKVVKWDRDM >XP_009248064.1 beta-2-microglobulin isoform X1 [Pongo abelii] MSRSVALAVLALLSLSGLEAIQRTPKIQVYTRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGVKIEKVE HSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKTVKWGKSYILL >XP_008267300.1 PREDICTED: beta-2-microglobulin [Oryctolagus cuniculus] MSRSVLGLALLALVLFPCLECVQRAPNVQVYSRHPAENGKPNFLNCYVSGFHPPQIDIELLKNGVKIENV EQSDLSFNKDWSFYLLVHTEFTPNDKDEYSCRVKHVTLKEPMTVKWDRDY >NP_001271408.1 beta-2-microglobulin precursor [Canis lupus familiaris] MAPRPALATAGFLALLLILLAACRLDAVQHPPKIQVYSRHPAENGKPNFLNCYVSGFHPPEIEIDLLKNG KEMKAEQTDLSFSKDWTFYLLVHTEFTPNEQDEFSCRVKHVTLSEPQIVKWDRDN >XP_008962050.1 beta-2-microglobulin isoform X1 [Pan paniscus] MSRSVALAVLALLSLSGLEAIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVE HSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWGKSYILL >XP_018866136.1 beta-2-microglobulin isoform X1 [Gorilla gorilla gorilla] MSRSVALAVLALLSLSGLEAIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVE HSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWGKSYILL >XP_005515552.2 beta-2-microglobulin [Columba livia] MTLRSSAPRLAAPDGVYKRRWLPQDGQAAGGAEREGAMGLGPKVGLLVLVALLGLGKANEAPKVEVYSRK IAALGQKNTLNCFVSGFHPPQIDITLLENGEPMEGVQYADMSFDDKWFFQRLVYVPFTPQKGSTYECRVA HSTFREPQSFRWDPDF >XP_017909307.1 PREDICTED: beta-2-microglobulin [Capra hircus] MAGFAALVLLGLLSLSGLDAIQRIPEVQVYSRHPPEDGKPNYLNCYVYGFHPPQIEIDLLKNGEKIKSEQ SDLSFSKDWSFYLLSHAEFTPNSKDQYSCRVNHVTLTQPKIVKWDRDL >XP_014455448.1 PREDICTED: beta-2-microglobulin [Alligator mississippiensis] MARAESFKTVLILLVALVGLACVEATQRSPKVQVYTRYPLGSKESNFLNCYVEGFHPPKIDIKLLKNGKE MDGVIVGDLSFSNDWTFQRLVYAPFAPNPNDVYSCRVNHDSLEQPKDVKWDPDN >XP_020952021.1 beta-2-microglobulin [Sus scrofa] MAPLVALVLLGLLSLSGLDAVARPPKVQVYSRHPAENGKPNYLNCYVSGFHPPQIEIDLLKNGEKMNAEQ SDLSFSKDWSFYLLVHTEFTPNAVDQYSCRVKHVTLDKPKIVKWDRDH
Mafft alignment of selected proteins >NP_004039.1 beta-2-microglobulin precursor [Homo sapiens] --------------------------------------MSRSV-ALAVLALLSLSGLEA- ------------------------------------------------------------ --------------------------------IQRTPKIQVYSRHPAENGKSNFLNCYVS GFHPSDIEVDLLKNG-ERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTL SQPKIVKWDRDM------------------------------------------------ - >NP_001001750.2 beta-2-microglobulin precursor [Gallus gallus] --------------------------------------MGKAA-AVVLVTLVALLGLAQ- ------------------------------------------------------------ --------------------------------ADLTPKVQVYSRFPASAGTKNVLNCFAA GFHPPKISITLMKDG-VPMEGAQYSDMSFNDDWTFQRLVHADFTPSSGSTYACKVEHETL KEPQVYKWDPEF------------------------------------------------ - >XP_030295460.1 beta-2-microglobulin-like [Sparus aurata] --------------------------------------MTTSV-FAVVFGLLCLQCSMA- ------------------------------------------------------------ --------------------------------KESPPKVQVYSRVPGEFGKANTLICHVS GFHPPEITIELLKDE-KEMPGAKQTDLAFEENWHYHLSRHVRFTPSEDEKYACRVTH--M GTSKTFIWEADM------------------------------------------------ - >XP_004083039.1 beta-2-microglobulin [Oryzias latipes] --------------------------------------MKGIV-VTVVL-LVCVDLGVS- ------------------------------------------------------------ ------IKER----------------------NEQAPKVQVYSRLPGTLGKENTLICHTS GFHPPEISIKLLKNG-NELPGGGQTDLAFEESWHYHLTKHAPFTPEKGESYTCVVTH--T TGTKTYTWEPDV------------------------------------------------ - >AAA88837.1 beta-2-microglobulin [Pongo pygmaeus] --------------------------------------MSRSV-ALAVLALLSLSGLEA- ------------------------------------------------------------ --------------------------------IQRTPKIQVYTRHPAENGKSNFLNCYVS GFHPSDIEVDLLKNG-VKIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTL SQPKTVKWDRDM------------------------------------------------ - >XP_015810442.1 PREDICTED: beta-2-microglobulin-like [Nothobranchius furzeri] --------------------------------------MKELV-YVVAL-LFLTELISA- ------------------------------------------------------------ --------------------------------KLAEPQVQVYSRNPGQYDKSNVLICHVS GFHPPEIRVDLLKNG-QEITAAKQTDLAFEEDWHYHMTKHVPFTPRTGDKFECRVSH--M GKTKHYFWEPDM------------------------------------------------ - >NP_001088585.1 uncharacterized protein LOC495464 precursor [Xenopus laevis] --------------------------------------MSGVS-VRVVSVLLTLSVCLSS SPPEDYVVQAKSQCYYRNGTDNVRYLQRYIYNQEECVYFDSDVGLFIAKTELGKVHFADY WNSQKEILEQKRAEVDTICRNNYQIFKPTAIDRKSQPNVKIVNTKTLDLEHENLITCLVD GFFPSMIKVTWLKNGIEEGEQVTSSELLQNGDWTFEIHVMLETTIKHGDTFTCRVEHSSL QQPVSVNWEPDVSDSARNKMLTGIVGFVLGSIFIIVGLVVYLRSKKTMTRFSMVQNENLM S >ABP37878.1 beta-2-microglobulin [Ovis aries] --------------------------------------MARFV-ALVLLGLLSLSGLDA- ------------------------------------------------------------ --------------------------------IQRIPEVQVYSRHPPEDGKPNYLNCYVY GFHPPQIEIDLLKNG-EKIK-SEQSDLSFSKDWSFYLLSHAEFTPNSKDQYSCRVNHVTL TQPKIVKWDRDL------------------------------------------------ - >KAB0337810.1 hypothetical protein FD755_025462 [Muntiacus reevesi] --------------------------------------MAGLA-ALVLLGLLSLSGLDA- ------------------------------------------------------------ --------------------------------VPRVPKVQVYSRHPPEDGKPNYLNCYVS GFHPPQIEIELLKNG-EKMK-SEQSDLSFSKDWSFYLLSHAEFTPNSQDTYSCRVSHITY PGPQTFVWDRDL------------------------------------------------ - >XP_043328732.1 beta-2-microglobulin [Cervus canadensis] --------------------------------------MARFA-ALVLLGLLSLSGLDA- ------------------------------------------------------------ --------------------------------IQRIPKVQVYSRHPPEDGKPNYLNCYVS GFHPPQIEIELLKNG-EKMK-SEQSDLSFSKDWSFYLLSHAEFTPNSKDQYSCRVKHITF AEPQIYAWDRDL------------------------------------------------ - >KAB0342900.1 hypothetical protein FD754_019826 [Muntiacus muntjak] ---------------------------------------------------MCLSGLYT- ------------------------------------------------------------ --------------------------------Y-SVPKVQVYSRHPPEDGKPNYLNCYVS GFHPPQIEIELLKNG-EKMK-SEQSDLSFSKDWSFYLLSHAEFTPNSKDKYSCRVSHVTF PGPQTFVWNRDL------------------------------------------------ - >NP_776318.1 beta-2-microglobulin precursor [Bos