PB0001
DATABASE


Click here to access PB0001 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0001 P02765 Alpha-2-HS-glycoprotein AHSG A2HS, AHS, APMR1, FETUA, HSGA Homo_sapiens Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions.

DomainsGene Ontology
PF00031 (Cystatin)
GO:0004866 (enables) endopeptidase inhibitor activity
GO:0004869 (enables) cysteine-type endopeptidase inhibitor activity
GO:0019210 (enables) kinase inhibitor activity
GO:0001501 (involved in) skeletal system development
GO:0001503 (involved in) ossification
GO:0006907 (involved in) pinocytosis
GO:0006953 (involved in) acute-phase response
GO:0010951 (involved in) negative regulation of endopeptidase activity
GO:0030500 (involved in) regulation of bone mineralization
GO:0030502 (involved in) negative regulation of bone mineralization
GO:0046627 (involved in) negative regulation of insulin receptor signaling pathway
GO:0050727 (involved in) regulation of inflammatory response
GO:0050766 (involved in) positive regulation of phagocytosis
GO:0031012 (is active in) extracellular matrix
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space
GO:0005788 (located in) endoplasmic reticulum lumen
GO:0005794 (located in) Golgi apparatus
GO:0031093 (located in) platelet alpha granule lumen
GO:0034774 (located in) secretory granule lumen
GO:0062023 (located in) collagen-containing extracellular matrix
GO:0070062 (located in) extracellular exosome
GO:0072562 (located in) blood microparticle

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences


Created by Puigbo and Nakamura @ University of Turku (2022)