taurus] --------------------------------------MARFV-ALVLLGLLSLSGLDA- ------------------------------------------------------------ --------------------------------IQRPPKIQVYSRHPPEDGKPNYLNCYVY GFHPPQIEIDLLKNG-EKIK-SEQSDLSFSKDWSFYLLSHAEFTPNSKDQYSCRVKHVTL EQPRIVKWDRDL------------------------------------------------ - >P21612.1 RecName: Full=Beta-2-microglobulin [Meleagris gallopavo] ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------DLTPKVQVYSRFPASAGTKNVLNCFAA GFHPPKISITLMKDG-VPMEGAQYSDMSFNDDWSFQRLVYADFTPSSDAVYTCKVDHETL KEPQVYKWDPEF------------------------------------------------ - >tr|B0UYS1|B0UYS1_DANRE Beta-2-microglobulin OS=Danio rerio OX=7955 GN=b2m PE=2 SV=1 --------------------------------------MRALI-TFALL-CLLYITVQG- ------------------------------------------------------------ --------------------------------KVSTPKVHVYSHFPGEYGKPNTLICYVS SFHPPDISIELLKNG-QVMSDTKQTDLAFEKGWQFHLTKSVAFTPEKGDEYTCSVRH--M KETKKFSWEPNM------------------------------------------------ - >OWK09923.1 B2M [Cervus elaphus hippelaphus] --------------------------------------MARFA-ALVLLGLLSLSGLDA- ------------------------------------------------------------ --------------------------------IQRIPKVQVYSRHPPEDGKPNYLNCYVS GFHPPQIEIELLKNG-EKMK-SEQSDLSFSKDWSFYLLSHAEFTPNSKDQYSCRVKHITF AEPQIYAWDRDL------------------------------------------------ - >KAF4008216.1 hypothetical protein G4228_019883 [Cervus hanglu yarkandensis] --------------------------------------MARFA-ALVLLGLLSLSGLDA- ------------------------------------------------------------ --------------------------------IQRIPKVQVYSRHPPEDGKPNYLNCYVS GFHPPQIEIELLKNG-EKMK-SEQSDLSFSKDWSFYLLSHAEFTPNSKDQYSCRVKHITF AEPQIYAWGKFSS------SLVN------------------------------------- R >XP_020756417.1 beta-2-microglobulin [Odocoileus virginianus texanus] --------------------------------------MPRLA-ALALLGLLSLSGLDA- ------------------------------------------------------------ --------------------------------ILRAPKIQVYSRHPPEDGKPNYLNCYVS GFHPPQIEIELLKNG-EKMK-SEQSDLSFSKDWSFYLLSHAEFTPNSQDRYSCRVTHVTY PQPQEVNWDRNL------------------------------------------------ - >NP_033865.2 beta-2-microglobulin precursor [Mus musculus] --------------------------------------MARSV-TLVFLVLVSLTGLYA- ------------------------------------------------------------ --------------------------------IQKTPQIQVYSRHPPENGKPNILNCYVT QFHPPHIEIQMLKNG-KKIPKVEMSDMSFSKDWSFYILAHTEFTPTETDTYACRVKHASM AEPKTVYWDRDM------------------------------------------------ - >NP_036644.1 beta-2-microglobulin precursor [Rattus norvegicus] --------------------------------------MARSV-TVIFLVLVSLAVVLA- ------------------------------------------------------------ --------------------------------IQKTPQIQVYSRHPPENGKPNFLNCYVS QFHPPQIEIELLKNG-KKIPNIEMSDLSFSKDWSFYILAHTEFTPTETDVYACRVKHVTL KEPKTVTWDRDM------------------------------------------------ - >XP_024204735.1 beta-2-microglobulin isoform X1 [Pan troglodytes] --------------------------------------MSRSV-ALAVLALLSLSGLEA- ------------------------------------------------------------ --------------------------------IQRTPKIQVYSRHPAENGKSNFLNCYVS GFHPSDIEVDLLKNG-ERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTL SQPKIVKWGKSYI------LL--------------------------------------- - >NP_001009876.1 beta-2-microglobulin precursor [Felis catus] --------------------------------------MARFV-VLVLLGLLYLSHLDA- ------------------------------------------------------------ --------------------------------VQHSPKVQVYSRHPAENGKPNFLNCYVS GFHPPQIDITLMKNG-KKME-AEQTDLSFNRDWTFYLLVHTEFTPTVEDEYSCQVNHTTL SEPKVVKWDRDM------------------------------------------------ - >XP_009248064.1 beta-2-microglobulin isoform X1 [Pongo abelii] --------------------------------------MSRSV-ALAVLALLSLSGLEA- ------------------------------------------------------------ --------------------------------IQRTPKIQVYTRHPAENGKSNFLNCYVS GFHPSDIEVDLLKNG-VKIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTL SQPKTVKWGKSYI------LL--------------------------------------- - >XP_008267300.1 PREDICTED: beta-2-microglobulin [Oryctolagus cuniculus] --------------------------------------MSRSVLGLALLALVLFPCLEC- ------------------------------------------------------------ --------------------------------VQRAPNVQVYSRHPAENGKPNFLNCYVS GFHPPQIDIELLKNG-VKIENVEQSDLSFNKDWSFYLLVHTEFTPNDKDEYSCRVKHVTL KEPMTVKWDRDY------------------------------------------------ - >NP_001271408.1 beta-2-microglobulin precursor [Canis lupus familiaris] M------------------------------APRPALATAGFL-AL-LLILLAACRLDA- ------------------------------------------------------------ --------------------------------VQHPPKIQVYSRHPAENGKPNFLNCYVS GFHPPEIEIDLLKNG-KEMK-AEQTDLSFSKDWTFYLLVHTEFTPNEQDEFSCRVKHVTL SEPQIVKWDRDN------------------------------------------------ - >XP_008962050.1 beta-2-microglobulin isoform X1 [Pan paniscus] --------------------------------------MSRSV-ALAVLALLSLSGLEA- ------------------------------------------------------------ --------------------------------IQRTPKIQVYSRHPAENGKSNFLNCYVS GFHPSDIEVDLLKNG-ERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTL SQPKIVKWGKSYI------LL--------------------------------------- - >XP_018866136.1 beta-2-microglobulin isoform X1 [Gorilla gorilla gorilla] --------------------------------------MSRSV-ALAVLALLSLSGLEA- ------------------------------------------------------------ --------------------------------IQRTPKIQVYSRHPAENGKSNFLNCYVS GFHPSDIEVDLLKNG-ERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTL SQPKIVKWGKSYI------LL--------------------------------------- - >XP_005515552.2 beta-2-microglobulin [Columba livia] MTLRSSAPRLAAPDGVYKRRWLPQDGQAAGGAEREGA-MGLGP-KVGLLVLVALLGLGK- ------------------------------------------------------------ --------------------------------ANEAPKVEVYSRKIAALGQKNTLNCFVS GFHPPQIDITLLENG-EPMEGVQYADMSFDDKWFFQRLVYVPFTPQKGSTYECRVAHSTF REPQSFRWDPDF------------------------------------------------ - >XP_017909307.1 PREDICTED: beta-2-microglobulin [Capra hircus] --------------------------------------MAGFA-ALVLLGLLSLSGLDA- ------------------------------------------------------------ --------------------------------IQRIPEVQVYSRHPPEDGKPNYLNCYVY GFHPPQIEIDLLKNG-EKIK-SEQSDLSFSKDWSFYLLSHAEFTPNSKDQYSCRVNHVTL TQPKIVKWDRDL------------------------------------------------ - >XP_014455448.1 PREDICTED: beta-2-microglobulin [Alligator mississippiensis] M------------------------------ARAE---SFKTV-LILLVALVGLACVEA- ------------------------------------------------------------ --------------------------------TQRSPKVQVYTRYPLGSKESNFLNCYVE GFHPPKIDIKLLKNG-KEMDGVIVGDLSFSNDWTFQRLVYAPFAPNPNDVYSCRVNHDSL EQPKDVKWDPDN------------------------------------------------ - >XP_020952021.1 beta-2-microglobulin [Sus scrofa] --------------------------------------MAPLV-ALVLLGLLSLSGLDA- ------------------------------------------------------------ --------------------------------VARPPKVQVYSRHPAENGKPNYLNCYVS GFHPPQIEIDLLKNG-EKMN-AEQSDLSFSKDWSFYLLVHTEFTPNAVDQYSCRVKHVTL DKPKIVKWDRDH------------------------------------------------ -
BMGE Cleaned alignment of selected proteins >NP_004039.1 beta-2-microglobulin precursor [Homo sapiens] MSRSVALAVLALLSLSGLEATPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM >NP_001001750.2 beta-2-microglobulin precursor [Gallus gallus] MGKAAAVVLVTLVALLGLAQTPKVQVYSRFPASAGTKNVLNCFAAGFHPPKISITLMKDGVPMEGAQYSDMSFNDDWTFQRLVHADFTPSSGSTYACKVEHETLKEPQVYKWDPEF >XP_030295460.1 beta-2-microglobulin-like [Sparus aurata] MTTSVFAVVFGLLCLQCSMAPPKVQVYSRVPGEFGKANTLICHVSGFHPPEITIELLKDEKEMPGAKQTDLAFEENWHYHLSRHVRFTPSEDEKYACRVTH--MGTSKTFIWEADM >XP_004083039.1 beta-2-microglobulin [Oryzias latipes] MKGIVVTVVL-LVCVDLGVSAPKVQVYSRLPGTLGKENTLICHTSGFHPPEISIKLLKNGNELPGGGQTDLAFEESWHYHLTKHAPFTPEKGESYTCVVTH--TTGTKTYTWEPDV >AAA88837.1 beta-2-microglobulin [Pongo pygmaeus] MSRSVALAVLALLSLSGLEATPKIQVYTRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGVKIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKTVKWDRDM >XP_015810442.1 PREDICTED: beta-2-microglobulin-like [Nothobranchius furzeri] MKELVYVVAL-LFLTELISAEPQVQVYSRNPGQYDKSNVLICHVSGFHPPEIRVDLLKNGQEITAAKQTDLAFEEDWHYHMTKHVPFTPRTGDKFECRVSH--MGKTKHYFWEPDM >NP_001088585.1 uncharacterized protein LOC495464 precursor [Xenopus laevis] MSGVSVRVVSVLLTLSVCLSQPNVKIVNTKTLDLEHENLITCLVDGFFPSMIKVTWLKNGEEGEQVTSSELLQNGDWTFEIHVMLETTIKHGDTFTCRVEHSSLQQPVSVNWEPDV >ABP37878.1 beta-2-microglobulin [Ovis aries] MARFVALVLLGLLSLSGLDAIPEVQVYSRHPPEDGKPNYLNCYVYGFHPPQIEIDLLKNGEKIK-SEQSDLSFSKDWSFYLLSHAEFTPNSKDQYSCRVNHVTLTQPKIVKWDRDL >KAB0337810.1 hypothetical protein FD755_025462 [Muntiacus reevesi] MAGLAALVLLGLLSLSGLDAVPKVQVYSRHPPEDGKPNYLNCYVSGFHPPQIEIELLKNGEKMK-SEQSDLSFSKDWSFYLLSHAEFTPNSQDTYSCRVSHITYPGPQTFVWDRDL >XP_043328732.1 beta-2-microglobulin [Cervus canadensis] MARFAALVLLGLLSLSGLDAIPKVQVYSRHPPEDGKPNYLNCYVSGFHPPQIEIELLKNGEKMK-SEQSDLSFSKDWSFYLLSHAEFTPNSKDQYSCRVKHITFAEPQIYAWDRDL >KAB0342900.1 hypothetical protein FD754_019826 [Muntiacus muntjak] ------------MCLSGLYTVPKVQVYSRHPPEDGKPNYLNCYVSGFHPPQIEIELLKNGEKMK-SEQSDLSFSKDWSFYLLSHAEFTPNSKDKYSCRVSHVTFPGPQTFVWNRDL >NP_776318.1 beta-2-microglobulin precursor [Bos taurus] MARFVALVLLGLLSLSGLDAPPKIQVYSRHPPEDGKPNYLNCYVYGFHPPQIEIDLLKNGEKIK-SEQSDLSFSKDWSFYLLSHAEFTPNSKDQYSCRVKHVTLEQPRIVKWDRDL >P21612.1 RecName: Full=Beta-2-microglobulin [Meleagris gallopavo] --------------------TPKVQVYSRFPASAGTKNVLNCFAAGFHPPKISITLMKDGVPMEGAQYSDMSFNDDWSFQRLVYADFTPSSDAVYTCKVDHETLKEPQVYKWDPEF >tr|B0UYS1|B0UYS1_DANRE Beta-2-microglobulin OS=Danio rerio OX=7955 GN=b2m PE=2 SV=1 MRALITFALL-CLLYITVQGTPKVHVYSHFPGEYGKPNTLICYVSSFHPPDISIELLKNGQVMSDTKQTDLAFEKGWQFHLTKSVAFTPEKGDEYTCSVRH--MKETKKFSWEPNM >OWK09923.1 B2M [Cervus elaphus hippelaphus] MARFAALVLLGLLSLSGLDAIPKVQVYSRHPPEDGKPNYLNCYVSGFHPPQIEIELLKNGEKMK-SEQSDLSFSKDWSFYLLSHAEFTPNSKDQYSCRVKHITFAEPQIYAWDRDL >KAF4008216.1 hypothetical protein G4228_019883 [Cervus hanglu yarkandensis] MARFAALVLLGLLSLSGLDAIPKVQVYSRHPPEDGKPNYLNCYVSGFHPPQIEIELLKNGEKMK-SEQSDLSFSKDWSFYLLSHAEFTPNSKDQYSCRVKHITFAEPQIYAWGKFS >XP_020756417.1 beta-2-microglobulin [Odocoileus virginianus texanus] MPRLAALALLGLLSLSGLDAAPKIQVYSRHPPEDGKPNYLNCYVSGFHPPQIEIELLKNGEKMK-SEQSDLSFSKDWSFYLLSHAEFTPNSQDRYSCRVTHVTYPQPQEVNWDRNL >NP_033865.2 beta-2-microglobulin precursor [Mus musculus] MARSVTLVFLVLVSLTGLYATPQIQVYSRHPPENGKPNILNCYVTQFHPPHIEIQMLKNGKKIPKVEMSDMSFSKDWSFYILAHTEFTPTETDTYACRVKHASMAEPKTVYWDRDM >NP_036644.1 beta-2-microglobulin precursor [Rattus norvegicus] MARSVTVIFLVLVSLAVVLATPQIQVYSRHPPENGKPNFLNCYVSQFHPPQIEIELLKNGKKIPNIEMSDLSFSKDWSFYILAHTEFTPTETDVYACRVKHVTLKEPKTVTWDRDM >XP_024204735.1 beta-2-microglobulin isoform X1 [Pan troglodytes] MSRSVALAVLALLSLSGLEATPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWGKSY >NP_001009876.1 beta-2-microglobulin precursor [Felis catus] MARFVVLVLLGLLYLSHLDASPKVQVYSRHPAENGKPNFLNCYVSGFHPPQIDITLMKNGKKME-AEQTDLSFNRDWTFYLLVHTEFTPTVEDEYSCQVNHTTLSEPKVVKWDRDM >XP_009248064.1 beta-2-microglobulin isoform X1 [Pongo abelii] MSRSVALAVLALLSLSGLEATPKIQVYTRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGVKIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKTVKWGKSY >XP_008267300.1 PREDICTED: beta-2-microglobulin [Oryctolagus cuniculus] MSRSVGLALLALVLFPCLECAPNVQVYSRHPAENGKPNFLNCYVSGFHPPQIDIELLKNGVKIENVEQSDLSFNKDWSFYLLVHTEFTPNDKDEYSCRVKHVTLKEPMTVKWDRDY >NP_001271408.1 beta-2-microglobulin precursor [Canis lupus familiaris] TAGFLAL-LLILLAACRLDAPPKIQVYSRHPAENGKPNFLNCYVSGFHPPEIEIDLLKNGKEMK-AEQTDLSFSKDWTFYLLVHTEFTPNEQDEFSCRVKHVTLSEPQIVKWDRDN >XP_008962050.1 beta-2-microglobulin isoform X1 [Pan paniscus] MSRSVALAVLALLSLSGLEATPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWGKSY >XP_018866136.1 beta-2-microglobulin isoform X1 [Gorilla gorilla gorilla] MSRSVALAVLALLSLSGLEATPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWGKSY >XP_005515552.2 beta-2-microglobulin [Columba livia] MGLGPKVGLLVLVALLGLGKAPKVEVYSRKIAALGQKNTLNCFVSGFHPPQIDITLLENGEPMEGVQYADMSFDDKWFFQRLVYVPFTPQKGSTYECRVAHSTFREPQSFRWDPDF >XP_017909307.1 PREDICTED: beta-2-microglobulin [Capra hircus] MAGFAALVLLGLLSLSGLDAIPEVQVYSRHPPEDGKPNYLNCYVYGFHPPQIEIDLLKNGEKIK-SEQSDLSFSKDWSFYLLSHAEFTPNSKDQYSCRVNHVTLTQPKIVKWDRDL >XP_014455448.1 PREDICTED: beta-2-microglobulin [Alligator mississippiensis] SFKTVLILLVALVGLACVEASPKVQVYTRYPLGSKESNFLNCYVEGFHPPKIDIKLLKNGKEMDGVIVGDLSFSNDWTFQRLVYAPFAPNPNDVYSCRVNHDSLEQPKDVKWDPDN >XP_020952021.1 beta-2-microglobulin [Sus scrofa] MAPLVALVLLGLLSLSGLDAPPKVQVYSRHPAENGKPNYLNCYVSGFHPPQIEIDLLKNGEKMN-AEQSDLSFSKDWSFYLLVHTEFTPNAVDQYSCRVKHVTLDKPKIVKWDRDH
PhyML tree of selected proteins (XP_020952021_1_beta_2_microglobulin__Sus_scrofa_:0.07651926,(((XP_043328732_1_beta_2_microglobulin__Cervus_canadensis_:0.00000001,OWK09923_1_B2M__Cervus_elaphus_hippelaphus_:0.00000001):0.00000001,(KAF4008216_1_hypothetical_protein_G4228_019883__Cervus_hanglu_yarkandensis_:0.03848326,(KAB0342900_1_hypothetical_protein_FD754_019826__Muntiacus_muntjak_:0.07609732,(XP_020756417_1_beta_2_microglobulin__Odocoileus_virginianus_texanus_:0.12916314,KAB0337810_1_hypothetical_protein_FD755_025462__Muntiacus_reevesi_:0.01961985):0.02121464):0.09169634):0.00000001):0.08647564,(NP_776318_1_beta_2_microglobulin_precursor__Bos_taurus_:0.03175087,(XP_017909307_1_PREDICTED__beta_2_microglobulin__Capra_hircus_:0.01828791,ABP37878_1_beta_2_microglobulin__Ovis_aries_:0.00000001):0.028949):0.02995573):0.08378056,((XP_008267300_1_PREDICTED__beta_2_microglobulin__Oryctolagus_cuniculus_:0.2010012,((AAA88837_1_beta_2_microglobulin__Pongo_pygmaeus_:0.0179084,(NP_004039_1_beta_2_microglobulin_precursor__Homo_sapiens_:0.00000001,(XP_009248064_1_beta_2_microglobulin_isoform_X1__Pongo_abelii_:0.03569864,(XP_008962050_1_beta_2_microglobulin_isoform_X1__Pan_paniscus_:0.00000001,(XP_024204735_1_beta_2_microglobulin_isoform_X1__Pan_troglodytes_:0.00000001,XP_018866136_1_beta_2_microglobulin_isoform_X1__Gorilla_gorilla_gorilla_:0.00000001):0.00000001):0.00000001):0.03515311):0.01731204):0.13457527,(NP_033865_2_beta_2_microglobulin_precursor__Mus_musculus_:0.13337339,NP_036644_1_beta_2_microglobulin_precursor__Rattus_norvegicus_:0.07917302):0.21032303):0.0294579):0.08815779,(NP_001271408_1_beta_2_microglobulin_precursor__Canis_lupus_familiaris_:0.18966819,(NP_001009876_1_beta_2_microglobulin_precursor__Felis_catus_:0.1100504,((NP_001088585_1_uncharacterized_protein_LOC495464_precursor__Xenopus_laevis_:2.35944833,(XP_014455448_1_PREDICTED__beta_2_microglobulin__Alligator_mississippiensis_:0.57124953,(XP_005515552_2_beta_2_microglobulin__Columba_livia_:0.48040586,(P21612_1_RecName__Full_Beta_2_microglobulin__Meleagris_gallopavo_:0.07992771,NP_001001750_2_beta_2_microglobulin_precursor__Gallus_gallus_:0.00850849):0.24068094):0.40254251):0.11508816):0.1523789,(tr_B0UYS1_B0UYS1_DANRE_Beta_2_microglobulin_OS_Danio_rerio_OX_7955_GN_b2m_PE_2_SV_1:0.50437848,(XP_015810442_1_PREDICTED__beta_2_microglobulin_like__Nothobranchius_furzeri_:0.43731279,(XP_004083039_1_beta_2_microglobulin__Oryzias_latipes_:0.45816417,XP_030295460_1_beta_2_microglobulin_like__Sparus_aurata_:0.33157583):0.09071811):0.16653055):0.58896201):0.18437887):0.0637426):0.03574633):0.04648797);
BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)